Clinical trials: Dementia Alzheimers
Agitation, Alzheimer's Disease
Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of Agitation in Participants With Alzheimer's Disease
The objectives of the study are to evaluate the safety, tolerability and efficacy of AVP-923 compared to placebo, for the treatment of symptoms of agitation in participants with Alzheimer's Disease (AD).
- Trial name
- NCT01584440
- Testing
- AVP-923-20, AVP-923-30
- Where
- 44 sites in United States
- Volunteers
- 220 people
- Sponsor
- Avanir Pharmaceuticals
Fall in Nursing Home
Autonomous Navigating Robot for Detecting Falls and Risk of Falls in Nursing Home Residents With Alzheimer Disease/ADRD - Feasibility Study
This study is a feasibility study to prove that an autonomously navigating robot can patrol nursing home rooms day and night and detect if a resident has fallen, turn on ambient light at night and a video camera and allow nursing…
- Trial name
- NCT07451223
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vigorous Mind, Inc.
Dementia, Agitation in Dementia, Including Alzheimer's Disease
Enhancing Calm in Arab Elderly With Dementia
The goal of this clinical trial is to evaluate the effectiveness of integrating Snoezelen methods with aromatherapy and personal items in reducing agitation in Arab elderly individuals with dementia.
- Trial name
- sn/dm (NCT06216275)
- Testing
- Integrated Snoezelen-Aromatherapy-Personal Item Therapy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mostafa Shaban
Down Syndrome, Alzheimer Disease
Cohort Study of Adult Patients With Down Syndrome at Risk of Developing Alzheimer's Disease (TriAL21)
TriAL21 study is an interventional, open, one arm, prospective, national and single center study. A total of 200 patients with Down syndrome, aged 35 years and over, without diagnosis of Alzheimer's disease will be enrolled into…
- Trial name
- NCT03901261
- Testing
- Neuro-imaging, Lumbar puncture
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Institut Jerome Lejeune
Alzheimer's Disease
Brain Characterization of Amyloid Protein and Glucose Metabolism of ALFA Project Participants
Study to understand factors related with the preclinical stages of Alzheimer's Disease and investigate markers that predict its progression.
- Trial name
- NCT02685969
- Testing
- 18F-Flutemetamol & 18F-FDG
- Where
- Spain
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Alzheimer Disease
Gamma-Music Based Intervention for Mild Alzheimer's Disease
The study will test and refine a novel brain-stimulation tool using gamma-frequency lights coupled with self-selected music for a gamma-music-based intervention for participants with mild Alzheimer's Disease.
- Trial name
- NUGammaMBI (NCT05984524)
- Testing
- Gamma-Music Based Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Alzheimer's Disease, Mild Cognitive Impairment
Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dementia/Mild Cognitive Impairment
This study aims to determine whether levodopa is effective in boosting learning and memory in healthy subjects and patients with dementia or Mild Cognitive Impairment.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Healthy
- Trial name
- NCT00306124
- Testing
- Levodopa
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Alzheimer Disease, Mild Cognitive Impairment
Biodistribution of [11C]PIB in Patients With Risk Factors for Alzheimer's Disease
Participants enrolled at the Alzheimer's Disease Research Center (ADRC) at Wake Forest School of Medicine will be invited to take part in this study.
- Trial name
- NCT03089827
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment, Alzheimer Dementia
Innate Immunity Stimulation Via TLR9 in Early AD
This single-center, double-blind, placebo-controlled study will recruit in total 39 participants with either Mild Cognitive Impairment due to Alzheimer's disease (MCI) or Mild Alzheimer's disease dementia (mild AD).
- Trial name
- NCT05606341
- Testing
- CpG1018
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- NYU Langone Health
Chronic Pain, Depression, Anxiety
Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain
The purpose of this research study is to refine customized in-app notifications in order to optimize users' experience with a mobile app called Wysa for Chronic Pain.
- Trial name
- NCT06978166
- Testing
- Just-In-Time Adaptive Interventions (JITAIs), Wysa for Chronic Pain
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Washington University School of Medicine
MCI, Mild Cognitive Impairment
The Interactive Physical and Cognitive Exercise System (v3) for Mild Cognitive Impairment (MCI)
The primary purpose of this study is to attempt to replicate and extend promising pilot findings regarding the cognitive benefits of in-home neuro-exergaming with iPACES (interactive Physical and Cognitive Exercise System v3) for…
- Conditions
- MCI, Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- iPACES (NCT05009524)
- Testing
- iPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- iPACES LLC
Alzheimer's Disease, Impaired Cognition
Predictive Value of Cognitive Tests Performed for the Diagnosis of Alzheimer's Disease and Related Disorders
The purpose of this study is to determine the predictive value of standardized cognitive tests performed in health examination centres for the diagnosis of Alzheimer's disease and related disorders among adults aged 65 years and…
- Conditions
- Alzheimer's Disease, Impaired Cognition, Memory Disorders
- Trial name
- EVATEM (NCT01316562)
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Mild CognitIve Impairment, Alzheimer's Disease
Effects of Exercise Training in Patients With Mild Cognitive Impairment and Early Alzheimer's Disease
The purposes of this study are: 1. To investigate whether a 3-month exercise training program would improve cognitive function, motor performance, integrity of brain fiber tracts and cerebral blood flow; 2.
- Trial name
- NCT02119546
- Testing
- Aerobic exercise, Stretch exercise
- Where
- Taiwan
- Volunteers
- 19 people
- Sponsor
- National Taiwan University Hospital
Alzheimer Disease
An Evaluation of Three Doses of NS 2330 in Patients With Mild to Moderate Dementia of the Alzheimer's Type
Objectives: The objective of this study will be to determine the safety, tolerability, drug blood levels, and efficacy of each of three doses of NS 2330 (Tesofensine) given once daily compared with placebo in patients with mild…
- Trial name
- NCT00153010
- Testing
- NS 2330 (Tesofensine)
- Where
- 87 sites in United States, Canada
- Volunteers
- 430 people
- Sponsor
- Boehringer Ingelheim
Alzheimer Disease
Study Evaluating The Efficacy And Safety Of Bapineuzumab In Alzheimer Disease Patients
This is a study to evaluate the efficacy and safety of multiple doses of bapineuzumab in patients with mild to moderate Alzheimer Disease. Patients will receive either bapineuzumab or placebo.
- Trial name
- NCT00667810
- Testing
- bapineuzumab
- Where
- 346 sites in United States, Argentina and 24 more
- Volunteers
- 901 people
- Sponsor
- Pfizer
Alzheimer Disease
Risk Evaluation and Education for Alzheimer's Disease (REVEAL) II
The REVEAL II study provides healthy adult children and siblings of Alzheimer's disease patients with genetic testing and information about their own chances of developing the disease.
- Trial name
- NCT00089882
- Testing
- APOE Genetic susceptibility testing
- Where
- 4 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Dementia, Dementia, Mixed
Uppsala-Dalarna Dementia and Gait Project
UDDGait™ is a multidisciplinary research project with the overreaching goal of providing an aid for early identification of cognitive impairment and risk of dementia development, thereby providing a basis for adequate symptom…
- Conditions
- Dementia, Dementia, Mixed, Dementia Senile, Dementia of Alzheimer Type
- Trial name
- UDDGait™ (NCT05893524)
- Testing
- Timed Up-and-Go (TUG single-task), Timed Up-and-Go dual-task (TUGdt), Clinical functional assessment
- Where
- 2 sites in Sweden
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Dalarna University
Alzheimer's Disease
ALADDIN Study - Phase III: Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation (VP-AD-301)
The study is designed to investigate the activity of the hormone drug leuprolide acetate in stabilizing cognitive function in mild-to-moderate AD patients.
- Trial name
- NCT00231946
- Testing
- VP4896
- Where
- 59 sites in United States, Canada
- Volunteers
- 555 people
- Sponsor
- Voyager Pharmaceutical Corporation
Alzheimer Disease
Targeting zDHHC Enzymes to Counteract Alzheimer's Disease
Alzheimer's disease (AD) is a growing problem for aging populations worldwide and represents one of the most demanding challenges for biomedical and pharmacological research.
- Trial name
- zTARGETAD (NCT06677632)
- Testing
- Palmitoylation Enzyme Expression Profiling Study
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Alzheimer Disease
A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD
This is a Phase 2A multi-center, randomized, double blind, placebo-controlled, parallel group study of varoglutamstat, with a stage gate to Phase 2B.
- Trial name
- VIVA-MIND (NCT03919162)
- Testing
- PQ912
- Where
- 22 sites in United States
- Volunteers
- 112 people
- Sponsor
- Vivoryon Therapeutics N.V.
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