Clinical trials: Dementia, completed
Cognitive Ability, General, High Blood Pressure
Assessing the Impact of Calcium Channel Blockers on COGnitive Function in the Very Elderly (AI-COG)
Older adults are at increased risk of high blood pressure and cognitive decline. High blood pressure itself also increases risk of cognitive decline.
- Trial name
- NCT01868165
- Where
- 7 sites in United Kingdom
- Volunteers
- 337 people
- Sponsor
- Imperial College London
HIV Infections
Clinical Trial of CNS-targeted HAART (CIT2)
CIT2 is a strategy for targeting HAART (Highly Active Antiretroviral Therapy) to the CNS (Central Nervous System) in patients with HIV associated neurocognitive impairment (HNCI).
- Trial name
- NCT00624195
- Testing
- FDA Approved Antiretroviral Therapy (see list below)
- Where
- 5 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of California, San Diego
Alzheimer's Disease, Dementia
Clinical and Genetic Study of Neurodegenerative Disorders With Cognitive Impairment
Patients with different types of dementia will be recruited and evaluated in national hospital departments for their usual neurological follow-ups.
- Conditions
- Alzheimer's Disease, Dementia, Neurodegenerative Disorders
- Trial name
- NCT00149175
- Testing
- Blood sampling, skin biopsy
- Where
- 12 sites in France
- Volunteers
- 2,256 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alzheimer Disease
A Program to Reduce Inappropriate Medications Among Older Adults With Alzheimer's Disease
Potentially inappropriate prescribing includes the use of medications that may no longer be necessary or that may increase the risk of harm.
- Trial name
- D-PRESCRIBE-AD (NCT05147428)
- Testing
- Educational Materials
- Where
- United States
- Volunteers
- 14,442 people
- Sponsor
- University of Massachusetts, Worcester
Delirium, Dementia, Amnestic, Cognitive Disorders, Arthroplasty, Hip Replacement
Cerebral Regional Oxygen Saturation and Markers of Brain Damage During Primary Hip Arthroplasty
Postoperative Cognitive Disorders (POCD) are common in hospitalized people > 60 year old, especially in orthopedic patients. Etiology of POCD is complex, and in some aspects still remains unclear.
- Trial name
- NCT02342236
- Testing
- cemented or cementless type of hip prothesis
- Where
- Poland
- Volunteers
- 18 people
- Sponsor
- Military Institute od Medicine National Research Institute
Aggression, Stress
The Therapeutic Effects of Equine-Assisted Psychotherapy
Equine-assisted interventions (EAI) are an emerging form of alternate psychotherapy that has been increasingly found to produce improvements in various treatment outcomes.
- Conditions
- Aggression, Stress, Psychopathy, Empathy
- Trial name
- EAP (NCT04200612)
- Testing
- Equine-Assisted Psychotherapy, Equine-Assisted Activities
- Where
- Singapore
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Chua Yi Rong Shawn
Alzheimer's Disease
Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
The primary purpose of this study is to determine whether ELND005 is effective in treating symptoms of agitation and aggression in patients with Alzheimer's disease
- Trial name
- NCT01735630
- Testing
- ELND005
- Where
- 70 sites in United States, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- OPKO Health, Inc.
Caregiver Burden, Alzheimer Disease
Virtual Training for Latino Caregivers to Manage Symptoms of Dementia
The goal of this pilot study is to improve the STAR-Caregivers Virtual Training \& Follow-up (STAR-VTF) intervention for Latino caregivers of people living with dementia.
- Conditions
- Caregiver Burden, Alzheimer Disease, Dementia, Behavioral Symptoms
- Trial name
- NCT05599100
- Testing
- STAR-Caregivers Virtual Training & Follow-up (STAR-VTF)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Washington
Nervousness, Restlessness
Effectiveness of NEURAPAS Balance in Children With Nervous Restlessness
Purpose: To document data on effectiveness of NEURAPAS® balance (NPB) in the treatment of nervous restlessness in children aged 6 to 12. Each patient is treated with NPB. No placebo group is established.
- Conditions
- Nervousness, Restlessness, Depression (Agitated), Affective Disorders
- Trial name
- NCT01125579
- Where
- Germany
- Volunteers
- 115 people
- Sponsor
- Pascoe Pharmazeutische Praeparate GmbH
Alzheimer's Disease
Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Alzheimer's Disease
This study evaluates the effect of ORM-12741 on agitation/aggression symptoms in Alzheimer's disease. Two thirds of the patients will receive ORM-12741 and one third will receive placebo.
- Trial name
- Nebula (NCT02471196)
- Testing
- ORM-12741
- Where
- Finland
- Volunteers
- 308 people
- Sponsor
- Orion Corporation, Orion Pharma
Alzheimer Disease
Sequential Dose-escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of TB006 in Healthy Subjects
This is a single dose, dose-escalation study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of TB006, a monoclonal antibody that will be studied as a disease modifying treatment for Alzheimer's disease.
- Trial name
- TB006SAD (NCT04920786)
- Testing
- TB006
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- TrueBinding, Inc.
Stroke, TBI
Characterization of the DELPhI System in Assessing Brain's Functionality in Different Neurological Disorders
We use Transcranial magnetic stimulation (TMS), combined with simultaneous registration of electroencephalograph (EEG),for examining human cortical functionality.
- Conditions
- Stroke, TBI, Fibromyalgia, PDD
- Trial name
- NCT03832413
- Testing
- DELPhI (TMS-EEG analysis)
- Where
- Israel
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Alzheimer Disease, Aging
Bilateral Brain Dynamics in Cognition and Aging
This project is focused on the gap in understanding of bilateral brain interactions and their role in helping normative and clinical elderly populations maintain cognitive health.
- Conditions
- Alzheimer Disease, Aging, MCI
- Trial name
- NCT03224988
- Testing
- TMS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Depressive Symptoms
A Ten-Week Online Acceptance and Commitment Therapy Intervention for Family Caregivers of People With Dementia
This randomized controlled trial aims to assess the effects of a coach-guided ten-week videoconferencing acceptance and commitment therapy (ACT) program on mental health outcomes in depressed family caregivers of people with…
- Trial name
- NCT05043441
- Testing
- Acceptance and commitment therapy (ACT), Psychoeducation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Alabama at Birmingham
Aggression
Aggression From the Perspective of Patients and Nurses
The research, was planned in a randomized controlled design, aiming to evaluate the effect of the training given to nurses working in psychiatric clinics on the use of aggression and BVC (Broset Violence Checklist) on the nurses'…
- Trial name
- NCT05946720
- Testing
- Training including aggression and the use of BVC.
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Muğla Sıtkı Koçman University
Aphasia, Primary Progressive, Anomia
Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia
The goal of this study is to remediate word-finding problems in patients who have Primary Progressive Aphasia (PPA) or Alzheimer's Disease and to delay the further progression of word-finding impairment.
- Conditions
- Aphasia, Primary Progressive, Anomia, Alzheimer Disease
- Trial name
- NCT02675270
- Testing
- Phonological, Orthographic, Semantic
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Georgetown University
Dementia, Physical Activity
Co-design and Pilot Study in VR-based Physical Activity and Cognitive Training
Physical activity and reminiscence therapy alone have been studied with no clear effectiveness in Alzheimer's disease, but their combined intervention remains unknown.
- Conditions
- Dementia, Physical Activity, Reminiscence Therapy, Co-design
- Trial name
- NCT06982170
- Testing
- A physical activity and reminiscence therapy
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology
Alzheimer Disease
Study Evaluating the Safety,Tolerability, PK and PD of SAM-531 in the Subjects With Mild to Moderate Alzheimer's Disease
The primary purpose of the study is to assess whether SAM-531, an investigational drug, is safe and well tolerated, compared with placebo (a medically inactive substance), in subjects with mild to moderate Alzheimer's disease.
- Trial name
- NCT00481520
- Testing
- SAM-531
- Where
- 7 sites in United States
- Volunteers
- 72 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Agitation Related to Dementia
The Effect of Cannabis on Dementia Related Agitation and Aggression
The most common syndrome in patients with severe dementia is agitated behavior, which is often characterized by a combination of violent behavior (physical or verbal), restlessness, and inappropriate loudness.
- Trial name
- NCT03328676
- Testing
- Cannabis
- Where
- Israel
- Volunteers
- 64 people
- Sponsor
- TO Pharmaceuticals
Occupational Stress
Feasibility of Stress Management Education Delivered Via Virtual Classroom in Nursing Homes: a Pilot Study of a RCT
The aim of this cluster-randomised pilot study is to assess the feasibility of a remote stress management programme to reduce occupational stress in healthcare workers in specialised care units of nursing homes.
- Trial name
- AGIT-RESTS-1 (NCT06727682)
- Testing
- Stress management
- Where
- 4 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GCS CIPS
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