Clinical trials: Delivery Outcomes, open to volunteers
Third Stage of Delivery
Maternal Outcomes Following Manual Lysis of the Placenta.
Comparison of maternal outcomes following manual lysis of placenta 15 vs 30 minutes after delivery. A primary outcome of the drop in hemoglobin will be compared between the two groups.
- Trial name
- NCT03626844
- Testing
- Manual Lysis of Placenta after 15 minutes (Intervention), Manual Lysis of Placenta after 30 minutes (Control)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Pregnancy
The Effect of Ultrasound Visual Feedback on Birth Outcomes in Nulliparous Women With Levator Ani Muscle Co-activation at Term Pregnancy
The study aims to evaluate the effect of ultrasound-based visual feedback training of the pelvic floor muscles in nulliparous women at term pregnancy who present co-activation of the levator ani muscle, on the duration of the…
- Trial name
- CoA_2025 (NCT07675642)
- Testing
- Ultrasound Visual Feedback Training
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Family Involvement/Empowerment, Family-centered Care
Effectiveness of Family-Integrated Newborn Care to Improve Outcomes for Preterm and Low-birth-weight Neonates
The goal of this quasi-experimental study is to learn if integrating family in newborn care units as a key partner can improve the outcomes of preterm and low-birth-weight neonates.
- Conditions
- Family Involvement/Empowerment, Family-centered Care, Intensive Care Units, Neonatal, Family Integrated Newborn Care
- Trial name
- FINC (NCT07364903)
- Testing
- Family Integrated Newborn Care, an intervention to integrate family in the care targeted their preterm and Low-birth weight neonates, Standard medical treatment
- Where
- 2 sites in Ethiopia
- Volunteers
- 1,020 people
- Sponsor
- Laerdal Foundation
Fertility Issues, Blastocyst IVF
A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant (5%) Versus Sequential (5%-2%) Oxygen Concentration Embryo Culture Protocols in Assisted Reproductive Technology
To evaluate whether there were significant differences in the effects of constant (5%) versus sequential (5%-2%) oxygen concentration protocols in embryo culture on term live birth rates.
- Conditions
- Fertility Issues, Blastocyst IVF, Embryo Culture
- Trial name
- NCT07050537
- Testing
- Constant oxygen concentration protocols in embryo culture, Sequential oxygen concentration protocols in embryo culture
- Where
- 6 sites in China
- Volunteers
- 980 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Preterm Birth
Effectiveness of Targeted Cervical Length Screening Guided by a Preterm Birth Risk Scoring System in Reducing the Rate of Preterm Birth
This cluster non-randomized controlled trial aims to evaluate the effectiveness and feasibility of a risk score-guided targeted cervical length screening strategy for the prevention of spontaneous preterm birth in routine…
- Trial name
- NCT07415070
- Testing
- Preterm birth risk scoring system, Transvaginal ultrasound cervical length measurement, Vaginal Progesterone
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ningbo University
Embryo Transfer, IVF
Effect of Pentoxyfilline on Endometrial Thickness and Frozen Embryo Transfer Outcomes
The aim of this work was to investigate the effect of different vasodilators as pentoxifylline in women with unexplained infertility using IVF
- Conditions
- Embryo Transfer, IVF, Infertility
- Trial name
- NCT07499817
- Testing
- pentoxifylline 400 mg, (control)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Depression, Postpartum
CODEPAD-III (Collaborative Outcomes of DEpression and Pain Associated With Delivery-III)
The childbirth process is associated with increased risk of having depression and persistent pain which may have adverse effects to mothers and their babies.
- Conditions
- Depression, Postpartum, Pain, Mental Health
- Trial name
- CODEPAD-III (NCT07773259)
- Testing
- Collaborative Psychological Model (CPM), Intervention common to both arms, Telephone-based support (Control)
- Volunteers
- 3,470 people
- Sponsor
- KK Women's and Children's Hospital
Respiratory Viral Infections, Adverse Pregnancy Outcomes
APOs Associated With Respiratory Viral Infections Before and During Early Pregnancy
Adverse pregnancy outcomes (APOs) are a collection of conditions that have short-term and long-term effects of complications related to pregnancy and childbirth on pregnant women and their fetuses, including hypertensive…
- Trial name
- APO (NCT07257952)
- Volunteers
- 1,440 people
- Sponsor
- Shanghai General Hospital, China
Thyroiditis, Autoimmune, Infertility
Effect of Prednisone and Aspirin on IVF-ET Outcome Among Patients With Thyroid Autoimmunity
This trial was a 1:1 (active:placebo) randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of prednisone and aspirin for the in vitro fertilization and embryo transfer outcome among patients with…
- Trial name
- NCT05578456
- Testing
- Prednisone and Aspirin
- Volunteers
- 540 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia
Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia
The aim of this prospective randomized double-blind study is to compare the effectiveness of routine antiemetic prophylaxis for the prevention of intraoperative nausea and vomiting (IONV) in non-fasted parturients undergoing…
- Conditions
- Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia, Ceserean Section, Antiemetic Therapy
- Trial name
- NCT07740577
- Testing
- Ondansetron 4mg, metoclopramide
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sanliurfa Education and Research Hospital
Preterm Birth Complication, Neonatal Morbidity and Mortality
Delayed Versus Immediate Cord Clamping in Preterm Birth
The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth.
- Conditions
- Preterm Birth Complication, Neonatal Morbidity and Mortality, Cord Clamping, Delayed Cord Clamping
- Trial name
- PREM-CORD (NCT07699666)
- Testing
- Delayed Umbilical Cord Clamping, Immediate Umbilical Cord Clamping
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Faculty of Medicine of Tunis
Infertility, Implantation Rate
Hyaluronan-enriched Medium and Euploid Blastocyst Transfers
It has been proposed that enriching transfer media with hyaluronan (EmbryoGlue medium) improves pregnancy outcomes compared with media containing lower concentrations of this molecule.
- Conditions
- Infertility, Implantation Rate, Clinical Pregnancy Rate, Live Birth Rate
- Trial name
- GluePloid (NCT06165367)
- Testing
- EmbryoGlue Medium
- Where
- United Arab Emirates
- Volunteers
- 783 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Chronic Endometritis
GnRH Agonist Pretreatment in Persistent Chronic Endometritis Undergoing FET
Women with PCE represent a treatment-resistant phenotype in whom the endometrial inflammatory and immune status remains abnormal despite antibiotic therapy.
- Trial name
- NCT07642700
- Testing
- Conventional estrogen-progesterone artificial cycle for endometrial preparation, GnRH agonist plus estrogen-progesterone for endometrial preparation
- Volunteers
- 150 people
- Sponsor
- Guoxia Yang
Embryo Transfer, Fertilization in Vitro
Does Sexual Intercourse Affect the Outcomes of Frozen-thawed Embryo Transfer?
The goal of this clinical trial is to test whether sexual intercourse the night after embryo transfer affects thawed embryo implantation rates.
- Conditions
- Embryo Transfer, Fertilization in Vitro, Coitus
- Trial name
- NCT06134609
- Testing
- Sexual intercourse
- Where
- Israel
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Pregnancy Outcomes, Child Development
Born In Guangzhou Intervention Study
The main objective of this study is to test the efficacy of an intervention package (dietary, physical and lifestyle modification) during pregnancy in improving the clinical outcomes of mother-infant dyads.
- Conditions
- Pregnancy Outcomes, Child Development, Pregnancy Complications
- Trial name
- BIGIS (NCT05503849)
- Testing
- Lifestyle modification
- Where
- 2 sites in China
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Premature Birth, Antibiotics
NICU Antibiotics and Outcomes (NANO) Follow-up Study
The NANO follow-up study is designed to determine whether a simple, cost-effective intervention- withholding antibiotics at birth- reduces clinically relevant outcomes such as behavioral and neurological impairment at 2 years of…
- Conditions
- Premature Birth, Antibiotics, Neurodevelopment
- Trial name
- NANO-FU (NCT05977400)
- Testing
- Ampicillin, Gentamicin
- Where
- 15 sites in United States, Canada
- Volunteers
- 802 people
- Sponsor
- Sharp HealthCare
Neovascular Age-related Macular Degeneration
A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD
The purpose of this study is to evaluate the effectiveness, safety, and PROs of the port delivery system with ranibizumab 100 milligrams/milliliters (mg/mL) refilled every 36 weeks (Q36W) in participants with nAMD.
- Trial name
- Sightspire (NCT06847542)
- Testing
- Susvimo PDS Implant, Ranibizumab
- Where
- 61 sites in Austria, Czechia and 11 more
- Volunteers
- 250 people
- Sponsor
- Hoffmann-La Roche
Adenomyosis of Uterus, Frozen Embryo Transfer (FET)
GnRH Agonist Pretreatment Duration and Letrozole Supplementation in Frozen Embryo Transfer for Adenomyosis Patients
This randomized clinical trial aims to assess the comparative effectiveness of different pre-treatment protocols prior to frozen embryo transfer (FET) among women with adenomyosis, providing evidence-based guidance for clinical…
- Trial name
- GOLD-FET (NCT07065539)
- Testing
- GnRH-a-1M, GnRH-a-2M, GnRH-a+LE-1M
- Where
- China
- Volunteers
- 432 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Aboriginal Health, Cultural Safety
The Communicate Study Partnership
The vision of the Communicate Study Partnership is to ensure more Aboriginal patients receive culturally safe healthcare in their first language.
- Conditions
- Aboriginal Health, Cultural Safety, Access to Interpreters, Healthcare Provider Training
- Trial name
- NCT05629416
- Testing
- Interventions to transform the culture of healthcare systems to achieve excellence in providing culturally safe care for First Nations peoples
- Where
- 4 sites in Australia
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Labor Duration, Cesarean Section Rate
The MOBY Study: Efficacy of Birth Mobility
This randomized clinical trial investigates whether and how maternal mobility during labor influences birth outcomes in primiparous women.
- Conditions
- Labor Duration, Cesarean Section Rate, Maternal Mobility, Healthy
- Trial name
- MOBY (NCT07052331)
- Testing
- Birth Mobility System
- Where
- Switzerland
- Volunteers
- 714 people
- Sponsor
- Vibwife AG