Clinical trials: Dementia, completed
Dementia
Supporting Family Caregivers With Technology for Dementia Home Care
This clinical trial will test the FamTechCare intervention that uses multidisciplinary professional guidance based on in-home video monitoring to support family caregivers in managing challenging behaviors of persons with…
- Trial name
- FamTechCare (NCT02483520)
- Testing
- FamTechCare
- Where
- 2 sites in United States
- Volunteers
- 189 people
- Sponsor
- University of Kansas Medical Center
Alzheimer Disease
Memesto Wearable Device for Persons With Dementia
An estimated 70% of the 7.2+ million people in the U.S. with Alzheimer's Disease and Alzheimer's Disease-Related Dementias experience agitation, characterized by poorly organized and purposeless psychomotor activity that…
- Trial name
- NCT05153161
- Testing
- Memesto
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Edgewater Safety Systems, Inc.
Alzheimer Dementia
Exploratory Study for the Validity of QuQu Scale
Examine the construct validity, the group discriminant ability, and the inter-rater reliability of a novel dementia rating scale (QuQu scale: QUick QUestion scale) candidate for the evaluation of patients with Alzheimer Dementia…
- Trial name
- QuQu (NCT02267486)
- Testing
- Standard therapy of Alzheimer Dementia (AD), Observation
- Where
- Japan
- Volunteers
- 972 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Mild Cognitive Impairment
Intervention to Reduce Sedentary Time
The purpose of this study is to determine whether the researchers can help people change the amount of time they spend in sitting activities and whether this change might improve health outcomes.
- Trial name
- ReST-MCI (NCT02878486)
- Testing
- Jawbone Up, Physical Activity Education, ActivPAL
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Kansas Medical Center
Mild Cognitive Impairment, Dementia
A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment
The purpose of this study is to determine whether treatment with the investigational drug ladostigil will delay the onset of Alzheimer's disease(AD) in patients with Mild Cognitive Impairment (MCI).
- Trial name
- NCT01429623
- Testing
- ladostigil hemitartrate
- Where
- 12 sites in Austria, Germany and 1 more
- Volunteers
- 210 people
- Sponsor
- Avraham Pharmaceuticals Ltd
Alzheimer Disease
Eye to Brain Connection
This is a non-randomized, non-treatment, observational study designed to discover correlations between retinal imaging and amyloid PET imaging. Subjects will be recruited to the clinical cohort from referring physicians.
- Trial name
- NCT05215782
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Optina Diagnostics Inc.
Huntington Disease
Proof of Concept of an Anaplerotic Study Using Brain Phosphorus Magnetic Resonance Spectroscopy in Huntington Disease
The purpose of this project is to study the efficacy of an anaplerotic treatment on brain energy profile evolution at an early stage of the Huntington disease.
- Trial name
- TRIHEP2 (NCT01882062)
- Testing
- Triheptanoin 1g/kg/day
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alzheimer's Disease, Dementia
Experimental Study to Validate the "Therapeutic Game" CONEM-BETA
The purpose of the study is to assess the efficacy of the systematic application of the CONEM-BETA game in the subjective welfare of family caregivers of patients with Alzheimer's disease or other advanced stage dementia.
- Trial name
- NCT01652222
- Testing
- CONEM-BETA + socio-educational training, Socio-educational training only
- Where
- 3 sites in Spain
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Alzheimer's Disease
A Study to Evaluate the Efficacy and Safety of ABBV-8E12 in Participants With Early Alzheimer's Disease
This study seeks to evaluate the efficacy and safety of ABBV-8E12 in participants with early Alzheimer's disease (AD).
- Trial name
- NCT02880956
- Testing
- ABBV-8E12
- Where
- 68 sites in United States, Australia and 9 more
- Volunteers
- 453 people
- Sponsor
- AbbVie
Cognitive Impairment
An Intervention Study to Reduce Drug-related Problems and Readmissions Among Old People With Dementia
The aim of this randomized controlled study is to investigate if medication reviews performed by a clinical pharmacist as part of a ward team can reduce drug related problems and reduce readmissions to hospital among elderly…
- Trial name
- NCT01504672
- Testing
- Medication review
- Where
- 2 sites in Sweden
- Volunteers
- 460 people
- Sponsor
- Umeå University
General Anesthesia
Markers of Alzheimers Disease After Propofol or Isoflurane Anesthesia
Previous work in animal models suggests that inhalational anesthetic agents may accelerate Alzheimer's disease pathogenesis, but it is unclear to what extent this may happen in humans.
- Trial name
- MAD-PIA (NCT01640275)
- Testing
- Propofol, Isoflurane
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Duke University
Parkinson's Disease With Dementia
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease
The project will investigate the effect of pharmacological and electric modulation of N-methyl-D-aspartate (NMDA) pathway on the cognitive flexibility and volitional movement preparation in patients with Parkinson's disease (PD).
- Trial name
- NCT01785628
- Testing
- Sarcosine Capsule
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Alzheimer's Disease
Trial of Carvedilol in Alzheimer's Disease
This is a 6-month pilot randomized double-blind placebo-controlled trial of carvedilol, with the primary objective being to determine whether carvedilol treatment is associated with improvement in Alzheimer's Disease (AD) as…
- Trial name
- NCT01354444
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Johns Hopkins University
Alzheimer Disease
Use of a Cannabinoids as a Treatment Strategy for Alzheimer's Disease
Brief Summary: The objective of the study is to evaluate the effect of cannabinoids on Alzheimer's Disease. This is a double-blind, randomized, placebo-controlled clinical trial.
- Trial name
- DAZACANN (NCT06570928)
- Testing
- Cannabis
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Federal University of Latin American Integration
Huntington's Disease
Study To Assess the Safety and Tolerability of Single Ascending Oral Doses of PBF-999 in Healthy Young Male Volunteers
Study To Assess the Safety and Tolerability of Single Ascending Oral Doses of PBF-999 ( 5 mg, 10 mg, 20 mg and 40 mg ) in Healthy Young Male Volunteers
- Trial name
- NCT02208934
- Testing
- PBF-999
- Where
- 2 sites in Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Alzheimer's Disease
EEG/ERP Longitudinal Study in Alzheimer's Disease (AD)
In a previous study, NCT00582127, two age-matched cohorts, one clinically diagnosed with mild Alzheimer's disease and the other healthy controls, were tested with a hand-held EEG/ERP system to determine if the cohorts could be…
- Trial name
- NCT02769234
- Testing
- ERP/EEG test, Psychometric testing
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Neuronetrix, Inc.
Cognition, Affect (Mental Function)
ETASCAI Pilot Project
This pilot study aims to investigate the chronic effects of ETAS® on cognitive, affective and inflammatory outcomes in healthy adults aged 60-80 years with mild to moderate subjective cognitive complaints.
- Conditions
- Cognition, Affect (Mental Function), Inflammation
- Trial name
- NCT06790849
- Testing
- Active 1 ETAS®, Active 2 ETAS®
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Reading
Alzheimer Disease, Dementia With Lewy Bodies
Neurological Soft Signs in Neurodegenerative Dementias
The goal of this observational study is to investigate the prevalence of Neurological Soft Signs (NSS) in various categories of dementia patients compared to matched controls.
- Conditions
- Alzheimer Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Corticobasal Degeneration
- Trial name
- DemeNSS (NCT06354933)
- Testing
- Neurological Soft Signs
- Where
- Italy
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Alzheimer Disease
Study to Evaluate DNL747 in Subjects With Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple oral doses of DNL747 in subjects with Alzheimer's disease when administered for 29 days in a cross-over design
- Trial name
- NCT03757325
- Testing
- DNL747
- Where
- 5 sites in United States, Netherlands
- Volunteers
- 16 people
- Sponsor
- Denali Therapeutics Inc.
Dementia
Constructing and Evaluating the Effectiveness of a Community-based Older Adults Dementia Prevention Education Program
This study adopted a mixed-methods approach and was conducted in two exploratory phases. The first phase focused on development and involved three focus group interviews with community-dwelling older adults.
- Trial name
- NCT06998836
- Testing
- Dementia prevention education, General Health Education Leaflet
- Where
- Taiwan
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
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