Clinical trials: Delivery Systems
Parkinson Disease
Safety and Efficacy of Adaptive Deep Brain Stimulation
The aim of this study is to assess the safety and the potential efficacy of personalized Local Field Potential (LFP)-based adaptive Deep Brain Stimulation (aDBS), using the implantable pulse generator (IPG) of the "AlphaDBS"…
- Trial name
- NCT04681534
- Testing
- AlphaDBS System
- Where
- 8 sites in Italy, Netherlands and 1 more
- Volunteers
- 15 people
- Sponsor
- Newronika
Gossyphiboma
Use of a Supplemental Radiofrequency Detection System Subsequent to Manual Counting of Vaginal Textiles Following Vaginal Birth
The purpose of this study is to evaluate the FDA-approved Radio Frequency Surgical Detection System (RFDS) as a non-radiological means to ease the process of detecting retained sponges and reconciling sponge counts in the labor…
- Trial name
- NCT02538887
- Testing
- Radio Frequency Surgical Detection
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Bronchopulmonary Dysplasia, Preterm Infant Development
PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants
The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks.
- Conditions
- Bronchopulmonary Dysplasia, Preterm Infant Development, Asthma Childhood, Bronchiolitis
- Trial name
- PremaBiom (NCT07411261)
- Testing
- Nasal swab, blood sampling, Mother milk sampling
- Where
- 6 sites in France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Caen
Hepatitis B Infection, Congenital Malformation
Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission
Immunoprophylaxis with two hepatitis B vaccinations following the hepatitis B immune globulin (HBIg) and hepatitis B vaccine at birth is largely effective in protecting infants from hepatitis B virus (HBV) infection.
- Conditions
- Hepatitis B Infection, Congenital Malformation, Birth Defect, Viremia
- Trial name
- NCT03476083
- Testing
- Tenofovir Disoproxil Fumarate (TDF) 300 mg oral daily.
- Where
- 7 sites in China
- Volunteers
- 280 people
- Sponsor
- New Discovery LLC
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
An Audit of the Impact of Tailored Information Delivered Via a Digital Learning Platform
The study intends to audit the impact of optimal insulin injection technique on clinical parameters and self-care behaviour of insulin treated diabetes patients in a prospective manner with a follow-up of 6 months.
- Trial name
- NCT04007003
- Testing
- training in optimal insulin injection technique
- Where
- 9 sites in Belgium
- Volunteers
- 170 people
- Sponsor
- Becton, Dickinson and Company
Pain
Use of Intrathecal Hydromorphone in Elective Cesarean Deliveries
The purpose of this study is to determine if intrathecal hydromorphone will relieve pain as well as intrathecal morphine after cesarean delivery, with fewer side effects.
- Trial name
- NCT01866254
- Testing
- Hydromorphone, Morphine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Grace Shih, MD
Parkinson's Disease, Multiple System Atrophy, Parkinson Variant
AB-1005 Long-Term Follow-up Study
This is an observational, long term, follow-up study for participants with Parkinson's disease (PD) or Multiple System Atrophy-Parkinsonian subtype (MSA-P) who participated in prior interventional studies with AB-1005.
- Trial name
- NCT07081841
- Testing
- Observation
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- AskBio Inc
Asthma
Characterization of Aerosol Generation and Transport in the Human Lung
This study is aiming at evaluating whether the number and size of exhaled particles changes during the increase and decrease of bronchial constriction in subjects with mild intermittent asthma.
- Trial name
- NCT01095627
- Testing
- Metacholine challenge
- Volunteers
- 10 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Alzheimer Disease
Improving Access to Care for Veterans With Memory Loss
This study evaluates a care delivery protocol to improve access to care for Veterans with Alzheimer's Disease and Related Disorders (ADRD).
- Trial name
- NCT07117162
- Testing
- ADRD Care Delivery Protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Pittsburgh Healthcare System
Hypoxia, Brain, Premature Birth
PREMOD2 With Near Infrared Spectroscopy Sub-study
Early hemodynamic effects (within 3 hours of life) of Delayed Cord Clamping compared to Umbilical Cord Milking are still unknown.
- Trial name
- PREMOD2 (NCT03145142)
- Testing
- Umbilical cord milking, Delayed Cord Clamping
- Where
- 4 sites in United States, Canada and 2 more
- Volunteers
- 121 people
- Sponsor
- Sharp HealthCare
Postpartum Depression, Postpartum Anxiety
The Mom and Infant Outcomes (MOMI) Study
The investigator's long-term goal is to mitigate pregnancy-related mortality (PRM) risk by systematically delivering scalable integrated clinical and supportive care that is effective for all.
- Conditions
- Postpartum Depression, Postpartum Anxiety, Cardiometabolic Syndrome
- Trial name
- NCT06277661
- Testing
- MOMI PODS, Enhanced Usual Care (EUC)
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- Ohio State University
Hemiplegia, Stroke
Upper Limb Cross-education in Subacute Stroke
This study evaluates how cross-education (unilateral training) affects muscle strength of the paretic limb in acute stroke patients.
- Trial name
- NCT04113369
- Testing
- TENS, Conventional rehabilitation, EMS
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bezmialem Vakif University
Type 2 Diabetes Mellitus
Evaluation of the Fully Closed Loop Omnipod® System in Type 2 Diabetes
A multi-center, 26-week randomized controlled trial (RCT) to evaluate the safety and efficacy of the fully closed loop Omnipod M System in adults with type 2 diabetes using basal/bolus insulin therapy or basal-only insulin…
- Trial name
- EVOLVE (NCT07521475)
- Testing
- Device: Omnipod M System with study CGM, Standard Therapy plus study CGM
- Where
- 27 sites in United States
- Volunteers
- 350 people
- Sponsor
- Insulet Corporation
Parkinson's Disease
Study of Subcutaneous Continuous Administration of Levodopa/Carbidopa Solution (ND0612) in Healthy Volunteers
It will be a single dose, single-center, randomized, double-blind, placebo-controlled dose escalation study of SC continuously-delivered LD/CD solution (ND-0612) for 24 hours in healthy volunteers. Objectives are to determine: 1.
- Trial name
- NCT01486628
- Testing
- ND0612
- Where
- Israel
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NeuroDerm Ltd.
Type 2 Diabetes Mellitus
Study of PaQ™ (a Simple Patch on Insulin Delivery Device) in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the ability of a patient, who has type 2 diabetes (T2DM) who is currently treated with basal/bolus insulin therapy, to use PaQ™ (a simple patch on insulin delivery device) to control…
- Trial name
- NCT01535612
- Testing
- PaQ™ insulin infusion device
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- CeQur Corporation
Symptomatic Aortic Stenosis
First in Human Experience of the St. Jude Medical TAVI Valve and Delivery System
The purpose of this first-in-human study is to assess the technical feasibility, deployment characteristics, and safety of the 23mm SJM Transfemoral Transcatheter Heart Valve and delivery system in subjects with severe…
- Trial name
- SJM TAVI FIH (NCT01487330)
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Abbott Medical Devices
Hepatitis B, Vaccination
Assessing the Reliability of Self-Reported Hepatitis B Vaccination Status in Outpatients: Evaluation of Individuals Born in France and Consulting at the CeGIDD in Saint-Denis.
This study aims to find out whether people accurately know their hepatitis B vaccination status. It focuses on individuals born in France who visit a sexual health clinic (CeGIDD) in Saint-Denis.
- Conditions
- Hepatitis B, Vaccination, Health Knowledge, Attitudes, Practice, Serologic Tests
- Trial name
- NCT06998992
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Diabetes Mellitus, Type 1, Diabetes Mellitus, Brittle
Diabeloop for Highly Unstable Type 1 Diabetes
Feasibility study, comparing experimental treatment (DBLHU closed-loop system) with reference treatment (Low Glucose Predictive Suspend system) in 7 patients going through a series of N-of-1 trials.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Brittle, Closed-Loop
- Trial name
- DBLHU (NCT04042207)
- Testing
- Low Glucose Predictive Suspend system, DBLHU System
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Physiological Effect of Drugs, Morphine
Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine
The purpose of this study is to show that the effect of 3% 2-chloroprocaine prior to epidural morphine administration will be not inferior to the effect of epidural 2% lidocaine with 1:200,000 epinephrine on total opioid use for…
- Conditions
- Physiological Effect of Drugs, Morphine, Analgesics, Analgesics, Opioid
- Trial name
- NCT04369950
- Testing
- 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cough, Wheezing
A Methodology Trial Using the VR647 Inhalation System in Pediatric Subjects Who Have Previously Received Inhaled Therapy
This is an open-label, non-drug methodology trial in which subjects undergo a stepwise series of tests to evaluate their ability to use a mouthpiece to deliver nebulized therapy.
- Trial name
- NCT04011709
- Testing
- VR647 Inhalation System + VR647 Smart Card 3 Secs, VR647 Inhalation System + VR647 Smart Card 2 Secs, VR647 Inhalation System + VR647 Smart Card 4 Secs
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Vectura Limited
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.