Clinical trials: Delirium, completed
Hip Fractures, Hip Arthropathy
Optimizing Cerebral Autoregulation During Surgery
The purpose of this study is to conduct a pilot trial to determine the feasibility, safety, and potential efficacy of targeting mean arterial blood pressure (MAP) within the limits of cerebral autoregulation during surgery…
- Conditions
- Hip Fractures, Hip Arthropathy, Surgery, Delirium
- Trial name
- NCT05308290
- Testing
- Blood pressure management according to cerebral autoregulation, Blood pressure management according to usual care
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Delirium
Dexmedetomidine Versus Morphine and Midazolam in Prevention and Treatment of Delirium After Adult Cardiac Surgery
This randomized double-blind parallel clinical study was conducted on 60 patients undergoing elective cardiac surgery under general anesthesia, at least 60 yr old, ASA I and II, 70-100 kg body weight and height 160-180 cm.
- Trial name
- NCT03078946
- Testing
- Dexmedetomidine Hydrochloride, Morphine and Midazolam
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Postoperative Pain, Preoperative Anxiety
Relationship Between Preoperative Anxiety, Postoperative Pain, and Emergence Delirium in Pediatric Surgery
The goal of this observational study is to learn if preoperative anxiety levels can predict the quality of early postoperative recovery, pain intensity, and the occurrence of emergence delirium in pediatric patients aged 2 to 7…
- Conditions
- Postoperative Pain, Preoperative Anxiety, Emergence Delirium in Pediatric Anesthesia, Urogenital Diseases
- Trial name
- NCT07343388
- Testing
- Standardized Perioperative Management and Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Aydin Adnan Menderes University
Salivary Alpha-amylase, Delirium
Perioperative Salivary Alpha-amylase as a Predictor of Delirium After Lower Extremity Vascular Bypass Surgery
The aim of this study is to evaluate the role of salivary Alpha-amylase as a predictor biomarker of POD in elderly patients undergoing limb bypass surgery.
- Conditions
- Salivary Alpha-amylase, Delirium, Lower Extremity, Vascular Bypass Surgery
- Trial name
- NCT06242275
- Testing
- Salivary Alpha-amylase
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Delirium
Influence of Apelin Levels on Postoperative Cognitive Disorders After Orthopedic Surgery in Elderlies (APOCOGNIT)
No successful strategy is proposed to patients submitted to important surgery to reduce the incidence of postoperative cognitive disorders (POCD) onset.
- Trial name
- APOCOGNIT (NCT02574234)
- Testing
- Determination of apelin and inflammatory cytokines, Assessment of cognitive functions, Liquid sampling cerebrospinal
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Toulouse
Delirium, Ischemic Stroke
White Cell Ratios as Markers of Delirium and Outcome in Acute Ischemic Stroke.
The aim of this study was to investigate the role of Neutrophil-to-Lymphocyte Ratio (NLR) and other derived white cell markers as early markers of delirium and outcome after acute ischemic stroke (AIS).
- Trial name
- DELIAS (NCT03944694)
- Testing
- Delirium assessment.
- Volunteers
- 1,001 people
- Sponsor
- Pomeranian Medical University Szczecin
Anesthesia, Delirium
Anesthesia Depth Increases the Degree of Postoperative Dementia, Delirium, and Cognitive Dysfunction
Anesthetics and anesthesia are suspicious to induce dementia or aggravate preexistent cognitive deficits with or without evoking postoperative delirium.
- Conditions
- Anesthesia, Delirium, Dementia, Bispectral Index Monitor
- Trial name
- BIS & Dementia (NCT02382445)
- Testing
- Anesthesia depth monitor, propofol and sevoflurane
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- Heidelberg University
Agitation, Anesthesia
Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children
Emergence delirium (ED) from general anesthesia posts risk and harm to pediatric population undergo general anesthesia. The purpose of the study is to compare the use of dexmedetomidine versus placebo in reducing the incidence…
- Conditions
- Agitation, Anesthesia, Pediatrics
- Trial name
- DexPeds (NCT00857727)
- Testing
- Dexmedetomidine, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Hip Arthroplasty, Postoperative Pain
Comparison of Pericapsular Nerve Group+ Lateral Femoral Cutaneous Nerve Block Versus Lumbar Erector Spinae Plane Block in Hip Arthroplasty Surgery
Hip replacement surgery (partial or total hip arthroplasty) is commonly performed in elderly patients and is associated with significant postoperative pain.
- Conditions
- Hip Arthroplasty, Postoperative Pain, Hip Fractures, Postoperative Delirium (POD)
- Trial name
- NCT07445009
- Testing
- PENG + LFCN Block, PENG + Lumbar ESP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Delirium, Fall Injury
Care.Coach Avatars for Improvement of Outcomes in Hospitalized Elders, Including Mitigation of Falls and Delirium: a Multi-Site Clinical Study
Through NINR project 1R44NR017842-01 which preceded the present study, the investigators enhanced the care.coach avatar platform to incorporate a robust suite of evidence-based protocols based on the Hospital Elder Life Program…
- Trial name
- AvatarHELP (NCT03832192)
- Testing
- care.coach Avatar (HELP-Protocolized)
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Victor Wang
Delirium on Emergence, Elderly
Music Timing for Emergence Delirium in Elderly
Emergence delirium (ED) after general anesthesia prolongs recovery, increases complications, and adds to nursing workload in elderly patients.
- Conditions
- Delirium on Emergence, Elderly, Satisfaction, Patient
- Trial name
- NCT06970249
- Testing
- Music intervention
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Wonkwang University Hospital
Cerebrovascular Circulation
NIRS vs TCD for Cerebrovascular Autoregulation During Non-cardiac Surgery
Postoperative neurocognitive disorders (NCD) are of high priority in perioperative management. The risk of suffering from NCD after surgery may be increased due to perioperative impairment of cerebrovascular autoregulation and…
- Trial name
- SONICA (NCT04978558)
- Testing
- Continuous assessment of cerebrovascular autoregulation with NIRS and TCD
- Where
- Germany
- Volunteers
- 509 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Complications, Delirium
Donepezil in the Prevention of Post-Operative Cognitive Decline
The purpose of this study is to evaluate the feasibility of using Donepezil to prevent post-operative cognitive decline (POCD) among individuals aged 65 and older who have a baseline mild cognitive impairment (MCI) and are…
- Trial name
- NCT00182845
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pfizer
Hypotension During Surgery
Controlled Hypotension in Rhinoplasty and Septoplasty: Incidence of Cognitive Dysfunction and Delirium
Controlled hypotension application is a commonly preferred anesthesia practice during surgical procedures, particularly in regions with rich tissue perfusion, aiming to reduce bleeding, enhance surgical field visibility, and…
- Trial name
- NCT06238973
- Testing
- Group Low, Group Middle
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hitit University
Lower Extremity Problem, Delirium
Intraoperative Sedatives and Postoperative Deilirium
Delirium occurs commonly in elderly patients. Its incidence after orthopedic surgery has been reported to be 5-61%. Delirium is classified into three sub-types: Hypoactive, hyperactive, and mixed.
- Conditions
- Lower Extremity Problem, Delirium, Propofol, Dexmedetomidine
- Trial name
- NCT03251651
- Testing
- Propofol, Dexmedetomidine
- Where
- South Korea
- Volunteers
- 748 people
- Sponsor
- Seoul National University Bundang Hospital
Alzheimer's Type Dementia
A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe Alzheimer's Disease
The objective is to demonstrate that donepezil hydrochloride 10 mg/day has superior efficacy compared with placebo in cognitive function in Chinese subjects with severe Alzheimer's Disease.
- Trial name
- NCT01404169
- Testing
- E2020
- Where
- 32 sites in China
- Volunteers
- 260 people
- Sponsor
- Eisai Limited
Pain, Agitation on Recovery From Sedation
Assessment and Management of Pain, Agitation, Delirium and Sleep Deprivation (PADS) in ICU by PADS Protocol, Thailand
The investigators proposed that pain, agitation, delirium and sleep deprivation protocol (PADS) will help improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free…
- Conditions
- Pain, Agitation on Recovery From Sedation, Delirium
- Trial name
- NCT04270331
- Testing
- PADS protocol
- Where
- Thailand
- Volunteers
- 509 people
- Sponsor
- Mahidol University
Postoperative Delirium
Association of Plasma Biomarkers for Neurological Injury and Postoperative Delirium After Cardiac Surgery
Delirium is one of the most common complications after cardiac surgeries, incidence of which is 20~70%. Causes and pathophysiology of delirium has not been elucidated yet, however, inflammatory response of the nervous system…
- Trial name
- NCT04194411
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Yonsei University
Sternotomy, Postoperative Delirium
Comparison of the Postoperative Analgesic Effectiveness of Erector Spinae Plane Block Versus Its Combination With Superficial Parasternal Intercostal Plane Block Within the ERACS Program
This prospective, randomized, double-blind, parallel-group clinical trial within the Enhanced Recovery After Cardiac Surgery (ERACS) program compares postoperative analgesic effectiveness of bilateral erector spinae plane (ESP)…
- Conditions
- Sternotomy, Postoperative Delirium, Postoperative Pain Management
- Trial name
- ERACS-ESP-SPIP (NCT07304635)
- Testing
- Procedure: Erector Spinae Plane (ESP) Block, Erector Spinae Plane (ESP) Block + Superficial Parasternal Intercostal Plane (SPIP) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara University
Neurological Injury, Stroke
Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms.
The objective of this study is to investigate the value of employing the aortic no-touch off-pump coronary artery bypass technique and the practice of carbon dioxide surgical field flooding for the prevention of type 1 and 2…
- Conditions
- Neurological Injury, Stroke, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- CANON (NCT03074604)
- Testing
- aortic no-touch OPCABG, OPCABG with partial clamp applying carbon dioxide, OPCABG with partial clamp
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Collegium Medicum w Bydgoszczy