Clinical trials: Dementia, completed
Alzheimer Disease
ALADDIN Study: Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation
ALADDIN is a research study to investigate the safety and effectiveness of leuprolide (a hormone drug) to improve the cognitive function and slow the progression of Alzheimer's disease (AD).
- Trial name
- NCT00063310
- Testing
- Leuprolide acetate
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Voyager Pharmaceutical Corporation
Alzheimer Disease
Pilot Study Assessing the Effects of PXT00864 in Patients With Mild Alzheimer Disease (AD)
The purpose of this study is to assess the safety and efficacy on cognitive impairment and functioning of several doses of PXT00864 (new fixed combination of acamprosate and baclofen at low dose) in patients with mild Alzheimer…
- Trial name
- PLEODIAL-I (NCT02361424)
- Testing
- PXT00864
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Pharnext S.C.A.
Parkinson Disease
Donepezil to Treat Dementia in Parkinson's Disease
This study will evaluate the safety and effectiveness of donepezil (Aricept) for treating mild dementia in patients with Parkinson's disease.
- Trial name
- NCT00030979
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dementia, Feeding Difficulties
Turkish Edinburgh Feeding Evaluation in Dementia (EdFed) Scale
This study was conducted to evaluate the psychometric properties, including interobserver agreement, of the Turkish version of the Edinburgh Feeding Evaluation in Dementia (EdFed) scale, which was developed to assess eating…
- Conditions
- Dementia, Feeding Difficulties, Reliability and Validity
- Trial name
- EdFed (NCT06889103)
- Testing
- Observation
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Istanbul University - Cerrahpasa
Covid19, Death
COVID-19 Infections and Mortality in Long-term Care Facilities During the First Wave
The medical charts of all COVID-19 cases (n=1200) from 17 long-term care facilities in Montreal, Canada will be reviewed, to compare patients who survived to patients who did not survive.
- Conditions
- Covid19, Death, Infection Viral, Infections, Respiratory
- Trial name
- NCT04782427
- Testing
- COVID-19 infection
- Where
- Canada
- Volunteers
- 1,197 people, healthy volunteers welcome
- Sponsor
- Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal
Huntington Disease, Alzheimer Disease
A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan
This drug-drug interaction study is being conducted to evaluate the potential effect of Dimebon on the pharmacokinetics on dextromethorphan, a probe substrate of the cytochrome P450 2D6 (CYP2D6) enzyme, after multiple dose…
- Trial name
- NCT00788047
- Testing
- Dextromethorphan, Dimebon + Dextromethorphan
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer
Alzheimer Disease
Virtual Reality Cognitive Therapy for Alzheimer's Disease
To evaluate the usability, feasibility, and acceptability of VRCT iteratively on 36 AD/ADRD individuals with mild to moderate CI.
- Trial name
- VRCT (NCT05788848)
- Testing
- VRCT
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Claritytek, Inc.
Alzheimer Disease
A Study of LY3002813 in Participants With Memory Damage Due to Alzheimer's Disease (AD) or AD
The study will evaluate the effect of LY3002813 on brain scans. The study will evaluate the safety of LY3002813 by looking at adverse events (side effects). The study will also look at the effect the body has on LY3002813.
- Trial name
- NCT02624778
- Testing
- LY3002813
- Where
- 9 sites in United States, Japan
- Volunteers
- 61 people
- Sponsor
- Eli Lilly and Company
Autism, Asperger's Disorder
An Open-Label Trial of Aripiprazole in Autism Spectrum Disorders
The aim of this study is to evaluate the efficacy, safety and tolerability of aripiprazole monotherapy in the treatment of children and adolescents suffering from Autism Spectrum Disorder (ASD) over a 12-week period.
- Conditions
- Autism, Asperger's Disorder, Pervasive Developmental Disorder
- Trial name
- NCT00308074
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Cambridge Health Alliance
Aggressive Behavior
Can Psychodrama Improve Aggressive Behavior and Social Adaptation in Adolescent Boys?
This randomized controlled trial evaluated the effectiveness of a 10-session psychodrama intervention on reducing aggressive behavior and improving social adjustment among male adolescents with high aggression and low social…
- Trial name
- NCT07311174
- Testing
- Psychodrama, Control
- Where
- Iran
- Volunteers
- 22 people
- Sponsor
- Kerman University of Medical Sciences
Cognitive Impairment, Dementia
Prevalence and Recognition of Cognitive Impairment in Hospitalized Patients: a Flash Mob Study
The aim of this multicenter, cross-sectional, observational flash mob study is to investigate the prevalence of cognitive impairment in hospitalized elderly aged 65 years or older, and the recognition of cognitive impairment by…
- Conditions
- Cognitive Impairment, Dementia, Alzheimer Disease, Delirium
- Trial name
- NCT05395559
- Where
- Netherlands
- Volunteers
- 757 people
- Sponsor
- University Medical Center Groningen
Dementia
Community Based Music and Dance Movement Therapy Group for Older Adults With Dementia
This study explores the value of a particular community based music and dance movement therapy group for older adults with dementia? To answer this question, the investigators intend to address the following two sub-questions: 1.
- Trial name
- NCT03404050
- Testing
- Music and dance movement therapy
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Edge Hill University
Caregivers
Pilot Study of Hospital GamePlan4Care
Hospital stays are stressful for the family and friends who care for adults with dementia. Following hospital discharge, adults with dementia often have increased care needs, which places new caregiving demands on their family…
- Trial name
- NCT06634368
- Testing
- Hospital GamePlan4Care, Health Education
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- VA Office of Research and Development
Patients Aged 65-85 (Both Included), Diagnosed of Mild Cognitive Impairment
Diabetes as an Accelerator of Cognitive Impairment and Alzheimer's Disease
This randomized controlled trial is aimed at studying the effects of an eHealth intervention on improving metabolic control and other cardiovascular risk factors (obesity, lipidic profile and hypertension) as the approach to…
- Conditions
- Patients Aged 65-85 (Both Included), Diagnosed of Mild Cognitive Impairment, Diagnosed of Type 2 Diabetes in Active Treatment (Hypoglycemic Agents) for a Period ≥5 Years
- Trial name
- DIALCAT (NCT03578991)
- Testing
- Smart pillbox, Interactive digital platform
- Where
- 8 sites in Spain
- Volunteers
- 54 people
- Sponsor
- Parc Sanitari Pere Virgili
Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients.
- Conditions
- Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
- Trial name
- NCT07649876
- Testing
- Virtual reality (VR) therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Dementia Alzheimers
Assessing an Intergenerational Music Program Delivered by Adolescents to Older Adults With Declining Cognition
Intergenerational music programming has been shown to benefit both young people and older adults in terms of quality of life, social connection, and promotion of positive cross-age attitudes.
- Trial name
- NCT04645017
- Testing
- Intergenerational Music Program
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pittsburgh
Alzheimer's Disease
Safety, Pharmacokinetics and Pharmacodynamics of Velusetrag in Healthy Elderly Subjects
This is a Phase 1, Randomized, Placebo-Controlled, Double-Blind, Study of Safety, Pharmacokinetics and Pharmacodynamics of Velusetrag in Healthy Elderly Subjects.
- Trial name
- NCT01467726
- Testing
- Velusetrag
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alfasigma S.p.A.
Chronic Post-Traumatic Stress Disorder
Using Emotion Regulation to Decrease Aggression in Veterans With PTSD
Impulsive aggression (IA) is common among Veterans with posttraumatic stress disorder (PTSD), and PTSD is one of the most prevalent post deployment mental health conditions affecting Afghanistan and Iraq Veterans.
- Trial name
- (EMDA) (NCT02724787)
- Testing
- Manage Emotions to Reduce Aggression (MERA)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Anxiety Disorders, Dementia
Cognitive Behavior Therapy for Treating Anxiety in People With Dementia
This study will evaluate the effectiveness of cognitive behavioral therapy in treating anxiety in older adults with dementia.
- Trial name
- NCT00596284
- Testing
- Cognitive Behavioral Therapy of Anxiety in Dementia (CBT-AD), Enhanced Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Baylor College of Medicine
Alzheimer's Disease
Lu AE58054 Added to Donepezil for the Treatment for Moderate Alzheimer's Disease
The purpose of this study is to accept or reject the hypothesis that Lu AE58054 improves cognition and functional outcomes in patients with moderate Alzheimer's Disease, already in treatment with donepezil.
- Trial name
- NCT01019421
- Testing
- Lu AE58054
- Where
- 51 sites in Australia, Canada and 5 more
- Volunteers
- 278 people
- Sponsor
- H. Lundbeck A/S
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