Clinical trials: Delivery Systems
Pain, Postoperative
An Open-Label Functionality, Safety and Efficacy Study in Patients Undergoing Elective Unilateral Knee Replacement
This study is being performed to evaluate the functionality of a device (Sufentanil NanoTab® PCA System) that has been developed for use by patients to self-administer the ARX-F01 pain medication (Sufentanil NanoTab 15 mcg) for…
- Trial name
- NCT00859313
- Testing
- Sufentanil NanoTab PCA System/15 mcg
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Talphera, Inc
Crohn's Disease, Rheumatoid Arthritis
OTIS Cimzia Pregnancy Registry
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Conditions
- Crohn's Disease, Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01797224
- Where
- United States
- Volunteers
- 925 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Asthma
Characterization of Aerosol Generation and Transport in the Human Lung
This study is aiming at evaluating whether the number and size of exhaled particles changes during the increase and decrease of bronchial constriction in subjects with mild intermittent asthma.
- Trial name
- NCT01095627
- Testing
- Metacholine challenge
- Volunteers
- 10 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Critically Ill Patients, Nutritional Support
Impact of Comprehensive Rehabilitation Nursing Combined With Refined Airway Management and Nutritional Support on Prognosis and Care Delivery Models in Critically Ill Patients
This combined intervention protocol effectively improves the prognosis of critically ill patients and optimizes nursing management models
- Conditions
- Critically Ill Patients, Nutritional Support, Pulmonary Infections, Gastrointestinal Bleeding
- Trial name
- NCT07025941
- Testing
- Standard Critical Care Nursing Protocol, ICU-PRO Nursing Protocol (Integrated Critical Care Protocol for Rehabilitation Outcomes)
- Where
- China
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Taizhou Hospital of Traditional Chinese Medicine
Stroke, Internet-Delivered Cognitive Behavioural Therapy
ICBT for Persons With Stroke
Despite evidence for ICBT among those with other chronic conditions, its efficacy has yet to be evaluated among those with neurological conditions, including stroke.
- Conditions
- Stroke, Internet-Delivered Cognitive Behavioural Therapy, Depression, Anxiety
- Trial name
- NCT04667754
- Testing
- Internet-delivered Cognitive Behavioural Therapy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Aortic Stenosis
PROVE ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis
Aortic valve sclerosis (aortic valve thickening and calcification without pressure gradient) is one of the most common valvular abnormalities in the Western world.
- Trial name
- PROVE (NCT05539573)
- Testing
- Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system.
- Where
- 27 sites in France, Germany and 2 more
- Volunteers
- 1,043 people
- Sponsor
- University of Leipzig
Respiratory Disease, Asthma
Digital App for Telerehabilitation in Respiratory Diseases
The purpose of this study is to evaluate the feasibility and the mid-term effects of a pulmonary rehabilitation intervention, delivered by digital App, on quality of life of patients affected by respiratory diseases.
- Conditions
- Respiratory Disease, Asthma, Long COVID, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05572346
- Testing
- Home-based telerehabilitation program delivered through digital devices
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- MedicAir Healthcare S.r.l.
Stroke, Broca's Aphasia
Assessment of Cortical Stimulation Combined With Rehabilitation to Enhance Recovery in Broca's Aphasia.
The primary objective of this feasibility study is to evaluate the safety and effectiveness of targeted sub-threshold epidural cortical stimulation delivered concurrent with speech-language rehabilitation activities to enhance…
- Trial name
- NCT00170703
- Testing
- Cortical Electrical Stimulation
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Northstar Neuroscience
Diabetes, Diabetes Mellitus, Type 2
A Study of the Treatment of Type 2 Diabetes With an Insulin Infusion Pump
This trial is conducted in the United States of America (USA). This is an in-patient trial investigating stepwise dose increase in a period of up to 3-weeks followed by a 10-week out-patient maintenance period.
- Conditions
- Diabetes, Diabetes Mellitus, Type 2, Delivery Systems
- Trial name
- NCT00115973
- Testing
- pump, insulin aspart
- Where
- 6 sites in United States
- Volunteers
- 71 people
- Sponsor
- Novo Nordisk A/S
Skin Irritation, Sensitization
A Skin Irritation Assessment of Once-Weekly Corplex™ Donepezil Transdermal Delivery System
A study to assess the skin irritation and sensitization potential of Corplex™ Donepezil Transdermal Delivery System (TDS)
- Trial name
- NCT03397862
- Testing
- Donepezil TDS, Vehicle TDS
- Where
- 2 sites in United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Corium, Inc.
Alcohol Use Disorder, Mild, Alcohol Use Disorder, Moderate
Substituting SMSs for Provider-delivered Care to Improve Alcohol Use Outcomes
The goal of this clinical trial is to test whether a technology-substituted intervention (mhGAP-Remote) derived from the World Health Organization's (WHO) Mental Health Gap Action Programme-Intervention Guide (mhGAP-IG) is…
- Trial name
- NCT05925270
- Testing
- mhGAP-Remote, mhGAP-Standard
- Where
- 3 sites in Lesotho
- Volunteers
- 255 people
- Sponsor
- University Hospital, Basel, Switzerland
Achilles Tendon Rupture, Achilles Tendon Surgery
Endoscopic Flexor Hallucis Longus Transfer vs Minimally Invasive Repair in Acute Achilles Tendon Rupture
The goal of this observational study is to compare the outcomes of two different surgical techniques (Endoscopic Flexor Hallucis Longus transfer - Group 1 vs Minimally Invasive primary repair - Group 2) for patients with acute…
- Conditions
- Achilles Tendon Rupture, Achilles Tendon Surgery, Achilles Tendon Injury
- Trial name
- NCT06114368
- Testing
- Surgery for the treatment of Acute Achilles tendon rupture
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Postoperative Enfectious Morbidity, Postoperative GİS Functionally Recovery
The Effect of Saline Irrigation in the Peritoneal Cavity at Cesarean Delivery
The investigators hypotheised that irrigating the abdominal cavity with saline at the time of cesarean delivery will increase Gastrointestinal System Disfunction without maternal infectious morbidity(especially febril morbidity).
- Trial name
- NCT01716091
- Testing
- irrigation in the peritoneal cavity
- Where
- Turkey (Türkiye)
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Istanbul Bakirkoy Maternity and Children Diseases Hospital
Premature Infants, Pierre Robin Sequence
Comparison of Sucking in Premature Infants and Infants With Pierre Robin Sequence
The NUTROBIN study aims to analyze sucking in two populations of vulnerable children who require intensive and prolonged care, and whose treatment has an impact on the subsequent development of oral function.
- Conditions
- Premature Infants, Pierre Robin Sequence, Feeding Disorder
- Trial name
- NUTROBIN (NCT07604818)
- Testing
- Succiometry
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Prematurity, Cerebral Palsy
NEO Rehab for Infants at Risk of Cerebral Palsy
Premature infants are at increased risk of developing cerebral palsy (CP). Early interventions for at risk infants have the potential to decrease disease severity and improve quality of life.
- Trial name
- NCT03372590
- Testing
- NICU-based rehabilitation bundle, Standard of care
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Virginia
Healthy, Multiple Sclerosis
Peginterferon Beta-1a (BIIB017) Autoinjector Pharmacokinetic Study in Healthy Volunteers
The purpose of this study is to characterize the pharmacokinetic (PK) profile, safety, and tolerability of peginterferon beta-1a (BIIB017) delivered by the single-use autoinjector or prefilled syringe (PFS) in healthy volunteers…
- Trial name
- NCT01610310
- Testing
- BIIB017 (peginterferon beta-1a) Pre-filled syringe (PFS), BIIB017 (peginterferon beta-1a) Autoinjector
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Biogen
Ulcerative Colitis
Effect and Mechanism of Baitouweng Decoction for Large Intestine Damp-heat Syndrome of Ulcerative Colitis
Baitouweng Decoction is traditionally used to treat large intestine damp-heat syndrome of ulcerative colitis (UC) by oral administration and rectal enema.The project applicant's invention of transendoscopic entral tubing (TET)…
- Trial name
- NCT06421818
- Testing
- Baitouweng Tang
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Acute Respiratory Failure
Evaluation of Oxygen Therapy Delivery Systems in Hypoxemic Acute Respiratory Failure
The main objective of this study is to evaluate the efficiency of the oxygen therapy delivery system Optiflow® compared to 2 others standard oxygen therapy delivery systems (Ospal®, non invasive ventilation).12 immunocompetent…
- Trial name
- OPTI O2 (NCT01243918)
- Testing
- Oxygen therapy delivery systems
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Nantes University Hospital
Multiple Sclerosis
TakeCharge: Telephone Delivered Self-management Intervention for People With Multiple Sclerosis (MS)
The proposed project will evaluate the efficacy of a telephone-delivered self-management (T-SM) intervention for reducing the impact of secondary conditions in persons with multiple sclerosis (MS), including chronic pain…
- Trial name
- TakeCharge (NCT00944190)
- Testing
- Self-management intervention, Education
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- University of Washington
Newborn Morbidity, Pain
Epidemiology of Painful Procedures in Neonates
Sick or premature neonates are exposed to frequent painful and stressful procedures during their stay in neonatal intensive care units.
- Conditions
- Newborn Morbidity, Pain, Procedures, Intratracheal Intubation
- Trial name
- EPIPPAIN (NCT01346813)
- Where
- 21 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Hôpital Armand Trousseau
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