Clinical trials: Delivery Systems
Polycystic Ovary Syndrome
The Influence Factors of Ovarian Response in PCOS Patients With IVF-ET Treatment
The purpose of this study is to explore the factors which affect ovarian response of PCOS patients with IVF-ET treatment, in order to provide predictive clinical index for the outcome of IVF-ET treatment in PCOS patients.
- Trial name
- NCT02331758
- Testing
- Lifestyle Counseling
- Volunteers
- 1,000 people
- Sponsor
- Peking University Third Hospital
Diabetes
Evaluation of Neurodevelopmental Trajectories in Children According to the Glycemic Profile Associated With Early Treatment Using an Automated Delivery System in Children With Type 1 Diabetes
ore than half of all new cases of type 1 diabetes (T1D) are diagnosed within the first decade of life. It has been reported that early onset of this disease may be associated with a decline in cognitive performance in adulthood…
- Trial name
- PROCEDE (NCT06461065)
- Testing
- AIDS, Brain MRI
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glaucoma, Ocular Hypertension
A Safety Study of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open Angle Glaucoma
The purpose of this study is to determine if the Punctal Plug Delivery System is safe and effective in controlling intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
- Trial name
- NCT00820300
- Testing
- Latanoprost-PPDS
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Mati Therapeutics Inc.
Chronic Periodontitis
Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis
Summary The aim of this study is to evaluate through clinical, microbiological and immunological parameters using PLGA microspheres (lactic-co-glycolic acid polyacid) containing doxycycline in periodontal therapy in smokers with…
- Trial name
- NCT02726646
- Testing
- Doxycycline, Mechanical debridement
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Asthma
Evaluation of the Prevalence of Asthma in a Cohort of Children Born After IVF (Aged 11-15) Compared With a Control Group
Assisted Reproduction Technologies (ART) are increasingly being used worldwide as a result of fertility decline likely caused by changes in both environment and social behaviour.
- Trial name
- EMCeFIV (NCT02636179)
- Testing
- Comparative epidemiological survey
- Where
- France
- Volunteers
- 1,792 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Hiv, HIV Infections
Adoptive Transfer of Haploidentical NK Cells and N-803
This is a pilot therapeutic study of related donor HLA-haploidentical NK-cell based therapy to determine if the treatment is safe and well-tolerated and if there is any measureable impact on virus reservoirs.
- Conditions
- Hiv, HIV Infections, Immune Deficiency
- Trial name
- NCT03899480
- Testing
- Haploidentical Natural Killer (NK) Cells
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota
Alpha 1-Antitrypsin Deficiency
Safety Dose Finding Study of ADVM-043 Gene Therapy to Treat Alpha-1 Antitrypsin (A1AT) Deficiency
The ADVANCE study is being conducted by Adverum Biotechnologies, Inc. as an open-label, multicenter, dose-escalation study in order to assess the safety and protein expression of ADVM-043 following a single intravenous or…
- Trial name
- ADVANCE (NCT02168686)
- Testing
- ADVM-043
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Adverum Biotechnologies, Inc.
HIV Infections, Pregnancy
Drug Interactions Between Lopinavir/Ritonavir and Oral or Patch Contraceptives in HIV Infected Women
The purpose of this study is to examine the drug interactions between a protease inhibitor (PI)-based regimen including lopinavir/ritonavir (LPV/r) and two forms of contraceptive medications in HIV infected women.
- Trial name
- NCT00125983
- Testing
- Lopinavir/ritonavir, Ortho Novum 1/35, Ortho Evra
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 32 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nutrient Pharmacokinetics
Vitamin Gum Pharmacokinetics
The present study will investigate the oral release and systemic pharmacokinetics of a panel water- and fat-soluble vitamins from two commercially-produced chewing gum formulations. Vitaball, Inc. (Ft.
- Trial name
- NCT03230396
- Testing
- Vitamingum Sport, Vitamingum Immunity
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Penn State University
Severe Combined Immunodeficiency Disease, X-linked
Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants
SCID-X1 is a genetic disorder of blood cells caused by DNA changes in a gene that is required for the normal development of the human immune system.
- Trial name
- LVXSCID-ND (NCT01512888)
- Testing
- CL20-i4-EF1α-hγc-OPT, Busulfan, CliniMacs
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- St. Jude Children's Research Hospital
Hepatitis B
Assess Feasibility of an Acellular Pertussis Vaccine (Pa) Given Soon After Birth, Followed by 3-dose Primary Vaccination With the DTPa-HBV-IPV/Hib Vaccine
This study will assess immunogenicity, safety and reactogenicity of primary and booster vaccination.
- Trial name
- NCT00289796
- Testing
- DTPa-HBV-IPV/Hib
- Where
- Germany
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2
Technology Delivered Diabetes-Modified Behavioral Activation Treatment
The overarching goal of this proposal is to test the efficacy of a multi-component, high intensity intervention, technology delivered, diabetes-modified behavioral activation treatment (TECH DM-BAT) that incorporates: 1) diabetes…
- Trial name
- TECHDMBAT (NCT03593694)
- Testing
- TECH DM-BAT, TECH DMBAT Active Comparator, TECH DMBAT Other
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Irritable Bowel Syndrome
Study of Fecal Microbiota Transplantation (FMT) in Severe IBS Patients
The objective of this protocol is to evaluate the efficacy of fecal microbiota transplantation (FMT) using oral capsules containing frozen stools vs sham FMT on IBS severity score at 12 weeks in patients with severe irritable…
- Trial name
- ICEBOAT (NCT06433180)
- Testing
- Administration of fecal microbiota transplantation ( FMT capsules)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease, Movement Disorders
Clinical Study to Test the Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease
This study evaluates the safety and tolerability of CDNF in patients with Parkinson's disease, when dosed directly into the brain using an implanted investigational drug delivery system (DDS).
- Conditions
- Parkinson Disease, Movement Disorders, Neurodegenerative Diseases, Nervous System Diseases
- Trial name
- NCT03295786
- Testing
- Cerebral Dopamine Neurotrophic Factor, Renishaw Drug Delivery System
- Where
- 3 sites in Finland, Sweden
- Volunteers
- 17 people
- Sponsor
- Herantis Pharma Plc.
Muscle Loss
The Effect of Leucine on Carnitine Transport to Skeletal Muscle
The primary aim of the current research project is to explore whether leucine stimulates carnitine transport, and thus affecting muscle carnitine content.
- Trial name
- ROL (NCT05009654)
- Testing
- L-carnitine, L-leucine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Developmental, Behavioral and Mental Health, Adhd
Using Telehealth to Deliver Mental Health Services in Primary Care Settings for Children in Underserved Areas
In partnership with a multi-site, Los Angeles-area community clinic consortium, North East Valley Health Corporation (NEVHC), the investigators will use telehealth to integrate pediatric developmental, behavioral and mental…
- Conditions
- Developmental, Behavioral and Mental Health, Adhd, Depression, Anxiety
- Trial name
- NCT02396576
- Testing
- Telehealth Intervention
- Where
- 6 sites in United States
- Volunteers
- 359 people
- Sponsor
- University of California, Los Angeles
Ocular Hypertension, Open-Angle Glaucoma
A Study of the L-PPDS With Adjunctive Xalatan® Eye Drops in Subjects With OH or OAG
The objective of this study is to investigate how the intraocular pressure (IOP)-lowering effect of the L-PPDS is altered by adjunctive Xalatan therapy.
- Trial name
- NCT01037036
- Testing
- Latanoprost Punctal Plug Delivery System, Xalatan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mati Therapeutics Inc.
Skin Laceration, Skin Abrasion
Retrospective, Observationnal Study to Investigate Procedural Analgesia Delivered to Patients With Lacerations, Abrasions, Burns and Leg Ulcers.
The main part of the study is a retrospective analysis of 200 reports concerning patients with skin wounds and injuries : 50 consecutive patient reports dealing with skin lacerations 50 consecutive patient reports dealing with…
- Conditions
- Skin Laceration, Skin Abrasion, Skin Burn, Leg Ulcer
- Trial name
- APPABU (NCT07350811)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Versailles Hospital
Type 1 Diabetes
Safety and Effectiveness of Automated Insulin Delivery (AID) Systems in Physically Active Adults With Type 1 Diabetes
Despite recent medical and technological advances, optimal glycemic control (time in range; TIR) and prevention of hypoglycemia remain significant challenges for people living with type 1 diabetes (T1DM).
- Trial name
- AIDE-1 (NCT05626725)
- Testing
- Automated insulin delivery system
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Ovarian Hyperstimulation Syndrome, Frozen-thawed Embryo Transfers
Association Between Live Birth Rate and Serum Progesterone During Hormonal Replacement Therapy
Nowadays, frozen-thawed embryo transfers (FET) are expending. This practice avoids risk of ovarian hyperstimulation syndrome (OHSS), as well as allowing better synchronization between endometrium and embryo, which is fundamental…
- Trial name
- PROGEVOL (NCT05588635)
- Testing
- Identification of predictive factors
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
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