Clinical trials: Dementia, completed
Chronic Traumatic Encephalopathy
Tau Imaging of Chronic Traumatic Encephalopathy
Chronic traumatic encephalopathy (CTE) is a progressive degenerative brain disease with symptoms that include memory loss, problems with impulse control, and depression that can lead to suicide.
- Trial name
- NCT02191267
- Testing
- [F18]-T807, [F18]-Florbetapir, MRI/MRS
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Alzheimer Disease
Indian Transforming Alzheimer's Care Training (INTACT)
INTACT will utilize a group-randomized trial, to test the effectiveness of a culturally informed provider training and "dementia friendly clinic" intervention for detection and appropriate management of AI/AN patients with ADRD…
- Trial name
- INTACT (NCT06397339)
- Testing
- INTACT Program
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Washington State University
Dementia Caregiving
Stress Reduction Study for Partners of Early Stage Dementia
This is a study designed to pilot a WOOP (Wish Outcome Obstacle Plan) intervention for spouses of persons with early stage dementia for the purposes of future research. The investigators will be using two cohorts.
- Trial name
- NCT03691428
- Testing
- Wish Outcome Obstacle Plan
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yale University
Alzheimer's Disease (AD)
Study to Assess Adverse Events, Change in Disease Activity and How Oral ABBV-552 Capsules Moves Through the Body of Participants Aged 50 to 90 Years With Mild Alzheimer's Disease
Alzheimer's disease (AD) is a progressive, irreversible neurological disorder and is the most common cause of dementia in the elderly population.
- Trial name
- Abroad (NCT05771428)
- Testing
- ABBV-552
- Where
- 64 sites in United States, Australia and 5 more
- Volunteers
- 263 people
- Sponsor
- AbbVie
Dementia, Behavior
Deprescribing Antipsychotics in Long-Term Care
Aggressive behaviours in long-term care (LTC) is a difficult health care issue to manage. One method that has been over-used is the prescription of antipsychotics for the behaviours and psychological symptoms of dementia (BPSD).
- Trial name
- NCT02958800
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- McMaster University
Dementia, Mild Cognitive Impairment
Virtual Chair Yoga for Older Adults and Caregivers: Randomized Controlled Trial
Over 700,000 Canadians are affected by dementia costing the health care system approximately $10 billion/year. Due to COVID-19, the government has urged individuals over the age of 70 to stay home, putting this population at risk…
- Trial name
- NCT04884529
- Testing
- Chair-yoga program
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Dementia, Agitation,Psychomotor
CAlming Touch for People With Agitation or Other Behavioural Symptoms of DEMentia - A Randomized Feasibility Trial
Dementia is an increasing health challenge among elderly citizens in Denmark. An estimated 87,000 Danes live with dementia, and this number is expected to increase to 130,000 in 2030.
- Trial name
- CADEM (NCT05272501)
- Testing
- Calming Touch
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University College Copenhagen
Alzheimer Disease 10, Dementia
Cognitive Stimulation Therapy
The concept of cognitive stimulation in AD is one of the most popular approaches. Cognitive Stimulation Therapy (CST) is stated to be evidence-based best practice with robust clinical trials, administered according to specific…
- Conditions
- Alzheimer Disease 10, Dementia, Apathy, Anxiety
- Trial name
- NCT05808530
- Testing
- Cognitive Stimulation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Hasan Kalyoncu University
Alzheimer Disease
National Bank Alzheimer
The Alzheimer's disease (MY) is a major problem of public health. The French National Database Alzheimer ( BNA) registers(records) all the medical acts made by units of memory(report) and of independent specialists in France.
- Trial name
- BNA (NCT03687112)
- Testing
- non ontervention / observational study
- Where
- France
- Volunteers
- 167,191 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cognitive Impairment
Harmonization of Teleneuropsychological Assessment in Dementia
The prevention and management of cognitive decline and dementia represent major healthcare challenges. Neuropsychological assessment is a key component of current diagnostic criteria for Mild Neurocognitive Disorder (mNCD) due to…
- Trial name
- NCT07664865
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Alzheimer's Disease
CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease
This is a Phase I clinical study to assess the safety, tolerability and biologic activity of in vivo AAV-mediated delivery of CERE-110. Up to 12 subjects will receive open label CERE-110 in dose-escalating fashion.
- Trial name
- NCT00087789
- Testing
- CERE-110: Adeno-Associated Virus Delivery of NGF
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Sangamo Therapeutics
Alzheimer's Disease, Frontotemporal Dementia
Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and Normal Controls.
Study 18F-AV-45-010 is designed to evaluate the cerebral uptake of florbetapir 18F as measured by PET imaging in frontotemporal disorder (FTD) in comparison to cognitively normal volunteers and subjects with Alzheimer's disease…
- Trial name
- NCT01890343
- Testing
- florbetapir 18F, 18F-FDG
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Dementia With Lewy Bodies
Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Dementia With Lewy Bodies
Dementia with Lewy Bodies (DLB) is an alphasynucleinopathy and the second most common form of dementia in the elderly. DLB shares striking neuropathological and clinical similarities with both Parkinson's disease (PD) and…
- Trial name
- NCT04002674
- Testing
- Nilotinib Oral Capsule
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Georgetown University
Alzheimer's Disease
Online Caregiver Psychoeducation and Support for Alzheimer's
This study is piloting an internet-based intervention to provide support for caregivers of VA patients with Alzheimer's disease or related memory difficulties (ADRD).
- Trial name
- NCT00416078
- Testing
- caregiver website support, caregiver brief supportive phone calls
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- US Department of Veterans Affairs
Alzheimer's Disease, Nervous System Disease
Genetic Studies in Alzheimer's Disease
Alzheimer's disease is a condition marked by the deterioration of mental function. The disease usually begins in late middle life and results in death in 5 to 10 years.
- Trial name
- NCT00001235
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, REM Sleep Behavior Disorder
Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder
This is a prospective cohort study to evaluate degenerative changes in the brain by performing functional imaging analysis in patients with RBD and its correlations with clinical symptoms and dopaminergic degeneration.
- Trial name
- NCT02984137
- Testing
- testing, evaluation, sampling
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Transthyretin (TTR) Amyloid Cardiomyopathy
Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy
This Phase 3 study will investigate the efficacy, safety and tolerability of an oral daily dose of 20 mg or 80 mg tafamidis meglumine capsules compared to placebo in subjects with either transthyretin genetic variants or…
- Trial name
- ATTR-ACT (NCT01994889)
- Testing
- Tafamidis
- Where
- 80 sites in United States, Belgium and 11 more
- Volunteers
- 441 people
- Sponsor
- Pfizer
Vestibular Diseases, Alzheimer Disease
Vestibular Physical Therapy for People With Alzheimer Disease
The purpose of this study is to assess the tolerability and preliminary efficacy of an 8-week home-based vestibular physical therapy program in people with cognitive impairment.
- Conditions
- Vestibular Diseases, Alzheimer Disease, Cognitive Impairment
- Trial name
- VPT in AD (NCT03887923)
- Testing
- Vestibular Physical Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pittsburgh
Dementia, Dementia Alzheimers
Persons With Dementia and Their Extended Family Caregivers
Immediate family members shoulder the majority of care responsibilities for persons living with dementia. However, due to various societal changes, elder care responsibilities have expanded to extended family members, including…
- Conditions
- Dementia, Dementia Alzheimers, Neuro-Degenerative Disease, Dementia of Alzheimer Type
- Trial name
- CareEx (NCT04863859)
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Karen Roberto
Dementia
Comparative Effectiveness of Dementia Care Strategies in Underserved Communities
Dementia is a condition that is growing in prevalence and which harms not only the afflicted individual but also adversely affects the health of their family and other informal caregivers.
- Trial name
- NCT01459783
- Testing
- Dementia care management
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- RAND
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