Clinical trials: Delirium Treatment
Delirium
MENDS Study: Trial in Ventilated ICU Patients Comparing an Alpha2 Agonist Versus a Gamma Aminobutyric Acid (GABA)-Agonist to Determine Delirium Rates, Efficacy of Sedation, Analgesia and Discharge Cognitive Status
Delirium has recently been shown as a predictor of death, increased cost, and longer length of stay in ventilated patients. Sedative and analgesic medications relieve anxiety and pain, but may contribute to patients'…
- Trial name
- NCT00095251
- Testing
- Dexmedetomidine, Lorazepam
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University
Delirium, Advanced Cancer
Early Recognition and Optimal Treatment of Delirium in Patients With Advanced Cancer
The investigators designed a randomised multicenter clinical trial for patients with advanced cancer who are admitted to the medical oncology ward or high-care hospice.
- Trial name
- NCT01539733
- Testing
- Olanzapine, Haloperidol
- Where
- 2 sites in Netherlands
- Volunteers
- 101 people
- Sponsor
- Amsterdam UMC, location VUmc
Emergence Agitation
Dexmedetomidine and Propofol in the Treatment of Emergence Agitation
1. This clinical research aims to compare the effects of dexmedetomidine and propofol on the treatment of emergence agitation in adult patients after general anesthesia. 2.
- Trial name
- NCT04142840
- Testing
- Dexmedetomidine, Propofol
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Delirium, Critical Illness
Recovery After ICU Treatment: A Prospective Cohort Study
This project aims to investigate the physical, mental and cognitive recovery after admission to the Intensive Care Unit (ICU). This will be done by a three and 12 month follow up after discharge.
- Conditions
- Delirium, Critical Illness, Quality of Life
- Trial name
- NCT02599428
- Where
- Denmark
- Volunteers
- 161 people
- Sponsor
- Zealand University Hospital
Delirium, Confusion
Transcranial Direct Current Stimulation for the Treatment of Delirium
Delirium is induced by changes in cortical excitability and transcranial direct current stimulation (tDCS), by using weak electrical fields, can modulate cortical excitability and spontaneous firing activities in the stimulated…
- Trial name
- NCT03256500
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- North Florida/South Georgia Veterans Health System
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
Delirium, Alzheimer Disease
Improving the Recovery and Outcome Every Day After the ICU
Primary Specific Aim: Determine the effect of the combined physical exercise and cognitive training on the cognitive function of ICU survivors aged 50 and older.
- Trial name
- IMPROVE (NCT03095417)
- Testing
- Physical Exercise Intervention, Cognitive Training Intervention, Stretching Control
- Where
- 6 sites in United States
- Volunteers
- 249 people
- Sponsor
- Indiana University
Delirium, Brain Tumor
A Study for Postoperative Delirium in Older Patients With Intracranial Tumors
Postoperative delirium is a common acute central nervous system syndrome, which often occurs 1-5 days after surgery. Postoperative delirium can prolong the length of hospital stay, increase the mortality rate, and is also…
- Trial name
- NCT07797660
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Beijing Tiantan Hospital
Delirium, Postoperative Cognitive Dysfunction
Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial
The purpose of this study is to determine whether preoperative administration of Rivastigmine prevents the incidence of postoperative delirium in patients undergoing major surgery as well as postoperative cognitive dysfunction.
- Trial name
- NCT00835159
- Testing
- Rivastigmine Patch
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pain, Delirium
Longitudinal Cohort Study - for the Treatment of Acute Postoperative Pain and Postoperative Delirium, Postoperative Cognitive Dysfunctions, and Chronic Pain.
Adequate pain therapy is important aspect of perioperative care. Sequelae of inadequate pain management are patient dissatisfaction, post-operative nausea and vomiting (PONV), inadequate nutrition, lack of mobilization, and an…
- Conditions
- Pain, Delirium, Postoperative Cognitive Dysfunction
- Trial name
- NCT03133858
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Delirium
Prevention of Delirium After Bone Marrow Transplantation
The purpose of this study is to find out if using bright light sessions during bone marrow transplant can prevent people from developing confusion also known as delirium.
- Trial name
- NCT01700816
- Testing
- Bright light therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia
Bifrontal and Bitemporal Electroconvulsive Therapy (ECT) in Treatment of Patients With Schizophrenia
Electroconvulsive therapy has been used in clinical practice since 1938, a number of randomized trials found significant differences favoring ECT in response rates between individuals with depression receiving real and sham ECT.
- Trial name
- ESBECT (NCT02511509)
- Testing
- Bifrontal electroconvulsive therapy, Bitemporal electroconvulsive therapy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lodz
Postoperative Insomnia, Postoperative Delirium
Efficacy of Suvorexant on Post-operative Sleep Disturbance
The study is a parallel group, double blind, randomized trial. Subjects will be recruited from individuals undergoing elective surgery for orthopedic, abdominal, urologic, gynecologic or spine reasons.
- Trial name
- NCT05823844
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Columbia University
Pain Intractable, Delirium
Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patients
Cancer patients with very difficult to control symptoms at the Abbotsford (AC) and Fraser Valley (FVC) Cancer Centers are referred and admitted to the Tertiary Palliative Care Units at the Abbotsford Regional Hospital and Cancer…
- Conditions
- Pain Intractable, Delirium, Dyspnea, Nausea
- Trial name
- NCT01687751
- Testing
- Dexmedetomidine, Midazolam
- Where
- Canada
- Sponsor
- Fraser Health
Myocardial Infarction (MI), Delirium, Intensive Care Unit, Randomised Controlled Trial
Mannitol Administration for Delerium Prevention
The aim of the study is to evaluate the efficacy of adjuvant administration of mannitol for the prevention of delirium in patients with myocardial infarction.
- Trial name
- MAD (NCT06759259)
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Alzheimer's Type Dementia
Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe Alzheimer's Disease
The purpose of this study is to compare 23 mg donepezil sustained release to the currently marketed formulation of 10 mg donepezil immediate release in patients with severe Alzheimer's disease.
- Trial name
- NCT01539031
- Testing
- E2020
- Where
- 54 sites in Japan
- Volunteers
- 351 people
- Sponsor
- Eisai Co., Ltd.
Procedural Sedation, Emergence Delirium
Positive Imagery Therapy and the Incidence of Emergence Reactions With the Use of Ketamine
The purpose of this study is to determine if positive imagery therapy while using ketamine in procedural sedation reduces the number of emergence reactions and impacts pre and post-procedural anxiety.
- Trial name
- NCT04746079
- Testing
- Positive Imagery Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mercy Health Ohio
Intensive Care Unit Syndrome, Mechanical Ventilation Complication
Ketamine Infusion as Sedative Analgesic in Severe ARDS
To evaluate whether ketamine is a safe sedative-analgesic agent to be used in an intensive care unit (ICU) setting as compared to traditionally used agents such as propofol, opioids, and midazolam
- Conditions
- Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
- Trial name
- KISS (NCT04818827)
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Interfaith Medical Center
Cognitive Decline, Heart Diseases
The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery.
Decline in cognitive function after surgery occurs most commonly in older patients and patients undergoing major surgeries, such as heart surgery.
- Conditions
- Cognitive Decline, Heart Diseases, Delirium
- Trial name
- NCT03324867
- Testing
- Regular insulin, Normal Saline Flush, 0.9% Injectable Solution
- Volunteers
- 316 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University