Clinical trials: Dementia Severe
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University
Psychomotor Agitation, Psychiatric Disorder
Randomised Trial Ketiapine Olanzapine Fast Sedation Agitated Patients Emergency Ward
comparison of intramuscular olanzapine and ketamine efficacy as first medication for fast sedation of patients with agitation and aggressive behavior.
- Conditions
- Psychomotor Agitation, Psychiatric Disorder, Emergency Psychiatric, Tranquilizers
- Trial name
- IM-OK-FAST (NCT03216941)
- Testing
- Ketamine
- Where
- Argentina
- Volunteers
- 500 people
- Sponsor
- Universidad Nacional de Rosario
Apathy in Dementia, Aged
Benefit of Virtual Reality Headset Use on Apathy in Older Adults With Major Neurocognitive Disorders
The goal of this clinical trial is to verify that virtual reality is tolerably compatible with apathetic pathologies in patients and residents with major neurocognitive disorders.
- Conditions
- Apathy in Dementia, Aged, Virtual Reality, Neurocognitive Disorders
- Trial name
- APATHIE_RV (NCT06047522)
- Testing
- Casque Lumeen
- Where
- 6 sites in France
- Volunteers
- 30 people
- Sponsor
- RIVAGES
Alzheimer Disease, Mild Cognitive Impairment
Validation of the Montreal Cognitive Assessment in Patients With Mild and Major Neurocognitive Disorder
The primary aim of our study is to investigate the specificity, the sensitivity, and the overall diagnostic accuracy of the MoCA for mild and major NCD in a German-speaking population.
- Trial name
- MoCA-Valid (NCT03581643)
- Where
- Switzerland
- Volunteers
- 430 people
- Sponsor
- Andreas Monsch
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Alzheimer s Disease
Deep Cervical Lymphovenous Anastomosis for Severe Alzheimer's Disease
Alzheimer's disease (AD) is a severe neurodegenerative disease with heavy social burden. Current drugs cannot reverse disease progression.
- Trial name
- DCLVA-AD (NCT07669272)
- Testing
- Deep Cervical Lymphovenous Anastomosis, Routine Treatment
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Southwest Hospital, China
Moderate to Severe Alzheimer's Disease
GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD)
The objective of this study is to evaluate the safety and efficacy of GV1001 administered subcutaneously in patients with moderate to severe Alzheimer's disease (AD).
- Trial name
- NCT05303701
- Testing
- GV1001 1.12mg
- Volunteers
- 750 people
- Sponsor
- Samsung Pharmaceutical Co., Ltd.
Alzheimer's Disease
Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
The primary purpose of this study is to determine whether ELND005 is effective in treating symptoms of agitation and aggression in patients with Alzheimer's disease
- Trial name
- NCT01735630
- Testing
- ELND005
- Where
- 70 sites in United States, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- OPKO Health, Inc.
Dementia
A Cohort Study of Early Onset Neurodegenerative Dementias Prognostic Factors
NEODEM is a multicenter cohort study of patients with early-onset degenerative dementia (before age 65), the main objective of which is to study behavioral disorders and in particular depression as functional prognostic factors…
- Trial name
- NEODEM (NCT04254094)
- Testing
- Neuropsychological scales
- Where
- France
- Volunteers
- 163 people
- Sponsor
- University Hospital, Bordeaux
Neurodegenerative Diseases, Stroke
The Role of Humanoid Robot in Neuropsychological Assessment and Cognitive Training.
The role of humanoid robot in neuropsychological assessment and conducting cognitive training in patients with dementia and severe brain injury" Objectives Use of robotic solutions to carry out diagnostic and rehabilitation…
- Trial name
- NCT05788133
- Testing
- treatment and screening by neuropsychological tests on humanoid robot
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Major Depressive Disorder, Dementia
Screening for Mental Health Concerns for at-Risk Community Living Chinese Seniors
The study is designed to answer the following research questions: 1. Evaluate the acceptability of mental health screening and of the instruments used in a sample of community living Chinese seniors; 2.
- Trial name
- NCT00433238
- Testing
- Participants will be screened for depression and cognitive impairment, then receive screening results.
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Major Depressive Disorder
Research on Pathophysiology and Treatment in Depression Using Brain Derived Neurotrophic Factor and Amyloid Neuroimaging
Target of the research Based on change of Brain-derived neurotrophic factor and other pro-inflammatory cytokine along with symptom improvement following treatment, the investigators are trying to find the new treatment target…
- Trial name
- NCT02983838
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Dementia, Dementia, Vascular
Advanced Cognitive Stimulation Therapy Hong Kong (ACST-HK)
This study is a feasibility randomized controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia in Hong Kong.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- NCT04555629
- Testing
- Advanced Cognitive Stimulation Therapy Hong Kong
- Volunteers
- 32 people
- Sponsor
- University College, London
Alzheimer Disease, Mild Cognitive Impairment
Turkish Speech Analysis Development Study
The aim of this observational study is to define speech alterations in the diagnosis of AD-related minor neurocognitive disorder (m-NBB) and major neurocognitive disorder (M-NBB).
- Trial name
- TurkSpeech (NCT05732519)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- mihrimah ozturk
Alzheimer Disease, Dementia
Faith-Based Toolbox for African Americans With Dementia
The purpose of this study is to create and test faith-based activities that might be useful for African American adults with moderate and severe dementia and their caregivers.
- Trial name
- NCT04325204
- Testing
- Faith-based Home Activity Toolbox (Faith-HAT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Emory University
Dementia, Alzheimer Disease
Treatment of Severe Alzheimer's Disease: Evaluation of Efficacy and Safety of Galantamine Hydrobromide in a Controlled Study
The purpose of this study is to assess the effectiveness and safety of galantamine hydrobromide treatment in patients with severe Alzheimer's disease.
- Trial name
- NCT00216593
- Testing
- galantamine hydrobromide
- Volunteers
- 415 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Parkinson's Disease, Alzheimer's Disease
Biomarkers in Neural Disorders
This study seeks to establish the sensitivity and specificity of what appears to be a unique brainstem biomarker of Parkinson's Disease (PD) - an electrically induced olygosynaptic nasotrigeminal reflex response - in…
- Conditions
- Parkinson's Disease, Alzheimer's Disease, Progressive Supranuclear Palsy, Essential Tremor
- Trial name
- NCT02761707
- Testing
- Electrical Brainstem Responses, Olfactory Tests, Visual Deprivation
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dementia, Major Neurocognitive Disorder
Confirmatory Clinical Trial for Verifying the Efficacy and Safety of 'ALZGUARD' as a Digital Dementia Diagnostic Aid-Tool for the Diagnosis of the Major Neurocognitive Disorders
The goal of this clinical trial is to evalute the efficacy of ALZGUARD, a smartphone-based digital therapeutic(DTx), in comparison to diagnosis by medical doctors, as weel as to assess the safety of the application.
- Trial name
- NCT06615167
- Testing
- ALZGUARD
- Where
- 3 sites in South Korea
- Volunteers
- 122 people
- Sponsor
- HAII corp.ltd
Traumatic Brain Injury, Mild Traumatic Brain Injury
Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons
Approximately 5.3 million people live with a long-term disability resulting from a traumatic brain injury (TBI) and between 5-8% of those older than 60 suffer from Alzheimer's disease or other forms of dementia (ADRD).
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Alzheimer's Disease, Brain Injury Traumatic Moderate
- Trial name
- NCT05048966
- Testing
- Group Wellness Class 1, Group Wellness Class 2
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Kessler Foundation
Alzheimer Disease
Imaging of New Learning in Severe Alzheimer's Disease Patients
This research attempts to better understand the altered and preserved memory mechanisms in Alzheimer disease, particularly to better apprehend learning implicit memory processes, and give a scientific support to non-pharmalogical…
- Trial name
- INCAS (NCT01839422)
- Testing
- Memory assessment, Brain imaging examination MRI
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen