Clinical trials: Deglutition Disorder
GERD
Pre- and Post-Therapy Evaluation of Air-Associated Symptoms in Patients With Gastro-esophageal Reflux Disease (GERD): Assessing the Role of Speech and Language Therapy
Patients with gastroesophageal reflux disease (GERD) may present with concomitant gas-related symptom (GRS) such as supragastric or gastric belching, and aerophagia.
- Trial name
- LAS (NCT07634614)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Prof Urs Zingg
Swallowing Function, Swallowing Risk
DDK Acoustic Analysis and Swallowing Indicators
This study examines whether simple speech tasks and a swallowing screening test can help identify swallowing risk in adults of different ages.
- Conditions
- Swallowing Function, Swallowing Risk, Dysphagia
- Trial name
- AAP-DDK (NCT07626749)
- Where
- Taiwan
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Gastroesophageal Reflux Disease, Erosive Esophagitis
Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets
The purpose of this study is to measure the in-vivo disintegration time of a single dexlansoprazole delayed-release orally disintegrating (OD) tablet.
- Conditions
- Gastroesophageal Reflux Disease, Erosive Esophagitis, Heartburn
- Trial name
- NCT02096458
- Testing
- Dexlansoprazole
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Takeda
Regurgitation, Gastric
Evaluation of the Tolerance and Safety of a New Partly Fermented Anti-regurgitation Infant Formula
A randomised, controlled, double-blind trial to evaluate the tolerance and safety of a new partly fermented anti-regurgitation infant formula containing prebiotics and locust bean gum in infants with regurgitation.
- Trial name
- Leopard (NCT03371615)
- Testing
- Anti-regurgitation infant formula
- Where
- 2 sites in Poland
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Deglutition Disorders, Dysphagia
Brief and Intensive Therapy for Dysphagia in Patients With Head and Neck Cancer
According to data in the literature, patients with head and neck cancer, who undergo combined treatment of radio-chemotherapy, have, to a greater or lesser extent, swallowing changes.
- Conditions
- Deglutition Disorders, Dysphagia, Head and Neck Cancer, Radiotherapy; Complications
- Trial name
- dysphagia (NCT03755921)
- Testing
- bried and intensive therapy
- Volunteers
- 20 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Achalasia
Mirabegron in Achalasia: A Clinical and Manometric Proof of Concept Pilot Study
This study evaluates whether a medication called mirabegron is better than placebo (sugar pill) in helping patients with achalasia swallow better.
- Trial name
- NCT03411252
- Testing
- Mirabegron 50 MG
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Thomas Jefferson University
Gastro Esophageal Reflux
Endoscopic Classification of Fundoplication Integrity Predicts Pathologic Reflux
This single-center, two-phase cohort study aimed to develop and validate a simple endoscopic classification of fundoplication integrity after anti-reflux surgery (ARS - Nissen or Toupet fundoplication).
- Trial name
- NCT07722663
- Where
- Italy
- Volunteers
- 153 people
- Sponsor
- IRCCS Policlinico S. Donato
Alzheimer Disease, Parkinson Disease
Telephone Call From Acute Care Physicians to Long Term Care Physicians: Impact on Transitional Care of Elderly Patients
A telephone call from a physician taking care of a patient in the hospital to a physician in the long term care setting at the time of discharge can improve transitional care for elderly patients.
- Conditions
- Alzheimer Disease, Parkinson Disease, Dysphagia
- Trial name
- NCT00281749
- Testing
- TELEPHONE CALL
- Where
- 2 sites in United States
- Sponsor
- Maimonides Medical Center
Thyroid Carcinoma
A Study Into the Effect of Seprafilm in Open Total Thyroidectomy
The investigators intend to determine the role of Seprafilm, a popular anti-adhesive agent in minimising internal adhesion formation in the neck after thyroid surgery and therefore reduce swallowing discomfort experienced by…
- Trial name
- NCT01865838
- Testing
- Seprafilm (Sanofi, USA)
- Where
- 2 sites in Singapore
- Volunteers
- 19 people
- Sponsor
- National Cancer Centre, Singapore
Dysphagia, Respiratory Tract Infections
Using Plain Water With Oral Care to Increase Hydration for Long Term Care Residents With Disordered Swallowing
The Frazier Free Water Protocol (FFWP) using plain, thin (unmodified) water is an accepted method to increase fluid intake and hydration in older adults with disordered swallowing and dementia.This study aims to take an…
- Trial name
- FFWP (NCT03672552)
- Testing
- FFWP and Improved Oral Care
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Memorial University of Newfoundland
Sleep Disorders, Non-Erosive Reflux Disease
Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders
The aim of the study was to evaluate the effect of pantoprazole on sleep disorders in patients with NERD (non-erosive reflux disease) or eGERD (erosive gastroesophageal reflux disease).
- Conditions
- Sleep Disorders, Non-Erosive Reflux Disease, Gastroesophageal Reflux Disease
- Trial name
- PANDA (NCT00830115)
- Testing
- Pantoprazole
- Where
- 201 sites in Germany
- Volunteers
- 1,045 people
- Sponsor
- Nycomed
Achalasia, Nutcracker Esophagus
Comparison of Esophageal and Anorectal Manometry Catheters
The primary objective of this study is to compare the accuracy of esophageal and anorectal manometric pressure measurements using a newly developed air filled balloon catheter with present standard solid state esophageal and…
- Conditions
- Achalasia, Nutcracker Esophagus, Scleroderma, Esophageal Spasm
- Trial name
- NCT00204763
- Testing
- Air filled balloon catheter, Solid state catheter
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Roux-en-y Anastomosis Site, Marginal Ulcer
Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment
The objective of the study is to investigate the treatment of marginal ulcers with Low Thermal plasma in an endoscopic setting. By a treatment of the ulcerated areas with argon plasma with low power settings (~ 1 W) we…
- Conditions
- Roux-en-y Anastomosis Site, Marginal Ulcer, Marginal Ulcer (Peptic) or Erosion, Ulcer
- Trial name
- AMULET (NCT06543316)
- Testing
- Low Thermal Plasma (LTP) Treatment, Standard of Care Ulcer Treatment (typically PPI Administration)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Dysphagia
The Effect of Food Taste, Temperature, and Viscosity on Swallowing Efficiency
The purpose of this study is to evaluate the effect of taste on swallowing efficiency, to evaluate the effect of temperature on swallowing efficiency, and to evaluate the effect of viscosity on swallowing efficiency.
- Trial name
- NCT01270204
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
GERD
Stretta Versus Conservative Treatment
Gastroesophageal reflux disease (GERD) is one of the most common diseases of the gastrointestinal tract. Obesity is a significant risk factor for GERD; however, treatment outcomes in obese patients remain challenging.
- Trial name
- NCT05781347
- Testing
- Radiofrequency Energy to the LES (Stretta Procedure), Stretta
- Where
- Czechia
- Volunteers
- 53 people
- Sponsor
- Military University Hospital, Prague
Valvular Heart Disease
The Bronx-Valve Registry
The Bronx-Valve Registry is designed to collect and assess data on all patients with valvular diseases referred to Montefiore Medical Center for echocardiographic exams.
- Trial name
- NCT05453526
- Where
- United States
- Volunteers
- 330,570 people
- Sponsor
- Montefiore Medical Center
Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy
Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy
The goal of this observational study is to learn whether bile acids and pepsin in saliva can help identify adults at higher risk of developing reflux-related esophageal disease after sleeve gastrectomy, including Los Angeles…
- Conditions
- Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy, Saliva Collection, Reflux Esophagitis (RE)
- Trial name
- ABSORB (NCT07607067)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Deglutition Disorders, Rehabilitation
Effectiveness of Video-game Based Swallowing Function Training in Patients With Dysphagia
The goal of this clinical trial is to investigate the effect of video-game on swallowing function in patients with dysphagia through a randomized controlled trial and whether it has additional benefits in improving swallowing…
- Conditions
- Deglutition Disorders, Rehabilitation, Video Game
- Trial name
- NCT05978700
- Testing
- Video-game, Conventional therapy
- Where
- China
- Volunteers
- 84 people
- Sponsor
- ZHANG Bohan
Bile Reflux
Omega Loop Gastric Bypass With And Without Anti-Reflux Sutures
This proposed trial is designed to answer the following questions: First, is biliary reflux to the distal esophagus present before OLGB and does it increase after the procedure? Second, does performing an OLGB with or without…
- Trial name
- NCT03097887
- Testing
- Omega Loop Gastric Bypass, Bilitec 2000™, V-Loc
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Cervical Spine Fusion
Measuring Dysphagia After ACDF Surgery Through A Novel Wearable Sensor
The purpose of this study is to assess the function and reliability of a noninvasive, skin-like electronic sensor. The investigators hypothesize that this skin sensor will address an unmet need to wirelessly and noninvasively…
- Trial name
- NCT04921800
- Testing
- Anterior Cervical Discectomy & Fusion, Application of ADAM mechanoacoustic skin sensor
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Northwestern University
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