Clinical trials: Dementia Alzheimers
Alzheimer's Disease
Safety and Pharmacodynamics of SHR-1707 in Alzheimer's Disease Patients
Evaluate the Safety, Tolerability and Pharmacodynamics of Intravenous Administration of SHR-1707 In Patients with Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease.
- Trial name
- NCT06199037
- Testing
- SHR-1707
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai Hengrui Pharmaceutical Co., Ltd.
Alzheimer Disease, Early Onset
Efficacy and Safety of AD-35 in Treatment of Subjects With Mild to Moderate Alzheimer's Disease
multi-center, randomized, double-blind, parallel-group,placebo-controlled study to evaluate the safety and tolerability, efficacy, and PK of 60 mg AD-35 administered QD during 6 months of double-blind treatment followed by a…
- Trial name
- ROAD (NCT03625401)
- Testing
- AD-35 60mg group
- Where
- 10 sites in United States
- Volunteers
- 55 people
- Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
Alzheimer's Disease
CALM-AD
Primary Aim To determine whether; Donepezil is significantly better than placebo in the management of agitation in Alzheimer's Disease that has not responded to, or is inappropriate for a standardised brief psychosocial treatment…
- Trial name
- NCT00142324
- Testing
- Donepezil
- Where
- 8 sites in United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Institute of Psychiatry, London
Lewy Bodies Disease, Alzheimer Disease
Diagnostic Evaluation of Dementia with Lewy Bodies Using a Multimodal Approach
Dementia with Lewy body disease (DLB) is the second leading cause of degenerative cognitive disorder after Alzheimer's disease (AD). Its variable clinical expression makes diagnosis difficult.
- Conditions
- Lewy Bodies Disease, Alzheimer Disease, Cognitive Impairment
- Trial name
- EEG-EDELY (NCT06068361)
- Testing
- EEG
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer Disease
Novel Personalized Non Invasive Combined Magnetic and Electrical Stimulation of the DMN in Mild AD Patients
Alzheimer's disease (AD) is increasingly recognized as a disorder marked by early synaptic dysfunction and disrupted brain network connectivity, beyond the traditional focus on amyloid pathology.
- Trial name
- CMES_AD (NCT07075770)
- Testing
- Combined iTBS-tACS
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Alzheimer's Disease
A Study Evaluating the Efficacy and Safety of Crenezumab Versus Placebo in Participants With Prodromal to Mild Alzheimer's Disease (AD).
This randomized, double-blind, placebo-controlled, parallel group study will evaluate the efficacy and safety of crenezumab versus placebo in participants with prodromal to mild AD.
- Trial name
- CREAD (NCT02670083)
- Testing
- Crenezumab
- Where
- 196 sites in United States, Australia and 28 more
- Volunteers
- 813 people
- Sponsor
- Hoffmann-La Roche
Dementia, Cognitive Decline
Ammonia Levels and Cognitive Impairment
The purpose and objective of this study is to determine the prevalence of elevated ammonia levels in subjects with cognitive impairment, and to observe if treating the cause of the elevated ammonia level improves mental status.
- Conditions
- Dementia, Cognitive Decline, Cognitive Impairment, Developmental Delay
- Trial name
- NCT02059356
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Alzheimer's Disease
A Confirmatory Trial of SK-PC-B70M in Mild to Moderate Alzheimer's Disease
The purpose of this study is to evaluate the efficacy and safety of SK-PC-B70M in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT01249196
- Testing
- SK-PC-B70M
- Where
- South Korea
- Volunteers
- 256 people
- Sponsor
- SK Chemicals Co., Ltd.
Dementia, Alzheimer Disease
DECIDE: Dyads and Families
The purpose of this study is to design and test a decision-making program that is tailored to support adult daughters making healthcare decisions for their parents who are living with memory loss to improve the quality of life of…
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burden
- Trial name
- NCT05139290
- Testing
- Prototype Intervention
- Where
- 4 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Mild Alzheimer's Disease
WeArable Neuromodulation DeVice for the TrEatment of Alzheimer's Disease
This is a double- blind, randomized controlled trial with an open label extension designed to evaluate the safety and potential efficacy of a non-invasive brainstem neuromodulation device for treating symptoms associated with…
- Trial name
- WAVE-AD (NCT05032482)
- Testing
- Non-invasive brainstem stimulation
- Where
- 5 sites in United States
- Sponsor
- Scion NeuroStim
Alzheimer Disease, Frontotemporal Dementia
Tanycytes in Alzheimer's Disease and Frontotemporal Dementia
Metabolic and hormonal deregulations are both a risk factor and a hallmark of Alzheimer's disease (AD) and frontotemporal dementia (FTD), occurring early in the course of the disease.
- Trial name
- BIOWATCH (NCT05288842)
- Testing
- Lumbar puncture, blood sample
- Where
- France
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Patients Aged 65-85 (Both Included), Diagnosed of Mild Cognitive Impairment
Diabetes as an Accelerator of Cognitive Impairment and Alzheimer's Disease
This randomized controlled trial is aimed at studying the effects of an eHealth intervention on improving metabolic control and other cardiovascular risk factors (obesity, lipidic profile and hypertension) as the approach to…
- Conditions
- Patients Aged 65-85 (Both Included), Diagnosed of Mild Cognitive Impairment, Diagnosed of Type 2 Diabetes in Active Treatment (Hypoglycemic Agents) for a Period ≥5 Years
- Trial name
- DIALCAT (NCT03578991)
- Testing
- Smart pillbox, Interactive digital platform
- Where
- 8 sites in Spain
- Volunteers
- 54 people
- Sponsor
- Parc Sanitari Pere Virgili
Cerebral Small Vessel Diseases, Stroke, Lacunar
LACunar Intervention (LACI-2) Trial-2
About 35,000 people each year in the UK have a type of stroke, called 'lacunar' or 'small vessel' stroke, which is different to other common types of stroke and for which there is no proven treatment.
- Trial name
- LACI-2 (NCT03451591)
- Testing
- Isosorbide Mononitrate XL (ISMN), Cilostazol, ISMN XL and Cilostazol
- Where
- United Kingdom
- Volunteers
- 363 people
- Sponsor
- University of Edinburgh
Alzheimer Disease, Dementia
The Retain Your Brain Health Study (RetainYourBrain.com)
The goal of this clinical trial is to test a cell phone-based online program that provides Alzheimer's risk assessments and memory tests over a 6-month period.
- Conditions
- Alzheimer Disease, Dementia, Healthy Participants, Brain Health
- Trial name
- NCT06027320
- Testing
- Brain Health Education, Alzheimer Disease Education
- Where
- United States
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- Retain Health, Inc
Alzheimer's Disease
TNF-Alpha Inhibition for Treatment of Alzheimer's Disease
It is widely believed that inflammation contributes to the pathogenesis of AD. TNF has been implicated in both AD and neurological inflammation. Anti-TNF therapy is therefore surmised to be of potential benefit for treating AD.
- Trial name
- NCT00203359
- Testing
- etanercept given by perispinal administration
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Tobinick, Edward Lewis, M.D.
Pain, Alzheimer Disease
Auricular Point Acupressure to Manage Pain in Patients With Alzheimer's Disease and Related Disorders
Pain is considered as one of the most important causal factors of behavioral and psychological symptoms in patients Alzheimer's disease and related disorders (ADRD).
- Trial name
- NCT03393546
- Testing
- Auricular Point Acupressure
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University
Alzheimer's Disease, Huntington's Disease
A Study Evaluating The Absorption Of Dimebon Into The Body From A Dimebon Solution Applied To The Skin
To estimate the absorption, safety, and tolerability of a dimebon transdermal solution relative to the dimebon immediate release oral formulation.
- Trial name
- NCT00990613
- Testing
- Dimebon IR, Dimebon Transdermal
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Pfizer
Dementia, Dysphagia
Family Caregiver Online Survey (Dementia and Swallowing Difficulties)
The Family Caregiver Survey is a one-time, 30-minute, online survey for people living with and caring for a family member with dementia.
- Conditions
- Dementia, Dysphagia, Dementia Alzheimers, Dementia, Vascular
- Trial name
- NCT06471660
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Alzheimer Type Dementia
Efficacy and Safety of DMB-I (INN: Latrepirdine) in Patients With Alzheimer Type Dementia
The goal of this clinical study is to learn if the study drug DMB-I (INN: Latrepirdine) works to treat Alzheimer type dementia in adults. It will also learn about the safety of DMB-I (INN: Latrepirdine).
- Trial name
- NCT07251023
- Testing
- DMB-I (INN: Latrepirdine), Memantine Hydrochloride 20 MG
- Where
- 12 sites in Russia
- Volunteers
- 450 people
- Sponsor
- Bigespas LTD
Alzheimer Disease
A Multiple Ascending Dose Study of COR388
The study is a randomized, double-blind, placebo-controlled, multiple ascending dose study to assess the safety and tolerability of ascending repeat doses of COR388 HCl in older healthy male and female subjects and a cohort of…
- Trial name
- NCT03418688
- Testing
- COR388
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Cortexyme Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.