Clinical trials: Dementia, completed
Alzheimer Disease
Effects of Heart Rate Oscillations During Meditation on Plasma Biomarkers of Alzheimer's Disease
In the current study, we will examine how two types of concentration meditation practices affect plasma biomarkers of Alzheimer's Disease (AD).
- Trial name
- NCT06210035
- Testing
- Belly-focus meditation, Belly-focus meditation with slow breathing
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Dementia
Community Based Music and Dance Movement Therapy Group for Older Adults With Dementia
This study explores the value of a particular community based music and dance movement therapy group for older adults with dementia? To answer this question, the investigators intend to address the following two sub-questions: 1.
- Trial name
- NCT03404050
- Testing
- Music and dance movement therapy
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Edge Hill University
Dementia
Art Museum Program for Seniors With Cognitive Disorders and Care-partners
As the population ages, there is increasing interest in developing innovative approaches to promote and sustain mental and emotional well-being.
- Trial name
- NCT04696549
- Testing
- Virtual visual art experience guided by Visual Thinking Strategies
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Early Alzheimer's Disease
Proof-of-concept, Open-label Study in Patients With Early Alzheimer's Disease
A Phase 2a study in men and women with early Alzheimer's disease to evaluate the pharmacodynamics, pharmacokinetics and safety of obicetrapib therapy.
- Trial name
- NCT05161715
- Testing
- Obicetrapib
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- NewAmsterdam Pharma
Dementia
Wheelchair-bound Senior Elastic Band (WSEB) Exercise Program for the Demented Seniors
The goals of this three-year research project were: 1) to develop and evaluate the feasibility of the Wheelchair-bound Senior Elastic Band (WSEB) for the demented, wheelchair-bound seniors in long-term care facilities, 2) to…
- Trial name
- WSEB (NCT02164617)
- Testing
- Wheelchair-bound Senior Elastic Band exercise program (WSEB)
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Kaohsiung Medical University
Sleep, Sleep Disorders
Trazodone for Sleep Disorders in Alzheimer's Disease
The purpose of this study is to determine whether trazodone is effective in the treatment of sleep disorders in Alzheimer's disease (AD).
- Conditions
- Sleep, Sleep Disorders, Insomnia, Alzheimer's Disease
- Trial name
- NCT01142258
- Testing
- Trazodone
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Brasilia University Hospital
Mild Cognitive Impairment (MCI)
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
This research is being done to find out if daily use of the drug levetiracetam can improve memory function in individuals with memory problems like those associated with Mild Cognitive Impairment (MCI) and Alzheimer's disease…
- Trial name
- NCT01044758
- Testing
- Levetiracetam 62.5mg, Levetiracetam 125mg, Levetiracetam 250mg
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Parkinson's, Alzheimer Disease
Sound Estimation and Accuracy Task
Participants will be assigned to complete computerized estimation tasks for which there is a component of accuracy, such as estimating the duration of sounds.
- Trial name
- NCT02271685
- Testing
- Instructions about Overestimates, Instructions about Parkinson's, Instructions about Underestimates
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Carnegie Mellon University
Spatial Navigation, Navigation, Spatial
Investigating the Effect of Training With a Virtual Reality Driving Simulator
The proposed study aims to investigate the use of a driving simulator in a virtual reality (VR) environment to improve the cognition state and spatial navigation of individuals with mild/moderate memory impairment.
- Conditions
- Spatial Navigation, Navigation, Spatial, Dementia
- Trial name
- NCT04074655
- Testing
- Driving Simulator in a Virtual Reality Environment
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Dementia, Alzheimer Disease
The Healthy Patterns Sleep Study
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT03682185
- Testing
- Attention-Control Condition, Timed Activity Intervention
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alzheimer Disease
Analysis of XTR006 PET Imaging in Non-cognitively Impaired Subjects, MCI Due toAD, and Mild to Moderate AD Subjects
This is an investigator-initiated clinical (IIT)study.The main purpose of this study was to evaluate the diagnostic efficacy of XTR006 PET qualitative reading and quantitative analysis in detecting mild cognitive…
- Trial name
- NCT06151808
- Testing
- XTR006
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sinotau Pharmaceutical Group
Alzheimer Disease
Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation (ALADDIN) VP 104 Study
ALADDIN is a research study to investigate the safety and effectiveness of leuprolide (a hormone drug) to improve the cognitive function and slow the progression of Alzheimer's disease (AD) in men 65 years and older with mild to…
- Trial name
- NCT00076440
- Testing
- Leuprolide acetate
- Where
- 13 sites in United States
- Volunteers
- 90 people
- Sponsor
- Voyager Pharmaceutical Corporation
Alzheimer's Disease, Dementia
Clinical Trial of Donepezil Between the Naive Group and the Switching Group
To compare the clinical efficacy of donepezil between the naive group and the switching group.
- Trial name
- NCT01023425
- Testing
- donepezil
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Samsung Medical Center
Alzheimer's Disease, Mild Cognitive Impairment
Preliminary Study of Fish Oil and Dementia
This preliminary study is aimed to investigate whether it is feasible to conduct a study to use fish oil compared to the placebo(olive oil) in people with cognitive impairment.
- Trial name
- NCT00628017
- Testing
- omega-3 polyunsaturated fatty acids ( EPA+DHA)
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- Taipei City Psychiatric Center, Taiwan
Hearing Loss, Hearing Loss, Age-Related
Sight and Hearing Investigation Into Effects on Delirium
The goal of this observational study is to learn about sensory loss in hospital patients with delirium. The main questions it aims to answer are: Are hearing and vision loss related to increased risk of having delirium? Do…
- Conditions
- Hearing Loss, Hearing Loss, Age-Related, Hearing Disability, Delirium
- Trial name
- SHIELD (NCT06176625)
- Testing
- Communication Signage, Amplifier Use
- Where
- United States
- Volunteers
- 1,543 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer's Disease, Dementia
Safety and Efficacy of High Dose, Rapid Titration Galantamine in Patients With Alzheimer's Disease
The purpose of this study was to determine the safety and effectiveness of a relatively high dose of galantamine, 32 mg /day in a three-times daily dosage, compared with placebo in treating patients with Alzheimer's disease.
- Trial name
- NCT00338117
- Testing
- Galantamine hydrobromide
- Volunteers
- 554 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Alzheimer Disease
Alzheimer's Disease Acitretin Medication
The trials investigates the changes of cerebral spinal fluid (CSF) soluble alpha-secretase cleaved APP (APPsα) levels under oral therapy with acitretin 30mg daily in patients with mild to moderate Alzheimer's disease (AD).The…
- Trial name
- ADAM (NCT01078168)
- Testing
- Acitretin
- Where
- 2 sites in Germany
- Volunteers
- 22 people
- Sponsor
- K. Lieb
Alzheimer's Disease
Safety and Tolerability of AZD0530 (Saracatinib) in Alzheimer's Disease
Alzheimer's disease is a devastating neurodegenerative disorder, for which there is currently no effective treatment to slow or halt progression.
- Trial name
- NCT01864655
- Testing
- saracatinib
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stephen M. Strittmatter
Alzheimer Disease, Cognitive Impairment
The REMIND Study- SPARK Neuro Software Study
The study utilizes investigational software, the SPARK Test, with an FDA-cleared electroencephalography (EEG) amplifier and EEG cap to collect and patient EEG data.
- Trial name
- NCT05406778
- Testing
- SPARK Test
- Where
- 7 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Spark Neuro Inc.
Mild Cognitive Impairment
Efficacy of MEMORMAX in Subjects With MCI
This is a single-center, randomized, double-blinded placebo for the first 6 months of treatment in subjects with mild cognitive impairment.
- Trial name
- ABO-MEMO (NCT03581929)
- Testing
- Memormax
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Aboca Spa Societa' Agricola