Clinical trials: Delivery Systems
HIV Infections, HIV Seronegativity
A Phase I Study to Evaluate the Safety and Immunogenicity of Recombinant HIV-1 Envelope Antigen in Children Born to HIV-Infected Mothers
PRIMARY: To determine the safety of envelope recombinant proteins rgp120/HIV-1MN (Genentech) and rgp120/HIV-1SF2 (Chiron/Biocine) in infants who are of indeterminate HIV status born to HIV-infected women.
- Trial name
- NCT00000774
- Testing
- rgp120/HIV-1MN, rgp120/HIV-1 SF-2
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Growth Hormone Disorder, Growth Hormone Deficiency in Children
Norditropin NordiFlex® Device Compared to the Device Previously Used by Patients or Parents
This study is conducted in Europe. The aim of this study is to compare the easiness of use of Norditropin NordiFlex® device to the device previously used by patients or parents.
- Conditions
- Growth Hormone Disorder, Growth Hormone Deficiency in Children, Foetal Growth Problem, Small for Gestational Age
- Trial name
- NCT01245374
- Testing
- Norditropin NordiFlex®
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Novo Nordisk A/S
Hepatitis C
Safety and Efficacy Study to Compare Continuous Infusion of Interferon With Standard of Care for Chronic Hepatitis C
The purpose of the study is to evaluate if continuous subcutaneous delivery of interferon alfa-2b using an external drug pump in combination with the use of oral ribavirin provides a safe and effective treatment for patients with…
- Trial name
- COPE-HCV (NCT00919633)
- Testing
- interferon alfa-2b, peginterferon alfa-2b, ribavirin, USP
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Medtronic Corporate Technologies and New Ventures
HIV Infections
Evaluate and Optimize an Online Care Model for PrEP Delivery: Pilot Study
Daily oral pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV acquisition, but uptake in Kenya remains low. Barriers to clinic-based PrEP delivery exist (e.g., long wait times, stigma), thus the delivery of…
- Trial name
- ePrEP Kenya (NCT05377138)
- Testing
- Online PEP/PrEP delivery
- Where
- Kenya
- Volunteers
- 2,357 people, healthy volunteers welcome
- Sponsor
- University of Washington
Asthma
Asthma and Quantifying Delivery Of Radio Labeled Aerosol
Introduction: Inhalation therapy has been established as an efficient route to treat asthma exacerbations, but coupled to noninvasive ventilation (NIV) remains quite challenging.
- Trial name
- NCT01823926
- Testing
- Noninvasive ventilation, Jet nebulizer, The vibrating mesh nebulizer (VMN)
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- Universidade Federal de Pernambuco
Type 2 Diabetes
Enhancing Telemedicine for T2D
The goal of this pilot clinical trial is to assess feasibility of an intervention to deliver comprehensive, high-quality diabetes care through telemedicine among adults with type 2 diabetes who use insulin and have multiple…
- Trial name
- NCT06740435
- Testing
- Enhanced Telemedicine for Type 2 Diabetes, Usual Telemedicine Endocrinology Care for T2D
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
HIV Infections
A Study of Zidovudine and T Lymphocyte Transfer in the Treatment of HIV Type III in Patients With AIDS
To determine the safety and efficacy of zidovudine (AZT) treatment combined with syngeneic or HLA identical allogeneic lymphocyte transfer in the presence of interleukin 2 (IL-2) as a treatment for AIDS.
- Trial name
- NCT00002285
- Testing
- Zidovudine
- Where
- United States
- Sponsor
- Glaxo Wellcome
Facial Neoplasms, Head and Neck Neoplasms
Clinical Trial of New Elastomer for Maxillofacial Prosthetics
The purpose of this study is to evaluate a new rubber material used to make prosthetic replacements of the face lost to cancer, trauma, or birth defects.
- Conditions
- Facial Neoplasms, Head and Neck Neoplasms, Head Injuries, Penetrating, Birth Injuries
- Trial name
- NCT00123097
- Testing
- Chlorinated polyethylene elastomer
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Louisville
Cystic Fibrosis
Effects of Sildenafil on CFTR-dependent Ion Transport Activity
Dehydrated airway surfaces resulting from sodium hyperabsorption and lack of chloride secretion are critical to the pathology that leads to the morbidity and mortality from Cystic Fibrosis (CF) lung disease.
- Trial name
- NCT01132482
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Jewish Health
Postpartum, Muscle Fatigue
Muscle Function After Childbirth
This study will evaluate lower extremity and trunk neuromuscular control in 78 nulligravid and postpartum women. Participants will attend two experimental sessions, approximately 1 week apart, to assess neuromuscular function.
- Conditions
- Postpartum, Muscle Fatigue, Force Steadiness, Nulligravid
- Trial name
- NCT05073224
- Testing
- Active Straight Leg Raise Test, Active Straight Leg Raise Fatigue Task, Lower Extremity Strength Testing
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Carroll University
Bacteremia, Infant, Very Low Birth Weight
Preventing Catheter-related Bacteremia When Administering Injectable Medications in Premature Infants.
This study evaluates the potential interest of a new multi-lumen infusion access device (Edelvaiss® Multiline NEO) in the prevention of catheter-related bacteremia when administering injectable drugs in premature infants.
- Trial name
- MultilineNEO (NCT02633124)
- Testing
- Edelvaiss Multiline NEO, Standard Infusion Set
- Where
- 4 sites in France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
HIV Infections
One-stop PrEP Care Pathway to Simplify PrEP Delivery in Kenya: The One-Stop PrEP Care Project
The goal of this cluster randomized study is to understand if using a One stop PrEP delivery model can improve the efficiency of PrEP service delivery, reduce the cost of providing PrEP and allow continuation on PrEP.
- Trial name
- NCT05905640
- Testing
- Method of PrEP delivery and consultation
- Where
- Kenya
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- University of Washington
Preterm, Surgery
An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponse
ASPIRE is a nutrition study focusing on the effect of arginine supplementation on immune function in postoperative infants. The investigators will explore the effect of current intravenous feeding (parenteral nutrition (PN))…
- Conditions
- Preterm, Surgery, Nutritional Deficiency, Immune System and Related Disorders
- Trial name
- ASPIRE (NCT05306925)
- Testing
- Arginine
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Liverpool
Multiple Myeloma
Comparing Treatments for Multiple Myeloma
Some drugs have the ability to push stem cells (the cells responsible for producing new cell types) out of the bone marrow and into the blood stream. The steps involved in this process are still poorly understood.
- Trial name
- NCT00001750
- Testing
- Stemgen
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anaplastic Astrocytoma, Glioblastoma
Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma
In this multinational Phase III study the efficacy and safety of 10 µM AP 12009 is compared to standard chemotherapy (temozolomide or BCNU or CCNU) in adult patients with confirmed recurrent or refractory anaplastic astrocytoma…
- Trial name
- SAPPHIRE (NCT00761280)
- Testing
- trabedersen, temozolomide, Drug delivery system for administration of AP 12009
- Where
- 68 sites in United States, Argentina and 14 more
- Volunteers
- 27 people
- Sponsor
- Isarna Therapeutics GmbH
Motor Neuron Disease
Telehealth in Motor Neurone Disease
Motor neurone disease (MND) is a rare but debilitating neurological condition that causes paralysis of the body's muscles leading to severe disability and eventually death.
- Trial name
- TiM (NCT02464748)
- Testing
- TiM telehealth arm
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
HIV Infections
Pilot Implementation of HIV Self-testing Delivery in Private Pharmacies Combined to a Respondent Driven Sampling Method to Improve HIV Testing for MSM and TGW in Phnom Penh - ANRS 0100s
The study aims to evaluate the feasibility of HIV self-testing (HIVST) delivery by a private pharmacy network among men who have sex with men (MSM) and transgender women (TGW) recruited through a classic and digital Respondent…
- Trial name
- NCT05745168
- Testing
- OraQuick
- Where
- Cambodia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
CIPN - Chemotherapy-Induced Peripheral Neuropathy, Diabetic Peripheral Neuropathy (DPN)
TRPM8 Activators for Peripheral Neuropathy
The goal of this pilot prospective cohort study is to evaluate the efficacy of a novel hand and foot mask in alleviating symptoms of peripheral neuropathy caused by chemotherapy or diabetes.
- Trial name
- NCT07583797
- Testing
- Hand and Foot Mask
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- SHIANG-SUO HUANG
Sepsis
Call for Life Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-attributable mortality in sub-Saharan Africa (sSA) is high, with in-hospital mortality in some settings approaching 40%.
- Trial name
- C4L-Sepsis (NCT07407868)
- Testing
- Interactive Voice Response system-Call for life IVR
- Where
- 2 sites in Uganda
- Volunteers
- 1,410 people
- Sponsor
- Makerere University
Cervical Dysplasia
Smoking Cessation in Women With Gynecological Conditions
This feasibility study will compare two smoking cessation methods, traditional nicotine replacement therapy and Electronic Nicotine Delivery Systems (electronic cigarettes) in patients with gynecological conditions.
- Trial name
- NCT01989923
- Testing
- Nicotine Replacement Therapy, Electronic Cigarettes
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
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