Clinical trials: Dementia
Aggression
Healthy Brains & Behavior: Understanding and Treating Youth Aggression
Understanding the joint neurobiological and social bases to aggression is critical to future attempts to tackle this major public health problem.
- Trial name
- HBB (NCT00842439)
- Testing
- CBI, NUT
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dementias With Lewy Bodies
A Study to Determine the Metabolism and Elimination of [14C]E2027 in Healthy Male Participants
The primary objective of the study is to achieve mass balance recovery of [14C]-radiolabel in urine and feces and to identify and quantify the main elimination pathways of E2027.
- Trial name
- NCT04023877
- Testing
- E2027
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Family Caregivers, Dementia
Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD
Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role.
- Conditions
- Family Caregivers, Dementia, Self-management, Depression
- Trial name
- NCT06928467
- Testing
- Building Better Caregivers workshop
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- University of California, San Francisco
Alzheimer Disease
Enhancing Consent for Alzheimer's Research
The purpose of this study is to evaluate the efficacy of an enhanced consent procedure for patients with mild-to-moderate Alzheimer disease, and to identify factors and patient characteristics that predict the degree to which…
- Trial name
- BWP-AD (NCT00453544)
- Testing
- Enhanced Consent Procedure, Routine Consent Procedure
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Dementia, Mild Cognitive Impairment
Prediction, Prevention, Predisposition: Applications in Neurology and Endocrinology
This project aims to introduce solutions for strengthening the management capabilities of two types of patients, in terms of care and prevention.
- Trial name
- PRECUBE2022 (NCT06227364)
- Testing
- MCI patients, metabolic patients
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Restlessness, Pain
Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia
Dexmedetomidine is a highly selective α2 adrenoreceptor agonist approved by the US FDA for short-term postoperative sedation and analgesia.It can also reduce the stress response without respiratory depression.
- Trial name
- NCT01517932
- Testing
- dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Fang Luo
Healthy Participants, Alzheimer Disease
A Phase 1 Study to Assess the Safety and Effects of Single and Multiple Doses of KS101 in Healthy Volunteers
This study is the first clinical trial involving study drug KS101. The goal of this clinical trial is to investigate whether KS101 is safe, whether it causes side effects, and how KS101 is broken down in the body, in healthy…
- Conditions
- Healthy Participants, Alzheimer Disease, Chronic Kidney Disease
- Trial name
- NCT07143331
- Testing
- Part 1 KS101, Part 2 with Food, Part 2 without food
- Where
- Australia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Klotho Sciences Australia Pty Ltd.
Alzheimer's Disease
Using a Wireless Controller to Deliver a Lighting Intervention to Persons With Dementia
To test the effect of a tailored lighting intervention controlled by the Readings At Desk (RAD) controller on sleep and mood in Alzheimer's disease participants.
- Trial name
- NCT05519137
- Testing
- Active lighting intervention, Control lighting intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chorea, Huntington's Disease
Treatment of Huntington's Chorea With Amantadine
Huntington's disease is a chronic disorder passed on through genetic autosomal dominant inheritance. The condition usually begins between the ages of 30 and 50 years and it is characterized by involuntary movements in the face…
- Trial name
- NCT00001930
- Testing
- Amantadine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pain, Agitation on Recovery From Sedation
Assessment and Management of Pain, Agitation, Delirium and Sleep Deprivation (PADS) in ICU by PADS Protocol, Thailand
The investigators proposed that pain, agitation, delirium and sleep deprivation protocol (PADS) will help improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free…
- Conditions
- Pain, Agitation on Recovery From Sedation, Delirium
- Trial name
- NCT04270331
- Testing
- PADS protocol
- Where
- Thailand
- Volunteers
- 509 people
- Sponsor
- Mahidol University
Alzheimer's Disease, Caregivers
Nurse Managed Clinic for Dementia Patients and Family Caregivers
This study evaluates the effectiveness of a nurse-managed interdisciplinary (nursing and occupational therapy) clinic serving community dwelling dementia patients and their spouse caregivers.
- Conditions
- Alzheimer's Disease, Caregivers, Dementia
- Trial name
- NCT00012831
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- US Department of Veterans Affairs
Alzheimer Disease
Study on Biomarkers for Early Diagnosis of Alzheimer's Disease
The project of Bio-AD is a population- based cohort study among the elderly in China. The project includes not only Alzheimer's disease (AD including familial AD and sporadic AD), but also other clinical stage of AD, as well as…
- Trial name
- NCT04575337
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Normal Pressure Hydrocephalus
White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is…
- Trial name
- OWN-NPH (NCT07103681)
- Testing
- Ventriculoperitoneal Shunt (VP), Brain and Skin Biopsy, MRI Brain
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Mental Health Issue
Delivery Format of Cognitive Behavioral Therapy Materials on Engagement and Outcomes: AI-Enabled App vs PDF Workbook
The goal of this clinical trial is to compare two different ways of delivering cognitive behavioral therapy (CBT) materials to people with symptoms of anxiety and depression. The main questions it aims to answer are: 1.
- Trial name
- NCT06459128
- Testing
- Limbic Care, Digital Workbook
- Where
- United Kingdom
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Limbic Limited
Dementia, Alzheimer Disease
Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers
The goal of this clinical trial is to evaluate Kinto's Care Coaching intervention for dementia caregivers. The main questions it aims to answer are: Does the intervention help caregivers to address their general caregiving goals…
- Conditions
- Dementia, Alzheimer Disease, Lewy Body Disease, Vascular Dementia
- Trial name
- NCT05916664
- Testing
- Kinto Care Coaching
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Kinto
Frontotemporal Dementia, Amyotrophic Lateral Sclerosis
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Background: Neurodegenerative disorders can lead to problems in movement or memory. Some can cause abnormal proteins to build up in brain cells.
- Conditions
- Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, Progressive Supranuclear Palsy
- Trial name
- NCT03225144
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer Disease, Cognitive Decline
Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study
The investigators will conduct tau positron emission tomography (PET) scans on 125 adults using the radiopharmaceutical Flortaucipir F18 ([18F]AV-1451).
- Trial name
- NCT04080544
- Testing
- [18F]AV-1451, Positron Emission Tomography
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Neil M Rofsky, MD, MHA
Dementia, Alzheimer Disease
REmote Assessment and Dynamic Response Intervention
The purpose of the READyR study (originally called SHARE-sense) is to redevelop and test an intervention program to remotely assess for changing dementia-related care needs.
- Conditions
- Dementia, Alzheimer Disease, Relationship, Marital, Caregiver Stress Syndrome
- Trial name
- READyR (NCT04542109)
- Testing
- READyR A, READyR B
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Huntington Disease
PHysical Activity and Exercise Outcomes in Huntington's Disease
Huntington's disease (HD) is a genetic, degenerative neurological disease that affects individuals in their third-fourth decade of life and individuals can live 15-20 years with manifest HD.
- Trial name
- PACE-HD (NCT03344601)
- Testing
- physical activity
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 116 people
- Sponsor
- Cardiff University
Parkinson Disease Dementia, Dementia With Lewy Bodies
ATH-1017 Treatment in Subjects With Parkinson's Disease Dementia or Dementia With Lewy Bodies (SHAPE Trial)
This study is designed to evaluate the safety and treatment effects of fosgonimeton (ATH-1017) in subjects with Parkinson's Disease Dementia or Dementia with Lewy Bodies, with a randomized treatment duration of 26 weeks.
- Trial name
- NCT04831281
- Testing
- ATH-1017
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- LeonaBio