Clinical trials: Dementia, completed
Aging, Mild Cognitive Impairment
My Healthy Brain: Preserving and Promoting Brain Health Through Evidence-based Practices
The objective of this trial is to demonstrate early proof-of-concept for My Healthy Brain, an 8-week group program that directly targets multiple lifestyle factors associated with brain health and prevention of cognitive decline.
- Conditions
- Aging, Mild Cognitive Impairment, Dementia, Old Age; Dementia
- Trial name
- NCT04537728
- Testing
- My Healthy Brain Version 2
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Alzheimer's Disease
Study Evaluating Safety, Tolerability, Pharmacokinetics and 5 HT1A Receptor Occupancy
The study will include a preliminary pharmacokinetics (PK) / safety / tolerability evaluation in healthy elderly subjects followed by the Receptor Occupancy (RO) evaluations in healthy elderly subjects and in Alzheimer's Disease…
- Trial name
- NCT00499200
- Testing
- SRA-444
- Where
- Sweden
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Dementia, Cognition Disorders
Cerebral Amyloid Imaging Using Florbetapir (AV-45)
This study is aimed at examining the interest of amyloid radiotracer Florbetapir (18F-AV-45) for the etiological diagnosis of poststroke cognitive impairment and dementia
- Trial name
- IDEA3 (NCT02813434)
- Testing
- florbetapir
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Alzheimer Disease
Neuroelectrical Biomarkers for Alzheimer's Disease Stages
Recent diagnostic criteria for Alzheimer's disease (AD) recognize an extended spectrum of AD stages as part of the disease, including a preclinical stage.
- Trial name
- ESTIMATE (NCT01880151)
- Testing
- EEG
- Where
- France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alzheimer Disease, H Pylori Infection
The Improvement of Black Raspberry in Obese and Mild AZ Patients Infected With H. Pylori
The current study was designed to check the impact of black raspberry (BR) on obese and mild Alzheimers (AZ) patients infected with Helicobacter pylori (H pylori).
- Trial name
- BR (NCT05680532)
- Testing
- Black raspberry
- Where
- Taiwan
- Volunteers
- 21 people
- Sponsor
- Chung Shan Medical University
Alzheimer's Disease, Dementia
Optimizing Dementia Care
The purpose of this randomized controlled pilot study is to examine the preliminary effectiveness, feasibility, and potential treatment moderators (i.e., behavioral symptoms and spousal relationship status) of a newly developed…
- Conditions
- Alzheimer's Disease, Dementia, Dementia, Vascular, Caregivers
- Trial name
- ODeC (NCT02585232)
- Testing
- Counseling (C), Care Consultation (CC)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- VA Office of Research and Development
Dementia, Cognition Disorders
Impact of Anticoagulation Therapy on the Cognitive Decline and Dementia in Patients With Non-Valvular Atrial Fibrillation
Patients will be screened at Intermountain Medical Center and at Intermountain-affiliated anticoagulation clinics in the Salt Lake City region. Patients with non-valvular atrial fibrillation will be considered for study.
- Conditions
- Dementia, Cognition Disorders, Cerebral Ischemic Events
- Trial name
- CAF (NCT03061006)
- Testing
- Dabigatran Etexilate, Warfarin
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Intermountain Health Care, Inc.
Alzheimer's Disease and Related Dementias
Reducing Behavioral and Psychological Symptoms of Dementia: Family Caregivers (Aim 1)
Persons with Alzheimer's Disease and Related Dementias (ADRD) account for 3.2 million hospital admissions per year and have over three times more hospitalizations than those without cognitive impairment, yet hospital caregivers…
- Trial name
- NCT04481568
- Testing
- PES-4-BPSD Model, The attention control condition
- Where
- 2 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Huntington's Disease
Individuals Patterns of Disclosure About Huntington s Disease (HD) and the Association With Adaptation to HD
This study will examine the ways in which people reveal their status as a carrier of Huntington s disease (HD) or of being at risk for the disease.
- Trial name
- NCT00491842
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Alzheimer Disease
Virtual Patient Behavioral Response Training for Family Caregivers
Our study is designed to help caregivers of someone with Alzheimer's Disease and related dementia to understand and deal with the difficult behaviors of a person with dementia.
- Trial name
- NCT04489303
- Testing
- Caring Response App, Traditional Educational/Resources Program
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Photozig, Inc.
Cognitive Decline, Cognitive Impairment, Mild
Evaluation of Pilot Community-based Multi-domain Program Older Adults at Risk of Cognitive Impairment
The multi-domain programme was adapted from a larger international multi-domain interventional study for the Singapore community of older adults at risk of cognitive impairment.
- Trial name
- NCT04440969
- Testing
- Multi-domain intervention
- Where
- Singapore
- Volunteers
- 199 people
- Sponsor
- Geriatric Education and Research Institute
Alzheimer Dementia, Dementia, Vascular
Tailored Music Therapy for Dementia
This study evaluates the effect and process of individualized music therapy for home-dwelling persons with mild to moderate dementia. The music therapy is administered individually and includes a close caregiver.
- Conditions
- Alzheimer Dementia, Dementia, Vascular, Dementia, Lewy Body, Dementia Parkinson's Disease
- Trial name
- NCT03011723
- Testing
- Resource oriented music therapy
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- University of Bergen
Neurobehavioral Disinhibition
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Participants With Traumatic Brain Injury
This is a multicenter, randomized, placebo-controlled study to evaluate AVP-786 for the treatment of neurobehavioral disinhibition including aggression, agitation, and irritability in participants with traumatic brain injury…
- Trial name
- NCT03095066
- Testing
- AVP-786-28, AVP-786-42.63
- Where
- 54 sites in United States
- Volunteers
- 168 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Alzheimer's Disease
Study of MK0677 for the Treatment of Alzheimer's Disease (0677-030)(COMPLETED)
An investigational drug (MK0677) will be studied to determine whether it helps the memory and cognition of patients with Alzheimer's Disease.
- Trial name
- NCT00074529
- Testing
- MK0677
- Volunteers
- 512 people
- Sponsor
- Merck Sharp & Dohme LLC
Mild Cognitive Impairment, Dementia, Mild
Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment
The goal of this clinical trial is to compare a precision medicine approach to the standard-of-care for people with mild cognitive impairment or early-stage dementia.
- Trial name
- EVANTHEA (NCT05894954)
- Testing
- Precision Medicine Approach, Hormones and Medications tailored to lab tests, combined with devices that support stress management and brain exercises, Standard-of-Care
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- Alzheimer's Prevention and Reversal Project, Inc.
Dementia
Reducing Inappropriate Medication Use for BPSD
Investigators previously developed a low-cost, practical, patient- and care partner-centric, evidence-informed systematic approach (the "DICE Approach" or DICE), to assess and manage behavioral and psychological symptoms of…
- Trial name
- NCT06040502
- Testing
- The DICE Approach
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of California, Davis
Eating Disorders
Augmenting Specialty Eating Disorder Clinical Treatment With a Smartphone Application
Cognitive behavioural therapy (CBT) is the most empirically supported and researched treatment for eating disorders. A central component of CBT for eating disorders is self-monitoring which involves patients keeping a paper food…
- Trial name
- NCT02484794
- Testing
- Standard Outpatient Treatment, Smartphone App
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- Nova Scotia Health Authority
Cigarette Smoking
Health-Kit Enabled Mobile App for Tobacco Cessation
Tobacco use is the leading preventable cause of death in the US, contributing to more than 480,000 premature deaths each year. The Tobacco Treatment Guidelines underscore the need to offer patients who use tobacco products brief…
- Trial name
- NCT06292130
- Testing
- refresh
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Pro-Change Behavior Systems
Alzheimer Disease
Salsalate in Patients Mild to Moderate Alzheimer's Disease
The purpose of the study is to test the safety and tolerability of twice daily Salsalate in patients with mild to moderate Alzheimer's Disease.
- Trial name
- SAL-AD (NCT03277573)
- Testing
- Salsalate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Adam Boxer
Alzheimer Disease
Cholinergic Markers Alzheimer's Disease
Several previous studies have assessed acetylcholine (Ach) and acetylcholinesterase activity (AchE-a) levels in Alzheimer's disease (AD) pathophysiology.
- Trial name
- CHOLINE (NCT03090854)
- Testing
- ADASCog
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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