Clinical trials: Dementia MCI (Mild Cognitive Impairment)
Alzheimer Disease, Mild Cognitive Impairment
Orientation in AD Patients: PET-MR Study
Despite the high prevalence of Alzheimer's disease (AD), its underlying mechanisms remain poorly understood. An emerging body of evidence supports disorientation as an early marker for AD-related neurodegeneration.
- Trial name
- NCT03030365
- Testing
- Siemens "Biograph mMR" PET-MR (3T)
- Volunteers
- 30 people
- Sponsor
- Assuta Medical Center
Subjective Cognitive Decline, Alzheimer Dementia
Davos Alzheimer's Collaborative Healthcare System Preparedness to Increase Cognitive Assessment Rates for Older Adults
In this study the investigators explore a pragmatic strategy to increase cognitive screening rates in the community. The investigators will compare the monetary value of different combinations of SCD questionnaires, digital…
- Trial name
- NCT06191952
- Testing
- Cognigram, Subjective cognitive decline questionnaire (SCD-Q), blood-based biomarkers
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Alzheimer Disease, Amyloid Angiopathy
Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study
To compare alternation of retinal microcirculation within the macula and optic disc in patients with dementia, mild cognitive impairment (MCI), and cognitively healthy subjects who had positive amyloid biomarkers (Aβ +) or not…
- Conditions
- Alzheimer Disease, Amyloid Angiopathy, Macular Ischemia, Dementia
- Trial name
- NCT05475158
- Where
- South Korea
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic
Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI
The goal of this clinical trial is to determine whether acoustic stimulation during sleep can enhance slow-wave sleep (SWS), improve cognitive function, and reduce AD-related pathology in individuals with mild cognitive…
- Conditions
- Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic, Cognitively Unimpaired
- Trial name
- PAS-MCI (NCT07529015)
- Testing
- Plase-Locked Acoustic Stimulation during slow-wave sleep
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Mild Cognitive Impairment, Mild Dementia
Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease
This study is a multicentre, randomized, double-blind, controlled trial that aims to investigate the efficacy of multi-domain life-style intervention including low inflammatory-index diet, exercise, and cognitive training in…
- Trial name
- SIM-2 (NCT05887674)
- Testing
- Diet intervention, Exercise, Cognitive training
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ruijin Hospital
Dementia, Alzheimer Disease
A Longitudinal Multidimensional Population Study on Brain Aging
Longitudinal observational study of cognitive functions, physical health and biological parameters in the whole population living in Abbiategrasso born between 1935 and 1939,1773 subjects, followed for six years in order to know…
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- InveCeAb (NCT01345110)
- Where
- Italy
- Volunteers
- 1,321 people
- Sponsor
- Fondazione Golgi Cenci
Alzheimer's Disease, Mild Cognitive Impairment
Cognition Platform Study in Participants at Risk for Alzheimer's Disease (AD) (MK-0000-413)
The main purpose of this study is to assess the ability of a repeated high-frequency site-based computerized cognitive assessment to evaluate the potential treatment effects of donepezil (MK-0000) compared with placebo among…
- Trial name
- NCT04730635
- Testing
- Donepezil
- Where
- 10 sites in United States, Australia
- Volunteers
- 44 people
- Sponsor
- Merck Sharp & Dohme LLC
Early Alzheimers Disease, Mild Cognitive Impairment Due to AD
A Study to Evaluate Safety and Tolerability of Different Doses and Efficacy of PQ912 in Subjects With MCI and Mild AD
This is a phase 2B multicenter, randomized, double-blind, placebo-controlled, parallel group dose finding study to evaluate the safety, tolerability and efficacy of PQ912, an inhibitor of the glutaminyl cyclase enzyme, in 250…
- Trial name
- VIVIAD (NCT04498650)
- Testing
- PQ912
- Where
- 21 sites in Denmark, Germany and 3 more
- Volunteers
- 259 people
- Sponsor
- Vivoryon Therapeutics N.V.
Dementia of Alzheimer Type, Alzheimer Disease, Late Onset
Genetic Studies in Familial Dementia
The purpose of this study is to identify genetic factors that contribute to or cause dementia (loss of memory) and related disorders across all ages and ethnic groups.
- Conditions
- Dementia of Alzheimer Type, Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Mild Cognitive Impairment
- Trial name
- NCT04680013
- Where
- United States
- Volunteers
- 4,884 people, healthy volunteers welcome
- Sponsor
- University of Miami
Neurodegenerative Diseases, Parkinson Disease
Saliva and Extracellular Vesicles for Neurodegenerative Diseases
Early diagnosis of Neurodegenerative diseases (NDDs) and accurate patient profiling are key goals needed to tailor prompt personalized therapeutic strategies that can significantly impact disease progression and patients' quality…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Alzheimer Disease, Parkinsonism
- Trial name
- MINERVA (NCT06869135)
- Testing
- Saliva collection, longitudinal
- Where
- 5 sites in Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
Alzheimer Disease, Mild Cognitive Impairment
tDCS and Cognitive Training for Mild Cognitive Impairment and Alzheimer's Dementia
There are currently no disease-modifying treatments for cognitive and behavioral symptoms associated with early clinical Alzheimer's disease (AD), and only minimally effective symptomatic treatments are available.
- Trial name
- NCT04507815
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Alzheimer Disease, Mild Cognitive Impairment (MCI)
Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
This early phase, open label, single arm clinical trial will determine the intraindividual safety, tolerability and effects of NPC1 (parthenolide and ipriflavone) on blood-based biomarkers of Alzheimer's disease (AD) pathology…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- NPC1-AD (NCT07236190)
- Testing
- natural product combination-1 (NPC1)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Alzheimer Dementia (AD), Elderly
Therapy of Alzheimer's Disease With Neurofeedback
The project aims to investigate in patients of Alzheimer's disease in a prodromal state (early state of the disease) compared to healthy subjects whether neurofeedback training with functional MRI (fMRI) can improve cognitive…
- Trial name
- NCT03070821
- Testing
- rtfMRI neurofeedback training, 3T MRI
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Aachen
Mild Cognitive Impairment, Mild Dementia
Combined Cognitive and Physical Exercises Through Computer Games in Elderly: The LLM Project
The study involved Information and Communication Technologies (ICT) and more specifically computer exercises blended with game activities.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Healthy
- Trial name
- LLM (NCT02267499)
- Testing
- LLM training
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Alzheimer Disease, Mild Cognitive Impairment
Tau Imaging With JNJ067
This protocol is designed to assess the utility of a new positron emission tomography (PET) radiopharmaceutical to image tau, [18F] JNJ067, invented by Janssen Pharmaceutical companies of Johnson \& Johnson.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Progressive Supranuclear Palsy
- Trial name
- NCT03926702
- Testing
- Radiopharmaceuticals
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Mild Cognitive Impairment, Mild Dementia
Assessing Cognitive Decline at Home
Neuropsychiatric symptoms (NPS) refer to a range of mental and emotional issues that can be observed through how patients move, perform daily tasks, and express feelings on their faces.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Dementia Alzheimers, Dementia
- Trial name
- NCT06704971
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stanford University
Alzheimer's Disease, Mild Cognitive Impairment
System-IGF-1 Pathway and Alzheimer's Disease
The aim is to assess the relationship between levels of IGF-I system components and cognitive status in patients with Alzheimer's disease (AD), in elderly subjects with normal cognitive function, and in patients with mild…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Cognitive Function 1, Social, Control With Normal Activities of Daily Living
- Trial name
- SIGAL (NCT00647478)
- Where
- France
- Volunteers
- 693 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer Disease, Insomnia Disorder
Daridorexant to Treat Insomnia in Patients With Mild Cognitive Impairment and Mild to Moderate Alzheimer Disease
DARIDOR-ALZ is a phase IV clinical trial designed to evaluate both the efficacy and safety of daridorexant, a selective dual orexin receptor antagonist that blocks the actions of the orexin neuropeptides at both orexin-1 and…
- Conditions
- Alzheimer Disease, Insomnia Disorder, Sleep
- Trial name
- DARIDOR-ALZ (NCT05924425)
- Testing
- Daridorexant 50 mg, Polysomnography, Neuropsychological assessment
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Montpellier
Mild Cognitive Impairment
Low-intensity Physical-cognitive Exercise and Cognitive Function
This study aims to examine the effects of low-intensity, combined physical-cognitive exercise on cognitive function of older people with mild cognitive impairment (MCI) and identify the mechanisms by which this exercise protocol…
- Trial name
- NCT06201533
- Testing
- combined physical-cognitive exercise
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Chiang Mai University