Clinical trials: Dementia, completed
Alzheimer's Disease, Cognitive Impairment
Effects of a Complex Cognitive Training in Mild Cognitive Impairment and Mild Alzheimer's Disease
A recent meta-analysis that included over 29.000 individuals found that the odds ratio (OR) of individuals with high brain reserve compared to low was 0.54 (p < 0.0001), a risk decrease of 46%.
- Trial name
- NCT00544856
- Testing
- complex cognitive training
- Volunteers
- 39 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Alzheimer's Disease, Obstructive Sleep Apnea
Role of Hypoxia Ans Sleep Fragmentation in Alzheimer's Disease. and Sleep Fragmentation.
Alzheimer's Disease (AD) is the most prevalent neurodegenerative disease, manifested as an initial deficit of episodic memory that evolves into a global cognitive and psychosocial dysfunction and which prevalence is increasing…
- Trial name
- NCT02814045
- Where
- 2 sites in Spain
- Volunteers
- 144 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Dementia With Lewy Bodies
Deep Brain Stimulation for Patients With Dementia With Lewy Bodies
This trial aims to collect pilot data to explore whether bilateral deep brain stimulation (DBS) of the Nucleus Basalis of Meynert (NBM) has beneficial effects on memory and thinking impairments among individuals with Dementia…
- Trial name
- NCT02263937
- Testing
- Bilateral Nucleus Basalis Meynert DBS
- Where
- 2 sites in United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Postpartum Depression, Postpartum Anxiety
Feasibility & Acceptability of App-based Cognitive Behavioral Therapy for Postpartum Depression Prevention
Postpartum depression (PPD) affects up 10-15% of mothers overall, but the rate of PPD can be as high as 25% among mothers with personal or obstetric risk factors.
- Conditions
- Postpartum Depression, Postpartum Anxiety, Stress
- Trial name
- NCT06365645
- Testing
- M.Bapp, App-based parenting education
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Alzheimer Disease, Battery
Prediction of Cognitive Properties of New Drug Candidates for Neurodegenerative Diseases in Early Clinical Development
The early assessment of new drugs for Alzheimer's disease remains difficult because of the lack of predictive end-point. The use of a battery including different parameters could improve this early development of new drugs.
- Trial name
- PharmacogWP3 (NCT01487395)
- Testing
- Donepezil .
- Where
- 3 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Mild Cognitive Impairment, Alzheimer Disease
The Effects of Intermittent Theta Burst Stimulation in MCI and Early AD
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique that is increasingly used for a growing number of research and clinical applications.Typically, this transient magnetic field is focally applied…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Cognitive Decline
- Trial name
- NCT04555941
- Testing
- intermittent theta burst stimulation
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Dementia
Producing a Fully Asynchronous Online Savvy Program
This is a pilot/feasibility study to develop and test a fully online, self-administered psychoeducation program to enhance the caregiving mastery of family and friends who provide unpaid care for persons living with Alzheimer's…
- Trial name
- NCT04951037
- Testing
- Fully Asynchronous Online Savvy Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Emory University
Alzheimer's Disease
Post-marketing Surveillance of Long-term Administration of Donepezil Hydrochloride -Investigation of the Clinical Condition and Safety in Patients With Alzheimer's Disease-
The purpose of this study is to investigate the following about donepezil hydrochloride administration in patients with mild or moderate Alzheimer's Disease in clinical practice: cognitive function, Functional Assessment Staging…
- Trial name
- NCT01129596
- Testing
- donepezil hydrochloride
- Where
- 722 sites in Japan
- Volunteers
- 10,238 people
- Sponsor
- Eisai Co., Ltd.
Alzheimer Disease
CBT for African Americans With Cognitive Impairment
The aim of the study is to test the feasibility and acceptability of a six-month cognitive-behavioral therapy (CBT) program (group based and phone-based) compared with usual care, and to determine if the intervention can improve…
- Trial name
- NCT03384069
- Testing
- Group-based Cognitive Behavioral Therapy (CBT), Phone-based Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Dementia
Animal-Assisted Therapy for People With Dementia
This study is a qualitative anthropological research that explores the effects of Animal-Assisted Therapy (AAT) for people with moderate and severe dementia living in a care facility.
- Trial name
- AATPD (NCT03946696)
- Testing
- Interactions with therapy-animals
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Aberdeen
Alzheimer's Disease
To Evaluate the Efficacy and Safety/Tolerability Profiles of G-CSF in Subjects With Mild to Moderate Alzheimer's Disease
With the enrichment of living environment and the progress of medicine, the scale of aging population has increased in many countries of the world.
- Trial name
- NCT03656042
- Testing
- Filgrastim (75mcg/0.3ml)
- Where
- Taiwan
- Volunteers
- 21 people
- Sponsor
- Chang Gung Memorial Hospital
Smoking Cessation, Health Behavior
So-Lo-Mo Intervention Applied to the Smoking Cessation Process
This is a randomized open-label parallel-group trial. 240 subjects will be recruited during 8 months and a 12 months follow-up will be carried out for each one of them.
- Conditions
- Smoking Cessation, Health Behavior, Lifestyle-related Condition
- Trial name
- So-Lo-Mo (NCT03553173)
- Testing
- So-Lo-Mo, Psychological advice, Bupropion Pill
- Volunteers
- 240 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Sleep, Sleep Disorders
Z-Drugs for Sleep Disorders in Alzheimer's Disease
The purpose of this study is to determine whether Zolpidem and Zoplicone are efective in the treatment of sleep disorders in Alzheimer's disease (AD)
- Conditions
- Sleep, Sleep Disorders, Insomnia, Alzheimer's Disease
- Trial name
- NCT03075241
- Testing
- Zolpidem, Zoplicone
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Brasilia University Hospital
Lewy Body Disease, Parkinson Disease
A Study of E2027 in Participants With Dementia With Lewy Bodies (DLB) or Parkinson's Disease Dementia (PDD) With or Without Amyloid Copathology
The purpose of study is to demonstrate the pharmacodynamic (PD) effects of E2027 on cerebrospinal fluid (CSF) cyclic guanosine monophosphate (cGMP) in participants with DLB and PDD with and without amyloid copathology after 9…
- Trial name
- NCT04764669
- Testing
- E2027
- Where
- 14 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Eisai Inc.
Huntington Chorea
Efficacy and Safety on SOM3355 in Huntington's Disease Chorea
Phase IIb, randomized, double-blind, placebo-controlled study in parallel groups assessing the efficacy and safety of two doses of SOM3355 in patients suffering from Huntington's Disease with choreic movements.
- Trial name
- NCT05475483
- Testing
- SOM3355 200 mg capsules, SOM3355 300 mg capsules
- Where
- 23 sites in France, Germany and 5 more
- Volunteers
- 139 people
- Sponsor
- SOM Innovation Biotech SA
Dementia
Microbiome and Dementia
From this study, it is hoped to learn if and how the gut microbiome composition, gut permeability and inflammation in patients with dementia are associated with each other.
- Trial name
- NCT03167983
- Where
- Austria
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Alzheimer's Disease
Apoe Impact Study on Brain Structure and Function, in a Population 45 to 75 Years Old
The purpose of this study is to investigate the influence of the APOE genotype on brain morphology, function and metabolism, related to other factors such as cognitive reserve, cognition and episodic memory, in subjects at…
- Trial name
- NCT02198586
- Where
- Spain
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Dementia, Gait Analysis
Role of Gait Analysis in Different Type of Dementia
Aim for the work is the studying of the existence and pattern of gait impairment in pre-dementia and dementia To examine the association between dual decline in gait and cognition
- Trial name
- NCT06713070
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cognitive Impairment, no Dementia (CIND)
ENLIGHTEN: Exercise and NutritionaL Interventions for coGnitive and Cardiovascular HealTh ENhancement
ENLIGHTEN will examine the effects of exercise, the dietary approaches to stop hypertension diet (DASH), and a combined exercise and DASH intervention on cognitive function among adults with cardiovascular disease (CVD) risk and…
- Trial name
- ENLIGHTEN (NCT01573546)
- Testing
- Aerobic Exercise, DASH diet, Health education control
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Duke University
Dementia
Effectiveness of Flash Mediation Therapy
In order to offer a non-drug intervention for caregivers in nursing home to respond promptly to a behavioral crisis with an appropriate response to each patient, a chariot has been developed by the Institute of Ageing Well Korian…
- Trial name
- NCT02933177
- Testing
- 2 months control condition - 4 months chariot-flash, 4 months control condition-2 months chariot flash
- Where
- France
- Volunteers
- 241 people
- Sponsor
- Hospices Civils de Lyon
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