Clinical trials: Delivery Systems
Multiple Myeloma
A Phase I/IIa Clinical Trial to Assess Feasibility, Safety and Antitumor Activity of Autologous SLAMF7 CAR-T Cells in Multiple Myeloma
Multiple myeloma (MM) is a rare hematologic malignancy of aberrant plasma cells. There is a high and currently unmet medical need for novel, innovative treatment concepts to improve the therapeutic outcome and prognosis of…
- Trial name
- NCT04499339
- Testing
- SLAMF7 CAR-T
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 38 people
- Sponsor
- Wuerzburg University Hospital
Hypogonadism
A Study to Evaluate the Potential for Interpersonal Transfer of Testosterone Following Single Dose Application
The hypotheses for this study is that there is no transfer of testosterone from male (donor) subjects to female (recipient) subjects when contact is made 2 hours post application of 2% Testosterone MD-Lotion® if the donor has a…
- Trial name
- NCT01172366
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Acrux DDS Pty Ltd
Healthy Volunteers
The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) on QT Intervals in Healthy Volunteers
The purpose of this study is to examine the effect of buprenorphine on QT interval corrected for heart rate (QTc) in healthy subjects.
- Trial name
- NCT01148537
- Testing
- Buprenorphine transdermal patch, Avelox (moxifloxacin hydrochloride) tablet
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP
Anesthesia
Anesthetic Depth Control Using CLADS vs. TCI in Patients With LVSDF
Advancement in techniques for anaesthetic drug delivery and real time monitoring has facilitated safe induction and maintenance of anaesthesia in severely compromised patients.
- Trial name
- NCT02645994
- Testing
- Target Controlled Infusion, Closed Loop Anesthesia Delivery System
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Type 1 Diabetes Mellitus
Adaptive Biobehavioral Control (ABC) of Automated Insulin Delivery
The purpose of this pilot study is to test the safety and feasibility of using two or three research modules in conjunction with an automated insulin delivery device (AID).
- Trial name
- NCT04784637
- Testing
- Web Simulation Tool (WST), Behavioral Adaptation Module (BAM), Auto Titration Module (ATM)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Cystic Fibrosis
A 4-week Study to Test Different Doses of BI 1265162 in Adolescents and Adults With Cystic Fibrosis Using the Respimat® Inhaler - BALANCE - CF™1
The primary objective of this trial is to assess the efficacy, safety and pharmacokinetics of twice daily inhaled doses of BI 1265162 delivered by Respimat® inhaler versus placebo in adolescents and adult patients with cystic…
- Trial name
- NCT04059094
- Testing
- BI 1265162
- Where
- 26 sites in United States, Belgium and 6 more
- Volunteers
- 52 people
- Sponsor
- Boehringer Ingelheim
Attention Deficit and Disruptive Behavior Disorders, Attention Deficit Hyperactivity Disorder
Optimizing Attention and Sleep Intervention Study
The goal of this pilot clinical effectiveness trial is to compare a brief parent behavioral intervention (PBI) to a modified sleep focused PBI (SF-PBI) delivered by therapists in pediatric primary care for families of children…
- Conditions
- Attention Deficit and Disruptive Behavior Disorders, Attention Deficit Hyperactivity Disorder, Child, Preschool, Sleep
- Trial name
- OASIS (NCT05683756)
- Testing
- Brief Parent Behavioral Intervention, Sleep-Focused Parent Behavioral Intervention
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Type 1 Diabetes
Artificial Pancreas With Different Stress Assessments in the Outpatient Setting
This feasibility study is a randomized crossover trial that will compare the efficacy and safety of an automated insulin delivery (AID) system in patients with type 1 diabetes using a Model Predictive Control (MPC) algorithm…
- Trial name
- NCT04142229
- Testing
- iAPS, Sensor-Augmented Pump
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Sansum Diabetes Research Institute
Vocal Cord Dysfunction, Speech Disorders
Clinical Feasibility & Validation of the Virtual Reality GlenxRose Speech-Language Therapies
Factors related to successful rehabilitation are often directly related to adherence; for instance, dosage, frequency, and intensity can burden the patient regarding time and motivational factors.
- Trial name
- NCT05695131
- Testing
- GlenXRose Virtual Reality Speech Therapies
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM)
Embecta AID System in Adults With Type 2 Diabetes
This is a multi-center, randomized control study that will evaluate the safety and effectiveness of the embecta Automated Insulin Delivery System in adults with Type 2 diabetes requiring insulin therapy
- Conditions
- Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM), Type 2 DM, T2DM With Inadequate Glycemic Control
- Trial name
- EMBRACE-T2D (NCT06692153)
- Testing
- An AID System., Standard of Care (SC)
- Where
- 9 sites in United States
- Sponsor
- Embecta Corp.
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Tongzhou
The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- PKUBC-T (NCT03814395)
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,426 people, healthy volunteers welcome
- Sponsor
- Peking University
Suicidal Ideation and Behavior, HIV
HIV Suicide Prevention With AI-DBT
One in four older persons living with HIV/AIDS (PLWHA) report at least one suicide attempt in their lifetime, and the risk for death by suicide is 100 times higher in PLWHA than in the general population.
- Conditions
- Suicidal Ideation and Behavior, HIV, AIDS (Acquired Immune Deficiency Syndrome)
- Trial name
- NCT07339189
- Testing
- AI-DBT
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Rutgers, The State University of New Jersey
Ulcerative Colitis, Inflammatory Bowel Diseases
Transfer of FRozen Encapsulated Multidonor Stool Filtrate for Active Ulcerative COlitis
FRESCO is a randomized, longitudinal, prospective, three arm, multicentre, double blind study to determine safety and efficacy of repeated faecal microbiota transplantation (FMT) or faecal microbiota filtrate transplantation…
- Trial name
- FRESCO (NCT03843385)
- Testing
- encapsulated faecal microbiota filtrate, encapsulated faecal microbiota
- Where
- 20 sites in Germany
- Volunteers
- 84 people
- Sponsor
- Andreas Stallmach
Tetraplegia, Spinal Cord Injuries
Nerve Transfer After Spinal Cord Injury- Multi-center
Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of like and long-term functional independence will provide a…
- Conditions
- Tetraplegia, Spinal Cord Injuries, Quadriplegia Flaccid
- Trial name
- NCT04023591
- Testing
- Surgery/Occupational Therapy
- Where
- 9 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Cystic Fibrosis in Children, Siblings
Internet-delivered Cystic Fibrosis Mental Health Prevention, Wellness, Resource Program: How Does it Work?
The goal of the clinical trial is to test whether a mental health program that is delivered through the Internet works well for children and adolescents with cystic fibrosis (CF) and their healthy siblings.
- Conditions
- Cystic Fibrosis in Children, Siblings, Mental Health, Internet-based Intervention
- Trial name
- iCF-PWR (NCT06020274)
- Testing
- Internet-delivered Cystic Fibrosis Mental Health Prevention, Wellness, and Resource (iCF-PWR) program
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University of Regina
Cystic Fibrosis, Contraception
Assessment of Contraceptive Safety and Effectiveness in Cystic Fibrosis
The long-term goal is to study the safety and effectiveness of hormonal contraception for women with cystic fibrosis (CF) and contribute to national guidelines that the Cystic Fibrosis Foundation and the Centers for Disease…
- Trial name
- CASE4CF (NCT04568980)
- Where
- 10 sites in United States
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- University of Washington
Intrathecal Drug Delivery, Refractory Cancer Pain
Intrathecal Therapy Versus Standard Care for Severe Cancer Pain
Approximately 66% of patients with advanced cancer experience pain, which is often inadequately controlled and associated with a decline in health-related quality of life (HRQoL).
- Conditions
- Intrathecal Drug Delivery, Refractory Cancer Pain, Conventional Medical Management
- Trial name
- CAREGIVER (NCT07691840)
- Testing
- Intrathecal Drug Delivery, Comprehensive Medical Management
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Universitair Ziekenhuis Brussel
Multiple Myeloma
A Study of Subcutaneous Delivery of JNJ-54767414 (Daratumumab) in Japanese Participants With Relapsed or Refractory Multiple Myeloma
The purpose of this study is to evaluate the tolerability and safety of subcutaneous (SC) delivery of co-formulated daratumumab and rHuPH20 preparation (DARA SC) in Japanese participants with relapsed or refractory multiple…
- Trial name
- NCT03242889
- Testing
- DARA SC
- Where
- 5 sites in Japan
- Volunteers
- 6 people
- Sponsor
- Janssen Pharmaceutical K.K.
Infectious Diseases
LoewenKIDS - Infections and the Development of the Immune System
The purpose of this study is to determine in what way infections, microbiome, and vaccinations during childhood interact in shaping the development of immunity and tolerance.
- Trial name
- LoewenKIDS (NCT02654210)
- Testing
- No Intervention
- Where
- 2 sites in Germany
- Volunteers
- 782 people
- Sponsor
- Helmholtz Centre for Infection Research
Encephalopathy
A Multi-Center Cohort Study of Risk Factors and Outcomes of Encephalopathy of Prematurity in China
The purpose of this study is to explore the perinatal risk factors of encephalopathy of prematurity and the morbidity of the following neurodevelopmental impairments in preterm infants with gestational age <32 weeks in China.
- Trial name
- NCT02831010
- Where
- 14 sites in China
- Volunteers
- 761 people
- Sponsor
- Children's Hospital of Fudan University
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