Clinical trials: Delirium, completed
Delirium, Anesthesia Awareness
Anesthesia Depth Increases Delirium Incidence
This study aimed to determine whether targeting bispectral index (BIS) readings of 55 (light anaesthesia) was associated with a lower incidence of delirium, dementia (POD), POCD and mortality but higher rates of awareness and…
- Trial name
- NCT05656703
- Testing
- BIS guidance of anesthesia, Standard of Care
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Heidelberg University
Post-operative Delirium
Benzodiazepine-free Anesthetic for Reduction of Delirium (B-Free)
The purpose of this two-centre pilot research study is to establish the feasibility of conducting a full trial that seeks to determine if a cardiac anesthesia policy that uses alternatives to benzodiazepine medications is better…
- Trial name
- B-Free (NCT03053869)
- Testing
- Benzodiazepine - limited use strategy, Benzodiazepine - Ad libitum strategy
- Where
- 2 sites in Canada
- Volunteers
- 480 people
- Sponsor
- McMaster University
Delirium, Delirium in Old Age
Eyecontrol coMmunication Platform for dEliRium manaGemEnt in Intensive Care Units (EMERGE)
The purpose of this research is to investigate whether addition of the EyeControl-Pro platform as an adjunct to standard guideline-based intensive care unit management of critically ill patients is effective in reducing delirium…
- Conditions
- Delirium, Delirium in Old Age, Critical Illness, Intensive Care Unit Delirium
- Trial name
- EMERGE (NCT06029244)
- Testing
- EyeControl-Pro, Control
- Where
- 3 sites in United States, Israel
- Volunteers
- 160 people
- Sponsor
- Beth Israel Deaconess Medical Center
Delirium, Psychomotor Agitation
Acupuncture for the Prevention of Emergence Delirium in Children Undergoing Myringotomy Tube Placement
Myringotomy tube placement is one of the most commonly performed operations in children. Emergence delirium after such procedures is common.
- Trial name
- NCT02383004
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Delirium
Neuronal Damage In Delirium Study
The purpose of this study is to evaluate associations between neuronal damage biomarkers (S100 calcium-binding protein beta [S-100β], neuron-specific enolase [NSE], ubiquitin carboxy-terminal hydrolase L1 [UCHL1], and…
- Trial name
- NDID (NCT03724201)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Renal Function Disorder, Postoperative Delirium
Conscious Sedation for Transcatheter Aortic Valve Implantation
Aortic valve stenosis is the heart valve disease with the highest prevalence among the elderly, and may lead to heart failure. Until recently, the only definitive treatment was surgical replacement (SAVR).
- Conditions
- Renal Function Disorder, Postoperative Delirium, Adverse Event, Death
- Trial name
- NCT05462938
- Testing
- Continuous infusion of propofol, Continuous infusion of dexmedetomidine
- Where
- Greece
- Volunteers
- 65 people
- Sponsor
- University of Ioannina
Postoperative Delirium
Predictors for Postoperative Delirium After Major Noncardiac Surgery in Adults
This research project is an observational cohort study by retrospective chart review of patients that underwent major noncardiac surgery at University Hospital Basel, Switzerland, in the years 2011-2015.
- Trial name
- PODMAS (NCT04460716)
- Testing
- Major noncardiac surgery
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Delirium (POD)
Validation of a Risk Assessment Model for Postoperative Delirium Based on Artificial Intelligence
Postoperative delirium (POD) is a frequent postoperative complication in the elderly, characterised by fluctuating disturbances in attention, awareness, and cognition.
- Trial name
- NCT05639348
- Testing
- Data collection on POD for calculation of the PIPRA score
- Where
- 3 sites in Switzerland
- Volunteers
- 993 people
- Sponsor
- University Hospital, Basel, Switzerland
Ambulatory Surgical Procedures
Effect of Dexmedetomidine on the Prevention of Emergence Agitation in Children Undergoing Day Surgery
Emergence agitation/delirium (EA/ED) is a common complication in pediatric surgery patients, which increases the risk of developing postoperative airway obstruction and respiratory depression.
- Trial name
- NCT03262090
- Testing
- 0.2ug/kg dexmedetomidine, 0.4ug/kg dexmedetomidine, 0.6ug/kg dexmedetomidine
- Where
- China
- Volunteers
- 389 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Coronary Artery Bypass, Delirium
Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane
Background: Different anaesthetic agents have been shown to have different protective effects upon heart, brain and renal function under ischaemic conditions (oxygen starvation).
- Conditions
- Coronary Artery Bypass, Delirium, Dementia, Amnesia
- Trial name
- NCT00400790
- Testing
- propofol, desflurane
- Where
- Australia
- Volunteers
- 182 people
- Sponsor
- University of Melbourne
Delirium
Delirium in the Emergency Department and Its Extension Into Hospitalization
Delirium occurs in 10% of older emergency department (ED) patients, yet it remains poorly understood. To date, the predominance of delirium studies have been conducted in hospitalized patients and therefore have limited…
- Trial name
- DELINEATE (NCT01651897)
- Where
- United States
- Volunteers
- 228 people
- Sponsor
- Vanderbilt University
Post-Intensive Care Syndrome
Collaborative Assessment of ICU Recovery Needs
The primary purpose of this study is to better understand the impact of the Society of Critical Care Medicine (SCCM) THRIVE Collaboratives on patients, their families and clinicians.
- Trial name
- CAIRN (NCT03513289)
- Testing
- Patient, Carer, and Clinician Interviews
- Where
- 2 sites in United States, Australia
- Volunteers
- 66 people
- Sponsor
- Vanderbilt University Medical Center
Delirium
Delirium, Electroencephalographic Alterations and Cortical Spreading Depression (CSD) in Critical Illness
Delirium in the intensive care unit is an acutely developed brain dysfunction affecting up to 80 % of patients. It is associated with significantly increased morbidity and mortality during admission and post-discharge.
- Trial name
- NCT01980251
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Delirium - Postoperative, Anxiety Acute
Pediatric Recovery Delirium in Pediatric Patients Undergoing Surgery
The primary aim of this observational study is to evaluate the effect of playing a mother's voice to a child while the patient is being awakened from anesthesia on postoperative delirium.
- Trial name
- Delirium (NCT07413289)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Enes Celik
Cohort Studies
Effect of Dexmedetomidine on Postoperative Mental Disorders and Long-term Survival in Elderly Patients
China's aging population is causing an increase in the number of senior persons undergoing surgery. More and more clinicians are paying attention to the postoperative survival and mental health of elderly surgical patients.
- Trial name
- NCT06362408
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Chinese PLA General Hospital
Emergence Delirium
Emergence Delirium in Children: Total Intravenous Anesthesia With Propofol and Remifentanil Versus Inhalational Sevoflurane Anesthesia
Emergence delirium (ED) refers to a wide variety of behavioural disturbances that are commonly seen in children following emergence from anesthesia.
- Trial name
- NCT00885443
- Testing
- Propofol, sevoflurane
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Delirium, Postoperative
Bis Monitoring Effect on Delirium Occurrence and Nursing Quality Improvement Recovering From General Anesthesia
①Effects of BIS Index (BIS) monitoring on delirium incidence in Post-anesthesia care unit (PACU) in patients undergoing general anesthesia ②Effects of BIS BIS Index (BIS) monitoring on the quality of nursing care in the…
- Trial name
- NCT06302517
- Testing
- BIS-guided
- Where
- China
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Post-operative Delirium
Postoperative Delirium in Patients Undergoing Radical Cystectomy
In this study, post-operative delirium will be measured in patients undergoing surgery for bladder resection, and associated microRNA biomarkers will be evaluated in patients considered delirious and non-delirious after surgery.
- Trial name
- NCT03132168
- Testing
- Assessments, Blood Draw, Standardized Anesthetic Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Delirium, ICU
PupillOmetry for Prediction of DelirIUM
Delirium in intensive care unit (ICU) is a serious event. It is associated with short-term complications (agitation, self-extubation, accidental removal of catheters, prolonged length of stay and ventilation), excess mortality…
- Trial name
- PODIUM (NCT05248035)
- Testing
- Adult patient hospitalized in ICU
- Where
- France
- Volunteers
- 209 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Emergence Delirium, Parasomnias
How Common Are Sleep Disorders and Problems With Emergence From Anesthesia in Surgical Patients
Emergence delirium (ED), also called emergence agitation or post-anesthetic excitement, is defined as a dissociated state of consciousness, occurring on awakening from general anesthesia, in which children exhibit psychomotor…
- Trial name
- NCT02980549
- Testing
- children's sleep habits questionnaire
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison