Clinical trials: Dementia Alzheimers
Gait Disorders, Neurologic
Gait Disorders in Patients With Cognitive Decline
The prevalence of neurodegenerative diseases will increase over the next decades driven by ageing population. It seems important to develop reliable, replicable and accessible diagnostic tools.
- Trial name
- NCT03399591
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Alzheimer Disease, Dementia With Lewy Bodies (DLB)
Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder
This is a retrospective observational study to evaluate the clinical utility of blood-based biomarkers in the diagnosis and management of patients with a neurodegenerative disease (ND) or mental disorder (MD).
- Conditions
- Alzheimer Disease, Dementia With Lewy Bodies (DLB), Frontotemporal Dementia (FTD), Major Depressive Disorder (MDD)
- Trial name
- Synapsing-BK (NCT07314190)
- Where
- Spain
- Volunteers
- 1,799 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Caregiver Burden
Pre-Pilot: Problem Adaptation THerapy in Caregivers
The proposed pre-pilot project seeks to adapt an evidence-based psychosocial intervention-Pain Adaptation Therapy (PATH)-that employs emotion regulation, behavioral activation, and problem-solving skills training, that will be…
- Trial name
- PATH-Care (NCT05567120)
- Testing
- PATH-Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Alzheimer's Disease, Amnestic Mild Cognitive Impairment
[18F]MK-6240 Positron Emission Tomography (PET) Tracer First-in-Human Validation Study (MK-6240-001)
This 2-part, open-label study was designed to investigate the safety, tolerability, and efficacy of [18F]MK-6240, a Positron Emission Tomography (PET) imaging agent, for the quantification of neurofibrillary tangle (NFT)…
- Trial name
- NCT02562989
- Testing
- [18F]MK-6240, ~185 MBq, [18F]MK-6240, ~160 MBq
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer's Disease
ELND005 Long-Term Follow-up Study in Subjects With Alzheimer's Disease
The purpose of this study is to evaluate the long-term safety and tolerability of ELND005 beyond the 18 months of treatment in original randomized and blinded clinical trail ELND005-AD201.
- Trial name
- NCT00934050
- Testing
- ELND005 (scyllo-inositol)
- Where
- 38 sites in United States, Canada
- Volunteers
- 103 people
- Sponsor
- OPKO Health, Inc.
Hearing Loss, Sensorineural, Bilateral Vestibulopathy
Effect of Hearing Loss and Vestibular Decline on Cognitive Function in Older Subjects
The world population has been growing and aging dramatically, with a rising prevalence of dementia. Worldwide, around 50 million people have dementia, with 10 million new cases added every year.
- Conditions
- Hearing Loss, Sensorineural, Bilateral Vestibulopathy, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- GECkO (NCT04385225)
- Testing
- Longitudinal follow-up
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Alzheimer Disease, Caregivers of Alzheimer's Disease or Memory Problem Patients
Psychological Counseling Program for Alzheimer's Patients' Caregivers
Purpose: To investigate the effects of a psychological counseling program (PsychoCP) applied to caregivers of Alzheimer's patients on perceived stress, psychological well-being and care burden.
- Conditions
- Alzheimer Disease, Caregivers of Alzheimer's Disease or Memory Problem Patients, Perceived Stress, Well-Being (Psychological Flourishing)
- Trial name
- PsychoCP (NCT06755476)
- Testing
- Psychological Counseling Program
- Volunteers
- 80 people
- Sponsor
- Aydan Akkurt Yalçıntürk
Alzheimer Disease, Alzheimer's Disease (Incl Subtypes)
Prediction of Amyloid and Mild Cognitive Impairment in Early Stage Alzheimer's Disease From Remote Speech Phenotyping
The S22 study investigates, in a cross-sectional study, the ability of algorithms that analyse acoustic and linguistic patterns of spoken language to predict the presence of amyloid positivity in early stage Alzheimer's disease…
- Conditions
- Alzheimer Disease, Alzheimer's Disease (Incl Subtypes), Mild Cognitive Impairment
- Trial name
- EARS (NCT04928690)
- Volunteers
- 140 people
- Sponsor
- Novoic Limited
Alzheimer's Disease
Curcumin in Patients With Mild to Moderate Alzheimer's Disease
The purpose of this study is to examine the safety and tolerability of curcumin, and to determine its effect on patients with mild to moderate Alzheimer's Disease (AD).
- Trial name
- NCT00099710
- Testing
- Curcumin C3 Complex
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- John Douglas French Foundation
Alzheimer Disease, Down Syndrome
Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study
This study plans to establish a large bank of blood, cerebral spinal fluid (CSF), imaging, and clinical data. These data and samples will be used for future research into the causes of Alzheimer's disease (AD), Down Syndrome (DS)…
- Conditions
- Alzheimer Disease, Down Syndrome, Mild Cognitive Impairment
- Trial name
- NCT02612376
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alzheimer Disease
A Phase 2 Study to Evaluate Efficacy and Safety of AL002 in Participants With Early Alzheimer's Disease
A phase 2 randomized, double blind, placebo controlled study evaluating the efficacy and safety of AL002 in participants with Early Alzheimer's Disease.
- Trial name
- INVOKE-2 (NCT04592874)
- Testing
- AL002
- Where
- 87 sites in United States, Argentina and 10 more
- Volunteers
- 356 people
- Sponsor
- Alector Inc.
Focus Groups
COACH-Cog Intervention Adaptation Focus Groups
To gather key stakeholder input for feedback on the adaption of the COACH GA intervention (i.e., develop COACH-Cog) to enhance triadic communication among oncologists, care partners and patients with ADRD.
- Trial name
- NCT05775991
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Rochester
Alzheimer's Disease
Central Auditory Processing Modulation Underlying Anxiety Reduction Using Clinically Designed Improvisatory Music
This study examines whether Clinically Designed Improvisatory Music (CDIM) can reduce anxiety in people living with Alzheimer's disease and anxiety (AD-A), and whether it can also lessen caregiver burden.
- Trial name
- NCT07775625
- Testing
- Clinically Designed Improvisatory Music, Listening to Storytelling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Alzheimer Disease
Study Safety and Efficacy of Deep Brain Stimulation (DBS) and Cervical Deep Lymphoid-venous Anastomosis (LVA) in Alzheimer's Disease
To investigate the safety of deep brain stimulation (DBS) and cervical deep lymphoid-venous anastomosis (LVA) in the treatment of severe Alzheimer's disease (AD); to investigate the effectiveness of DBS and LVA in the treatment…
- Trial name
- NCT07094438
- Testing
- Deep Brain Stimulation, DBS, Deep cervical lymphatic-venous anastomosis, LVA, Recognized pharmacological treatments for AD.
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Chinese PLA General Hospital
Gait Disorders, Neurologic, Parkinson Disease
Gamma Sensory Flicker for Parkinson's Disease Patients With Freezing of Gait
This study aims to answer the question: to assess the safety, and tolerability of gamma light in Parkinson's disease (PD) patients with freezing of gait (FOG).
- Trial name
- Flicker w FOG (NCT06295458)
- Testing
- David Delight Plus Device
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Emory University
Alzheimer's Disease
Imaging of Cognition, Learning, and Memory in Aging
This investigation is designed to study how the brain functions when it is performing explicit memory tasks, and furthermore how the brain systems supporting performance on these tests change as a function of aging.
- Trial name
- NCT01297114
- Testing
- Florbetaben
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Yaakov Stern
Alzheimer Disease, Early Onset
Efavirenz for Patients With Alzheimer's Disease
This will be a two-center, placebo controlled blinded clinical trial to evaluate the safety and tolerability of efavirenz (EFV) in 36 clinically stable subjects with mild cognitive impairment/early dementia due to Alzheimer's…
- Trial name
- EPAD (NCT03706885)
- Testing
- Sustiva Pill
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Western Reserve University
Alzheimer Disease
Effects of Dual-Task Training In Individuals With Alzheimer
The purpose of this study is to investigate the effects of dual-task training on balance, fear of falling, cognitive functions, dual-task performance, depression and quality of life in individuals with Alzheimer.
- Trial name
- NCT05765552
- Testing
- Dual-Task Training, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Ege University
Dementia, Alzheimer's Disease
Indiana University Dementia Screening Trial
The purpose of the study is to conduct a randomized clinical trial assessing the harms and benefits of screening for dementia, compared to no screening for dementia, among 4,000 older adults, cared for in typical, primary care…
- Conditions
- Dementia, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- IU-CHOICE (NCT01699503)
- Testing
- Collaborative Dementia Care Program
- Where
- 3 sites in United States
- Volunteers
- 4,005 people
- Sponsor
- Indiana University
Dementia, Alzheimer's Disease
Translation of COPE for Publicly-Funded Home Care Clients and Their Families
This community-based translational trial tests the value of a proven non-pharmacologic intervention for older adults living with dementia and informal caregivers when this intervention is incorporated into a publicly-funded home…
- Trial name
- COPECT (NCT02365051)
- Testing
- Care of Persons with Dementia in their Environments
- Where
- United States
- Volunteers
- 582 people
- Sponsor
- UConn Health
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