Clinical trials: Dementia Alzheimers
Dementia Alzheimers
ImGTS for Patients With Behavioral and Psychological Symptoms of Dementia (Phase 2)
The proposed research project aims to answer the question "Are immersive technology systems effective in the management and treatment of patients with BPSD?".
- Trial name
- NCT06072014
- Testing
- Virtual reality
- Where
- Philippines
- Volunteers
- 30 people
- Sponsor
- Augmented eXperience E-health Laboratory
Alzheimer's Disease
The Detection of Early Dementia With the Digital Game Memory
The investigators are going to test if it is possible to detect early dementia with the digital game "memory". The investigators are going to test 15 healthy people and 15 patients with early dementia.
- Trial name
- NCT02041728
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mild Cognitive Impairment
Neurotrack Test Validation Protocol
This protocol describes a study to validate Neurotrack's visual paired comparison task, aimed at early detection and monitoring of memory impairment.
- Trial name
- NCT02608021
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alzheimer's
Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Alzheimer's Disease
This project explores Ginkgo biloba ester dispersible tablets influence on cognitive function in patients with mild-to-moderate elderly, to observe the effects of different intervention time on cognitive function, for alzheimer's…
- Trial name
- NCT03090516
- Testing
- Ginkgo biloba dispersible tablets, Donepezil, Ginkgo biloba dispersible tablets and Donepezil
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Alzheimer Disease
Effect of Indomethacin on the Progression of Alzheimer's Disease
The purpose of this study is determine whether indomethacin is able to retard disease progression in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT00432081
- Testing
- indomethacin
- Where
- 2 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Radboud University Medical Center
Severe Alzheimer's Disease
Evaluating The Impact Of Donepezil Hydrochloride (Aricept) On Behavioral And Psychological Symptoms In Patients With Severe Alzheimer's Disease
A 12-week, multicenter, randomized, double-blind, placebo-controlled phase IV study. Approximately 200 subjects will be enrolled, half will receive active drug (donepezil hydrochloride) and half will receive matching placebo at…
- Trial name
- NCT00711204
- Testing
- Donepezil Hydrochloride (Aricept)
- Where
- United States
- Sponsor
- Eisai Inc.
Cognitive Impairment, Alzheimer Disease
Disease-modifying Properties of Lithium in the Neurobiology of Alzheimer's Disease
Lithium salts have been used for the treatment of psychiatric disorders for over five decades, mostly as a mood-stabilizing drug.
- Trial name
- NCT01055392
- Testing
- Lithium Carbonate
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
Alzheimer Disease
Impact of Therapeutic Educational Programme on the Alzheimer's Disease Affected Patient's Quality of Life
Therapeutic education expands in Alzheimer's Disease management in France. Several studies revealed a positive impact on caregiver's burden and/or quality of life.
- Trial name
- THERAD (NCT01796314)
- Testing
- Therapeutic Educational Program
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Toulouse
Stress, Psychological, Stress, Systemic
Systemic Stress Prevention Via Application SysLife© for Companies
The purpose of this study is to investigate the efficacy of systemic stress prevention via SysLife© application in a prospective, interventive, balanced, monocentric, explanatory pilot randomized controlled trial (RCT), with…
- Conditions
- Stress, Psychological, Stress, Systemic, Application
- Trial name
- NCT05828693
- Testing
- SysLife©, SysLife©, as intervention after closing the RCT-design
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University of Witten/Herdecke
Alzheimer Disease (AD)
Intravenous Infusion of Umbilical Cord Blood as an Adjunctive Treatment for Alzheimer's Disease
This study is a single-center, prospective, double-blind, randomized controlled clinical trial (RCT). Employing a parallel-group design, the trial plans to enroll 30 clinically diagnosed AD patients, who will be randomly assigned…
- Trial name
- NCT07208344
- Testing
- Intravenous infusion of mononuclear cells from umbilical cord blood, Conventional medical treatment：donepezil, rivastigmine or galantamine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Anhui Provincial Hospital
Alzheimer Disease
Effect on the Electrocardiographic QT Interval Corrected for Heart Rate (QTc) in Healthy Subjects
The purpose of this study is to determine the effect of BMS-708163 on the QTc interval (QT interval corrected for heart rate).
- Trial name
- NCT00979316
- Testing
- BMS-708163, Moxifloxacin
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Agitation Associated With Alzheimer's Dementia
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia
This is a multicenter, randomized, double-blind, placebo-controlled, flexible-dose study of the efficacy, safety, and tolerability of ITI-1284 in patients with agitation associated with Alzheimer's dementia.
- Trial name
- NCT06651567
- Testing
- ITI-1284
- Where
- 71 sites in United States, Bulgaria and 6 more
- Volunteers
- 320 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Alzheimer's Disease and Related Dementias
Reducing Behavioral and Psychological Symptoms of Dementia: Hospital Caregivers (Aim 2)
Persons with Alzheimer's Disease and Related Dementias (ADRD) account for 3.2 million hospital admissions per year and have over three times more hospitalizations than those without cognitive impairment, yet hospital caregivers…
- Trial name
- NCT04179721
- Testing
- PES-4-BPSD Model, The attention control condition
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Alzheimer Disease
Follow-up Trial to Assess the Long-term Safety and Tolerability of Talsaclidine in Patients With Mild to Moderate Dementia of the Alzheimer Type
Safety and tolerability. Quality of life (EQ-5D, ACQLI) and health economic impact (health resource utilisation, living and employment status) assessments, will not be performed at the centers in the united kingdom (UK)
- Trial name
- NCT02248116
- Testing
- Talsaclidine
- Volunteers
- 198 people
- Sponsor
- Boehringer Ingelheim
Primary Progressive Aphasia, Alzheimer Disease
Clinical Evaluation of Florbetapir in Primary Progressive Aphasia
The purpose of this research is to better understand how dementia affects activity in different parts of the brain.
- Conditions
- Primary Progressive Aphasia, Alzheimer Disease, Dementia
- Trial name
- PPA (NCT04726527)
- Testing
- Florbetapir F 18, Positron Emission Tomography
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Chicago
Alzheimer's Disease
Pilot Study of Aerobic Exercise in Early Alzheimer's Disease(AD)
The current project is a natural extension of a programmatic line of investigation into the relationship between exercise, brain aging, and AD that Dr. Burns has developed over the last four years.
- Trial name
- NCT01128361
- Testing
- Aerobic Exercise, Stretching
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Jeff Burns, MD
Alzheimer Disease or Associated Disorder
Sweet Night (Musical Diffusion by Caregivers ): Effects of Musical Diffusion by Caregivers on Sleep Onset and Behavioral Regulation in a Protected Living
As the Alzheimer's disease progresses, caregivers and family members often focus on behavioral difficulties. In response to crises, immediate actions tend to favor restraints, either through medication or physical means.
- Trial name
- Sweet nightMDC (NCT07207642)
- Testing
- Music intervention - passive listening, Audio books intervention - active listening
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Mild Cognitive Impairment, Alzheimer's Disease
Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease
This study is being conducted to determine the safety, tolerability, pharmacokinetics, and effects of EVP-0962 on cerebral spinal fluid Amyloid concentrations in healthy subjects and in subjects with mild cognitive impairment or…
- Trial name
- NCT01661673
- Testing
- EVP-0962
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- FORUM Pharmaceuticals Inc
Cognitive Symptoms
Efficacy and Safety of Rivastigmine in Patients With Mild Cognitive Impairment
This study is designed to investigate the efficacy and safety of rivastigmine compared with placebo in patients with mild cognitive impairment (MCI).
- Trial name
- NCT00134953
- Testing
- Rivastigmine
- Volunteers
- 24 people
- Sponsor
- Novartis
Alzheimer's Disease
[18F]AV45(Aβ) and [18F]AV1451(Tau)PET/CT in the Diagnosis of Early Pathological Changes of Alzheimer's Disease
To investigate the primary brain regions of precursors of Alzheimer's disease and Alzheimer's disease by novel molecular probe [18F]AV45(Aβ) and [18F]AV1451(Tau)PET/CT imaging.
- Trial name
- NCT06833645
- Testing
- molecular probe [18F]AV45(Aβ) and [18F]AV1451(Tau)
- Where
- China
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
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