Clinical trials: Dementia, completed
Dementia, Mild Cognitive Impairment
Virtual Chair Yoga for Older Adults and Caregivers: Randomized Controlled Trial
Over 700,000 Canadians are affected by dementia costing the health care system approximately $10 billion/year. Due to COVID-19, the government has urged individuals over the age of 70 to stay home, putting this population at risk…
- Trial name
- NCT04884529
- Testing
- Chair-yoga program
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Dementia, Psychiatric Disorders Mood
Genetic Evaluation for Medication Selection (GEMS) Study
Investigators propose to determine whether knowing details about how a person's genes affect the way medicines work in the brain and body will help doctors pick more effective or safer medicine for that person.
- Conditions
- Dementia, Psychiatric Disorders Mood, Behavior Disorders
- Trial name
- GEMS (NCT03736057)
- Testing
- Delayed results of pharmacogenomic results
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Neurobehavioral Disinhibition
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Participants With Traumatic Brain Injury
This is a multicenter, randomized, placebo-controlled study to evaluate AVP-786 for the treatment of neurobehavioral disinhibition including aggression, agitation, and irritability in participants with traumatic brain injury…
- Trial name
- NCT03095066
- Testing
- AVP-786-28, AVP-786-42.63
- Where
- 54 sites in United States
- Volunteers
- 168 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Alzheimer's Disease, Brain Neoplasm
PET Scan of Brain Metabolism in Relation to Age and Disease
The main source of energy for the brain comes from a combination of oxygen and glucose (sugar). For brain cells to function normally they must receive a constant supply of these nutrients.
- Conditions
- Alzheimer's Disease, Brain Neoplasm, Niemann Pick Disease
- Trial name
- NCT00001972
- Testing
- 15 O Water
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer's Disease
A Study to Show That the Change of Attention Measure is Correlated With the Changes of Caregiver's Burden After Treatment With Galantamine in Patients With Alzheimer's Disease
The purpose of this study is to demonstrate that the change of attention measure is correlated with the changes of caregiver's burden after treatment with galantamine.
- Trial name
- NCT01734395
- Testing
- Galantamine
- Volunteers
- 1,882 people
- Sponsor
- Janssen Korea, Ltd., Korea
Huntington Disease, Juvenile
REGISTRY-JHD - an Observational Study of the European Huntington's Disease Network (EHDN)
The study aims to monitor the progression of symptoms and signs of those affected by JHD using modified UHDRS scales of motor and function (functional assessment, TFC).
- Trial name
- JHD (NCT01590602)
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 78 people
- Sponsor
- European Huntington's Disease Network
Huntington's Disease
Exercise Effects in Huntington's Disease
Huntington's disease (HD) is an incurable and fatal disorder characterised by progressive degeneration of the basal ganglia and the cerebral cortex.
- Trial name
- NCT01879267
- Testing
- Exercise training
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Gut Microbiota, Mild Cognitive Impairment
Intervention of Intestinal Microorganism in Mild Cognitive Impairment
Alzheimer's disease (AD) is the most common form of neurodegenerative disorders leading to dementia. Currently, there has been no effective drugs targeting this disease.
- Conditions
- Gut Microbiota, Mild Cognitive Impairment, Dementia, Alzheimer Type, Neuroimaging
- Trial name
- NCT03991195
- Testing
- Probiotic supplemented intervention
- Where
- China
- Volunteers
- 90 people
- Sponsor
- XuanwuH 2
Caregiver Burden
Building a Bridge (BAB) Between Clinical and Community Care
Dementia diagnosis triggers a transitional phase for the individuals and their families, often causing emotional distress and family conflicts due to the ambiguity of the illness and future trajectories.
- Trial name
- BAB (NCT03932812)
- Testing
- Options Counselor Health Educator (OC-HE) Intervention
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Sato Ashida
Alzheimers Disease, Dementia
University of Central Florida Music Study
The purpose of this study is to scientifically validate the impact of music therapy on Alzheimer's disease (AD) by analyzing molecular biomarkers in salivary exosomes.
- Conditions
- Alzheimers Disease, Dementia, Dementia Alzheimer Type
- Trial name
- NCT07306065
- Testing
- Music intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Dementia, Caregiver Burden
Comprehensive Home-based Dementia Care Coordination for Medicare-Medicaid Dual Eligibles in Maryland
This Center for Medicare and Medicaid funded health care innovation award will implement the MIND at Home dementia care coordination program (called MIND at Home-Plus) through two community-based service agencies (Jewish…
- Trial name
- NCT02395731
- Testing
- MIND at Home-Plus Intervention
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- Johns Hopkins University
Alzheimer Disease, Parkinson Disease
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients
This double-blind, randomized, placebo-controlled, investigator-initiated, multi-centre trial aims to establish metabolic improvements in AD and PD subjects by dietary supplementation with cofactors N-acetylcysteine, L-carnitine…
- Trial name
- NCT04044131
- Testing
- Metabolic Cofactor Supplementation, Sorbitol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medipol University Hospital
Alzheimer Disease, Mild Cognitive Impairment
Identification of Patients With a High Probability of Meeting Eligibility Criteria for an Alzheimer's Disease Clinical Trial (APHELEIA)
Apheleia-001 is a prescreener that aims to identify and characterize participants with reported cognitive impairment using demographic information, clinical history, brief cognitive assessments, and blood-based biomarkers to…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Memory Loss, Memory Disorders
- Trial name
- NCT05364307
- Testing
- Prescreener database
- Where
- 19 sites in United States, Canada
- Volunteers
- 1,555 people
- Sponsor
- Global Alzheimer's Platform Foundation
Dementia, Alzheimer Disease
A Study to Evaluate the Efficacy and Safety of Galantamine in Patients With Mild Cognitive Impairment
The purpose of this study is to evaluate the efficacy and safety of galantamine treatment in patients with mild cognitive impairment.
- Trial name
- NCT00236431
- Testing
- Galantamine hydrobromide
- Volunteers
- 1,063 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Dementia
SHARED DECISION MAKING IN LONG-TERM CARE FACILITIES
Shared Decision Making (SDM) is defined as a process where healthcare professionals and patients make decisions together, using the best available evidence.
- Trial name
- NCT02118701
- Testing
- Shared Decision-Making educational training
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Alzheimer's Disease, Dementias
Cerebrospinal Fluid (CSF) Biomarkers Alzheimer's Disease (AD) and Non-AD Dementias
To establish a cutoff value using a ratio of CSF tau to Aβ42 (tau/Aβ42) for distinguishing patients wth mild to moderate Alzheimer's disease (AD) from health elderly control subjects.
- Trial name
- NCT01730430
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Dementia Frontal
Music and Physical Activity in Persons With Dementia
Fronto lobe dementia constitutes 10-20 % of dementia conditions within younger persons (>65). People with neuronal degeneration in frontal and temporal lobes demonstrate a decline in social conduct, apathy, loss of insight that…
- Trial name
- NCT03447444
- Testing
- music and physical activity
- Where
- Norway
- Volunteers
- 8 people
- Sponsor
- Oslo Metropolitan University
Dementia, Behavioral Symptoms
Evaluating the Effectiveness of a Community Based Intervention for Persons With Dementia and Their Caregivers in a Developing Country
The aim of this trial was to apply a home based, flexible, stepped-care intervention designed to improve the awareness and knowledge of family caregivers regarding dementia, to maximise their caregiving resources and to improve…
- Conditions
- Dementia, Behavioral Symptoms, Mental Health
- Trial name
- NCT00479271
- Testing
- Home based, flexible, stepped care intervention, Home based, flexible, stepped care intervention after 6 months. Families will be free to choose any health care they desire during the waiting period.
- Where
- India
- Sponsor
- London School of Hygiene and Tropical Medicine
Cognitive Impairment, Mild, Dementia
Effects of Training Dose on Computerized Cognitive Training in Patients With Cognitive Impairment
The goal of this observational study is to explore the optimal dose of computerized cognitive training in patients with cognitive impairment.
- Trial name
- NCT05922319
- Testing
- Computerized cognitive training with different training doses
- Where
- China
- Volunteers
- 21,845 people
- Sponsor
- Xuanwu Hospital, Beijing
Dementia
Technologies to Reduce Caregiver Burden for Informal Caregivers of People With Dementia
This randomized controlled trial aims to recruit a total of 320 dyads composed by persons with dementia living in community settings and their primary informal caregivers.
- Trial name
- TECH@HOME (NCT02733939)
- Testing
- Home monitoring kit
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Lund University
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