Clinical trials: Dementia, completed
Alzheimer's Disease
Autopsy Follow-up of Subjects Previously Imaged With Florbetapir F 18 (18F-AV-45) PET in Trial 18F-AV-45-A07
This study is designed to test the relationship between measurements of brain amyloid using florbetapir F 18 PET imaging and true levels of amyloid plaque density as measured by histopathological assessment.
- Trial name
- NCT01447719
- Testing
- florbetapir F 18
- Where
- 22 sites in United States
- Volunteers
- 110 people
- Sponsor
- Avid Radiopharmaceuticals
Dementia, Vascular
A Placebo-controlled Trial to Evaluate the Safety and Efficacy of Galantamine in the Treatment of Vascular Dementia
This is a trial to evaluate the safety and effectiveness of galantamine in patients with dementia secondary to blood vessel disease in the brain.
- Trial name
- NCT00035191
- Testing
- galantamine
- Volunteers
- 254 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cognition Disorders
Brain Imaging and Mental Disorders of Aging Intervention
The goal of this project is to determine if a cholinesterase inhibitor is more effective than placebo in delaying cognitive and brain functional decline in people at risk for Alzheimer's disease.
- Trial name
- NCT00267163
- Testing
- donepezil
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- National Institute on Aging (NIA)
Cognitive and Behavioral Impairment, Sensory and Perceptual Impairment
Using SPOZ Technology to Support and Enhance the Vitality Acupunch (VA) Exercise Program for Older Adults With Dementia
This project was aimed to examine the effects of a six-month VA exercise program incorporate the SPOZ technology in improving the cognitive behavioral impairment and sensory perceptual impairment of older adults with dementia in…
- Trial name
- NCT06941506
- Testing
- VA-SPOZ exercise program, Control
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- Kaohsiung Medical University
Huntington Disease
Resveratrol and Huntington Disease
The purpose of this study is to evaluate the therapeutic potential of Resveratrol on the caudate volume in HD patients, using volumetric MRI.
- Trial name
- REVHD (NCT02336633)
- Testing
- Resveratrol
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mild Cognitive Impairment
ENHANCING PHYSICAL and COGNITIVE EFFICIENCY in INDIVIDUALS AT RISK of DEMENTIA USING WHOLE-BODY ELECTROMYOSTIMULATION
This study aimed to evaluate the effectiveness of twelve weeks whole-body electrical muscle stimulation combined with aerobic exercises.
- Trial name
- NCT06669598
- Testing
- Whole Body Electromyostimulation, control group
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- University of Molise
Alzheimer's Disease
Health Evaluation in African Americans Using RAS Therapy
The purpose of this study is to determine if telmisartan, an FDA approved blood pressure medication, may also have beneficial effects on Alzheimer's disease prevention in African Americans, who are at high risk for Alzheimer's…
- Trial name
- HEART (NCT02471833)
- Testing
- Telmisartan 20mg, Telmisartan 40mg
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Emory University
Alzheimer's Disease
Safety and Pharmacokinetics of Single Ascending Doses and Multiple Ascending Doses of CS6253 in Healthy Volunteers
Phase 1A SAD: Five or more cohorts of 8 healthy volunteers (HVs) will receive a single IV bolus injection of study drug or placebo. The first 4 cohorts will be male only.
- Trial name
- NCT05965414
- Testing
- CS6253 Solution for Injection
- Where
- Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Artery Therapeutics, Inc.
Dementia Caregiver
Dementia Family Caregiver Study
The proposed study will test a 3-month, community health worker (CHW) delivered home visit, culturally and language-appropriate intervention for ethnic and underserved dementia family caregivers of persons with dementia (PWD)…
- Trial name
- NCT04894006
- Testing
- Community Health Worker (CHW) Home Visit Intervention, Attention Control Group with WIoT Technology, Usual Care
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Alzheimer's Disease
Vanquishing Apathy Through E-inclusion Using Realistic Virtual Environment Project
Virtual environments and information communication technologies (ICT) offer large perspectives in the field of assistive care and rehabilitation.
- Trial name
- VERVE (NCT01798199)
- Testing
- The training by Verve System
- Where
- 3 sites in France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vascular Cognitive Impairment no Dementia
Cog-VACCINE: Cognitive Training in Patients With Vascular Cognitive Impairment, no Dementia
This study evaluates the efficacy and mechanism of internet-based cognitive training in patients with subcortical VCIND. Half of participants will receive multi-domain adaptive internet-based training program, while the other…
- Trial name
- Cog-VACCINE (NCT02640716)
- Testing
- multi-domain internet-based adaptive training program
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Friendship Hospital
Dementia
Lifestyle Integrated Functional Exercise for People With Dementia: a Home-based Physical Activity Program
Physical activity improves cognitive function and the ability to perform activities of daily living in people with dementia and reduces caregivers' burden thus, enhancing quality of life of people with dementia and their…
- Trial name
- LiFE4D (NCT03757806)
- Testing
- Experimental group
- Where
- Portugal
- Volunteers
- 56 people
- Sponsor
- Aveiro University
Alzheimer's Disease, Dementia
Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs)
The University of Washington's Northwest Research Group on Aging is partnering with Area Agencies on Aging (AAA) in Washington and Oregon to complete this translational investigation of RDAD (Reducing Disabilities in Alzheimer's…
- Conditions
- Alzheimer's Disease, Dementia, Memory Impairment, Cognitive Impairment
- Trial name
- RDAD (NCT01708304)
- Testing
- RDAD
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- University of Washington
Alzheimer's Disease, Dementia
Care Management for Patients With Alzheimer Disease and Their Family Caregivers
This is a clinical trial to test the effectiveness of current guideline for the care of older adults with Alzheimer's disease. The study focuses on the primary care setting using a nurse care manager to facilitate guideline-level…
- Trial name
- NCT00246896
- Testing
- care management
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Insomnia, Alzheimers Disease Related Dementias
Enhanced CBTi for Older Adult Sleep and Cognition
This randomized clinical trial on 60+ aged and independent-living healthy individuals with symptoms of insomnia will attempt to improve sleep and health outcomes related to sleep with enhancement of a clinical intervention…
- Trial name
- R44 (NCT05015803)
- Testing
- CBTi with Application, CBTi, Sleep Hygiene Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Penn State University
Alzheimer's Disease (AD), Parkinson's Disease (PD)
Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects
The goal of this study is to assess [18F]MNI-777 PET imaging as a tool to detect tau pathology in the brain of individuals who carry a clinical diagnosis of a tauopathy, including: Alzheimer's Disease (AD),Parkinson's disease…
- Conditions
- Alzheimer's Disease (AD), Parkinson's Disease (PD), Chronic Traumatic Encephalopathy (CTE), Progressive Supranuclear Palsy (PSP)
- Trial name
- NCT02103894
- Testing
- [18F]T807 ([18F]MNI-777)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
De-escalation Skills
Evaluation of Training in De-escalation
The purpose of the study is to evaluate one of the chapters in the new national Norwegian training manual (MAP). The chapter that is selected to be evaluated is the chapter on de-escalation.
- Trial name
- NCT03924141
- Testing
- Training in de-escalation
- Where
- Norway
- Volunteers
- 45 people
- Sponsor
- Bergen University College
FOXP1 Syndrome
Psychiatric Phenotype Characterization of Individuals With FOXP1 Syndrome
FOXP1 syndrome is a rare genetic disorder with a variable phenotype, characterized somatically by facial dysmorphia, dysphagia, hypotonia, relative or real macrocephaly, which may be associated with cerebral, cardiac, urogenital…
- Trial name
- FOXP1-PP (NCT06211673)
- Testing
- Semi-structured interviews, Heteroquestionnaires
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Herpes Zoster, Dementia
Postherpetic Neuralgia After Herpes Zoster and Incident Dementia Risk
This retrospective observational cohort study uses de-identified electronic health record data from the TriNetX Global Collaborative Network to evaluate whether postherpetic neuralgia after herpes zoster is associated with an…
- Conditions
- Herpes Zoster, Dementia, Postherpetic Neuralgia (PHN)
- Trial name
- NCT07399288
- Testing
- Exposure: postherpetic neuralgia
- Where
- Taiwan
- Volunteers
- 73,404 people
- Sponsor
- China Medical University Hospital
Autism Spectrum Disorder
CPI Training for Parents of Children With ASD
The purpose of this 24-week study is to determine whether the "Parent-based Crisis Prevention Institute (CPI) physical management training program" (i.e., P-CPI) is effective in increasing self-efficacy in parents of children…
- Trial name
- NCT03537261
- Testing
- Parent-based Crisis Prevention Institute (CPI) physical management training program (P-CPI)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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