Clinical trials: Dementia Prevention
Alzheimer Disease, Dementia
Follow-up Study of the Alzheimer's Disease Anti-Inflammatory Prevention Trial
The Alzheimer's Disease Anti-inflammatory Prevention Trial - Follow-up Study (ADAPT-FS) will continue observations of the declared primary outcomes of the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT) in the…
- Trial name
- ADAPT-FS (NCT01417130)
- Where
- 6 sites in United States
- Volunteers
- 1,650 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Memory Disorders, Alzheimer's Disease
Prevention of Cognitive Decline in Alzheimer's Disease by Ingested Interferon Alpha
In this phase I-II parallel design, randomized, double-blind clinical trial we will determine if 3,000 or 30,000 units ingested hrIFN-a prevents deterioration of cognitive functioning in patients with dementia of Alzheimer's type…
- Trial name
- NCT00031018
- Testing
- Aricept, IFN-alpha2A
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Agitation
Transbucal Dexmedetomidine for Prevention of Sevoflurane Emergence Agitation in Pre-school Children
The aim of this study is to evaluate the efficacy of transbucal dexmedetomidine given in preschool children undergoing tonsillectomy operations in the prevention sevoflurane agitation.
- Trial name
- NCT02720705
- Testing
- Dexmedetomidine, saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Dementia Prevention, Mild Cognitive Impairment
Brain Health Support Program
The Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP, or CTU) is a comprehensive and innovative program aimed to develop, implement and evaluate an interactive and compelling…
- Conditions
- Dementia Prevention, Mild Cognitive Impairment, Subjective Cognitive Impairment, Cognitive Change
- Trial name
- CTU: BHSP (NCT05347966)
- Testing
- Brain Health PRO
- Where
- 7 sites in Canada
- Volunteers
- 354 people
- Sponsor
- Baycrest
Diabetic Retinopathy (DR), Age-related Macular Degeneration (AMD)
Photobiomodulation & Ketogenic Diet for Treatment of Mid-periphery Retinal Disorders for Alzheimer's Disease Prevention
The study will explore the impact of photobiomodulation (PBM), pulsating at frequencies of red (660nm) and near-infrared (810nm)(NIR), concurrent with a ketogenic dietary protocol (serum ketones @ .5 - 2.0 mmol/L) to mediate…
- Conditions
- Diabetic Retinopathy (DR), Age-related Macular Degeneration (AMD), Mid-peripheral Drusen Formation, Diabetic Macular Edema (DME)
- Trial name
- NCT03859245
- Testing
- Photobiomodulation, Ketogenic diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristlecone Health, Inc.
Alzheimer's Disease
Early Identification of Markers in Alzheimer's Families / ALFA
The ALFA study is a long term, prospective, observational study of AD patients' adult children aimed at studying and characterizing key physio-pathological features of the preclinical phase of AD.
- Trial name
- ALFA Cohort (NCT02485730)
- Where
- Spain
- Volunteers
- 419 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Cognitive Decline, Dementia Risk Factors
GOIZ ZAINDU Feasibility Multi Domain Trial to Prevent Dementia.
GOIZ ZAINDU ("caring early" in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) methodology to the Basque population and evaluate feasibility and…
- Conditions
- Cognitive Decline, Dementia Risk Factors, Prevention, Multidomain Intervention
- Trial name
- GOIZ_ZAINDU (NCT06163716)
- Testing
- Multidomain intervention (MD-Int) group
- Where
- Spain
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Fundacion CITA-alzheimer
Alzheimer Disease, Cognitive Decline
Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
Alzheimer's disease (AD) neuropathology is characterized by deposits of insoluble amyloid β-peptide (Aβ) in extracellular plaques and aggregated tau protein, which is found largely in the intracellular neurofibrillary tangles.
- Trial name
- (PENSA) (NCT03978052)
- Testing
- EGCG, Healthy lifestyle recommendations, Multimodal lifestyle intervention
- Where
- 2 sites in Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Diabetes Mellitus, Congestive Heart Failure
Relative Impacts on Preventative Primary Care--a Longitudinal Evaluation of COVID-19:Phase 1
The goal of this observational study is to describe the impacts of COVID-19 on primary care chronic condition management in Canada within various patient populations.
- Conditions
- Diabetes Mellitus, Congestive Heart Failure, Chronic Kidney Diseases, Chronic Obstructive Pulmonary Disease
- Trial name
- RIPPLE-C (NCT05813652)
- Testing
- Pre-pandemic time period (Jun 22, 2018 to March 12, 2020), Peri-pandemic time period (March 13, 2020 to December 3, 2021)
- Where
- Canada
- Volunteers
- 919,928 people
- Sponsor
- McMaster University
Aging, Alzheimer Disease
The Nightlight Falls Prevention Study
This project will test the effectiveness of a novel intervention consisting of unobtrusive, low-intensity, horizontal and vertical lights that outline the bathroom or entry way doorframe in residents' rooms and provide visual…
- Conditions
- Aging, Alzheimer Disease, Dementia Alzheimers, Dementia of Alzheimer Type
- Trial name
- NCT05973448
- Testing
- Novel Lighting Condition, Control Lighting Condition
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- University of North Carolina, Chapel Hill
Elderly, Alzheimer Disease
Orexin and Tau Pathology in Cognitively Normal Elderly
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles.
- Trial name
- NCT03053908
- Testing
- Actigraphy, Nocturnal Polysomnograpahy (NPSG)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Accidental Falls
Effects of Tai-chi Programme on Mobility of People With Dementia
This study evaluates the feasibility and the preliminary effects of a simplified 10-step Tai-chi programme (a dyadic approach) on the mobility performance of people with mild to moderate dementia.
- Trial name
- NCT03341091
- Testing
- Tai-chi group
- Where
- 2 sites in Hong Kong
- Volunteers
- 26 people
- Sponsor
- The Hong Kong Polytechnic University
Sleep Disordered Breathing, Alzheimer's Disease
Sleep, Aging and Risk for Alzheimer's Disease
Our preliminary data show for in cognitively-normal elderly, that Sleep Disordered Breathing (SDB) is associated with the increase of cerebrospinal fluid (CSF) phosphorylated-Tau (P-Tau) and total-Tau (T-Tau), decreases in medial…
- Trial name
- SARA (NCT01962779)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- 2 sites in United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alzheimer's Dementia
European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS)
Brain changes associated with Alzheimer's disease may precede symptoms of Alzheimer's Dementia by over 20 years. The Investigators hope to be able to identify Alzheimer's disease at its very earliest stages when in theory…
- Trial name
- EPAD-LCS (NCT02804789)
- Where
- 30 sites in Belgium, France and 7 more
- Volunteers
- 2,095 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Stress, Psychological, Stress, Systemic
Systemic Stress Prevention Via Application SysLife© for Companies
The purpose of this study is to investigate the efficacy of systemic stress prevention via SysLife© application in a prospective, interventive, balanced, monocentric, explanatory pilot randomized controlled trial (RCT), with…
- Conditions
- Stress, Psychological, Stress, Systemic, Application
- Trial name
- NCT05828693
- Testing
- SysLife©, SysLife©, as intervention after closing the RCT-design
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University of Witten/Herdecke
Alzheimer's Disease
Health Evaluation in African Americans Using RAS Therapy
The purpose of this study is to determine if telmisartan, an FDA approved blood pressure medication, may also have beneficial effects on Alzheimer's disease prevention in African Americans, who are at high risk for Alzheimer's…
- Trial name
- HEART (NCT02471833)
- Testing
- Telmisartan 20mg, Telmisartan 40mg
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Emory University
Risk Behavior, Cognitive Decline
Efficacy of a Multidomain Intervention on Lifestyle Risk Factors for Dementia Prevention
Alzheimer's Disease (AD) and other Dementias have far-reaching consequences on the lives of sufferers and their loved ones, not to mention the impact on the healthcare system.
- Trial name
- NCT06748625
- Testing
- Luci Coach-Assisted Intervention
- Where
- Canada
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- LuciLab
Alzheimer Disease, Dementia
BarcelonaBeta Dementia Prevention Research Clinic: a Study on Risk Factors Disclosure
Alzheimer's disease (AD) is the leading cause of dementia and its prevalence is estimated to exceed 100 million affects by 2050, becoming the main public health problem worldwide.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT03847038
- Testing
- Preventive strategies advice and dementia risk estimate disclosure
- Where
- Spain
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Down's Syndrome, Dementia
Memantine and Down's Syndrome
This is a study to assess whether memantine is effective and safe in preventing age related cognitive deterioration and dementia in people with Down's syndrome (DS) age 40 and over.
- Conditions
- Down's Syndrome, Dementia, Learning Disabilities
- Trial name
- NCT00240760
- Testing
- Memantine Hydrochloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 180 people
- Sponsor
- King's College London
Alzheimer Disease, Dementia
The Retain Your Brain Health Study (RetainYourBrain.com)
The goal of this clinical trial is to test a cell phone-based online program that provides Alzheimer's risk assessments and memory tests over a 6-month period.
- Conditions
- Alzheimer Disease, Dementia, Healthy Participants, Brain Health
- Trial name
- NCT06027320
- Testing
- Brain Health Education, Alzheimer Disease Education
- Where
- United States
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- Retain Health, Inc