Clinical trials: Dementia, Lewy Body
Vascular Parkinsonism, Drug-induced Parkinsonism
AI-Enhanced Optimization of Acute Levodopa Challenge Test
A quantitative evaluation method was developed for Parkinson's disease and other atypical parkinonism by integrating an innovative motor paradigm with perception technologies and artificial intelligence.
- Conditions
- Vascular Parkinsonism, Drug-induced Parkinsonism, Corticobasal Degeneration (CBD), Parkinson Disease (PD)
- Trial name
- NCT06949865
- Testing
- video recording
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Patients With Synucleinopathies, Neurogenic Orthostatic Hypotension
Natural History Study of Synucleinopathies
Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein α-synuclein in the nervous system. Onset is usually in late adulthood at age 50 or older.
- Conditions
- Patients With Synucleinopathies, Neurogenic Orthostatic Hypotension, Pure Autonomic Failure, REM Sleep Behavior Disorder
- Trial name
- NCT01799915
- Where
- 8 sites in United States, Argentina and 2 more
- Volunteers
- 800 people
- Sponsor
- NYU Langone Health
Alzheimer's Disease, Dementia
Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia
The objective of the study is to define the performance of blood-based signatures for Alzheimer's Disease (AD) in different patients populations including AD, non-AD dementia, and non-demented controls.
- Trial name
- NCT00880347
- Testing
- Blood sampling
- Where
- 21 sites in France
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Exonhit
Mild Cognitive Impairment, Mild Dementia
NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)
A Study to Evaluate NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Associated With Parkinson's Disease or Prodromal or Manifest Lewy Body Dementia
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Parkinson Disease, Lewy Body Disease
- Trial name
- NCT04148391
- Testing
- NYX-458
- Where
- 26 sites in United States
- Volunteers
- 99 people
- Sponsor
- Aptinyx
Obstructive Sleep Apnea, Alzheimer Disease
ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with vascular cognitive impairment (VCI) and Alzheimer's disease (AD), and exacerbates the cognitive deficits seen in…
- Conditions
- Obstructive Sleep Apnea, Alzheimer Disease, Vascular Dementia, Mild Cognitive Impairment
- Trial name
- ENCHANT (NCT04335994)
- Testing
- In-laboratory polysomnography, Home Sleep Apnea Test
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Lewy Body Dementia, Non-DLB Dementia
Dopamine Transporter Scintigraphy Imaging (DAT-Imaging) in Patients With Lewy Body Dementia
The study is designed to determine the diagnostic efficacy of the visual assessment of SPECT scans in differentiating between probable dementia with Lewy Bodies (DLB) and non-DLB dementia subjects determined by the clinical…
- Conditions
- Lewy Body Dementia, Non-DLB Dementia, Alzheimer's, Vascular Dementia
- Trial name
- NCT00209456
- Testing
- DatSCAN
- Where
- Germany
- Volunteers
- 326 people
- Sponsor
- GE Healthcare
Dementia With Lewy Bodies
Deep Brain Stimulation for Patients With Dementia With Lewy Bodies
This trial aims to collect pilot data to explore whether bilateral deep brain stimulation (DBS) of the Nucleus Basalis of Meynert (NBM) has beneficial effects on memory and thinking impairments among individuals with Dementia…
- Trial name
- NCT02263937
- Testing
- Bilateral Nucleus Basalis Meynert DBS
- Where
- 2 sites in United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Alzheimer Disease (AD), Frontotemporal Lobar Degeneration
ADDIA Proof-of-Performance Clinical Study
The objective of the ADDIA clinical Proof-of-Performance study is to validate the performance of ADDIA' blood biomarkers for diagnosis of Alzheimer's disease (AD).
- Conditions
- Alzheimer Disease (AD), Frontotemporal Lobar Degeneration, Dementia with Lewy Bodies (DLB), Parkinson Disease Dementia (PDD)
- Trial name
- ADDIA (NCT03030586)
- Testing
- volumetric MRI
- Where
- 13 sites in Belgium, France and 3 more
- Volunteers
- 821 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Dementia, Alzheimer Disease
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease…
- Conditions
- Dementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia
- Trial name
- CRND TorCA (NCT06529744)
- Where
- 4 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Lewy Body Disease
Safety and Efficacy of Galantamine in Patients With Dementia With Lewy Bodies
TRIAL SUMMARY: This is an open-label, 24-week, investigator initiated study to evaluate the safety and efficacy of galantamine (16 8 to 24 mg/day; flexible dosing) in the treatment of Dementia with Lewy bodies.
- Trial name
- NCT00230997
- Testing
- Galantamine
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Neurological Research Center
"Alzheimer's Disease" and "Lewy Body Disease"
Alpha-synuclein in Cerebrospinal Fluid to Differentiate Alzheimer's Disease From Lewy Body Disease.
Patients with memory disorders are experiencing different trends which are difficult to predict. Moreover, the distinction between Lewy body disease and Alzheimer's disease is not easy as both diseases can present similar…
- Trial name
- AlphaLewyMa (NCT01876459)
- Testing
- MRI, lumbar puncture, neuropsychological tests
- Where
- France
- Volunteers
- 265 people
- Sponsor
- University Hospital, Strasbourg, France
Dementia, Movement Disorders
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.
The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner.
- Conditions
- Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy
- Trial name
- NCT07595666
- Testing
- Standard-of-care PET/CT, NeuroEXPLORER
- Where
- Belgium
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Dementia, Mild Cognitive Impairment
SAMi Intervention Study to Evaluate Smartwatch Interventions in Persons With MCI and Dementia
Assistive Technologies (ATs) can help people living with dementia (PwD) maintain their everyday activity. Still, there is a gap between potential and supply. Involving future users can close the gap.
- Conditions
- Dementia, Mild Cognitive Impairment, Alzheimer Disease, Dementia With Lewy Bodies
- Trial name
- SAIN_UMR (NCT05885620)
- Testing
- drinking reminder and cognitive task (smartwatch-based application)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Rostock
Lewy Body Disease, Healthy Aging
Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment
Lewy body diseases (LBDs) represents a group of neurodegenerative disorders characterized by the abnormal accumulation of aggregates of α-synuclein protein leading to the formation of Lewy bodies (LB) and Lewy neurites resulting…
- Trial name
- LANG-LBD (NCT05847985)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Idiopathic Anosmia, Idiopathic Hyposmia
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
Test of early warning signs and RT-QuIC in patients with idiopathic olfactory dysfunction
- Conditions
- Idiopathic Anosmia, Idiopathic Hyposmia, Idiopathic Olfactory Dysfunction
- Trial name
- AROMA (NCT05740683)
- Testing
- RT-QuiC
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Dementia Research Centre
Caregiver Stress, Dementia
A Study to Evaluate Caregiver Connections Via Technology for Patients With Alzheimer's and Other Types of Dementia
This research is being done to develop a unique matching process for caregivers of persons living with dementia, such as Alzheimer's disease, Lewy body dementia, frontotemporal degeneration, or other dementia syndromes.
- Conditions
- Caregiver Stress, Dementia, Alzheimer Dementia, Lewy Body Dementia
- Trial name
- NCT05497817
- Testing
- Algorithm, Random Match
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Dementia, Lewy Body
ANeED Joint Effort 21: eHealth and a PPI Program in Dementia With Lewybodies (DLB)
The goal of the study is to develop predictive algorithms and digital biomarkers to capture disease fluctuations in (prodromal) dementia with lewybodies (DLB) patients and to improve treatment, diagnosis and prognosis of the…
- Trial name
- JointEffort21 (NCT05773443)
- Testing
- Digital biomarkers
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Bergen
Dementia, Cognitive Impairment
Implementation and Evaluation of Improved Access to Medical Imaging for Geriatric Patients of The Royal Ottawa Hospital
In this study, the investigators implement FDG-PET imaging for clients in the Geriatric Psychiatry department at The Royal Ottawa Hospital (ROH) and evaluate the impact of this advanced imaging technique on client care.
- Conditions
- Dementia, Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT05428475
- Testing
- [18F]FDG-PET Scan
- Volunteers
- 15 people
- Sponsor
- Tim Lau
Lewy Body Dementia
Diagnostic of Lewy Body Dementia by Combining Scintigraphy (SPECT) Using a Specific Transporter and Magnetic Resonance Imaging (MRI)
The aim of this study is to improve the diagnostic of Lewy body dementia by combining the scintigraphy (SPECT) usig a spécific transporter and magnetic resonance imaging (MRI).
- Trial name
- DatScan (NCT00820937)
- Testing
- Single photon emission computed tomography and Magnetic Resonance Imaging
- Where
- 3 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Limoges