Clinical trials: Dementia, Familial
Amyloid, Amyloid Cardiomyopathy
18F-florbetaben PET-CT to Non-invasively Diagnose Cardiac AL Amyloidosis
Amyloidoses are systemic or acquired disorders characterized by the deposition in the extracellular spaces of amyloid fibers formed by proteins codified by mutated genes or non-mutated but misfolded proteins.
- Trial name
- PETAL (NCT06048601)
- Testing
- 18F-florbetaben PET/CT
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio
Alzheimer Disease
Impact of Therapeutic Educational Programme on the Alzheimer's Disease Affected Patient's Quality of Life
Therapeutic education expands in Alzheimer's Disease management in France. Several studies revealed a positive impact on caregiver's burden and/or quality of life.
- Trial name
- THERAD (NCT01796314)
- Testing
- Therapeutic Educational Program
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Toulouse
Caregiving Stress, Caregiver Burden
SAGE LEAF 2: An Online Program to Reduce Dementia Caregiver Burden
The goal of this clinical trial is to learn if the SAGE LEAF (Social Augmentation of self-Guided Electronic delivery of the Life Enhancing Activities for Family caregivers) online positive emotion skill-building program delivered…
- Trial name
- SAGE LEAF 2 (NCT06708182)
- Testing
- SAGE LEAF Positive Emotion Skills Course
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Mild Cognitive Impairment(MCI), Alzheimer Disease, Late Onset
China Cognition and Aging Study
The aim of this study is to establish and perfect the China Cognition and Aging Study (China COAST) cohort, to clarify the epidemiology, influencing factors, genetic characteristics, pathogenesis, disease characteristics and…
- Conditions
- Mild Cognitive Impairment(MCI), Alzheimer Disease, Late Onset, Familial Alzheimer Disease (FAD), Vascular Dementia (VaD)
- Trial name
- COAST (NCT03653156)
- Where
- 65 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Amyloidosis; Heart (Manifestation), Senile Cardiac Amyloidosis
Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy
The objective of the study is to determine whether the combination of the bile acid TUDCA, and doxycycline will slow the progression of familial and senile amyloidosis.
- Trial name
- NCT01855360
- Testing
- Tauroursodeoxycholic Acid and Doxycycline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Dementia
GamePlan4Care: Online Support for Family Caregivers
As the population of older adults grows, almost doubling in size from 2012 to 2040, so too will the need for family caregiving. Caregiving can lead to negative psychosocial outcomes such as depression, anxiety, and burden; social…
- Trial name
- GP4C (NCT04540198)
- Testing
- GamePlan4Care, Resources4Care
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Frontotemporal Dementia, Alzheimer Disease
Young Onset Dementia - the Difficult Diagnosis and the Stressful Life for the Whole Family
People diagnosed with young onset dementia are today mostly assigned to the same healthcare services as people developing dementia at an older age.
- Trial name
- NCT02055092
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Norwegian Centre for Ageing and Health
Caregivers
Pilot Study of Hospital GamePlan4Care
Hospital stays are stressful for the family and friends who care for adults with dementia. Following hospital discharge, adults with dementia often have increased care needs, which places new caregiving demands on their family…
- Trial name
- NCT06634368
- Testing
- Hospital GamePlan4Care, Health Education
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- VA Office of Research and Development
Dementia, Cognitive Impairment
Functionally-tailored Oral Care Intervention for Community-dwelling Older Adults With Dementia and Their Caregivers
The specific aims of this study are: Aim 1. Develop a staged and modifiable dyadic oral care intervention to provide functionally-tailored oral care rehabilitation for community-dwelling persons with dementia (PWD) and need-based…
- Trial name
- NCT04238520
- Testing
- Functionally Tailored Oral Care Intervention, Control Intervention
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Xi Chen
Alzheimer's Disease (Incl Subtypes), Depressive Symptoms
Beyond Listening: A Music-based Intervention
Study will be conducted to determine if caregivers who use music at home will feel less burden and whether the person they are caring for will demonstrate decreased symptoms of dementia.
- Trial name
- NCT04840173
- Testing
- Music
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- MJHS Institute for Innovation in Palliative Care
Dementia
A Phone Intervention for Family Dementia Caregivers in Vietnam
This is a cluster randomized controlled trial to examine the feasibility, acceptability, and preliminary efficacy of the phone version of REACH VN, a psychosocial culturally adapted Alzheimer's family caregiving intervention, to…
- Trial name
- NCT05481320
- Testing
- REACH VN Phone Intervention, Enhanced Control
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Cerebral Amyloid Angiopathy, CAA - Cerebral Amyloid Angiopathy
Effect of the Mediterranean Diet in Patients Affected by CADASIL and Cerebral Amyloid Angiopathy.
The study is divided into two phases: Phase 1 (observational) and Phase 2 (dietary intervention). The goal of Phase 1 is to assess the nutritional status and dietary habits of two cohorts of patients with CADASIL and CAA.
- Trial name
- DIETETICA (NCT06933212)
- Testing
- Mediterranean Diet with Extra Virgin Olive Oil, Mediterranean Diet with Walnuts, Low-Fat Control Diet
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Stress, Dementia
Life Enhancing Activities for Family Caregivers
Life Enhancing Activities for Family Caregivers is a six-week program designed to increase positive affect in people who care for a family member with dementia.
- Conditions
- Stress, Dementia, Affect
- Trial name
- LEAF (NCT01825681)
- Testing
- Positive Affect
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dementia, Depression
A Support Program for Carers of Persons With Dementia
Dementia is one of the most common and devastating diseases in the elderly, it leads to helplessness, no cure exists and therefore care is necessary to provide.
- Trial name
- DIF2 (NCT01287767)
- Testing
- A multidimensional support program
- Where
- Norway
- Volunteers
- 230 people
- Sponsor
- Norwegian Centre for Ageing and Health
Alzheimer Disease, Dementia
Technology and Family Thriving Study
The purpose of this project is to test the impact of different forms of technology (virtual reality vs. video chat) on quality of life and family relationships in older adults who reside in senior living communities and an adult…
- Conditions
- Alzheimer Disease, Dementia, Caregiver Burnout, Quality of Life
- Trial name
- Thrive (NCT05150990)
- Testing
- Virtual Reality, Video Chat
- Where
- 27 sites in United States
- Volunteers
- 186 people
- Sponsor
- University of California, Santa Barbara
Psychological Distress
Acceptance and Commitment Therapy for Family Caregivers of People With Dementia
The pilot project aims to investigate the feasibility and the preliminary efficacy of a guided online acceptance and commitment therapy (ACT) intervention for distressed family caregivers of people with dementia.
- Trial name
- NCT04458870
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Alabama at Birmingham
Alzheimer Disease, Dementia
The Residential Care Transition Module
Emerging research on family caregiving and institutionalization has emphasized that families do not disengage from care responsibilities following a relative's admission to residential long-term care settings.
- Trial name
- RCTM (NCT02915939)
- Testing
- The Residential Care Transition Module
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Dementia
The Development and Evaluation of a Culturally Tailored Support Group Program on the Psychosocial Wellbeing of Family Caregivers of Individuals Living With Dementia in Hong Kong
Hong Kong is also facing the increasing prevalence of dementia. Evidence states that dementia caregivers have poor psychosocial wellbeing including stress, depression and anxiety.
- Trial name
- NCT04334200
- Testing
- Cultivate yourself: support for caregivers of dementia persons
- Volunteers
- 49 people
- Sponsor
- Chinese University of Hong Kong
Family Caregiver, Dementia
Pair 2 Care: Peer Support for Caregivers of Black Americans Living With Dementia
The purpose of this study is to test a peer support intervention for caregivers who are caring for a loved one living with dementia.
- Conditions
- Family Caregiver, Dementia, Peer Support
- Trial name
- Pair 2 Care (NCT06064955)
- Testing
- Peer Support
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Ohio State University
Dyadic Family Caregiver-person With Dementia Online Intervention
Living Memory Home-4-Dementia Care Pairs
The purpose of this study is to evaluate an online platform -- the Living Memory Home for Dementia Care Pairs (LMH-4-DCP) for persons with dementia and their family caregivers to engage in reminiscence activities together and…
- Trial name
- LMH-4-DCP (NCT06225986)
- Testing
- LMH-4-DCP, LMH-4-DCP access without reminiscence activities
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University