Clinical trials: Delirium and Post-operative Cognitive Dysfunction (POCD)
Postoperative Cognitive Dysfunction, Delirium, Postoperative
Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass
Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures.
- Trial name
- NCT07000461
- Testing
- Transcranial Doppler measurement of the middle cerebral artery
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Postoperative Delirium, Cerebral Oxygen Saturation
Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation
This study compares the effects of ibuprofen administered during surgery and within the first 24 hours after surgery, versus no ibuprofen, on cerebral oxygenation, postoperative changes in consciousness (postoperative delirium…
- Conditions
- Postoperative Delirium, Cerebral Oxygen Saturation, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- NCT07399184
- Testing
- ibuprofen
- Volunteers
- 54 people
- Sponsor
- Ondokuz Mayıs University
Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction
BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine
The purpose of this clinical investigation is to evaluate the clinical performance, safety, and clinical benefit of the BrainProtect System in reducing early postoperative neurological complications in adult participants…
- Conditions
- Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- BrainProtect (NCT07872982)
- Testing
- BrainProtect System, Standard perioperative management
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 304 people
- Sponsor
- Scienceforbrain, UAB
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Postoperative Delirium (POD), Postoperative Cognitive Deficit (POCD)
Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog)
The research leading consortium to these results has received funding from the European Union Seventh Framework Programme [FP7/2007-2013] under grant agreement no 602461 (www.biocog.eu).
- Trial name
- BioCog (NCT02265263)
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 1,054 people
- Sponsor
- Charite University, Berlin, Germany
Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD)
Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO)
Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis. Despite improved procedural outcomes, neurocognitive complications such as postoperative delirium (POD) and postoperative…
- Conditions
- Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD), Delirium - Postoperative, Neurocognitive Disorders
- Trial name
- HVU-NEURO (NCT07626567)
- Volunteers
- 500 people
- Sponsor
- Heart and Brain Research Group, Germany
Post-operative Delirium, Post-operative Cognitive Dysfunction
Risk Communication About Post-operative Delirium (POD) and Post-operative Cognitive Dysfunction (POCD)
The purpose of this study is to assess the awareness of post-operative delirium (POD) and post-operative cognitive dysfunction (POCD), their respective risk factors and effective preparation and treatment options in a…
- Trial name
- NCT03953313
- Where
- Germany
- Volunteers
- 223 people
- Sponsor
- Charite University, Berlin, Germany
Postoperative Cognitive Dysfunction, Postoperative Delirium
Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) occur in 11-51% of patients after surgery, and its prevalence increases with age.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Chronic Post Operative Pain
- Trial name
- NCT05439707
- Testing
- transaricular vagus nerve stimulation, fake transaricular vagus nerve stimulation
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Xuzhou Central Hospital
Postoperative Cognitive Dysfunction, Delirium
Peri-Anesthetic Imaging of Cognitive Dysfunction
Recent data suggests that anesthetics can have prolonged effects on gene expression, protein synthesis and processing as well as cellular function in ways that the investigators are only beginning to understand, especially in the…
- Conditions
- Postoperative Cognitive Dysfunction, Delirium, Dementia, Neurotoxicity
- Trial name
- PAICOD (NCT01322672)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Postoperative Delirium, PD
Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve
Elderly patients who undergo anesthesia and non-cardiac surgery are subject to deterioration of brain function including the development of postoperative delirium (PD) and postoperative cognitive dysfunction (POCD).
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00561678
- Testing
- Precedex (Dexmedetomidine)
- Where
- 10 sites in United States
- Volunteers
- 404 people
- Sponsor
- Icahn School of Medicine at Mount Sinai