Clinical trials: Dementia, Vascular
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Coronary Atherosclerosis, Coronary Artery Disease
Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging
In a prospective international multicenter observational study, 1080 stable chest pain patients (REALITY Advanced registry of CCTA patients) with the suspected chronic coronary syndrome will be enrolled.
- Conditions
- Coronary Atherosclerosis, Coronary Artery Disease, Contrast-induced Nephropathy, Cerebrovascular Disease
- Trial name
- REALITY (NCT02440646)
- Testing
- Coronary computed tomography angiography, Quantitative coronary angiography, intravascular imaging with percutaneous intervention
- Where
- 4 sites in Estonia, Netherlands and 1 more
- Volunteers
- 1,080 people
- Sponsor
- Central Clinical Hospital of the Russian Academy of Sciences
Haemorrhagic Stroke, Ischaemic Stroke
Digital Application for Stroke Health
Stroke is a leading cause of death and long-term disability worldwide. Despite substantial advances in acute stroke care, there remains a lack of evidence-based digital solutions to support patients after hospital discharge.
- Conditions
- Haemorrhagic Stroke, Ischaemic Stroke, Transient Ischemic Attack (TIA)
- Trial name
- DASH (NCT07511868)
- Testing
- StrokeApp, Standard care
- Where
- 7 sites in Austria
- Volunteers
- 500 people
- Sponsor
- VASCage GmbH
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Alzheimer Disease, Cerebral Amyloid Angiopathy
Auburn University Research on Olive Oil for Alzheimer's Disease (AU-ROOAD)
Until now there is no medical treatment and/or intervention that can slow, stop or reverse the underlying neurodegenerative of Alzheimer's disease (AD).
- Trial name
- (AU-ROOAD) (NCT03824197)
- Testing
- EVOO, OO
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Auburn University
Alzheimer's Disease, Small Vessel Disease White Matter Hyperintensities Subtype
Amyloid and Glucose PET Imaging in Alzheimer and Vascular Cognitive Impairment Patients With Significant White Matter Disease
The prevalence of both Alzheimer's Disease (AD) and stroke doubles each decade over 65 years old. Both are major causes of dementia, currently estimated to affect 46 million people worldwide.
- Conditions
- Alzheimer's Disease, Small Vessel Disease White Matter Hyperintensities Subtype, Vascular Cognitive Impairment
- Trial name
- MITNEC C6 (NCT02330510)
- Where
- 8 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Dr. Sandra E Black
Alzheimer Disease, Amyotrophic Lateral Sclerosis
The Ontario Neurodegenerative Disease Research Initiative
The Ontario Neurodegenerative Disease Research Initiative (ONDRI) is a province-wide collaboration studying dementia and how to improve the diagnosis and treatment of neurodegenerative diseases including: Alzheimer's disease (AD)…
- Conditions
- Alzheimer Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Parkinson Disease
- Trial name
- ONDRI (NCT04104373)
- Testing
- Observational Cohort
- Where
- 12 sites in Canada
- Volunteers
- 522 people
- Sponsor
- Ontario Neurodegeneration Disease Research Initiative
Cerebrovascular Disorders
Daphnetin Capsule In the Treatment of VaScular COgnitive Impairment Without Dementia
The purpose of this clinical trial is to understand and evaluate the clinical efficacy and safety of Daphnetin Capsule in patients with vascular cognitive impairment.
- Trial name
- DISCO (NCT06507488)
- Testing
- Daphnetin Capsule
- Where
- China
- Volunteers
- 206 people
- Sponsor
- First People's Hospital of Shenyang
Stroke
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training
The rates of cognitive decline and dementia after stroke are disproportionately high. Strategies that can protect the brain early after the stroke event could reduce the future risk of cognitive decline and dementia in these…
- Trial name
- PROTECT (NCT07445841)
- Testing
- Multimodal Training, Balance, Toning and Stretching
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McGill University
Dementia, Dementia, Vascular
Virtual Individual Cognitive Stimulation Therapy: a Proof of Concept Study
Due to COVID-19, the routine treatment for dementia, Cognitive Stimulation Therapy (CST), is currently suspended in multiple countries. Access to treatment is, therefore, paramount.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- V-iCST (NCT04828434)
- Testing
- Virtual Individual Cognitive Simulation Therapy
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
CADASIL, CADASIL (Diagnosis)
RAre, But Not aLone: a Large Italian Network to Empower the Impervious diaGNostic Pathway of Rare cerEbrovascular Diseases (ALIGNED)
Cerebrovascular diseases (CVDs) are one leading cause of morbidity and mortality worldwide. Despite intensive investigations, more than 30% of strokes remain of undetermined origin.
- Conditions
- CADASIL, CADASIL (Diagnosis), Moya Moya Disease, Moyamoya
- Trial name
- ALIGNED (NCT06935578)
- Where
- 17 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Alzheimer Disease, Dementia, Vascular
Cerebral Vascular Reserve in Small Vessel Disease and Alzheimers Disease
Alzheimers disease and cerebral small vessel disease have a considerably overlap in patients and have common risk factors. The diseases are difficult to separate in individual patients and we hypothesize that a reduced cerebral…
- Trial name
- NCT05443308
- Testing
- Cerebral [15O]H2O PET before and after diamox infusion
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Dementia, Alzheimer Disease
Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias
The investigators aim to study the effects of a 24-week remote-based resistance exercise training program on cardiovascular disease risk factors, cognitive function, and quality of life in older adults living with mild cognitive…
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT05004558
- Testing
- Remote-based Resistance Exercise Training
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Drexel University
CADASIL
Safety Study of Dabigatran in CADASIL
This study is a Phase II, randomized, crossover trial designed to compare one fixed dose of dabigatran with open-label use of ASA in patients affected by CADASIL; the study is a safety trial, and the primary objective is to…
- Trial name
- SONICA (NCT01361763)
- Testing
- Dabigatran, Antiplatelets
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- S. Andrea Hospital
Parkinson Disease, Dementia With Lewy Bodies
[18F]-MFBG Versus [123I]-MIBG and [18F]-PE2I in PD vs. MSA and DLB vs. AD
Study goal: The goal of this prospective head to head comparison is to evaluate the effectiveness of [18F]-MFBG PET in assessing cardiac innervation, comparing it with [123I]-MIBG SPECT The study's primary focus is on…
- Conditions
- Parkinson Disease, Dementia With Lewy Bodies, MSA - Multiple System Atrophy, Alzheimer Disease
- Trial name
- NCT06120049
- Testing
- [18F]-MFBG PET CT, [18F]-FE-PE2I PET CT or PET MRI, [123I]-MIBG SPECT CT
- Where
- 2 sites in Belgium
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Vascular Cognitive Impairment, Mild Cognitive Impairment
Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)
People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory.
- Trial name
- EXPRESS-V (NCT05079464)
- Testing
- tDCS, Exercise, Treatment as usual
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cerebral Microangiopathy, CADASIL
Impact of tDCS on Cerebral Autoregulation
The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.
- Conditions
- Cerebral Microangiopathy, CADASIL, Migraine With Aura, ICA Stenosis
- Trial name
- NCT01865604
- Testing
- Anodal tDCS, Cathodal tDCS
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Hypertension, Hypercholesterolemia
Vascular Intervention Strategies Trial for Alzheimer's
The proposed pharmacist-led study is a feasibility pilot trial for the management of vascular risk factors of hypertension and hypercholesterolemia in 10 APOE ε4 carriers, 50-75, at-risk for dementia.
- Conditions
- Hypertension, Hypercholesterolemia, Dementia Risk Factors
- Trial name
- VISTA (NCT07447206)
- Testing
- Angiotensin Receptor Blockers (ARBs), Hydrophilic Statins or Non-Statin Alternative
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Mild Cognitive Impairment
Rehabilitation of Attention in Patients With MCI and Brain Subcortical Vascular Changes Using the APT-II
Background: Subcortical Vascular Dementia (VaD), consequent to deep brain small vessel disease (SVD), is the most frequent form of VaD.
- Trial name
- RehAtt (NCT02033850)
- Testing
- Attention Process Training-II
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Dementia-related Psychosis
Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis
The purpose of this study is to evaluate the efficacy of pimavanserin compared to placebo in preventing relapse of psychotic symptoms in subjects with dementia-related psychosis who responded to 12 weeks of open label…
- Trial name
- NCT03325556
- Testing
- Pimavanserin 34 mg, Pimavanserin 20 mg
- Where
- 83 sites in United States, Bulgaria and 11 more
- Volunteers
- 392 people
- Sponsor
- ACADIA Pharmaceuticals Inc.