Clinical trials: Delirium in Old Age
Delirium in Old Age
Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery
Investigators propose this multi-center randomised controlled study to test the preventive effect of intravenouse acetaminophen in delirium over 5 postoperative days among older patients recovering from major non-cardiac surgery.
- Trial name
- NCT06653465
- Testing
- Acetaminophen, Saline
- Volunteers
- 1,930 people
- Sponsor
- RenJi Hospital
Delirium
Quetiapine in Prevention of Delirium
The aim is to study the effectiveness of Quetiapine in preventing delirium in the elderly patients with multiple risks for delirium.
- Trial name
- NCT05793632
- Testing
- Quetiapine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Dexmedetomidine, Postoperative Delirium
Dexmedetomidine Prevents Postoperative Delirium After Deep Brain Stimulation in Patients With Parkinson's Disease
Postoperative delirium (POD) is a common complication, and the incidence of POD after deep brain stimulation(DBS) implementation ranges from 10% to 40%.
- Conditions
- Dexmedetomidine, Postoperative Delirium, Deep Brain Stimulation
- Trial name
- NCT05197439
- Testing
- Dexmedetomidine, 0.9% saline
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Delirium, Sarcopenia
Effect of Preoperative Sarcopenia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery
The goal of this observational study is to compare Incidence of postoperative delirium in Sarcopenic and non-sarcopenic elderly patients undergoing gastrointestinal surgery.
- Conditions
- Postoperative Delirium, Sarcopenia, Gastrointestinal Surgery, Anesthesia
- Trial name
- NCT05847296
- Where
- China
- Volunteers
- 334 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Postoperative Delirium (POD)
Perioperative Dezocine Administration and Postoperative Delirium in Elderly Cardiac Surgery Patients
Postoperative delirium (POD) is a common complication in elderly patients undergoing cardiac surgery and is associated with prolonged hospitalization, increased morbidity, and poor recovery.
- Trial name
- NCT07768150
- Testing
- Dezocine, Normal Saline (NS)
- Where
- 2 sites in China
- Volunteers
- 640 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Delirium
Delirium in the Emergency Department: Novel Screening
Delirium is an acute confusional state characterized by altered or fluctuating mental status, inattention, and either disorganized thinking or an altered level of consciousness.
- Trial name
- NCT01162343
- Where
- United States
- Volunteers
- 498 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Delirium
Biomarkers and Postoperative Delirium in Elderly Patients
This study intends to verify and explore the correlation of neuroinflammation biomarkers in cerebrospinal fluid and plasma of elderly patients undergoing hip replacement with postoperative delirium, so as to achieve a new method…
- Trial name
- NCT05454228
- Testing
- postoperative delirium
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Henan Provincial People's Hospital
Postoperative Delirium
The Comparison of Incidence and Risk Factors of Postoperative Delirium in Elderly Patients After Lower Extremity Surgery
The aim of this study is to compare the risk factors and the incidence of delirium following orthopedic surgery under the general or regional anesthesia in elderly patients.
- Trial name
- NCT02360982
- Testing
- propofol and esmeron(rokuronyum), marcaine and fentanyl
- Volunteers
- 120 people
- Sponsor
- Cukurova University
Sleep Apnea
Prevention Of Delirium in Elderly With Obstructive Sleep Apnea (PODESA)
Delirium is a common complication in elderly patients following surgery. Patients who develop delirium after surgery are at increased risk for serious complications, and even death.This multi-centre randomized controlled trial…
- Trial name
- PODESA (NCT02954224)
- Testing
- CPAP treatment
- Where
- 3 sites in Canada
- Volunteers
- 220 people
- Sponsor
- University Health Network, Toronto
Postoperative Complications, Postoperative Delirium
Acupoint Stimulation Improve Postoperative Delirium in Elderly Patients
Postoperative delirium is with increased incidence in elderly patients. Previous studies have shown that acupuncture related techniques could induce protection against brain ischemia and improve outcome after cerebral diseases.
- Trial name
- AICE (NCT03726073)
- Testing
- Transcutaneous acupoint electrical acupoint stimulation(TEAS) and auricular acupressure, Usual care
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Air Force Military Medical University, China
Post-Operative Confusion, Long Term Adverse Effects
Depth of Anaesthesia and Long-term Survival: The Balanced Anaesthesia Follow-up Study
Anaesthetic depth and complications after major surgery: an international, randomised controlled trial - The BALANCED trial. In this large, international, randomised controlled trial that enrolled patients aged 60 years and over…
- Conditions
- Post-Operative Confusion, Long Term Adverse Effects, Surgery--Complications, Cognitive Dysfunction, Postoperative
- Trial name
- BALANCEDLT (NCT04965324)
- Testing
- Anaesthesia Depth
- Where
- New Zealand
- Volunteers
- 6,644 people
- Sponsor
- Auckland City Hospital
Postoperative Delirium, Anesthesia
Effect of Prophylactic Application of 40Hz Transcranial Stimulation in AICU on Incidence of Postoperative Delirium in Elderly Patients Undergoing Elective Gastrointestinal Surgery
Postoperative delirium is an acute central nervous system dysfunction caused by surgical stress, which is manifested by postoperative acute, non-specific changes in consciousness level, attention, cognitive ability and…
- Conditions
- Postoperative Delirium, Anesthesia, Elderly
- Trial name
- NCT06542978
- Testing
- 40Hz stimulation
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Henan Provincial People's Hospital
Hypoactive Delirium
Treatment of Hypoactive Delirium and Outcome Measures
Haloperidol and Non-Pharmacologic Treatment are recognized treatments for delirium. This study will evaluate which is the best treatment for hypoactive delirium.
- Trial name
- THDOM (NCT02345902)
- Testing
- Haloperidol, non-pharmacologic measures
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Cognitive Impairment, Frail Elderly Syndrome
Preoperative Cognitive Screening in Older Spinal Surgical Patients
The objectives of this study are to determine whether identifying patients with baseline cognitive deficits or frailty predict postoperative delirium.
- Trial name
- NCT02922634
- Testing
- Mini Cog
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Vagus Nerve Stimulation
Transcutaneous Auricular Vagus Nerve Stimulation Prevents Postoperative Delirium in Elderly Patients
According to the 3D-CAM scale, evaluate the incidence of Postoperative Delirium within 5 days after surgery in elderly patients receiving taVNS.The results are expected to provide evidence of the safety and efficacy of…
- Trial name
- Vnstar (NCT06421077)
- Testing
- transauricular auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 1,776 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Delirium
Modified Tian Wang Bu Xin Dan Hydrogel Patch in Preventing Postoperative Delirium in Elderly Patients
The purpose of this study is to determine whether preoperative administration of Modified Tian Wang Bu Xin Dan Hydrogel Patch prevents the incidence of postoperative delirium in elderly patients undergoing major surgery.
- Trial name
- NCT04947761
- Testing
- modified Tian Wang Bu Xin Dan hydrogel patch
- Where
- 3 sites in China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Diabetes Mellitus, Geriatric
Burst Suppressions in Diabetic Elderly
This observational study aims to learn about the effects of diabetes mellitus in intraoperative electroencephalography (EEG) of elderly patients receiving general anesthesia.
- Conditions
- Diabetes Mellitus, Geriatric, General Anaesthesia, Electroencephalography
- Trial name
- NCT07037186
- Testing
- Electroencephalogram
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Postoperative Delirium, Hip Fractures
Association Between Preoperative Hyperglycemia and Postoperative Delirium in Geriatric Hip Fracture Patients
This retrospective study aims to collect electronic medical record data from Dandong central hospital spanning from January 2013 to November 2023.
- Conditions
- Postoperative Delirium, Hip Fractures, Hyperglycemia
- Trial name
- NCT06473324
- Where
- China
- Volunteers
- 2,031 people
- Sponsor
- Wenbo Ding
Dementia, Mild Cognitive Impairment
Evaluation of the Effect of Cataract Surgery on Cognitive Function in Very Elderly Patients
The study intends to measure the evolution over time of the cognitive capacity of patients undergoing cataract surgery in relation to the opaque lens removal surgery (cataract) in a population considered to be at risk of…
- Conditions
- Dementia, Mild Cognitive Impairment, Cataract Senile, Cataract
- Trial name
- NCT04047485
- Testing
- Visual Acuity, CAM (Confusion Assesment Method), CATQUEST 9-SF
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
General Anesthetic Drug Adverse Reaction
Effect of Remimazolam on Postoperative Delirium
Remimazolam is a novel benzodiazepine with ultra-short onset and offset of its effect. It can be used for general anesthesia. However, classical benzodiazepine such as midazolam was reported to increase the risk of postoperative…
- Trial name
- RED (NCT06180876)
- Testing
- remimazolam, propofol
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Zhihong LU