Clinical trials: Dementia Alzheimers
Neurodegenerative Disease, Dementia
Cognition and Affective Research in China
This is a prospective cohort study of patients with cognitive impairment mood disorders and behavioral disorders. Comprehensive baseline and longitudinal follow-up assessments include clinical and epidemiological data, cognitive…
- Conditions
- Neurodegenerative Disease, Dementia, Alzheimer's Disease, Parkinson's Disease
- Trial name
- CARE (NCT07833267)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Dementia
Technologies to Reduce Caregiver Burden for Informal Caregivers of People With Dementia
This randomized controlled trial aims to recruit a total of 320 dyads composed by persons with dementia living in community settings and their primary informal caregivers.
- Trial name
- TECH@HOME (NCT02733939)
- Testing
- Home monitoring kit
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Lund University
Dementia, Dysphagia
Interventions for Patients With Alzheimer's Disease and Dysphagia
The overall purpose of this project is to develop effective dysphagia rehabilitative interventions for patients with Alzheimer's Disease and related dementias at risk for pneumonia development.
- Conditions
- Dementia, Dysphagia, Alzheimer Disease
- Trial name
- NCT03682081
- Testing
- Isometric tongue strengthening facilitated by Iowa Oral Performance Instrument (IOPI), Biotene Oral Balance Gel
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease, Early Onset, Alzheimer Disease
A Safety Study of PTI-125 in Healthy Volunteers
A Phase I, Single Center, Randomized, Double-blind, Placebo-controlled, Single Ascending Dose, Pharmacokinetic and Safety Study of PTl-125 in Healthy Volunteers
- Trial name
- NCT03784300
- Testing
- 50 mg PTI-125, 100 mg PTI-125, 200 mg PTI-125
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pain Therapeutics
Alzheimer's Disease
Memantine and Validation of a New Alzheimer's Disease Scale
To validate a new Alzheimer's Disease scale against other rating tools in subjects with dementia of Alzheimer's type, treated with memantine.
- Trial name
- NCT00804271
- Testing
- memantine
- Where
- Germany
- Volunteers
- 487 people
- Sponsor
- Merz Pharmaceuticals GmbH
Neurodegenerative Diseases, Alzheimer Disease
[18F]MC225-PET in Neurodegenerative Disease
P-glycoprotein, an efflux transporter at the blood-brain barrier plays an important role in de development of neurodegenerative disease.
- Conditions
- Neurodegenerative Diseases, Alzheimer Disease, Parkinson Disease, Mild Cognitive Impairment
- Trial name
- NCT05853471
- Testing
- [18F]MC225
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Disseminated Sclerosis
A Monocenter, Cross-sectional Study to Compare Different Type of Cognitive Impairment in Multiple Sclerosis Patients and Cerebrospinal Fluid Biomarkers (Beta Amyloid, Total Tau Protein and Tau-phosphorylated Protein).
In multiple sclerosis (MS) sub cortical cognitive impairments are frequently reported. Nevertheless, cortical cognitive troubles, with hippocampic memory troubles have been described.
- Trial name
- BioCogS (NCT00978536)
- Testing
- Cognitive impairment of multiple sclerosis
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Nantes University Hospital
Dementia of the Alzheimer's Type
Long Term Extension Safety Study in Patients With Dementia of the Alzheimer's Type Who Completed Study CPC-001-07
This is a long-term-safety roll-over extension study for a Phase II Study (Protocol CPC-001-07).
- Trial name
- NCT02434666
- Testing
- CPC-201
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- Chase Pharmaceuticals Corporation, an affiliate of Allergan plc
Alzheimer Disease, Dementia
A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT)
The main goals of this study are to further determine whether the study drug donanemab is safe and effective in participants with Alzheimer's disease and to validate neuropsychological assessments administered over…
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT04640077
- Testing
- No Intervention, donanemab
- Where
- 27 sites in United States, Canada
- Volunteers
- 95 people
- Sponsor
- Eli Lilly and Company
Breast Cancer, Colorectal Cancer
Multicenter Prospective Cohort of Informal Caregivers in Burgundy and Franche-Comté
Medical progress and modification of lifestyles have prolonged life expectancy, despite the development of chronic diseases. The support and care are often provided by a network of informal caregivers composed of family, friends…
- Conditions
- Breast Cancer, Colorectal Cancer, Prostate Cancer, Alzheimer Disease
- Trial name
- ICE (NCT02626377)
- Testing
- Support provided by social worker, Information booklet receipt
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
MCI, Alzheimer's Disease
Usability of Virtual Reality in Subjects With Mild Cognitive Impairment or Alzheimer's Disease
Cognitive and memory problems characterize Alzheimer's disease (AD). Along with these disorders, psychological and behavioral symptoms (also known as neuropsychiatric symptoms) , as well as pathophysiological processes are…
- Trial name
- MeMO-RV2 (NCT02176629)
- Testing
- Condition virtual reality (VR) then Condition classic cognitive stimulation (CCS), Condition classic cognitive stimulation (CCS) then Condition virtual reality (VR)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Depression, Pain
Efficacy of Pain Treatment on Depression in Patients With Dementia
The purpose of this study is to determine whether pain treatment can reduce symptoms of depression in patients suffering from dementia and depression. Depression is commonly diagnosed in patients with dementia.
- Conditions
- Depression, Pain, Dementia
- Trial name
- DEP-PAIN-DEM (NCT02267057)
- Testing
- Paracetamol, Buprenorphine
- Where
- Norway
- Volunteers
- 163 people
- Sponsor
- University of Bergen
Mild Cognitive Impairment, Alzheimer Disease
Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Dementia
The purpose of this study is to investigate whether a blood pressure medication, spironolactone, can be tolerated by older African American adults that have memory and thinking problems, also called mild cognitive impairment…
- Trial name
- STAND (NCT04522739)
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Alzheimer's Disease
Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study
The purpose of this study is to evaluate the safety of administration and effects of valproic acid on clusterin expression in cognitively-intact, healthy, elderly subjects.
- Trial name
- VPA (NCT01729598)
- Testing
- Valproic Acid
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Gregory Jicha, 323-5550
Mild Cognitive Impairment, Alzheimer's Disease
Multi-modality MRI Study on Prediction for Mild Cognitive Impairment Conversion
The purpose of this study is to find the characteristics of mild cognitive impairment (MCI) using technology of Multi-Modality MRI , including structural MRI, functional MRI and diffusion tensor imaging(DTI).
- Trial name
- NCT02353884
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- XuanwuH 2
Alzheimer's Disease
A Study to Evaluate the Effects of Itraconazole on MK-1708 in Healthy Participants (MK-1708-003)
The goal of the study is to see what happens to levels of MK-1708 a person's body over time. Researchers will compare what happens to MK-1708 in the body when it is given with or without a medicine called itraconazole.
- Trial name
- NCT06586606
- Testing
- MK-1708, Itraconazole
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer Disease
A Study of 18F-AV-45 in Healthy Volunteers
This study will determine how florbetapir F 18 (18F-AV-45) radioactivity is distributed throughout the body.
- Trial name
- NCT01564706
- Testing
- florbetapir F 18
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Alzheimer's Disease
Study of Memantine in Assessment of Selected Measures of Volumetric Magnetic Resonance Imaging (MRI) and Cognition in Moderate AD (Alzheimer's Disease)
The purpose of this study is to characterize the progression of disease using volumetric MRI techniques and cognitive outcome measures in patients with moderate dementia of the Alzheimer's type treated with open-label memantine.
- Trial name
- NCT00334906
- Testing
- memantine HCl
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Forest Laboratories
Alzheimer's Disease, Blood Brain Barrier
Pilot Clinical Trial to Assess the Safety of NMS-01 in Patients With Mild to Moderate Alzheimer's Disease
A single-center, single-arm, prospective, open-label, pilot clinical trial to evaluate the safety and efficacy of the Focused ultrasound stimulator system (NMS-01) for transient Blood-Brain Barrier (BBB) opening in patients with…
- Trial name
- NMSBBBOYUSH01 (NCT07869238)
- Testing
- NMS-01
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Neumous Inc.
Polypharmacy, Alzheimer Disease and Related Dementias
Aligning Medications With What Matters Most
The Aligning Medications with What Matters Most (ALIGN) study will assess the feasibility and preliminary efficacy of a deprescribing intervention to reduce medication regimen complexity and treatment burden for people living…
- Trial name
- ALIGN (NCT04938648)
- Testing
- Pharmacist-led deprescribing intervention
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
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