Clinical trials: Dementia
Alzheimer Disease, Late Onset
Synaptic Injury and Functional Connectivity in Alzheimer's Disease
The purpose of this study is to examine cross-sectional associations between CSF markers of synaptic injury (Ng and SNAP-25) and functional connectivity in default and semantic memory networks using 3T- fMRI in individuals with…
- Trial name
- NCT03300726
- Testing
- CSF analysis, Functional MRI
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Dementia
Improving How People Living With Dementia Are Selected for Care Coordination
Many people living with dementia (PLWD) and their care partners may benefit from the assistance of a care coordinator, a member of the medical team who facilitates communication among all the people involved.
- Trial name
- NCT05651308
- Testing
- Care coordination delivered based on perceived need, Care coordination delivered based on usual care (e.g. discharge from hospital)
- Where
- United States
- Volunteers
- 385 people
- Sponsor
- Weill Medical College of Cornell University
Dementia
Connecting Caregivers With Community Services: The Care Buddy Platform
The study aims to develop a mobile-app (Care Buddy) which will be a one-stop integrated source of information and technology-based solutions for caregivers of people with dementia (PWDs).
- Trial name
- NCT06817876
- Testing
- Care Buddy
- Where
- Singapore
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Alzheimer's Disease, Dementia
Safety and Efficacy of High Dose, Rapid Titration Galantamine in Patients With Alzheimer's Disease
The purpose of this study was to determine the safety and effectiveness of a relatively high dose of galantamine, 32 mg /day in a three-times daily dosage, compared with placebo in treating patients with Alzheimer's disease.
- Trial name
- NCT00338117
- Testing
- Galantamine hydrobromide
- Volunteers
- 554 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Alzheimer Disease, Dementia
Old School Hip Hop: Parent Follow-Up & Spanish Speakers Inclusion
These are the exploratory aims of the original trial cohort study "Old School Hip Hop RCT (AAAR5473)," which recruited 783 parents. 1.
- Trial name
- NCT06699589
- Testing
- Old SCHOOL Hip-Hop (Dementia Education), My Plate (Nutrition Education)
- Where
- United States
- Volunteers
- 278 people
- Sponsor
- Columbia University
Alzheimer Disease
Effects of Exercise and Rivastigmine on Quality of Life of Alzheimer's Disease Patients
The purpose of this study is to determine whether a exercise program when combined with rivastigmine (Exelon patch) drug treatment compared with rivastigmine drug treatment alone would improve quality of life, ability to perform…
- Trial name
- NCT01183806
- Testing
- Rivastigmine, Exercise training program
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Bahia
Forensic Psychiatry Patients, Anger Management
Acceptance and Commitment Therapy-Based Anger Management Training in Forensic Psychiatry Patients
The goal of this interventional study is to determine the effect of acceptance and commitment therapy (ACT)-based anger management training on the aggression levels of forensic psychiatry patients.
- Conditions
- Forensic Psychiatry Patients, Anger Management, Agression
- Trial name
- NCT07857148
- Testing
- Acceptance and Commitment Therapy-based Anger Management Training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hatice Polat
Alzheimer's Disease
Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Mild to Moderate Alzheimer's Disease
A Phase II clinical research study to evaluate the efficacy and safety of two different dose levels of an injectable investigational treatment (ACC-001) in subjects with Mild-to-Moderate Alzheimer's disease.
- Trial name
- ACCTION (NCT01284387)
- Testing
- ACC-001 (vanutide cridificar)
- Where
- 25 sites in United States
- Volunteers
- 126 people
- Sponsor
- JANSSEN Alzheimer Immunotherapy Research & Development, LLC
Cognitive Decline
Preventing Cognitive Decline with Metformin
A randomised control study of metformin in people with mild cognitive impairment and without diabetes mellitus to determine effects on cognitive decline and neuroimaging over 3 years.
- Trial name
- MetMemory (NCT04511416)
- Testing
- Metformin XR, 500-2000mg nocte
- Where
- Australia
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Traumatic Brain Injury, Cerebral Palsy
Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy
This prospective observational study collects real world data on participants receiving regenerative therapies administered internationally and delivered intranasally via the Kurve Therapeutics ViaNase device.
- Conditions
- Traumatic Brain Injury, Cerebral Palsy, Hypoxic Ischemic Encephalopathy, Neurologic Disorders
- Trial name
- MuSE-INSIGHT (NCT07521384)
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Healing Hope International
Alzheimer's Disease (AD), Dementia
δ in Dementia Clinical Trials
The goal of this clinical trial is to demonstrate potential improvements in clinical trial methods relating to dementia and cognitive decline.
- Conditions
- Alzheimer's Disease (AD), Dementia, Cognitive Decline, Mild Cognitivie Impairment (MCI)
- Trial name
- δND (NCT05592678)
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Alzheimer's Disease
Study to Evaluate the Preliminary Safety, Efficacy, PK and PD of Bryostatin 1 in Patients With Alzheimer's Disease
This study is being done to evaluate the safety, tolerability and potential effectiveness of a new investigational drug, bryostatin 1, in patients with Alzheimer's disease (AD).
- Trial name
- NCT02221947
- Testing
- Bryostatin 1
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Neurotrope Bioscience, Inc.
Hiv, HIV/AIDS
AllyQuest: Engaging HIV+ YMSM in Care Through Social Networking and Gamification
AllyQuest is a novel, high impact secondary prevention intervention delivered via mobile phones to improve linkage and engagement in care among newly diagnosed HIV+ young men who have sex with men (YMSM).
- Trial name
- AQ (NCT03090958)
- Testing
- AllyQuest
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
SAH, Dementia
Ferritin and Iron Burden in SAH sIRB
Ruptured cerebral aneurysms lead to subarachnoid hemorrhage (SAH),that has a high morbidity and mortality rate, the severity of which is predicted by the "Hunt-Hess grade" (HHG).
- Trial name
- NCT03754725
- Testing
- Deferiprone pill, Montreal Cognitive Assessment
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- Duke University
Alzheimer's Disease
Central Auditory Processing Modulation Underlying Anxiety Reduction Using Clinically Designed Improvisatory Music
This study examines whether Clinically Designed Improvisatory Music (CDIM) can reduce anxiety in people living with Alzheimer's disease and anxiety (AD-A), and whether it can also lessen caregiver burden.
- Trial name
- NCT07775625
- Testing
- Clinically Designed Improvisatory Music, Listening to Storytelling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Loneliness, Emotional Stress
Twitter Based Social Support for Hispanic and Black Dementia Caregivers
The prevalence of dementia is higher in Hispanics and African Americans than non-Hispanic Whites. Moreover, dementia caregivers often experience loneliness as well decreased health status.
- Trial name
- Tweet-S2 (NCT03865498)
- Testing
- Twitter for Hispanic caregivers, Twitter for African American caregivers
- Where
- United States
- Volunteers
- 966 people, healthy volunteers welcome
- Sponsor
- Columbia University
Sleep, Alzheimer Disease
Sleep Trial to Prevent Alzheimer's Disease
The purpose of this study is to determine if treatment with the sleep aid suvorexant can decrease the rate of amyloid-β (Aβ) accumulation in the brain.
- Trial name
- SToP-AD (NCT04629547)
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Vascular Cognitive Impairment, Post-stroke Depression
Cognition and Affect After Stroke: a Prospective Evaluation of Risks
Stroke is a leading cause of disability, affecting about 34,000 to 41,000 individuals in the Netherlands of middle and old age every year.
- Conditions
- Vascular Cognitive Impairment, Post-stroke Depression, Post-stroke Apathy, Post-stroke Dementia
- Trial name
- CASPER (NCT02585349)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Maastricht University Medical Center
Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Dementia (FTD)
Tau PET Imaging With 18F-AV-1451 in Subjects With MAPT Mutations
The study will investigate the ability of a new PET tracer, 18F-AV-1451, to detect depositions of a protein, called tau, in the brains of people with a mutation in the tau gene that causes deposition of the protein, and in people…
- Conditions
- Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Dementia (FTD), Tauopathies
- Trial name
- NCT02676843
- Testing
- 18F-AV-1451
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alzheimer Disease
Modulators of Gamma tACS in Alzheimer's Disease (Mod-GammAD)
Brain oscillations are ubiquitous in the human brain and have been implicated in cognitive and behavioral states defined in precisely tuned neural networks.
- Trial name
- Mod-GammAD (NCT04842955)
- Testing
- Gamma tACS (40 Hz) over the superior parietal cortex
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia