Clinical trials: Dementia Alzheimers
Presbycusis, Bilateral, Alzheimer Disease 2 Due to Apoe4 Isoform
Hearing Aid and Individuals With Cognitive Disorders
This is a pilot study with the aim of evaluating the feasibility of the procedures of a future clinical trial that will help determine the impacts of hearing aid interventions on older patients with Alzheimer's Disease and…
- Conditions
- Presbycusis, Bilateral, Alzheimer Disease 2 Due to Apoe4 Isoform, Mild Cognitive Impairment
- Trial name
- NCT04049643
- Testing
- Audiologist-based fitting, Service-only Fitting, Device-only fitting
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Yu-Hsiang Wu
Alzheimers Disease
The Feasibility of Florbetapir Quantitation
The overall objective of the study is to assess the feasibility of implementing a quantitative process of florbetapir F 18 scan interpretation.
- Trial name
- NCT01946243
- Testing
- Florbetapir F18
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Avid Radiopharmaceuticals
Alzheimer's Disease
A Trial of SK-PC-B70M in Mild to Moderate Alzheimer's Disease
The purpose of this study is to find optimistic dose and to evaluate the efficacy and safety of SK-PC-B70M in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT00443417
- Testing
- SK-PC-B70M
- Where
- South Korea
- Volunteers
- 188 people
- Sponsor
- SK Chemicals Co., Ltd.
Dementia, Alzheimer Disease
Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders
The Multidisciplinary Expert System for the Assessment \& Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through…
- Conditions
- Dementia, Alzheimer Disease, Epilepsy, Sleep Disorder
- Trial name
- MES-CoBraD (NCT05171725)
- Testing
- EEG,PSG, biosample collection (blood and CSF), neuropsychological testing
- Where
- 4 sites in Greece, Israel and 2 more
- Volunteers
- 635 people, healthy volunteers welcome
- Sponsor
- Neurological Institute of Athens
Alzheimer Disease, Cognitive Impairment, Mild
Comparing Smartphone Technology and a Memory Strategy on Improving Prospective Memory in Alzheimer's Disease
Alzheimer's disease is a debilitating condition for patients and their caregivers marked by hallmark cognitive symptoms (e.g., memory loss) as well as an impact on quality of life.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Mild, Dementia, Mild
- Trial name
- NCT03384043
- Testing
- Smartphone Personal Assistant, Implementation Intention
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor University
Alzheimer Dementia, Family Caregivers
Rehabilitation of Facial Emotion Recognition in Alzheimer's Disease
This study aims to evaluate impacts of an emotion recognition rehabilitation program, named Training of Affect Recognition, on social cognition abilities in Alzheimer's disease (AD).
- Trial name
- EYE-TAR(MA) (NCT04730440)
- Testing
- AD-TAR, AD-Cognitive Stimulation
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Princesse Grace
Mild Cognitive Impairment
Impact of Grape Consumption on Brain Metabolism and Neuropsychological Performance Over 1 Year
Constituents of grapes have been studied for their antioxidant, anti-inflammatory, and anticarcinogenic properties. In the past decade, there has been emerging evidence regarding a potential role for grapes in slowing cognitive…
- Trial name
- NCT03361410
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Los Angeles
Alzheimer Disease
Efficacy, Safety of Astragalus Membranaceus in Mild-to-Moderate Alzheimer's Disease
Alzheimer's disease (AD), the most common cause of dementia, is characterized by cognitive impairment, mental and behavioural abnormalities, and social dysfunction.
- Trial name
- NCT06694597
- Testing
- Astragalus Membranaceus Root
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Fujian Medical University Union Hospital
Alzheimer's Disease
Study of SB-742457 or Donepezil Versus Placebo in Subjects With Mild-to-moderate Alzheimer's Disease
The study is designed to investigate the efficacy, safety and tolerability of SB-742457 versus placebo in subjects with mild-to-moderate Alzheimer's disease.
- Trial name
- NCT00708552
- Testing
- SB-742457, Donepezil
- Where
- 72 sites in Bulgaria, Chile and 9 more
- Volunteers
- 576 people
- Sponsor
- GlaxoSmithKline
Healthy
A Pilot Study of the Effects of BCG Immunization on CSF and Blood-based Biomarkers in Older Adults.
A pilot study of the effects of Bacillus Calmette-Guérin (BCG) immunization on cerebrospinal fluid and blood-based biomarkers in older adults.
- Trial name
- NCT04507126
- Testing
- Bacillus Calmette-Guerin (BCG)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease
Memory for Music: Individual Intensive Musical Training in Alzheimer's Disease
This project, called Memory for Music, focuses on the increasing number of people worldwide living with dementia, especially Alzheimer's disease (AD).
- Trial name
- M4M (NCT06611878)
- Testing
- Music training - intensive, Music training - minimal, Treatment as Usual (TAU)
- Where
- 6 sites in Argentina, Austria and 1 more
- Volunteers
- 113 people
- Sponsor
- NORCE Norwegian Research Centre AS
Alzheimer's Disease, Parkinson's Disease
Rajavtihi Neuronal Adult Stem Cells Project
To study the success of Oligodendrocyte progenitor cell culture project in Rajavithi Hospital to identify an unlimited clone human neuronal progenitor stem cells from the human brain in the Biomolecular Research Center.
- Conditions
- Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis
- Trial name
- RNASc (NCT00927108)
- Testing
- Progenitor Stem Cell Culture
- Where
- Thailand
- Volunteers
- healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Alzheimer's Dementia
European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS)
Brain changes associated with Alzheimer's disease may precede symptoms of Alzheimer's Dementia by over 20 years. The Investigators hope to be able to identify Alzheimer's disease at its very earliest stages when in theory…
- Trial name
- EPAD-LCS (NCT02804789)
- Where
- 30 sites in Belgium, France and 7 more
- Volunteers
- 2,095 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Alzheimer Disease
Olfactory Neuroepithelial Tissue of Alzheimer Disease
The purpose of this study is to evaluate the olfactory neuroepithelium as a biomarker of Alzheimer disease. The early diagnosis of Alzheimer disease is of importance for obtaining better response to treatment, but recently…
- Trial name
- NCT02129452
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Amnestic Mild Cognitive Impairment - aMCI, Insomnia
Targeting Sleep and Slow-Wave Activity to Enhance Cognition in MCI
Study Description As most clinical trials in Alzheimer's disease (AD) have been unsuccessful to date, it has become increasingly crucial to focus on treating earlier stages of the disease.
- Trial name
- TASSLE (NCT07911826)
- Testing
- active intervention, Control Intervention
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Caregiver Burden, Caregiver Burnout
Peer Support for Family Caregivers of Older Adults Living With Dementia
Family caregivers of people living with dementia are at high risk of poor health when caregiving for their loved one. Peer Support for Family Caregivers of Older Adults Living with Dementia (Pair 2 Care©) is a simple…
- Conditions
- Caregiver Burden, Caregiver Burnout, Caregiver Anxiety, Alzheimer Disease Dementia
- Trial name
- Pair 2 Care (NCT07868718)
- Testing
- Peer Support, Usual Care
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Ohio State University
Preclinical Alzheimer's Disease, Alzheimer Disease
AV-1959R Vaccine in Individuals With Preclinical Alzheimer's Disease
This Phase 2 study will evaluate the safety, tolerability, immunogenicity, and amyloid-lowering effect of AV-1959R in cognitively unimpaired adults with preclinical Alzheimer's disease.
- Trial name
- AREVIA (NCT07827768)
- Testing
- AV-1959R
- Volunteers
- 160 people
- Sponsor
- Institute for Molecular Medicine
Alzheimer's Disease
MK-1942/Donepezil Interactions in Participants With Alzheimer's Disease (MK-1942-005)
The study investigated the effects on safety and pharmacokinetics (PK) of MK-1942 and donepezil when co-administered to participants with Alzheimer's Disease with mild-to-moderate cognitive impairment stably treated with…
- Trial name
- DDI (NCT04308304)
- Testing
- MK-1942, Donepezil
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer's Disease, Depression
Depression in Alzheimer's Disease-2
The purpose of this study is to learn whether treating individuals with Alzheimer's disease and depression with the anti-depressant medication sertraline (Zoloft) is helpful to people with Alzheimer's disease and to their…
- Trial name
- DIADS-2 (NCT00086138)
- Testing
- Sertraline (Zoloft)
- Where
- 5 sites in United States
- Volunteers
- 131 people
- Sponsor
- Johns Hopkins University
Alzheimer's Disease (AD)
Recombinant Human Serum Albumin in the Treatment of Mild-to-moderate AD (Alzheimer's Disease) Exploratory Clinical Trial
This clinical trial is an open-label, parallel-group, exploratory study of recombinant human serum albumin in patients with mild to moderate Alzheimer's Disease (AD).
- Trial name
- NCT06489015
- Testing
- Recombinant Human Serum Albumin
- Where
- 5 sites in China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Protgen Co., Ltd.
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