Clinical trials: Dementia Disorders
Apathy, Alzheimer's Dementia
Repetitive Transcranial Magnetic Stimulation for Apathy in Alzheimer's Dementia
Alzheimer's Dementia (AD) is a major public health problem. Apathy, a profound loss of motivation, is seen in majority of patients with AD.
- Trial name
- NCT02190084
- Testing
- Neurostar repetitive transcranial magnetic stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Central Arkansas Veterans Healthcare System
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University
Alzheimer's Disease
The Role of Mid-Life Adiposity in Functional Brain Connectivity
The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat.
- Trial name
- NCT01777789
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Parkinson's Disease, Apathy
Study of Rivastigmine to Treat Parkinsonian Apathy Without Dementia
Apathy usually refers to a set of behavioural, emotional and cognitive features as a reduced interest and participation in main activities of daily life, a lack of initiative, a trend toward an early withdrawal from started…
- Conditions
- Parkinson's Disease, Apathy, no Dementia
- Trial name
- CHoPA-I (NCT00767091)
- Testing
- rivastigmine
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Alzheimer Disease, Preclinical Alzheimer's Disease
Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - FUTURE Extension
The primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech, can predict change in Preclinical Alzheimer's Clinical Composite with semantic processing (PACC5)…
- Conditions
- Alzheimer Disease, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer's Disease (Incl Subtypes)
- Trial name
- FUTURE-US (NCT04951284)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Alzheimer's Disease
A Pilot Study of Curcumin and Ginkgo for Treating Alzheimer's Disease
The purpose of this study is to develop procedures for testing the effectiveness of curcumin on slowing Alzheimer's disease (AD) progression.
- Trial name
- NCT00164749
- Testing
- Curcumin and ginkgo extract
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- Chinese University of Hong Kong
Major Depressive Disorder
Research on Pathophysiology and Treatment in Depression Using Brain Derived Neurotrophic Factor and Amyloid Neuroimaging
Target of the research Based on change of Brain-derived neurotrophic factor and other pro-inflammatory cytokine along with symptom improvement following treatment, the investigators are trying to find the new treatment target…
- Trial name
- NCT02983838
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease
Assessing Clinical Outcomes in Alzheimer's Disease Agitation
This is a multi-center, double-blind, placebo-controlled, randomized withdrawal study to evaluate the efficacy and safety of AXS-05 compared to placebo in the treatment of agitation symptoms in subjects with agitation associated…
- Conditions
- Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation,Psychomotor
- Trial name
- ACCORD (NCT04797715)
- Testing
- AXS-05
- Where
- 63 sites in United States, Canada
- Volunteers
- 178 people
- Sponsor
- Axsome Therapeutics, Inc.
Alzheimer Disease, Mild Cognitive Impairment (MCI)
Alzheimer's Disease Research Center (ADRC) PET Component Study
The purpose of this study is to further engage and characterize Alzheimer's Disease Research Center (ADRC) participants through additional research opportunities, particularly PET imaging.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- ADRC PET (NCT07758660)
- Testing
- 18F-MK6240, 18F-Florbetaben (FBB)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Patrick Lao
Hearing Loss, Mild Cognitive Impairment
OTC Hearing Aid and MCI
The goal of this study is to better understand if, in patients with mild to moderate hearing loss who are also experiencing mild cognitive impairment (MCI) or Alzheimer's disease and related dementias (ADRD), Over-the-Counter…
- Conditions
- Hearing Loss, Mild Cognitive Impairment, Alzheimer Disease and Related Dementias (ADRD)
- Trial name
- NCT06112860
- Testing
- Over the counter hearing aid, Communication Strategies Information/Counseling
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Northwestern University
Alzheimer's Disease
A Postmarketing Study of LEQEMBI in South Korean Participants With Alzheimer's Disease
The primary purpose of this study is to evaluate safety of LEQEMBI in the real-world clinical setting as reported by events of amyloid-related imaging abnormalities (ARIA)-edema (ARIA-E), ARIA-hemosiderin deposition (ARIA-H)…
- Trial name
- NCT06810960
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Eisai Korea Inc.
Type 2 Diabetes
The Effect of Exercise on the Brain in Type 2 Diabetes
The goal of this clinical trial is to learn if exercise training of high or moderate intensity is most optimal to improve brain health and prevent neurodegeneration in type 2 diabetes patients.
- Trial name
- SAINT (NCT06734546)
- Testing
- Exercise intervention
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- Hasselt University
Alzheimer's Disease
Randomized, Double-blind Study to Evaluate the Tolerability of 2 Different Titration Methods of Rivastigmine Patch in AD Patients (MMSE 10-20)
To evaluate the tolerability, safety and efficacy of 3-step titration versus 1-step titration of Rivastigmine patch in the Japanese population.
- Trial name
- NCT01614886
- Testing
- Active Comparator, ENA713
- Where
- 50 sites in Japan
- Volunteers
- 216 people
- Sponsor
- Novartis Pharmaceuticals
Dementia, Prisoners
Computer-Based Learning to Enhance Dementia Care in Prison
The mission of corrections is to provide care, custody, and control for incarcerated individuals. United States prisons are required by law to provide adequate care for growing numbers of older people who are incarcerated-a group…
- Trial name
- NCT05497882
- Testing
- E-Learning Prototype for Dementia Care
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Alzheimer Disease, Positron Emission Tomography
Establishment of the Chinese Preclinical Alzheimer's Disease Study With Multiple Neuroimaging
The goal of this observational study is to investigate neuroimage and biomarkers in the Alzheimer's continuum in Chinese population.
- Trial name
- NCT06827678
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Alcohol Use Disorder, Heavy Drinking
Online Insomnia Intervention to Reduce Alcohol Use
Alcohol use disorder (AUD) inflicts enormous physical, emotional, and financial burdens on the individual and society at large. Insomnia is highly prevalent among individuals with AUD, and disrupted sleep contributes…
- Trial name
- NCT05630118
- Testing
- SHUTi Intervention, Web-Based Insomnia Education Program
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Jessica Weafer
Dementia, Family Caregivers
Group-based Acceptance and Commitment Therapy for Family Caregivers of People With Dementia in Japan
Along with more people worldwide having dementia, the number of people with dementia and their family caregivers have increased in Japan.
- Trial name
- NCT04898413
- Testing
- Group-based acceptance and commitment therapy (ACT), Group-based cognitive behavioral therapy (CBT)
- Where
- Japan
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Meiji Gakuin University
Alzheimer's Disease
Specific Care and Assistance Plan for Alzheimer's Disease
The main objective of this work is to assess the feasibility and efficacy of a specific Care and Assistance Plan for Alzheimer's disease (PLASA).
- Trial name
- PLASA (NCT00480220)
- Testing
- Global care and support program
- Where
- 40 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Toulouse
Cardiovascular (CV) Risk, Preeclampsia (PE)
Cardiovascular Risk Assessment in Young Women After Index Pregnancy With and Without Placental Complications
In this project, the investigators aim to study how all these factors determine the cardiovascular status of a total of 1,800 mothers, 3 to 6 years after delivery.
- Conditions
- Cardiovascular (CV) Risk, Preeclampsia (PE), Fetal Weight
- Trial name
- CARDIOMOM (NCT07356817)
- Where
- Spain
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Nursing Caries
Culture-Based Multicomponent Cognitive Training Program
To provide care without exacerbating behavioral and psychological problems and preventing functional decline, a multi-component, cognitive training program was designed.
- Trial name
- NCT06090188
- Testing
- A Culture-Based Multicomponent Cognitive Training Program
- Where
- 4 sites in Taiwan
- Volunteers
- 56 people
- Sponsor
- National Tainan Junior College of Nursing