Clinical trials: Delayed Cerebral Ischemia
Organ Transplantation
Remote Ischemic Preconditioning in Neurological Death Organ Donors
The purpose of this study is to determine whether application of lower limb remote ischemic preconditioning (RIPC) after determination of brain death improves donor stability, organ quality, organ yield, and early post transplant…
- Trial name
- RIPNOD (NCT01515072)
- Testing
- RIPC (Remote Ischemic Preconditioning)
- Where
- 2 sites in United States
- Volunteers
- 321 people
- Sponsor
- Rutgers, The State University of New Jersey
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral, Endothelial Dysfunction
- Trial name
- SUSHI (NCT03318783)
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Aneurysmal Subarachnoid Hemorrhage
Clinical Research Study With Clazosentan to Evaluate Its Effects on Preventing Complications Due to the Narrowing of the Blood Vessels (Vasospasm) in the Brain, Caused by Bleeding Onto the Surface of the Brain
This study will evaluate if clazosentan (on top of normal routine medical care) can reduce the risk of developing complications related to cerebral vasospasm and permanent brain damage as compared to normal routine medical care…
- Trial name
- REACT (NCT03585270)
- Testing
- Clazosentan
- Where
- 80 sites in United States, Austria and 13 more
- Volunteers
- 409 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Cerebral Aneurysm, Stroke
Variability in Transcranial Doppler Technique in Neuro-Critical Care Patients
This study aims to determine the inter- and intra-variability of Transcranial Doppler (TCD) ultrasound in neuro-critical care patients who are planned for consecutive daily TCD evaluations.
- Conditions
- Cerebral Aneurysm, Stroke, Vasospasm, Cerebral, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- NCT04583163
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Hackensack Meridian Health
Subarachnoid Hemorrhage
Preconditioning for Aneurismal Subarachnoid Hemorrhage
In remote preconditioning, ischemia in one organ protects distant organs from ischemic insults. e.g. brief induced limb ischemia protects the brain from an otherwise more severe stroke.
- Trial name
- NCT01110239
- Testing
- remote limb preconditioning
- Volunteers
- 34 people
- Sponsor
- University of Miami