Clinical trials: Delirium, completed
Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients.
- Conditions
- Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
- Trial name
- NCT07649876
- Testing
- Virtual reality (VR) therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Silent Stroke, Cognitive Decline
Detection and Neurological Impact of Cerebrovascular Events in Cardiac Surgery Patients
The investigators conducted a prospective observational pilot study to explore the incidence of peri-operative covert strokes (detected by brain MRI) and the potential impact on delirium and cognitive decline in post-operative…
- Trial name
- NCT04241289
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Population Health Research Institute
Major Depressive Disorder, Catatonia
Clonidine to Prevent Delirium After Electroconvulsive Therapy.
Electroconvulsive therapy (ECT) is a highly effective treatment for some psychiatric disorders like major depressive or bipolar disorder, but may lead to agitation and delirium after the procedure in up to 65% of patients.
- Conditions
- Major Depressive Disorder, Catatonia, Bipolar Disorder, Delirium Postseizure
- Trial name
- ECaTa (NCT04828226)
- Testing
- Clonidine
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Dementia, Depression
3D Team Care for Cognitively Vulnerable Older Adults
This study addresses how to achieve better outcomes for cognitively vulnerable community-dwelling older adults and their families.
- Conditions
- Dementia, Depression, Delirium
- Trial name
- NCT02945085
- Testing
- Home Based Care Team, Telephone Based Care Team
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- UConn Health
General Anesthetic Drug Adverse Reaction
Effect of Remimazolam on Postoperative Delirium
Remimazolam is a novel benzodiazepine with ultra-short onset and offset of its effect. It can be used for general anesthesia. However, classical benzodiazepine such as midazolam was reported to increase the risk of postoperative…
- Trial name
- RED (NCT06180876)
- Testing
- remimazolam, propofol
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Zhihong LU
Postoperative Cognitive Dysfunction, Postoperative Delirium
Study of Prevention of Postoperative Delirum to Reduce Incidence of Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction describes a condition where cognitive functions such as attention, perception, concentration, learning, abstract thinking and problem solving are impaired postoperatively.
- Trial name
- DelPOCD (NCT03060174)
- Testing
- monitoring and non-medical prophylaxis of delirium
- Where
- Germany
- Volunteers
- 638 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Older Patients, Nasal Administration
Dexmedetomidine-esketamine Combined Nasal Administration and Emergence Delirium
Emergence delirium is common in older patients after surgery and associated with worse perioperative outcomes, including increased postoperative delirium.
- Conditions
- Older Patients, Nasal Administration, Dexmedetomidine, Esketamine
- Trial name
- NCT06566469
- Testing
- Dexmedetomidine, Esketamine, Normal saline
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Peking University First Hospital
Delirium, Intensive Care Unit Syndrome
Delirium at the Intensive Care Unit - a Retrospective Cohort Study
This project seeks to describe the incidence of delirium in the Intensive Care Unit (ICU) and to identify risk and preventive factors associated with development of delirium.
- Trial name
- NCT02603731
- Where
- Denmark
- Volunteers
- 183 people
- Sponsor
- Zealand University Hospital
Delirium, Elderly Patient
Evaluation of the Efficiency of Neutrophil-Lymphocyte Ratio in Predicting Delirium in Geriatric Patients Undergoing Hip Fracture Surgery
Aim: Postoperative delirium (POD) is one of the most common complications in elderly patients and is associated with increased morbidity, mortality, length of hospital stay and medical care costs.
- Conditions
- Delirium, Elderly Patient, Hip Fracture Surgery, Neutrophil Lymphocyte Ratio
- Trial name
- NCT07741175
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders
Ramelteon in the Prevention of Post-operative Delirium
This trial focuses on a Phase II randomized masked clinical trial testing the effectiveness and safety of peri-operative administration of ramelteon, a melatonin agonist in the prevention of postoperative delirium.
- Conditions
- Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders, Delayed Emergence From Anesthesia, Cognitive Disorders
- Trial name
- RECOVER (NCT02324153)
- Testing
- Ramelteon, Microcrystalline Cellulose, Riboflavin 100 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Postoperative Delirium, Transcranial Magnetic Stimulation, Repetitive
Continuous Theta Burst Stimulation (cTBS) and Postoperative Delirium
To investigate the impact of cTBS on the incidence of postoperative delirium and changes of cognitive function in elderly patients after surgery.
- Trial name
- NCT04661904
- Testing
- Continuous theta burst stimulation (cTBS)
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Shanghai 10th People's Hospital
Adult Patients, Intensive Care Unit
Functional Recovery Over the First Year After ICU Discharge
Intensive Care Unit Acquired Delirium (ICU-AD) and Intensive Care Unit Acquired Weakness (ICU-AW) are common in critically ill, mechanically ventilated adult patients.
- Trial name
- NCT04206306
- Where
- Taiwan
- Volunteers
- 407 people
- Sponsor
- National Taiwan University Hospital
Hip Fractures, Hip Disease
CLIC1 in Patients Presenting PD
In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia.
- Trial name
- NCT05446181
- Testing
- Perioperative delirium, Hip surgery
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Seoul National University Bundang Hospital
Delirium
Rivastigmine in the Management of Delirium
The aim of this study is to evaluate the efficacy of an anticholinesterase treatment in patients aged 75 and over, hospitalized with delirium.
- Trial name
- confuriv (NCT01487317)
- Testing
- Rivastigmine transdermal patch
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Effect of Drug, Complication of Treatment
Dexmedetomidine as a Sole Premedication for BMT Placement
There is very little evidence or research documenting any single method of sedation/analgesia for myringotomy tube (BMT) placement as being more effective than others.
- Trial name
- BMT (NCT05903326)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Nemours Children's Clinic
Hearing Loss, Hearing Loss, Age-Related
Sight and Hearing Investigation Into Effects on Delirium
The goal of this observational study is to learn about sensory loss in hospital patients with delirium. The main questions it aims to answer are: Are hearing and vision loss related to increased risk of having delirium? Do…
- Conditions
- Hearing Loss, Hearing Loss, Age-Related, Hearing Disability, Delirium
- Trial name
- SHIELD (NCT06176625)
- Testing
- Communication Signage, Amplifier Use
- Where
- United States
- Volunteers
- 1,543 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Delirium, Postoperative, Surgical Procedure
Polish Validation 4AT Tool
Delirium is a phenomenon which affects patients with various disorders and representing various age groups. Screening instruments make it possible to diagnose the condition at an early stage and to prevent its development.
- Trial name
- NCT04563858
- Testing
- Validation
- Where
- Poland
- Volunteers
- 444 people
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
Aged, Surgical Procedures, Operative
Dexmedetomidine and Long-term Outcome in Elderly Patients After Surgery
Delirium is a frequent postoperative complication. Its occurrence is associated with worse long-term outcomes. In a previous randomized controlled trial, prophylactic low-dose dexmedetomidine infusion during the early…
- Conditions
- Aged, Surgical Procedures, Operative, Delirium, Dexmedetomidine
- Trial name
- NCT02809937
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Peking University First Hospital
Delirium, Intensive Care Unit Syndrome
Education for Recognition and Management of Delirium
Delirium is a disturbance in consciousness with reduced ability to focus, sustain, or shift attention that occurs over a short period of time and tends to fluctuate over the course of the day.
- Conditions
- Delirium, Intensive Care Unit Syndrome, Nurse-Patient Relations
- Trial name
- NCT03642249
- Testing
- OSCEs, Lecture, E-learning
- Where
- Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Delirium, Sleep Disturbance
De-escalating Vital Sign Checks
The overall goals for this study are: 1) to develop a predictive model to identify patients who are stable enough to forego vital sign checks overnight, 2) incorporate this predictive model into the hospital electronic health…
- Trial name
- NCT04046458
- Testing
- Nighttime Vital Sign EHR Alert, No EHR alert
- Where
- United States
- Volunteers
- 1,436 people
- Sponsor
- University of California, San Francisco