Clinical trials: Dementia Alzheimers
Alzheimer Disease
Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease
We are studying subjects with mild to moderate Alzheimer's disease who have been on a stable dose of any cholinesterase inhibitor [donepezil (Aricept), rivastigmine (Exelon), or galantamine (Razadyne)] for at least 3 months, and…
- Trial name
- NCT00551161
- Testing
- memantine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwell Health
Alzheimer's Disease
Chronic Electrical Stimulation of Hypothalamus/Fornix in Alzheimer's Disease
Alzheimer's Disease (AD) is the most common cause of dementia for which no treatment has shown consistent efficacy to stop or slow down the disease.
- Trial name
- NCT00888056
- Testing
- Bilateral chronic electrical stimulation of the hypothalamus/fornix
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Mild Cognitive Impairment, Alzheimer Disease
Spatial Navigation for the Early Detection of Alzheimer's Disease.
Alzheimer's Disease (AD) is the most common form of dementia and may contribute to 60-70 % of all cases. An early, accurate diagnosis of AD will become increasingly important with disease-modifying therapies.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Healthy Aging
- Trial name
- ALLO-task (NCT06385951)
- Testing
- Procedure for patients, Procedure for healthy controls
- Where
- Belgium
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Alzheimer Disease and Related Dementias (ADRD)
Veech Ketone Ester to Support Brain Energy in Mild Cognitive Impairment and Early Alzheimer's Disease
It is projected that by 2030, one in every five Americans will be of retirement age, and this demographic shift is expected to result in more people suffering from dementia.
- Trial name
- NCT06767124
- Testing
- Ketogenic Supplement
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University of Pennsylvania
Alzheimer Disease
Study of ASN51 in Adults With Early Alzheimer's Disease
The main purpose of this study is to evaluate the safety, tolerability, and effect on biomarkers of disease pathophysiology and pathology, pharmacokinetics (PK), and preliminary effects on measures of clinical efficacy of…
- Trial name
- NCT06677203
- Testing
- ASN51
- Where
- 7 sites in United States
- Volunteers
- 123 people
- Sponsor
- Asceneuron S.A.
Alzheimer's Disease, rTMS Stimulation
The Underlying Neural Mechanism of TMS in Improving the Imbalance of "Microbiota-brain-gut Axis" in Alzheimer 's Disease Population
What is this study about? This study focuses on Alzheimer's Disease (AD), a common neurodegenerative disease that affects memory, thinking, and daily life.
- Trial name
- NCT07346794
- Testing
- TMS
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Healthy, Alzheimer Disease
A Study to Measure CSF Proteins in Elderly Healthy Volunteers and Volunteers With Mild Cognitive Impairment or Alzheimer's Disease
The purpose of this study is to investigate changes of cerebral spinal fluid (CSF) proteins over time using continuous CSF sampling for 36 hours in elderly healthy volunteers and volunteers with mild cognitive impairment or…
- Trial name
- NCT01436188
- Testing
- Standard CSR sampling procedure, Alternate frequency CSR sampling procedure, Standard frequent CSR sampling procedure with 800 mg ibuprofen
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Dementia, Alzheimer Disease
Effects of Visual Arts Training on Dementia
The study will use a randomized controlled trial to test the efficacy of two interventions (visual arts and music) for individuals with dementia, focusing on dementia of the Alzheimer's type (DAT).
- Trial name
- NCT02432222
- Testing
- Visual Arts Training, Music Training
- Volunteers
- 23 people
- Sponsor
- York University
Dementia, Alzheimer Disease
Dementia in Migrants Living in Italy: Promoting a Diversity-sensitive Clinical Approach and Provision of Care
The number of older migrants with cognitive impairment and dementia living in Italy and attending national healthcare services is rapidly increasing.
- Trial name
- NCT06416137
- Testing
- Neuropsychological tests
- Volunteers
- 3,000 people
- Sponsor
- Istituto Superiore di Sanità
Low Back Pain
Randomised Controlled Trial for the selfBACK Project
The intervention consists of a digital decision support system delivering a weekly plan of suggested activities that the participant can use to self-manage their low back pain (LBP) via an smartphone app.
- Trial name
- selfBACK (NCT03798288)
- Testing
- selfBACK, Usual care
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 461 people
- Sponsor
- University of Southern Denmark
Alzheimer's Disease, Huntington's Disease
A Phase I Study To Estimate The Effect Of Ketoconazole And Omeprazole On The Pharmacokinetics Of Dimebon In Healthy Subjects Who Are Normal Or Poor CYP2D6 Metabolizers
This study will evaluate the potential for a drug-drug interaction of Dimebon with ketoconazole and omeprazole, potent inhibitors of the drug metabolizing enzymes CYP3A4 and CYP2C19, respectively.
- Trial name
- NCT00931073
- Testing
- Dimebon alone, Dimebon + Ketoconazole, Dimebon + Omeprazole
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Alzheimer Disease
Evaluation of [18F] PBR111 and PET as a Marker of Inflammation in Subjects With Neurological Conditions
The underlying goal of this study is to assess PBR-111 positron emission tomography (PET) imaging as a tool to detect microglial activation in the brain of Alzheimer disease (AD) research participants and age- and gender-matched…
- Trial name
- PBR111 (NCT01209156)
- Testing
- [18F] PBR111
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Alzheimer's Disease
Screening and Evaluation of Patients With Signs and Symptoms of Alzheimer's Disease
Background: Individuals who demonstrate symptoms of Alzheimer s disease, such as progressive memory loss, may be eligible to participate in National Institutes of Health research studies.
- Trial name
- NCT00955422
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimer Disease, Mild Cognitive Impairment
Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Alzheimer Disease
The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety…
- Trial name
- NCT04771845
- Testing
- Transcranial Magnetic Stimulation
- Volunteers
- 73 people
- Sponsor
- The New York Memory Services
Alzheimer Disease
Effect of Art Therapy on Cognitive and Hand Functions of Alzheimer's Patients
This randomized controlled trial aims to investigate the effects of art therapy on cognitive functions and hand functions in individuals with Alzheimer's disease.
- Trial name
- NCT07163377
- Testing
- Experimental Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Fenerbahce University
Effectiveness, Virtual Reality
Evaluation of the Effectiveness of Virtual Reality Headsets With Hypnotic Scenarios for Hygiene Care in Patients With Alzheimer's Disease or Related Disorders With Behavioral Disturbances
A device combining a virtual reality (VR) headset with hypnotic scenarios may represent an effective tool to reduce anxiety and opposition during hygiene care in patients with neurocognitive disorders presenting with behavioral…
- Conditions
- Effectiveness, Virtual Reality, Hypnotic Scenarios, Hygiene Care
- Trial name
- HYPNOGER 2 (NCT07264439)
- Testing
- VR headset, standard cares
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
PARKINSON DISEASE (Disorder), Alzheimer s Disease
Precision Medicine and Neurodegenerative Diseases: Advanced Systems for the Diagnosis and Treatment of Parkinson's Disease and Alzheimer's Disease.
In recent decades, advances in medicine have significantly improved both quality of life and life expectancy. However, these positive effects are also associated with a considerable increase in the prevalence of age-related…
- Conditions
- PARKINSON DISEASE (Disorder), Alzheimer s Disease, Diabete Type 2
- Trial name
- NEUROTECHNO (NCT07467460)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Major Depressive Disorder, Alzheimer Disease
Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults
This project aims to explore the feasibility and effects of a symptom-specific, brain-circuit-based, home-based neuromodulation therapy for addressing mood and memory symptoms in older adults with major depressive disorder (MDD)…
- Conditions
- Major Depressive Disorder, Alzheimer Disease, Dementia, Nervous System Diseases
- Trial name
- NCT05976659
- Testing
- Transcranial direct current stimulation (tDCS); Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hebrew SeniorLife
Alzheimer´s Disease
Follow-up Study to Assess Safety and Clinical Activity of Continued AFFITOPE® AD02 Vaccinations of Patients Who Participated in AFF006
This is a follow-up study to assess safety and clinical activity of continued AFFITOPE® AD02 vaccinations in patients with Alzheimer's disease.
- Trial name
- NCT02008513
- Testing
- AFFITOPE® AD02
- Where
- 27 sites in Austria, Croatia and 4 more
- Volunteers
- 194 people
- Sponsor
- Affiris AG
Alzheimer Dementia, Dementia Disorders
Medication Repurposing to Stop Cognitive Decline in Dementia
Dementia creates a great personal and societal burden and there are currently no treatments to stop memory loss. Many patients with dementia take medications to treat other conditions, e.g. high blood pressure and cholesterol.
- Trial name
- NCT05817188
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 100,000 people
- Sponsor
- Karolinska Institutet
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.