Clinical trials: Dementia, Mixed
Dementia, Vascular, Alzheimer Disease
LEAD IT! An App to Enable Persons With Early Stage Dementia to Lead Group Activities for Their Peers
The proposed Phase 2 project will involve the further development and evaluation of LEAD IT!, which is a tablet-based app designed to enable persons with dementia to lead activities for their peers (i.e., other persons with…
- Conditions
- Dementia, Vascular, Alzheimer Disease, Dementia, Mixed
- Trial name
- NCT05516342
- Testing
- LEAD IT! Programming
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- Hopeful Aging
Dementia of Alzheimer Type, Alzheimer Disease
Telehealth-enabled Integrated Palliative Care for People With Dementia
In prior work, this team developed a telehealth primary care model (TIPC), designed in close partnership with patients and clinicians to address a widespread increase in telehealth use during the COVID-19 pandemic.
- Conditions
- Dementia of Alzheimer Type, Alzheimer Disease, Frontotemporal Degeneration, Lewy Body Dementia
- Trial name
- IBC (NCT05524181)
- Testing
- Telehealth Integrated Primary Care (TIPC)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Dementia, Dysphagia
Family Caregiver Online Survey (Dementia and Swallowing Difficulties)
The Family Caregiver Survey is a one-time, 30-minute, online survey for people living with and caring for a family member with dementia.
- Conditions
- Dementia, Dysphagia, Dementia Alzheimers, Dementia, Vascular
- Trial name
- NCT06471660
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Alzheimer's Disease, Dementia
Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia
The objective of the study is to define the performance of blood-based signatures for Alzheimer's Disease (AD) in different patients populations including AD, non-AD dementia, and non-demented controls.
- Trial name
- NCT00880347
- Testing
- Blood sampling
- Where
- 21 sites in France
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Exonhit
Alzheimer Disease, Vascular Dementia
A Study of the Safety and Effectiveness of Galantamine Versus Placebo in the Treatment of Patients With Vascular Dementia or Mixed Dementia
The purpose of this study is to evaluate the safety and efficacy of galantamine (a drug for treating dementia) compared to placebo in the treatment of patients with dementia related to cerebrovascular disease (vascular dementia)…
- Trial name
- NCT00261573
- Testing
- galantamine hydrobromide
- Volunteers
- 593 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
DEM, Dementia
Advanced Cognitive Stimulation Therapy (ACST)
This study is a feasibility randomised controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia.
- Conditions
- DEM, Dementia, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT04550975
- Testing
- Advanced Cognitive Stimulation Therapy
- Volunteers
- 32 people
- Sponsor
- University College, London
Dementia, Dementia, Vascular
Home-based Family Caregiver-delivered Music and Reading Interventions for People With Dementia
This international study evaluates the impact of home-based caregiver-delivered music and reading interventions for people with dementia.
- Conditions
- Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia, Mixed
- Trial name
- HOMESIDE (NCT03907748)
- Testing
- Music Intervention, Reading Intervention
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 864 people
- Sponsor
- Anglia Ruskin University
Dementia; Alzheimer, Mixed Type (Etiology)
Non-invasive Brain Stimulation Using Transcranial Direct Current Stimulation for Neuropsychiatric Symptoms of Dementia
Agitation and aggression impose a tremendous burden on the individuals living with dementia, their families, caregivers, and healthcare systems.
- Trial name
- NCT03638284
- Testing
- Transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer Disease, Mild Dementia
Improving Everyday Task Performance Through Repeated Practice in Virtual Reality.
There are very few effective interventions that promote functional independence in people with Alzheimer's disease (AD) and related dementias.
- Conditions
- Alzheimer Disease, Mild Dementia, Mild Cognitive Impairment, Dementia
- Trial name
- VKI (NCT04315337)
- Testing
- Virtual Kitchen Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Temple University
Frontotemporal Dementia, Dementia
Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (PACE)
The protocol is organized into three Phases - In Phase I an online training program will be developed in "Care of Persons with Dementia in their Environments" (COPE) -an evidence-based bio-behavioral dementia program -using…
- Conditions
- Frontotemporal Dementia, Dementia, Multi-Infarct Dementia, Vascular Dementia
- Trial name
- NCT04165213
- Testing
- Care of Older Persons in their Environment (COPE) online module training
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Major Neurocognitive Disorder, Alzheimer Disease
Exergaming Revolution in Dementia
This pilot randomized controlled trial evaluates the effect of a 12 weeks exergaming training in people with major neurocognitive disorders (MNCD) living in long-term care facilities.
- Conditions
- Major Neurocognitive Disorder, Alzheimer Disease, Parkinson Disease, Lewy Body Dementia
- Trial name
- GameDementia (NCT06631742)
- Testing
- Exergaming on Dividat Senso, Usual Care
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
Dementia, Dementia Alzheimers
Brain Attack Surveillance in Corpus Christi--Cognitive (BASIC-Cognitive)
The Mexican American population in the U.S. is rapidly growing and aging. This project seeks to determine the prevalence and outcomes of cognitive impairment and dementia in Mexican Americans.
- Conditions
- Dementia, Dementia Alzheimers, Dementia, Vascular, Dementia, Mixed
- Trial name
- BASIC-C (NCT03403257)
- Testing
- No interventions
- Where
- United States
- Volunteers
- 634 people
- Sponsor
- University of Michigan
Dementia, Home-dwelling
Live@Home.Path: Innovating the Clinical Pathway for Home Dwelling Persons With Dementia and Their Families
This study aims at developing, implementing and evaluating a complex intervention involving Learning, Innovation, Volunteers and Empowerment for home dwelling persons with dementia and their caregivers.
- Conditions
- Dementia, Home-dwelling, Caregiver
- Trial name
- LIVE (NCT04043364)
- Testing
- LIVE
- Where
- Norway
- Volunteers
- 280 people
- Sponsor
- University of Bergen
Anxiety Disorders, Specific Phobia
Analyzing the Benefits of Using SYMPTOMS-JIT for in Vivo Exposure in Anxiety Disorders
The aim of this study is to develop and test the efficacy of first-of-its-kind, fully instrumented sensor-based smartphone-guided in-vivo exposure therapy using a just-in-time intervention for anxiety disorder.
- Conditions
- Anxiety Disorders, Specific Phobia, Panic Disorder, Agoraphobia
- Trial name
- NCT06788119
- Testing
- Cognitive behavioral therapy with in vivo exposure, Cognitive behavorial therapy with in vivo exposure plus SYMPTOMS-JIT
- Where
- Spain
- Volunteers
- 158 people
- Sponsor
- Universitat Jaume I
Alzheimer's Disease, Weight Loss
Mirtazapine in Alzheimer-associated Weight Loss
Weight loss is a frequent problem associated with Alzheimers disease (AD). Mirtazapine has weight loss as a frequent side effect.
- Conditions
- Alzheimer's Disease, Weight Loss, Mixed Dementia, Dementia
- Trial name
- NCT01505504
- Testing
- mirtazapine
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Brugmann University Hospital
Hyperactive Delirium, Delirium of Mixed Origin
Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care
The goal of this multi-centre phase I/II open-label, single-arm study is to determine the feasibility, optimal dose, and preliminary efficacy of dexmedetomidine to manage agitated delirium among patients near the end of life…
- Trial name
- NCT04824144
- Testing
- Dexmedetomidine Hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Bruyère Health Research Institute.
Caregiver Burden, Behavioral and Psychiatric Symptoms of Dementia
Acceptance Commitment Therapy for Caregivers of People with Memory Loss
Family caregivers for persons with dementia report high levels of depression, stress, and burden. Caregivers' limited time, transportation constraints, and unpredictable schedules make on-line, self-guided interventions more…
- Conditions
- Caregiver Burden, Behavioral and Psychiatric Symptoms of Dementia, Depressive Symptoms, Quality of Life
- Trial name
- NCT05749939
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Utah State University
Breast Cancer, Chronic Myeloproliferative Disorders
Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant
RATIONALE: Alemtuzumab and glucocorticoids, such as prednisone or methylprednisolone, may be an effective treatment for acute graft-versus-host disease caused by a donor stem cell transplant.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00410657
- Testing
- alemtuzumab, methylprednisolone, prednisone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Alzheimer Disease, Frontotemporal Degeneration (FTD)
PST for Care Partners of Adults With Alzheimer's and Alzheimer'S-related Dementia
Caregivers of individuals with Alzheimer's disease and related dementia rarely get the preparation or training they need to manage their caregiving responsibilities and to successfully balance their own self-care and their…
- Conditions
- Alzheimer Disease, Frontotemporal Degeneration (FTD), Lewy Body Dementia (LBD), Vascular Contributions to Cognitive Impairment and Dementia (VCID)
- Trial name
- NCT04748666
- Testing
- Problem Solving Training
- Where
- 3 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cerebral Small Vessel Diseases, Dementia, Mixed
Dementia Risk Registry Across the Multidimensional Lifespan: A 10-Year Study
Age-related cerebral small-vessel disease (CSVD) is a major cause of dementia, predominantly affecting individuals over 60 years of age, with a prevalence exceeding 70% in the elderly population.
- Conditions
- Cerebral Small Vessel Diseases, Dementia, Mixed, Health Behavior, Health Behavior, Risky
- Trial name
- DREAM-10 (NCT06164262)
- Testing
- Individuals with CSVD
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhejiang Provincial People's Hospital