Clinical trials: Delivery; Injury, open to volunteers
Anxiety
An Informative Video About Perineal Tears During Labor for Anxiety Reduction: A Randomized Controlled Trial
This study evaluates the impact of an informative video about perineal tears on maternal anxiety during labor. Perineal trauma during childbirth, especially severe tears such as obstetric anal sphincter injuries (OASIS), is…
- Trial name
- VITAL (NCT07064213)
- Testing
- Behavioral: Educational Video
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Cesarean Section, Surgical Wound Infection
Timing of Cesarean Wound Dressing Removal on Wound Healing in Women With BMI ≥ 30 kg/m²
Cesarean delivery is one of the most common surgical procedures in obstetric care. Women with obesity (body mass index [BMI] of 30 kg/m² or higher) are at increased risk for postoperative wound complications, including surgical…
- Conditions
- Cesarean Section, Surgical Wound Infection, Wound Healing, Obesity
- Trial name
- NCT07846930
- Volunteers
- 726 people
- Sponsor
- Assiut University
Major Depressive Disorder, Post Traumatic Stress Disorder
Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)
This observational registry aims to collect real-world data on ketamine use in psychiatric inpatients within a regional tertiary-reference center.
- Conditions
- Major Depressive Disorder, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder, Somatoform Disorders
- Trial name
- KetGD (NCT05565352)
- Testing
- Ketamine Hydrochloride
- Where
- Poland
- Volunteers
- 140 people
- Sponsor
- Medical University of Gdansk
Bronchopulmonary Dysplasia (BPD)
Enteral Lipid Supplementation and Bronchoplumonary Dysplasia of Premature Infants
The Impact of Omega-3 (DHA - Docosahexaenoic Acid) and Omega-6 (ARA - Arachidonic Acid) Supplementation on the Development of Bronchopulmonary Dysplasia in Extremely and Very Preterm Infants (24-29 weeks of gestational age).
- Trial name
- PRELUDE (NCT07652684)
- Testing
- Enteral supplementation with ARA and DHA (in a 2:1 ratio) in addition to standard care and feeding, Standard care and feeding
- Where
- Greece
- Volunteers
- 74 people
- Sponsor
- Aristotle University Of Thessaloniki
Wound of Skin, Burns
Pilot Study: KeraStat® Gel for Topical Delivery of Morphine for Management of Non-Healing, Painful Open Wounds and Ulcers
This study is intended to provide information from subjects who currently have painful, chronically open wounds and assess the pain reduction capacity of KeraStat® Gel with Morphine.
- Trial name
- NCT05217160
- Testing
- KeraStat® Gel with Morphine application, KeraStat® Gel application
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The Metis Foundation
Bronchopulmonary Dysplasia (BPD)
Metformin for Premature Infants With Bronchopulmonary Dysplasia
The overall objective of this study is to investigate the role of metformin in decreasing lung injury and promoting lung growth in premature infants. There are two phases to this pilot study.
- Trial name
- NCT07120971
- Testing
- Metformin (open-label)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Stress Disorders, Post-Traumatic, Psychological Trauma
Postnatal Debriefing After Adverse Obstetric Events
Adverse or unexpected obstetric events can negatively affect women's psychological well-being and childbirth experience, increasing the risk of postpartum traumatic stress.
- Conditions
- Stress Disorders, Post-Traumatic, Psychological Trauma, Obstetric Labor Complications, Postpartum Period
- Trial name
- DBIRTH (NCT07579273)
- Testing
- Structured Postnatal Debriefing, Usual Care
- Volunteers
- 142 people
- Sponsor
- Parc de Salut Mar
TBI (Traumatic Brain Injury), Depressive Disorder, Major
InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI
The purpose of this randomized controlled trial is to evaluate whether the InMotion intervention, delivered via telehealth (using a HIPAA-compliant video platform or phone), which uses evidence-based behavioral and motivational…
- Conditions
- TBI (Traumatic Brain Injury), Depressive Disorder, Major, Clinical Depression, Mood Depressed
- Trial name
- NCT06005194
- Testing
- InMotion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Anterior Cruciate Ligament (ACL)
Preoperative Rehabilitation for Patient With an ACL Injury
Muscle qualities are critical for the recovery after an anterior cruciate ligament (ACL) injury. Before ACL reconstruction (ALCR), resistance training aims to maintain patient strength and volume in order to optimize recovery.
- Trial name
- K-POP (NCT07411625)
- Testing
- Resistance training, Traditional exercises
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Nantes University Hospital
Spinal Cord Injury, Delayed Admission
Complications Associated With Delayed Admission to Spinal Injury Unit
The aim of this study is to determine the prevalence of complications including PUs at time of admission to a regional spinal injury rehabilitation unit (MCSI), the relationship between wait time to admission for specialist SCI…
- Trial name
- NCT07015099
- Where
- United Kingdom
- Volunteers
- 1,400 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Brain Injuries, Traumatic, Brain Injury Traumatic Severe
Online Memory Intervention for Individuals with Traumatic Brain Injury
This study will examine the behavioural and neurophysiological efficacy and feasibility of an online spatial navigation intervention for improving memory and brain health in individuals who have sustained moderate-severe…
- Conditions
- Brain Injuries, Traumatic, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, Brain Injury, Chronic
- Trial name
- NCT04331392
- Testing
- Spatial Navigation Intervention, Educational Videos
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Toronto Rehabilitation Institute
Obstetric Labor Complications, Obstetric Trauma
Prelabor Visual Biofeedback by a Self-operated Ultrasound Device
A substantial number of women report fear of childbirth and negative birth experiences. The objective of the study is to assess the efficacy of visual biofeedback before labor using a self-operated home ultrasound for maternal…
- Trial name
- NCT06049784
- Testing
- Visual Biofeedback using self operated home ultrasound device, Visual Biofeedback using ultrasound at hospital
- Where
- Israel
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Premature Infants, Very Premature Infants
Anakinra Pilot 2 - A Study to Optimise Dose and Route of Administration of Anakinra in Preterm Infants
A phase 2 randomised, three-arm, parallel-group, dose-ranging trial to determine safety, efficacy and optimal dosing of intravenous anakinra in premature neonates, with subcutaneous pharmacokinetic sub-study.
- Conditions
- Premature Infants, Very Premature Infants, Inflammation
- Trial name
- AP2 (NCT07254000)
- Testing
- Anakinra (Kineret®)
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 24 people
- Sponsor
- Monash Medical Centre
Coronary Heart Disease, Acute Myocardial Infarction
Twenty-year Follow-up of the Inter99 Cohort
Being born small increases your risk of developing Type 2 diabetes (T2D) with age. Furthermore, data even suggest that some of the diseases ("complications") in the eyes, kidneys, nerves, liver, blood vessels and heart often seen…
- Conditions
- Coronary Heart Disease, Acute Myocardial Infarction, Cardiovascular Diseases, Type 2 Diabetes
- Trial name
- NCT05166447
- Where
- Denmark
- Volunteers
- 4,000 people
- Sponsor
- Bispebjerg Hospital
Cartilage Injury, Cartilage Disease
Long-term Outcome Evaluation of Patients Undergoing Autologous Chondrocyte Transplantation Delivered on Biomaterial
Chondro-Long study is prospective observational study for a long-term clinical evaluation (follow-up up to 25 years) in patients treated with autologous chondrocyte transplantation delivered on biomaterial for full-thickness…
- Trial name
- NCT06238947
- Volunteers
- 200 people
- Sponsor
- Istituto Ortopedico Rizzoli
Maternal Pushing Techniques, Perineal Trauma
Vocalization and Spontaneous Pushing in the Second Stage of Labor
The second stage of labor, defined as the period from full cervical dilatation to fetal birth, is a critical phase in which maternal pushing techniques may significantly affect maternal and neonatal outcomes (1-5).
- Conditions
- Maternal Pushing Techniques, Perineal Trauma, Maternal Fatigue, Labor
- Trial name
- NCT07316348
- Testing
- The vocalization straining technique will be used.
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Shock
CRUISE System in Flight
This is a prospective, observational, blinded clinical study with the purpose of assessing the safety of a non-invasive decision support system for the identification and management of shock (the CRUISE system).
- Trial name
- CRUISE (NCT07637240)
- Testing
- Observation blinded group with the purpose of assessing the safety of a non-invasive decision support system for the identification and management of shock (the CRUISE system).
- Volunteers
- 60 people
- Sponsor
- Hernando Gomez
Traumatic Brain Injury, Stroke
Internet Delivered Cognitive Rehabilitation for Mild Cognitive Impairments
Acquired brain injury and neurological disorders cause cognitive deficits, which in turn cause reduced participation in everyday life.
- Conditions
- Traumatic Brain Injury, Stroke, Multiple Sclerosis, Parkinsons Disease (PD)
- Trial name
- eRehabCog (NCT06973018)
- Testing
- eRehabCog, CogMed QM
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Aniko Bartfai
Urea Cycle Disorder, Organic Acidemia
Systemic Biomarkers of Brain Injury From Hyperammonemia
Ammonia is a waste product of protein and amino acid catabolism and is also a potent neurotoxin. High blood ammonia levels on the brain can manifest as cytotoxic brain edema and vascular compromise leading to intellectual and…
- Conditions
- Urea Cycle Disorder, Organic Acidemia, Maple Syrup Urine Disease, Glutaric Acidemia I
- Trial name
- NCT04602325
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Children's National Research Institute
Perineal Trauma, Postpartum Pain
RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or Episiotomy
Perineal tears and episiotomies are common after vaginal birth and may cause persistent pain, impaired wound healing, pain during sexual activity, and concerns about genital appearance.
- Conditions
- Perineal Trauma, Postpartum Pain, Episiotomy, Perineal Laceration
- Trial name
- RELIEVE (NCT07727213)
- Testing
- Autologous Non-Activated Platelet-Rich Plasma, Saline (0.9%, sterile, for infusion)
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva