Clinical trials: Delirium, completed
Cognitive Impairment, Emergency Care
Pathway to Detection & Differentiation of Delirium & Dementia in the Emergency Department
This is an observational study of the pragmatic implementation of an ED screening, outpatient referral, and care coordination process for older ED patients who may have UCID.
- Conditions
- Cognitive Impairment, Emergency Care, Dementia, Delirium
- Trial name
- IMPACT (NCT04846322)
- Testing
- PD4ED 3-step intervention (ED assessment, outpatient assessment, Brain health plan)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Post Operative Delirium
Dexmedetomidine Dosage for Postoperative Delirium and Cognitive Function in Elderly TKA Patients
This study aims to evaluate the efficacy of dexmedetomidine in reducing the incidence of postoperative delirium and cognitive dysfunction in elderly patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT06614881
- Testing
- Dexmedetomidine Injection [Precedex], Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML), Normal saline
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Tanta University
Alzheimer's Type Dementia
A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe Alzheimer's Disease
The objective is to demonstrate that donepezil hydrochloride 10 mg/day has superior efficacy compared with placebo in cognitive function in Chinese subjects with severe Alzheimer's Disease.
- Trial name
- NCT01404169
- Testing
- E2020
- Where
- 32 sites in China
- Volunteers
- 260 people
- Sponsor
- Eisai Limited
Lactium, Emergence Agitation
Preemptive Oral Lactium to Prevent Emergence Agitation
This prospective randomized controlled study will be conducted to evaluate the effects of preoperative lactium on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane…
- Conditions
- Lactium, Emergence Agitation, Adenotonsillectomy
- Trial name
- NCT07172594
- Testing
- Lactium
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Tanta University
Emergence Delirium
Ketamine Versus Dexmedetomidine for Prevention of Postoperative Delirium
Delirium is a common postoperative complication in the elderly, often caused by multiple factors. It is defined as an acute neuropsychiatric disorder characterized by fluctuating disturbances in attention, awareness, and…
- Trial name
- NCT05341154
- Testing
- Ketamine Hcl 50Mg/Ml Inj
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Huda Fahmy Mahmoud, PhD
Closed Reduction Surgery for Nasal Bone Fracture
The Relationship Between the Surgery-related Anxiety and HRV: Prediction for Aggressive Emergence Behavior
Heart rate variability (HRV) is known to reflect the balance of autonomic nervous system. Anxiousness, which tend to result from the deficient action of parasympathetic nervous system, likely to show low HRV.
- Trial name
- NCT02282865
- Where
- South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Postoperative Delirium, Postoperative Cognitive Dysfunction
The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study
The objective of this study is to test the effects of caffeine on neurocognitive and clinical recovery after major surgery. Specifically, this trial tests the primary hypothesis that caffeine will reduce the incidence of…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
- Trial name
- NCT05574400
- Testing
- Dextrose Water, Caffeine citrate
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Michigan
Emergence Agitation
Comparison Between Propofol and Fentanyl for Prevention of Emergence Agitation in Children After Sevoflurane Anesthesia
The occurrence of emergence agitation (EA) in pediatric patients who have received sevoflurane anesthesia is a common postoperative problem.
- Trial name
- NCT01506622
- Testing
- Administration of propofol, Administration of fentanyl, Administration of saline
- Where
- South Korea
- Volunteers
- 222 people
- Sponsor
- Yonsei University
Delirium in the Intensive Care Unit
Methadone vs. Transdermal Fentanyl for Opioid Withdrawal Syndrome
Many patients in the general intensive care unit experience pain, as a result of an injury or underlying disease, surgery or an invasive procedure.
- Trial name
- NCT05697783
- Testing
- Administration of methadone instead of fentanyl patch
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Meir Medical Center
Delirium
Acetylcholinesterase in Postoperative Delirium
The level of acetylcholinesterase is suspected to correlate with postoperative delirium. The investigators therefore score patients once preoperatively and twice postoperatively with the german version of the delirium-score…
- Trial name
- NCT02315846
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Heidelberg University
Anxiety State, Child Behavior
The Effect of Child Choice With Accompanying Parent on Postoperative Delirium During Induction of Anesthesia
Induction of anesthesia can be distressing both for children and their parents. Nonpharmacological behavioral interventions can reduce the anxiety of children without significant adverse effects as seen with sedative drugs.
- Conditions
- Anxiety State, Child Behavior, Postoperative Delirium
- Trial name
- NCT05931770
- Testing
- Selection of parent(mother or father) according to children preference, Parent (mother or father) selection according to parents' preference
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Delirium, Intensive Care Unit Delirium
PREdiction of DELIRium in Medical ICU Patients
In intensive care unit (ICU) patients, the ability to predict delirium may help reduce its incidence, duration, and severity. The PREdiction of DELIRium in ICU (PRE-DELIRIC) model was recently developed for this purpose.
- Trial name
- NCT04218461
- Testing
- PRE-DELIRIC model
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Istanbul Demiroglu Bilim University
Delirium
Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery
Investigators will assess the incidence and duration of postoperative delirium in patients ≥60 years old undergoing coronary artery bypass grafting (CABG), with/without valve surgery (aortic and/or mitral) based on different…
- Trial name
- DEXACET (NCT02546765)
- Testing
- IV acetaminophen & IV propofol, IV acetaminophen & IV dexmedetomidine
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Beth Israel Deaconess Medical Center
Delirium, Intensive Care Unit Syndrome
Education for Recognition and Management of Delirium
Delirium is a disturbance in consciousness with reduced ability to focus, sustain, or shift attention that occurs over a short period of time and tends to fluctuate over the course of the day.
- Conditions
- Delirium, Intensive Care Unit Syndrome, Nurse-Patient Relations
- Trial name
- NCT03642249
- Testing
- OSCEs, Lecture, E-learning
- Where
- Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Cognitive/Functional Effects, Delirium
Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer
RATIONALE: Donepezil and vitamin E may be able to decrease side effects caused by radiation therapy given to prevent brain metastases in patients with small cell lung cancer.
- Conditions
- Cognitive/Functional Effects, Delirium, Depression, Lung Cancer
- Trial name
- NCT00006349
- Testing
- vitamin E, donepezil hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 9 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Delirium, Coma
Effect of Minocycline on Delirium Incidence in Critically Ill Patients
Delirium is a disorder of consciousness characterized by an acute onset and fluctuating course of impaired cognitive functioning.
- Trial name
- NCT04219735
- Testing
- Minocycline
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Delirium, Older Patients
Delirium in Geriatric Hospital Single-bed and Multibed Rooms
To investigate whether single-bed rooms can prevent and reduce incidence and duration of delirium compared to multi-bed rooms in elderly patients admitted to a geriatric department.
- Conditions
- Delirium, Older Patients, Admittance to Single-bed Rooms or Multi-bed Rooms
- Trial name
- NCT03199768
- Where
- Denmark
- Volunteers
- 1,014 people
- Sponsor
- Aarhus University Hospital
Delirium
Subsyndromal Delirium in Intensive Care Unit
Subsyndromal delirium (SSD) is a condition characterized by a less severe cognitive impairment in comparison to delirium. To date there is no published consensus on SSD definitions and has been commonly reported as an…
- Trial name
- SubSynD (NCT03813459)
- Where
- Portugal
- Volunteers
- 400 people
- Sponsor
- Centro Hospitalar Lisboa Ocidental
Delirium
Melatonin Supplementation for Delirium Prevention in Acutely Hospitalized Elderly
122 people over 70 who were admitted to hospital were enrolled to the study. Half got .5 mg a night of melatonin, half got a placebo.
- Trial name
- NCT00873379
- Testing
- melatonin
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postoperative Delirium
The Comparison of Incidence and Risk Factors of Postoperative Delirium in Elderly Patients After Lower Extremity Surgery
The aim of this study is to compare the risk factors and the incidence of delirium following orthopedic surgery under the general or regional anesthesia in elderly patients.
- Trial name
- NCT02360982
- Testing
- propofol and esmeron(rokuronyum), marcaine and fentanyl
- Volunteers
- 120 people
- Sponsor
- Cukurova University