Clinical trials: Delivery, open to volunteers
Dravet Syndrome
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
ENDEAVOR is a Phase 1/2, 2-part, multicenter study to evaluate the safety and efficacy of ETX101 in participants with SCN1A-positive Dravet syndrome aged ≥6 to <36 months (Part 1A), aged ≥48 months to <18 years (Part 1B), and…
- Trial name
- ENDEAVOR (NCT05419492)
- Testing
- ETX101
- Where
- 14 sites in United States, Australia and 1 more
- Volunteers
- 113 people
- Sponsor
- Encoded Therapeutics
Data Accuracy, Agency
Empowerment Training for Personal Agency Development of Primary Health Care Workers
This study evaluates an Empowerment Agency Training (EAT) intervention within the SPHERES programme that aims to strengthen personal agency among workers in primary healthcare centers (Puskesmas) in Indonesia.
- Conditions
- Data Accuracy, Agency, Burnout, Service Evaluation
- Trial name
- NCT07509931
- Testing
- Empowerment Agency Training (EAT)
- Where
- 2 sites in Indonesia
- Volunteers
- 200 people
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Pregnancy Related
eDoula Feasibility and Acceptability
eDoula is an app that will give patients reading material and videos to watch based on their due date. It also provides helpful postpartum guidance.
- Trial name
- NCT06785467
- Testing
- eDoula App
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Chronic Pain
VETERANS AFFAIRS AUGUSTA
Chronic pain is a prevalent and debilitating condition among Veterans, often accompanied by depression, anxiety, sleep disturbances, and social isolation.
- Trial name
- NCT07776600
- Testing
- My AI Companion
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Companion IQ, Inc
Diabetes Mellitus (Type 2), Glycemic Control for Diabetes Mellitus
Video-Based Lifestyle Counseling in Adults With Type 2 Diabetes.
This study evaluates the effectiveness of a 3-month video-based lifestyle intervention, focused on promoting healthy lifestyle habits (healthy eating and increased physical activity), on adults with type 2 diabetes mellitus…
- Conditions
- Diabetes Mellitus (Type 2), Glycemic Control for Diabetes Mellitus, Physical Activity, Healthy Eating
- Trial name
- LIDM2 (NCT07557264)
- Testing
- Video-based lifestyle intervention (own physician), Video-based lifestyle intervention (unknown physician)
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Cardenal Herrera University
Genetic Disease, Multiple Malformation
Genomic Sequencing and Personalized Treatment for Birth Defects in Neonatal Intensive Care Units
The purpose of study is to evaluate the benefits of using the Next Generation Sequencing Technology to diagnose birth defects and genetic diseases.
- Conditions
- Genetic Disease, Multiple Malformation, Congenital Malformation
- Trial name
- NCT02551081
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Children's Hospital of Fudan University
Premature, Premature Lungs
Baby ABS (Abdominal Binder Study)
The primary outcome of this study is to determine if the use of the FDA-approved DandleLion NeoBellyBand increases the thickness of the rectus abdominis muscle in premature babies receiving continuous positive pressure…
- Conditions
- Premature, Premature Lungs, Ventilator Lung; Newborn, Rectus Abdominis
- Trial name
- NCT07049900
- Testing
- NeoBelly Band
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Primipara Pregnant, Primipara Labour
The Effect of Birth Positions on Labor
This study is a randomized controlled trial aimed at evaluating the effects of positions used during labor on pelvic floor muscle strength and the severity and nature of perineal pain in primiparous pregnant women.
- Trial name
- NCT07243522
- Testing
- Semi-sitting birth position
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ege University
Neurodevelopmental Disorders, Autism Spectrum Disorder (ASD)
Pai.ACT - An Artificial Intelligence Driven Chatbot Assisted ACT (Full Scale RCT)
Interventions for parents of children with NDD face two pivotal challenges. Firstly, many overlook the consequential influence of parenting stress, symptoms of parental anxiety and depression on the well-being of parent-child…
- Conditions
- Neurodevelopmental Disorders, Autism Spectrum Disorder (ASD), Attention Deficit Disorder With Hyperactivity (ADHD)
- Trial name
- NCT06779422
- Testing
- Pai.ACT, Positive parenting advice
- Where
- Hong Kong
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Very Preterm Infants Born < 30 Weeks of Gestation
Quantitative 3D UltraSound Brain Imaging: Development of New Bedside Biomarkers to Better Predict Neurodevelopmental Outcomes in Preterm Infants
Prematurity is a leading cause of neurodevelopmental disorders (NDDs) tightly associated with white matter damage, including punctate white matter lesions (PWMLs).
- Trial name
- QUSBI (NCT07358819)
- Testing
- Cranial ultrasound, Brain MRI, PARCA-R questionnaire
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood Loss, Surgical, Blood Loss, Postoperative
Prophylactic Intravenous Calcium Gluconate to Decrease Blood Loss at Time of Cesarean Delivery in Pregnant Patients at High Risk for Uterine Atony
This research study is being done to learn what effect a single dose of calcium gluconate will have on blood loss at the time of cesarean delivery in pregnancy patients at high risk for uterine atony.
- Conditions
- Blood Loss, Surgical, Blood Loss, Postoperative, Uterine Atony
- Trial name
- NCT07217899
- Testing
- Calcium Gluconate, Saline
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Michigan
Postpartum Depression (PPD), Perinatal Anxiety
Midwife-led Childbirth Review and Psychological Outcomes in New Parents
The aim of this clinical trial is to support psychological well-being and facilitate adjustment to parenthood among postpartum mothers and fathers through a midwife-led childbirth review (MLCR).
- Conditions
- Postpartum Depression (PPD), Perinatal Anxiety, Postpartum Mental Health
- Trial name
- CROWN (NCT07678801)
- Testing
- Midwife-led childbirth review (MLCR)
- Where
- 2 sites in Czechia
- Volunteers
- 1,300 people
- Sponsor
- Charles University, Czech Republic
Bronchopulmonary Dysplasia (BPD), Preterm Birth Complication
Parent Perceptions of OptiPAP Junior
To evaluate how different forms of respiratory support affect parent interaction, how parents feel about different methods of support, and how their child's current respiratory support level is perceived in the setting of…
- Conditions
- Bronchopulmonary Dysplasia (BPD), Preterm Birth Complication, Pulmonary, CPAP
- Trial name
- NCT07837700
- Testing
- Nasal CPAP interface: OptiPAP Junior, Nasal CPAP interface: FlexiTrunk
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sharp HealthCare
Labor Complication, Induced; Birth
SAINT: Safe Induction of Labor Trial
Over the past years, the rates of labor induction have increased steadily, and at present more than one in four births occurs after induced labor in Norway.
- Conditions
- Labor Complication, Induced; Birth, Pregnancy Related
- Trial name
- SAINT (NCT05719467)
- Testing
- Buscopan 20 MG/ML Injectable Solution, Sodium bicarbonate, Nacl 0.9%
- Where
- 5 sites in Norway
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Chronic Endometritis
GnRH Agonist Pretreatment in Persistent Chronic Endometritis Undergoing FET
Women with PCE represent a treatment-resistant phenotype in whom the endometrial inflammatory and immune status remains abnormal despite antibiotic therapy.
- Trial name
- NCT07642700
- Testing
- Conventional estrogen-progesterone artificial cycle for endometrial preparation, GnRH agonist plus estrogen-progesterone for endometrial preparation
- Volunteers
- 150 people
- Sponsor
- Guoxia Yang
Refractory/Relapsed B-cell Lymphoma
Clinical Study of Oncolytic Vaccinia VIrus Delivering Targeted CD19 in Vivo CAR-T/M Therapy for Refractory/Relapsed B-cell Lymphoma
To study the safety and effectiveness of oncolytic Vaccinia VIrus-Delivered Targeted CD19 In Vivo CAR-T/M Therapy for Refractory/Relapsed B-Cell Lymphoma
- Trial name
- NCT07398963
- Testing
- CD19-CAR novel oncolytic vaccinia virus
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pregnancy in Adolescence, Fear
Effect of MBSR Training on Childbirth Fear, Bonding and Breastfeeding in Adolescent Pregnant Women
This randomized controlled study aims to evaluate the effect of Mindfulness-Based Stress Reduction (MBSR) training given to adolescent pregnant women and their partners on fear of childbirth, maternal and paternal bonding, and…
- Conditions
- Pregnancy in Adolescence, Fear, Mother-Child Relations, Mindfulness
- Trial name
- NCT07540923
- Testing
- Mindfulness-Based Stress Reduction (MBSR) Training
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Inonu University
Labor Pain
Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Management During Labor.
This is a randomized, double-blind, crossover clinical trial to evaluate the efficacy of transcutaneous electrical nerve stimulation (TENS) as a non-pharmacological therapeutic intervention for reducing pain in women during the…
- Trial name
- TENS-LABOR (NCT07401147)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS); TENSCARE Perfect Mama+ TENS unit
- Where
- 2 sites in Honduras
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Ricardo A Gutierrez Ramirez, MD, MSc, FACOG
Preterm Delivery, Obstetrical Complications
Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial
This is a phase-III multi-center double-blind randomized clinical trial of 1,800 individuals with a history of prior preterm birth at less than 35 weeks gestation who are randomized to either 162 mg aspirin or 81 mg aspirin…
- Trial name
- ADEPT (NCT06980025)
- Testing
- 162mg Aspirin, 81mg Aspirin
- Where
- 14 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Obstetrical Complications, Labor and Delivery Complication
Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial
This is a phase-III multi-center double-blind randomized controlled trial of 8,000 individuals undergoing a scheduled or prelabor cesarean delivery who are randomized to either adjunctive azithromycin prophylaxis or to placebo.
- Conditions
- Obstetrical Complications, Labor and Delivery Complication, Cesarean Delivery
- Trial name
- PRECEDE (NCT06605118)
- Testing
- Azithromycin Injection, Standard of Care Preoperative antibiotics
- Where
- 14 sites in United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
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