Clinical trials: Dementia Alzheimers
Alzheimer Disease
CBT for African Americans With Cognitive Impairment
The aim of the study is to test the feasibility and acceptability of a six-month cognitive-behavioral therapy (CBT) program (group based and phone-based) compared with usual care, and to determine if the intervention can improve…
- Trial name
- NCT03384069
- Testing
- Group-based Cognitive Behavioral Therapy (CBT), Phone-based Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Alzheimer's Disease
To Evaluate the Efficacy and Safety/Tolerability Profiles of G-CSF in Subjects With Mild to Moderate Alzheimer's Disease
With the enrichment of living environment and the progress of medicine, the scale of aging population has increased in many countries of the world.
- Trial name
- NCT03656042
- Testing
- Filgrastim (75mcg/0.3ml)
- Where
- Taiwan
- Volunteers
- 21 people
- Sponsor
- Chang Gung Memorial Hospital
Smoking Cessation, Health Behavior
So-Lo-Mo Intervention Applied to the Smoking Cessation Process
This is a randomized open-label parallel-group trial. 240 subjects will be recruited during 8 months and a 12 months follow-up will be carried out for each one of them.
- Conditions
- Smoking Cessation, Health Behavior, Lifestyle-related Condition
- Trial name
- So-Lo-Mo (NCT03553173)
- Testing
- So-Lo-Mo, Psychological advice, Bupropion Pill
- Volunteers
- 240 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Memory Disorders, Alzheimer Disease
Memory Problems Perceptions Among Patients and Accompaniers During Diagnosis Process :
This study aims to prospectively examine the memory problem perceptions of patients with memory complaints [MCs] and their accompaniers during the diagnostic process.
- Trial name
- REMAD (NCT02299154)
- Testing
- Psychological questionnaires
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Sleep, Sleep Disorders
Z-Drugs for Sleep Disorders in Alzheimer's Disease
The purpose of this study is to determine whether Zolpidem and Zoplicone are efective in the treatment of sleep disorders in Alzheimer's disease (AD)
- Conditions
- Sleep, Sleep Disorders, Insomnia, Alzheimer's Disease
- Trial name
- NCT03075241
- Testing
- Zolpidem, Zoplicone
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Brasilia University Hospital
Alzheimer Disease, Aerobic Exercise
The Effects of Exercise Program in Alzheimer's Patients With Mild to Moderate Stage Alzheimer's Disease
The primary aim of this trial is to investigate the feasibility of an exercise program consisting of respiratory exercises, aerobic exercises and strengthening exercises in mild to moderate Alzheimer's disease.
- Conditions
- Alzheimer Disease, Aerobic Exercise, Breathing Exercise, Resistance Training
- Trial name
- NCT04021888
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dokuz Eylul University
Stress, Anxiety
Yoga for Family Caregivers of Alzheimers Disease Patient
This study evaluates the effects of the practice of yoga in combination with compassion meditation on the quality of life, attention, vitality and self-compassion of family caregivers of patients with Alzheimer's disease.
- Conditions
- Stress, Anxiety, Compassion
- Trial name
- NCT02563483
- Testing
- yoga and compassion meditation program
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Alzheimer Disease, Dementia
Alzheimer Prevention Trials (APT) Webstudy
The goal of the Alzheimer Prevention Trials (APT) Webstudy is to accelerate enrollment for Alzheimer's disease (AD) clinical trials by identifying and tracking individuals who may be at higher risk for developing AD dementia.
- Trial name
- NCT03638583
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alzheimer's Disease
Apoe Impact Study on Brain Structure and Function, in a Population 45 to 75 Years Old
The purpose of this study is to investigate the influence of the APOE genotype on brain morphology, function and metabolism, related to other factors such as cognitive reserve, cognition and episodic memory, in subjects at…
- Trial name
- NCT02198586
- Where
- Spain
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Adaptation
Living With Frontotemporal Dementia
Background: Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia. Alzheimer s disease is the most common.
- Trial name
- NCT01738386
- Where
- 3 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Dementia
Effectiveness of Flash Mediation Therapy
In order to offer a non-drug intervention for caregivers in nursing home to respond promptly to a behavioral crisis with an appropriate response to each patient, a chariot has been developed by the Institute of Ageing Well Korian…
- Trial name
- NCT02933177
- Testing
- 2 months control condition - 4 months chariot-flash, 4 months control condition-2 months chariot flash
- Where
- France
- Volunteers
- 241 people
- Sponsor
- Hospices Civils de Lyon
Alzheimer Disease
Evaluation of [123I] AV94 and SPECT in Subjects With Alzheimer Disease in Comparison to Healthy Subjects
The main objectives of this proposal are as follows: To assess the dynamic uptake and washout of 123-I AV94, a potential imaging biomarker for β-amyloid burden in brain, using single photon emission computed tomography (SPECT) in…
- Trial name
- AV94 (NCT00605059)
- Testing
- [123I]AV94
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Alzheimer Disease
PhosphoRus, Proton Imaging and Amyloid BuRdEn (PREPARE) ON AMYLOID BURDEN AND COGNITION
Normal cells primarily produce energy with the help of the "mitochondria". These "small organs" are also called the "powerhouses of the cell" turn the sugars, fats and proteins that is eaten into forms of chemical energy that the…
- Trial name
- PREPARE (NCT03999879)
- Testing
- Measure of OxPhos upregulation, lactate (measured with 1H-MRSI)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- NYU Langone Health
Dementia, Alzheimer's Disease
Caregiver Burden and Depression: Caring for Those Who Care for Others
The purpose of this study is to examine the effectiveness of support group intervention for primary caregivers of a person with dementia or similar cognitive impairment.
- Trial name
- NCT02690896
- Testing
- UCF Caregiver Support Group, Community Support Groups
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Alzheimer's Disease
Efficacy, Safety and Tolerability of Tideglusib to Treat Mild-to-Moderate Alzheimer's Disease Patients
The main purpose of this study is to evaluate the cognitive changes after administration of tideglusib versus placebo at two oral doses and two treatment regimes for 26 weeks in patients with mild to moderate Alzheimer's disease.
- Trial name
- ARGO (NCT01350362)
- Testing
- tideglusib
- Where
- 6 sites in Belgium, Finland and 4 more
- Volunteers
- 306 people
- Sponsor
- Noscira SA
Alzheimer Disease, Dementia
Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers
There is a need for caregiver-initiated and -implemented non-pharmacological interventions directly to and for the person with dementia, including environmental assessment and modification, as first-line treatments for behavioral…
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT05202223
- Testing
- Harmony at HOME (H@H)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Elizabeth K Rhodus
Alzheimer Disease, Mild Cognitive Impairment
Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation
Presently, few studies have evaluated the clinical impact of rTMS in Alzheimer's disease. Though some studies have demonstrated an improvement, there have been conflicting results, as others do not seem to demonstrate beneficial…
- Trial name
- StimoLaMente (NCT04866979)
- Testing
- Experimental: Continuous TBS (cTBS), Intermittent TBS (iTBS), Cognitive training (CT).
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi di Trento
Alzheimer Disease
Neuroinflammation and Cognitive Decline in Alzheimer Disease
The purpose of this study is to assess the level of neuroinflammation in Alzheimer Disease subject (mild to moderate) estimated with Binding Potential (BP) of [18F]DPA-714, and its relationship with the kinetics of cognitive…
- Trial name
- NICAD (NCT02377206)
- Testing
- ADAS-Cog evaluation
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Tours
Alzheimer Disease
Combined Aerobic Exercise and Cognitive Training in Seniors at Increased Risk for Alzheimer's Disease
The study aims to investigate the effect of a long-term combined aerobic exercise and cognitive training program on cognitive function and blood exosomal synaptic protein levels in seniors at increased risk for Alzheimer's…
- Trial name
- NCT05163626
- Testing
- Combined aerobic exercise and cognitive training program
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Mild Cognitive Impairment, Dementia
A Study of CST-2032 and CST-107 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's or Alzheimer's Disease
This is a Phase 2a, randomized, placebo-controlled, double-blind, crossover study to evaluate the effects CST-2032 administered with CST-107 on cognition in participants with Mild Cognitive Impairment (MCI) or mild dementia.
- Trial name
- NCT05104463
- Where
- 15 sites in United States, New Zealand
- Volunteers
- 64 people
- Sponsor
- CuraSen Therapeutics, Inc.
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