Clinical trials: Dementia, completed
Huntington's Disease
[PETDE10] Imaging of PDE10A Enzyme Levels in Huntington's Disease Gene Expansion Carriers and Healthy Controls With PET.
The aim of this study is to measure the availability of the PDE10A enzyme in Huntington disease gene expansion carriers (HDGECs) using the recently developed radioligand [18F]MNI-659.
- Trial name
- PEARL-HD (NCT02061722)
- Testing
- PET Imaging with [18F]MNI-659
- Where
- 8 sites in Denmark, Netherlands and 2 more
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- CHDI Foundation, Inc.
Dementia
A Home-based Training Program for Elderly Patients With Dementia
The illness course and symptoms of dementia is usually very long and characterized with behavioral, psychological and physical changes. Family caregivers' stresses change during the illness trajectory as well.
- Trial name
- NCT02667951
- Testing
- A home-based caregiver-training program
- Volunteers
- 129 people
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer's Disease
Disrupted Sleep, Neuroendocrine Status and the Behavioral Symptoms of AD
Over 5 million Americans have Alzheimer's disease or a related dementia, a progressive and irreversible neurodegenerative condition, affecting also close to 15 million family caregivers (CG).
- Trial name
- NCT01920672
- Testing
- Timed Planned Activity, Home Safety and Education Program
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Erysipelas, Impetigo
Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo
The purpose of this study is to demonstrate the validity and utility of a tele-dermatology system in the midterm periodic screening of non-widespread skin lesions of recent onset or for which a specialized early classification is…
- Conditions
- Erysipelas, Impetigo, Herpes Zoster, Molluscum Contagiosum
- Trial name
- NCT02902822
- Testing
- Screening, Tele-dermatology
- Where
- Italy
- Volunteers
- 461 people
- Sponsor
- Centro Studi Gised
Aging, Mild Cognitive Impairment
SMART: Somatotrophics, Memory, and Aging Research Trial
The purpose of the SMART study was to better understand whether the body's own production of growth hormone (GH) would improve memory and problem solving ability, or cognitive function.
- Trial name
- NCT00257712
- Testing
- TH9507 human growth hormone releasing hormone (GHRH)
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alzheimer Disease
Evaluation of Galantamine in the Treatment of Alzheimer's Disease
Galantamine is an experimental drug being evaluated in the United States for the treatment of Alzheimer's disease. Results from previous clinical trials suggest that galantamine may improve cognitive performance in individuals…
- Trial name
- NCT00000172
- Testing
- Galantamine
- Where
- 55 sites in United States
- Sponsor
- Janssen, LP
Schizophrenia, Schizoaffective Disorder
Intramuscular (IM) Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia
The aim of this study was to compare the efficacy and safety of intramuscular 10 mg olanzapine versus intramuscular 5 mg haloperidol plus lorazepam 2 mg in the treatment of acute agitated schizophrenic patients of Taiwanese…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Agitation
- Trial name
- NCT00797277
- Testing
- IM olanzapine, IM haloperidol plus lorazepam
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- National Taiwan University Hospital
Procedural Anxiety, Procedural Pain
Auditory Intraoperative Stimulation Effects on Pain and Agitation at Awakening (AUDIOPAW)
Adenotonsillectomy (AT) is one of the most common pediatric surgical procedures. The management of postoperative pain and agitation after AT is still a controversial issue.
- Conditions
- Procedural Anxiety, Procedural Pain, Adenotonsillitis
- Trial name
- AUDIOPAW (NCT04112979)
- Testing
- Music, Mother's lap, Soundproof earplugs
- Where
- Italy
- Volunteers
- 115 people
- Sponsor
- IRCCS Burlo Garofolo
Sleep Disorders, Circadian Rhythm, Cognitive Impairment
High-frequency tRNS for Sleep Disturbances in Neurocognitive Disorders Due to Vascular Disease
The investigators aim to 1) investigate and compare the safety, efficacy and sustainability of hf-tRNS, tACS and sham transcranial current stimulation (tCS) over left inferior parietal lobe (IPL) in mild neurocognitive disorder…
- Conditions
- Sleep Disorders, Circadian Rhythm, Cognitive Impairment, Vascular Dementia
- Trial name
- NCT06169254
- Testing
- Transcranial current stimulation (tCS)
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Alzheimer Disease
New Virtual Reality Technologies and Telemedicine for Cognitive Rehabilitation in Alzheimer's Disease
Main objective: To verify the effectiveness of a cognitive rehabilitation program in Alzheimer patients, based on virtual reality, delivered remotely, at the patient's home, with two distinct methods: a tablet or an App (on the…
- Trial name
- TaskCog-IVN (NCT05697354)
- Testing
- Cognitive rehabilitation using interactive tablet, Cognitive rehabilitation using smartphone App Medico Amico
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ospedale San Raffaele
Huntington Disease
An Open-Label Extension Study to Evaluate Long-Term Safety and Tolerability of RO7234292 (RG6042) in Huntington's Disease Participants Who Participated in Prior Roche and Genentech Sponsored Studies
This study will evaluate the long-term safety and tolerability of RO7234292 (RG6042) in participants who have completed other F.
- Trial name
- NCT03842969
- Testing
- RO7234292 (RG6042)
- Where
- 38 sites in United States, Austria and 6 more
- Volunteers
- 236 people
- Sponsor
- Hoffmann-La Roche
Appetitive Aggression
Addressing Heightened Levels of Aggression in Traumatized Offenders With Psychotherapeutic Means
Heightened levels of aggression are fuelling violent incidents at all levels, especially in post-war regions. Narrative Exposure Therapy for Forensic Offender Rehabilitation (FORNET) aims to address trauma symptoms along with…
- Trial name
- NCT02992561
- Testing
- FORNET (adapted version)
- Where
- Germany
- Volunteers
- 402 people
- Sponsor
- University of Konstanz
No Specific Conditions
Acceptance and Commitment Therapy for Informal Caregivers of People With Dementia
Dementia has a major impact on people with dementia and their family. Informal caregivers of people with dementia are at higher risk of developing depressive symptoms compared to informal caregivers of people with other chronic…
- Trial name
- ACT-IC (NCT05064969)
- Testing
- Blended intervention based in acceptance and commitment therapy
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cognitive Impairment, Alzheimer Disease
The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study
A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults…
- Conditions
- Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dementia
- Trial name
- SINGER (NCT05007353)
- Testing
- Structured Lifestyle Intervention, Self-Guided Intervention
- Where
- 3 sites in Singapore
- Volunteers
- 1,212 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Ischemic Stroke, Cognitive Decline
Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke
Aim of this randomized controlled study is to test if intensive polyintervention therapy including life style modifications targeting at reduction of modifiable risk factors of stroke can reduce the risk of post-stroke cognitive…
- Conditions
- Ischemic Stroke, Cognitive Decline, Dementia
- Trial name
- ASPIS (NCT01109836)
- Testing
- Motivation and lifestyle intervention
- Where
- 5 sites in Austria
- Volunteers
- 202 people
- Sponsor
- Danube University Krems
Alzheimer Disease
Effects of Enriched Gardens in Nursing Home Residents With Dementia
Comparing the effect of the frequentation of an enriched garden vs sensory conventional garden by nursing home residents with Alzheimer disease.
- Trial name
- NCT04903171
- Testing
- INCENTIVE VISITING A GARDEN : ENRICHED OR CONVENTIONAL SENSORY GARDEN
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- RIVAGES
Alzheimer's Disease
Gray Matters Alzheimer's Disease Prevention Intervention
This is a randomized controlled trial to develop and test the efficacy of a multi-domain lifestyle behavioral intervention designed to promote healthier lifestyle behaviors linked to lower Alzheimer's disease risk among persons…
- Trial name
- NCT02290912
- Testing
- Health education program
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Utah State University
Dementia
Cholinesterase Inhibitor Discontinuation
This study tries to determine if stopping certain medications that are used to treat dementia will cause worsening from the patient and family perspective.
- Trial name
- CID (NCT02248636)
- Testing
- Cholinesterase inhibitor
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- VA Office of Research and Development
Dementia, Senile, Family Members
Smart-Cloth Care System for Dementia
The purpose of this study is to develop and examine the preliminary effects of a smart cloth care system for facilitating family caregiving for persons with dementia in the home setting.
- Trial name
- NCT05063045
- Testing
- smart-cloth assisted home nursing care
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Mild Cognitive Impairment, Dementia
An Open Platform of Serious Games for Cognitive Intervention
Computer games are increasingly utilized as tools for studying cognitive skills, aging, individual differences, and development.
- Conditions
- Mild Cognitive Impairment, Dementia, Alzheimer Disease, Aging
- Trial name
- NCT06366867
- Testing
- VibrantMinds
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Alberta
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