Clinical trials: Dementia, completed
Dementia
Metabolic Cerebral Imaging in Incipient Dementia (MCI-ID)
A brain PET scan is recognized as "reasonable and necessary" for some patients with "a recently established diagnosis of dementia" (Centers for Medicare and Medicaid Services, Decision Memo CAG-00088R, 2004), but evidence is less…
- Trial name
- NCT00329706
- Testing
- FDG-PET brain scan
- Where
- 9 sites in United States
- Volunteers
- 710 people
- Sponsor
- University of California, Los Angeles
Skin Disease
Washing Without Water: Cost-effectiveness of a Rapidly Spreading Nursing Intervention in Bedridden Patients'
The purpose of this study is to compare the traditional bed bath with 'washing without water' on 1) effects on skin integrity 2) patient and nurse satisfaction and 3) costs.
- Trial name
- WWW (NCT01187732)
- Testing
- Washing without water
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Betsie van Gaal
Huntington Disease, Chorea
Atomoxetine and Huntington's Disease
The purpose of this research study is to evaluate the effect of atomoxetine (also known as Strattera) compared to placebo (inactive substance) on daily activities such as attention and focus, thinking ability and muscle movements…
- Trial name
- NCT00368849
- Testing
- atomoxetine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Iowa
Alzheimer's Disease, Psychosis
Treatment of Psychosis and Agitation in Alzheimer's Disease
Clinically, many patients with AD show no response or minimal response to antipsychotics for symptoms of agitation/aggression or psychosis, or they have intolerable side effects on these medications.
- Conditions
- Alzheimer's Disease, Psychosis, Agitation
- Trial name
- NCT02129348
- Testing
- Lithium
- Where
- 4 sites in United States
- Volunteers
- 77 people
- Sponsor
- New York State Psychiatric Institute
Caregiver Burden, Alzheimer Disease
Reducing Burden in Care Partners of Community-Dwelling Persons With Dementia and Oropharyngeal Dysphagia
The goal of this clinical trial is to learn if a newly-created website tool, called WeCareToFeedDysphagia, helps to reduce feelings of burden in care partners of patients with Alzheimer's disease and related dementias (AD/ADRD)…
- Conditions
- Caregiver Burden, Alzheimer Disease, Dementia, Oropharyngeal Dysphagia
- Trial name
- NCT06557863
- Testing
- WeCareToFeedDysphagia web tool
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwell Health
Frontotemporal Dementia, Pick's Disease
Oxytocin and Social Cognition in Frontotemporal Dementia
Investigations into the components of cognition damaged in frontotemporal dementia (FTD) demonstrate that patients with FTD show deficits in facial and verbal expression recognition, lack insight into what others think or might…
- Trial name
- NCT01002300
- Testing
- intranasal oxytocin
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Dementia Syndromes
The Women's Health Initiative Memory Study (The WHIMS Study)
Excessive memory decline or dementia affects an increasing number of women as they become older. The frequency of dementia doubles every 5 years beginning at age 60, making the discovery of ways to prevent or slow the disease…
- Trial name
- NCT00685009
- Testing
- Estrogen hormone therapy, Estrogen plus progesterone hormone therapy
- Where
- United States
- Volunteers
- 7,525 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Insomnia
Efficacy and Safety of Ramelteon in Subjects With Mild to Moderate Alzheimer's Disease
The purpose of this study is to determine the efficacy of ramelteon, once daily (QD), in subjects with mild to moderate Alzheimer's Disease and sleep disturbance
- Trial name
- NCT00325728
- Testing
- Ramelteon
- Where
- 72 sites in United States
- Volunteers
- 74 people
- Sponsor
- Takeda
Alzheimer Disease
A Program to Reduce Inappropriate Medications Among Older Adults With Alzheimer's Disease
Potentially inappropriate prescribing includes the use of medications that may no longer be necessary or that may increase the risk of harm.
- Trial name
- D-PRESCRIBE-AD (NCT05147428)
- Testing
- Educational Materials
- Where
- United States
- Volunteers
- 14,442 people
- Sponsor
- University of Massachusetts, Worcester
Dementia With Vitamin B12 Deficiency
The Role of Methycobalamin in Early Dementia Patients With Vitamin B12 Deficiency and Hyperhomocysteinaemia.
Patients who fit the inclusion criteria are admitted into the study. They are given 3 IV injection of MBL in the first week and one tablet three times a day for 16 weeks.
- Trial name
- NCT00165711
- Testing
- Mecobalamin
- Where
- China
- Sponsor
- Eisai Co., Ltd.
Alzheimer Disease
Assessment the Efficacy of Acetyl-L-carnitine in Patient With Alzheimer's Disease
clinical trial to assess the efficacy of Acetyl-L-carnitine
- Trial name
- NCT02955706
- Testing
- Acetyl-L-Carnitine
- Where
- South Korea
- Volunteers
- 265 people
- Sponsor
- Dong-A ST Co., Ltd.
Alzheimer's Disease
Observational Study on Costs and Caregiver Burden in Alzheimer's Disease
Objective of study is to assess the costs of care, objective and subjective caregiver burden and quality of life in relation to disease severity measured by cognitive function, ADL capabilities and presence of behavioral…
- Trial name
- NCT00698165
- Where
- 82 sites in United States, Spain and 2 more
- Volunteers
- 2,400 people
- Sponsor
- AstraZeneca
Sexually Transmitted Diseases, Safe Sex
P3 (Prepared, Protected, emPowered)
P3 (Prepared, Protected, emPowered) is an interactive smartphone app for HIV-uninfected YMSM and YTW that utilizes social networking and game-based mechanics as well as a comprehensive understanding of what constitutes "best…
- Conditions
- Sexually Transmitted Diseases, Safe Sex, Adherence, Medication
- Trial name
- P3 (NCT03320512)
- Testing
- P3, P3+, Control
- Where
- 9 sites in United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Alzheimer Disease, Dementia
Care Coordination System for People With Dementia
Dementia, a chronic disease of aging, is characterized by progressive cognitive decline that interferes with independent functioning.
- Conditions
- Alzheimer Disease, Dementia, Dementia Alzheimers
- Trial name
- NCT04308512
- Testing
- Active Nili device, Passive Nili system
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bijan Najafi, PhD
Alzheimer's Disease
Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of BMS-708163
The purpose of the study is to evaluate the pharmacokinetics, safety and tolerability of BMS-708163 administered as single and multiple doses in Chinese subjects
- Trial name
- NCT01079819
- Testing
- BMS-708163
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- Bristol-Myers Squibb
Sepsis, Respiratory Failure
Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure
Patients with infections in their blood often become very sick. These patients are usually put in an intensive care unit for careful observation and treatment.
- Conditions
- Sepsis, Respiratory Failure, Agitation
- Trial name
- PRO-DEFENSE (NCT02203019)
- Testing
- Propofol, Dexmedetomidine, Fentanyl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Texas Tech University Health Sciences Center
Optical Coherence Tomography, Optical Coherence Tomography Angiography
Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers
Alzheimer disease is hard, long and expensive to diagnose. In order to help the clinician, a new biomarker in Alzheimer disease seems to be very useful.
- Conditions
- Optical Coherence Tomography, Optical Coherence Tomography Angiography, Retinal Thickening, Alzheimer Disease
- Trial name
- RETEVAL (NCT04794634)
- Testing
- Optical coherence tomography (OCT), Optical coherence tomograpohy angiography (OCTA)
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Schizophrenia
Staccato Loxapine in Agitation (Proof of Concept)
The purpose of this study is to assess efficacy and safety of Staccato Loxapine in the treatment of acute agitation in schizophrenic patients.
- Trial name
- NCT00369577
- Testing
- Inhaled Loxapine 5 mg, Inhaled Loxapine 10 mg
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Alexza Pharmaceuticals, Inc.
Dementia Alzheimers
Interest of the Reborn® Doll as a TO in the Care of Residents With Alzheimer's Disease or a Related Disorder
The primary objective of this study is to evaluate the benefits of the Reborn®doll as an OT for the care of residents with Alzheimer's disease or related disorders, by assessing the frequency of resident agitation.
- Trial name
- PROTMA (NCT06396377)
- Testing
- Reborn doll (Therapeutic object - OT)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Alzheimer Disease, Cognition Disorder
Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of ACD856
The multiple ascending dose (MAD) design of the study is based on the aim to study safety, tolerability, PK and pharmacodynamics of selected doses of ACD856 in a limited number of healthy volunteers.
- Trial name
- NCT05077501
- Testing
- ACD856
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AlzeCure Pharma
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