Clinical trials: Delirium, completed
Anxiety
Prognosis of Anxiety in Intensive Care Unit
Anxiety is commonly considered as an epiphenomenon of the cognitive and emotional response to a threat. Anxiety is a consequence of the reciprocal interaction between stress and the neuroendocrine, autonomic and immune systems.
- Trial name
- PAN-ICU (NCT02355626)
- Where
- France
- Volunteers
- 391 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Complications, Delirium
Donepezil in Preventing Delirium in Hospitalized Elderly
The purpose of this study is to explore the efficacy of a perioperative daily dose of Donepezil (a cholinergic enhancer) in reducing the incidence and severity of delirium.
- Trial name
- NCT00182884
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University Health
Delirium, Cognitive Impairment
Effects of a Dementia-friendly Program
Frail older persons with cognitive impairment are at special risk of experiencing delirium during acute hospitalisation. The purpose of this study was to investigate whether a dementia-friendly hospital program contributes to…
- Conditions
- Delirium, Cognitive Impairment, Dementia
- Trial name
- NCT04737733
- Testing
- The dementia friendly program
- Where
- Norway
- Volunteers
- 423 people
- Sponsor
- University Hospital, Akershus
Postoperative Delirium
Validation of the Greek Version of the Confusion Assessment Method Diagnostic Algorithm (CAM) and the Nursing Delirium Screening Scale (Nu-DESC) and Their Inter-rater Reliablity
This study attempts to validate the Greek version of the CAM Diagnostic Algorithm and Nu-DESC in patients undergoing surgery under general anesthesia.
- Trial name
- NCT04154176
- Testing
- CAM, Nu-DESC
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Thessaly
Ischemic Stroke
Post-stroke Delirium in Ischemic Stroke Patients
This study is to investigate the predictors of post-stroke delirium, develop and validate a nomogram of post-stroke delirium in the ischemic stroke patients.
- Trial name
- NCT06005636
- Testing
- Test delirium state
- Where
- China
- Volunteers
- 985 people
- Sponsor
- Jinan University Guangzhou
Post-operative Pain, Post-operative Delirium
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
The goal of this clinical trial is to assess whether the use of intermittent superficial parasternal intercostal plane blocks reduces opioid usage in patients undergoing cardiac surgery with median sternotomy.
- Conditions
- Post-operative Pain, Post-operative Delirium, Post-cardiac Surgery, Chronic Pain
- Trial name
- EPOCH (NCT06028126)
- Testing
- Intermittent Superficial Parasternal Intercostal Plane Block - Experimental
- Where
- 4 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Emergence Agitation
Preemptive Intravenous Micro-dose Dexmedetomidine to Prevent Emergence Agitation in Adult Patients Undergoing Septoplasty Surgeries
This prospective randomized controlled study will be conducted to evaluate the effect of preoperative single, micro-dose of dexmedetomidine (0.3μg/kg) on the incidence and severity of EA in adults undergoing Septoplasty surgeries
- Trial name
- NCT07302815
- Testing
- Dexmedetomidine, Saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Emergence Delirium
Decreasing Emergence Delirium With Personalized Music
This is a prospective randomized controlled trial in children 3-9 years of age undergoing myringotomies at Washington University in St.
- Trial name
- DEAP Music (NCT06236477)
- Testing
- Personalized Music, No Music
- Where
- United States
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Delirium, Psychomotor Agitation
Acupuncture for the Prevention of Emergence Delirium in Children Undergoing Myringotomy Tube Placement
Myringotomy tube placement is one of the most commonly performed operations in children. Emergence delirium after such procedures is common.
- Trial name
- NCT02383004
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Analgesia, Critical Illness
Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study
The aim of this prospective, randomized, active control, double blinded study is to assess the effect and safety of continuous infusion nefopam in mechanically ventilated ICU patients compared to standard of care.
- Conditions
- Analgesia, Critical Illness, Mechanical Ventilation, Sedation
- Trial name
- NCT05071352
- Testing
- Nefopam, Standard of care in the ICU for assessment and management of pain, sedation, and delirium.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Alcoholism, Alcohol Related Disorders
Laboratory Studies on Oxytocin for Treatment of Alcohol Use Disorder
This study will examine the utility of the neuropeptide oxytocin (OT) as a potential new medication for the treatment of Alcohol use disorder (AUD).
- Trial name
- NCT02407340
- Testing
- oxytocin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Impaired Cognition, Quality of Life
The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery
The primary aim of this study is to establish if it is possible for patients who have undergone major body surgery to complete a home based exercise training program and complete the assessments required to measure physical and…
- Conditions
- Impaired Cognition, Quality of Life, Surgery, Delirium
- Trial name
- POETold (NCT03064308)
- Testing
- Exercise Programme
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Nottingham
Depth of Anaesthesia, EEG
EEG Monitoring Under Anaesthesia in Children: Towards Personalized Anaesthesia Care
Electroencephalographic recordings (EEG) present an opportunity to monitor changes in human brain electrical activity during changing states of consciousness during general anesthesia.
- Conditions
- Depth of Anaesthesia, EEG, Anesthesia Emergence Delirium
- Trial name
- EEGPAC (NCT04103138)
- Testing
- Sedline EEG sensor placement, Sedline EEG monitoring
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- KK Women's and Children's Hospital
Emergence Agitation
Emergence Agitation in Pediatric Strabismus Surgery
This study was performed to assess the effects of continuous remifentanil infusion and single bolus administration of fentanyl on the incidence of emergence agitation in pediatrics undergoing strabismus surgery.
- Trial name
- NCT03807011
- Testing
- fentanyl group, remifentanil group
- Where
- 2 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Yeungnam University College of Medicine
Intensive Care Unit Delirium
Impact of Aromatherapy on the Delirium of Patients in Intensive Care Unit
The primary objective of this monocenter randomized controlled trial is to assess the efficacy of aromatherapy to prevent delirium in patients hospitalized in an intensive care unit.
- Trial name
- AROMADELI (NCT04529395)
- Testing
- Blending of essential oils, Apricot vegetable oil
- Where
- France
- Volunteers
- 161 people
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Postoperative Delirium
Postoperative Delirium - European Society of Anaesthesiology Survey
The ESA is currently preparing a guideline on the management of postoperative delirium (POD), which attempts to reduce the impact of postoperative delirium and provide recommendations for prevention, diagnostics and treatment of…
- Trial name
- NCT02513537
- Where
- 4 sites in Germany, Italy and 2 more
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Critically Ill Adult Patients in Intensive Care Units
Effects of Patient-Directed Interactive Music Therapy on Sleep, Delirium and Melatonin Levels is Critically Ill Elderly Patients
(Background) Adults in intensive care units (ICU), especially elderly patients often suffer from a lack of sleep or frequent sleep disruptions due to physical, emotional stress such as pain, inflammation, and anxiety.
- Trial name
- NCT03156205
- Testing
- interactive music therapy, passive music listening, passive earphone-use
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Yonsei University
Specified Sedative, Hypnotic
Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric
The purpose of this study is to investigate the effect of diphenhydramine on the prevention of sevoflurane induced emergence delirium/ agitation in pediatrics.
- Trial name
- NCT02463929
- Testing
- Diphenhydramine, normal saline, Ketamine
- Volunteers
- 50 people
- Sponsor
- Universitas Diponegoro
Sleep Quality of Patients Undergoing TURP
Postoperative Sleep Quality of Patients Sedation With i.v. Dexmedetomidine or Midazolam Undergoing TURP
The investigators designed a study to determine whether dexmedetomidine versus midazolam combined with spinal anesthesia would provide same postoperative sleep quality in patients undergoing transurethral prostatic resection.
- Trial name
- NCT02142595
- Testing
- dexmedetomidine, Midazolam
- Where
- China
- Volunteers
- 111 people
- Sponsor
- China Medical University, China
Postoperative Delirium (POD)
The Impact of Methylprednisolone Sodium Succinate on Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgery: A Target Trial Emulation Study
Glucocorticoids can be used to inhibit postoperative systemic inflammatory response syndrome. They may reduce the risk of major complications and mortality.
- Trial name
- NCT07271394
- Testing
- Administration of methylprednisolone sodium succinate during general anesthesia induction, No administration of methylprednisolone sodium succinate during general anesthesia induction
- Where
- China
- Volunteers
- 25,800 people
- Sponsor
- Chinese PLA General Hospital