Clinical trials: Delayed Emergence From Anesthesia
Postoperative Pulmonary Complications
Influence of Neostigmine vs. Sugammadex on PORC and PPCs by Ultrasonography
This trial aims to compare the incidence of postoperative residual curarisation (PORC) and postoperative pulmonary complications (PPCs) in the SUG and NEO group by means of diaphragm ultrasonography and LUS, so as to conclude…
- Trial name
- NCT05040490
- Testing
- sugammadex as reversal drugs
- Volunteers
- 414 people
- Sponsor
- Peking Union Medical College Hospital
Residual Neuromuscular Blockade
Predictor of Residual Neuromuscular Blockade in Recovery Room After General Anesthesia
Background When general anesthesia was performed, neuromuscular blocking agents (NMBAs) are frequently used for facilitate tracheal intubation and keep patient still and relax during surgery.
- Trial name
- NCT02146859
- Where
- Thailand
- Volunteers
- 222 people
- Sponsor
- Mahidol University
Neuromuscular Blockade, Cholecystectomy
Acceleromyography Versus Electromyography for Neuromuscular Recovery Assessment at the End of Surgery
This prospective observational study aims to evaluate the agreement between acceleromyography and electromyography for measuring train-of-four (TOF) ratio at the end of surgery before reversal of neuromuscular blockade.
- Trial name
- NCT07739862
- Testing
- Simultaneous Acceleromyography and Electromyography Monitoring
- Where
- Chile
- Volunteers
- 70 people
- Sponsor
- Clínica Dávila
Delayed Emergence From Anesthesia
Propofol-Ketamine vs Remifentanyl-Ketamine for Sedation in Pediatric Patients Undergoing Colonoscopy
Ketamine and propofol have been used most frequently agents and remifentanil is used with increasing frequency in recent years. Investigators will compare ketamine-propofol and ketamine-remifentanyl effects on drug consumption…
- Trial name
- NCT02602743
- Testing
- Remifentanyl, Propofol, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Anesthesia, Intravenous, Pain, Postoperative
Virtual Reality in the Operating Room
This is a randomized, controlled trial designed to investigate whether the use of virtual reality immersive relaxation during hand/arm operations can allow for a relaxing operating room experience for patients while potentially…
- Conditions
- Anesthesia, Intravenous, Pain, Postoperative, Delayed Recovery From Anesthesia, Satisfaction
- Trial name
- OR-VR (NCT03614325)
- Testing
- Virtual Reality Immersive Relaxation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders
Ramelteon in the Prevention of Post-operative Delirium
This trial focuses on a Phase II randomized masked clinical trial testing the effectiveness and safety of peri-operative administration of ramelteon, a melatonin agonist in the prevention of postoperative delirium.
- Conditions
- Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders, Delayed Emergence From Anesthesia, Cognitive Disorders
- Trial name
- RECOVER (NCT02324153)
- Testing
- Ramelteon, Microcrystalline Cellulose, Riboflavin 100 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Delayed Emergence From Anesthesia
Effect of Calling the Patient's Name on Recovery From General Anesthesia
The purpose of this study is to find if we can shorten the recovery time by calling the patient's name during anesthesia reversal.
- Trial name
- NCT02149745
- Testing
- Calling the patient's name, Not calling the patient's name
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Seoul National University Hospital
Delayed Emergence From Anesthesia
General Anesthesia Emergence Induced by Methylphenidate
The purpose of this study is to assess whether methylphenidate affects time of emergence from isoflurane general anesthesia. Time to emergence was defined as the time from termination of isoflurane to extubation.
- Trial name
- MPOrtho (NCT02327195)
- Testing
- Methylphenidate HCl
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Nicoleta Stoicea
Residual Neuromuscular Blockade
Electromyographic Assessment of Onset and Recovery of Neuromuscular Blockade
Residual neuromuscular blockade (weakness) is a common occurrence in the postanesthesia care unit when muscle relaxant drugs have been used in the operating room.
- Trial name
- NCT01678625
- Testing
- Train-of-four ratio calculation (T4-EMG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Endeavor Health
Tachycardia, Hypertension
To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU.
The goal of this clinical trial is to to observe the haemodynamic parameters including Heart Rate Blood pressure Respiratory rate and Oxygen Saturation with or without giving reversal agent on extubation in patients receiving…
- Conditions
- Tachycardia, Hypertension, Hypoxia, Hyperventilation
- Trial name
- NCT07097441
- Testing
- neostigmine (reversal agent)
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ziauddin University
Postoperative Residual Curarization
Postoperative Residual Curarization in 2018
The primary objective of this study is to evaluate the incidence of postoperative residual curarization, as defined by a train-of-four <90%, upon postanaesthesia care unit arrival.
- Trial name
- NCT03665805
- Testing
- neuromuscular transmission monitoring
- Where
- Belgium
- Volunteers
- 587 people
- Sponsor
- Onze Lieve Vrouw Hospital
Residual Neuromuscular Blockade
Incidence of Postoperative Neuromuscular Blockade in Post-Anesthesia Care Unit at Parkland Hospital: Does Size Matter?
This prospective, observational study will assess 100 subjects in the post-anesthesia care unit (PACU) at Parkland Hospital. Upon arrival to the PACU, patients' train-of-four (TOF) ratio will be calculated using the StimPod…
- Trial name
- NCT03111082
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Texas Southwestern Medical Center
Postoperative Residual Curarization
Muscle Relaxants and Post-Anesthesia Complications
This Germany-wide, multi-center, epidemiologic study is designed to evaluate the incidence of post-operative/anesthesia effects of muscle relaxants (i.e.
- Trial name
- PORC (NCT00753389)
- Testing
- None (anesthesia)
- Where
- Germany
- Volunteers
- 20,000 people
- Sponsor
- Technical University of Munich
Neuromuscular Blockade, Neuromuscular Blockade, Residual
A Comparison of Rocuronium 0.3 mg/kg, and 0.9 mg/kg for Induction of Anesthesia in Elderly Patients.
The number of elderly patients above 80 years is increasing and a large proportion of these patients will require surgery and anesthesia.
- Conditions
- Neuromuscular Blockade, Neuromuscular Blockade, Residual, Anesthesia, Intubation Complication
- Trial name
- NCT04512313
- Testing
- Rocuronium 0,3mg/kg, Rocuronium 0,9mg/kg
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
Comparison of Sugammadex and Sugammadex-neostigmine Combination in the Antagonism of Moderate Neuromuscular Block
In this prospective randomized controlled study the investigators compare the sugammadex-neostigmine combination and single dose sugammadex in terms of side effects and cost for the antagonism of moderate neuromuscular block…
- Trial name
- NCT05228223
- Testing
- Neuromuscular monitoring, reverse of NMB with sugammadex, reverse of NMB with Sugammadex and neostigmin low dose
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Delayed Emergence From Anesthesia, Postoperative Delirium
Trajectory of Recovery in the Elderly
The purpose of this study is to understand how elderly individuals regain their cognitive skills following general anesthesia. The investigators will compare an age stratified group of volunteers who will be evaluated with a…
- Conditions
- Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- TORIE (NCT02275026)
- Testing
- Functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obstructive Sleep Apnea, Delayed Emergence From Anesthesia
Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea
The purpose of this study is to determine whether modafinil use in patients with obstructive sleep apnea will improve postoperative delayed emergence after general anesthesia.
- Trial name
- ModOSA (NCT02494102)
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Milton S. Hershey Medical Center
Neuromuscular Blockade
Comparison of Mechanomyographic 100 Versus 200 Hz 5 Second Tetanic Fade Ratios During Neuromuscular Block Recovery
Two recent pilot studies suggested the potential interest of 100 and 200 Hz tetanic stimulations to detect with mechanomyography (MMG) very low levels of residual neuromuscular blockade (NMB).
- Trial name
- NCT05474638
- Testing
- Isometric Thumb Force (isometric mechanomyography) compared to TOF-Watch SX (acceleromyography)
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire UCLouvain Namur
Delayed Emergence From Anesthesia
Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index.
Bispectral monitoring anesthesia with remifentanil-desflurane has a better post-operative recovery than remifentanil-propofol.
- Trial name
- NCT02631525
- Testing
- Desflurane, Propofol
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Postoperative Residual Curarization, Neuromuscular Block
Reversal With Low Doses of Sugammadex in Patients Undergoing Non-cardiac Surgery
Neuromuscular blocking agents (NMBA) are among the most commonly used drugs during general anesthesia and may induce complete muscle paralysis.They are used clinically to facilitate endotracheal intubation and to optimize…
- Trial name
- NCT03460509
- Testing
- Sugammadex
- Volunteers
- 144 people
- Sponsor
- The Hospital of Vestfold