Clinical trials: Demyelinating Autoimmune Diseases, CNS
Multiple Sclerosis, Urinary Incontinence
Effects of Spinal Stabilization on the Pelvic Floor in Women With Multiple Sclerosis
The purpose of this study was to investigate the effects of spinal stabilization exercises focusing on the pelvic floor on core stability, urinary symptoms and pelvic floor muscle function in women with Multiple Sclerosis and…
- Conditions
- Multiple Sclerosis, Urinary Incontinence, Lower Urinary Tract Symptoms
- Trial name
- NCT07074587
- Testing
- Pelvic floor muscle exercises, Spinal stabilization exercises focusing on the pelvic floor + Pelvic floor muscle exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Abant Izzet Baysal University
Multiple Sclerosis
Use of Two Deep Brain Stimulation (DBS) Electrodes to Treat Post-Traumatic Tremor
The purpose of this research study is to: 1. Determine whether deep brain stimulation (DBS) with two leads (very thin coiled wires) placed unilaterally (on one side of the brain) is beneficial to patients with multiple sclerosis…
- Trial name
- NCT00954421
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Florida
Multiple Sclerosis
The MS-LINK™ Outcomes Study
The Multiple Sclerosis (MS) Leadership and Innovation Network (MS-LINK™) is comprised of networks working cooperatively to advance Multiple Sclerosis (MS) science and improve MS participant outcomes.
- Trial name
- NCT04735406
- Where
- 9 sites in United States
- Volunteers
- 2,182 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Multiple Sclerosis, Fatigue
Dalfampridine for Imbalance in Multiple Sclerosis
Dalfampridine is a new medication that was FDA approved in 2010 to improve walking speed in people with Multiple Sclerosis (MS).
- Trial name
- NCT01444300
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Acquired Brain Injury (Including Stroke), Spinal Cord Injury
Clinical Investigation to Validate the Safety and Performance of Integrating Functional Electrical Stimulation Into the ABLE Exoskeleton
The primary objective of this study is to validate the safety and clinical performance of the ABLE Exoskeleton with integrated Functional Electrical Stimulation (ABLE FES) in individuals with neurological conditions that impair…
- Conditions
- Acquired Brain Injury (Including Stroke), Spinal Cord Injury, Multiple Sclerosis
- Trial name
- NCT07550699
- Testing
- ABLE Exoskeleton with Functional Electrical Stimulation (ABLE FES)
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- ABLE Human Motion S.L.
Multiple Sclerosis
Chewing Under Dual-Tasking in MS
This study aims to investigate the effects of visual, auditory, and motor dual-task conditions on chewing performance in individuals with multiple sclerosis, compared with healthy controls.
- Trial name
- NCT07366216
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Multiple Sclerosis
This is an Open-Label Study to Assess the Safety and Efficacy of GC012F in Patients With Multiple Sclerosis
This is an open-label,early-stage exploratory clinical study to evaluate the safety and preliminary efficacy of GC012F CAR T cell injection in Multiple Sclerosis subjects.
- Trial name
- NCT07364487
- Testing
- GC012F CAR-T Cell Injection
- Where
- China
- Sponsor
- Huashan Hospital
Relapsing-remitting Multiple Sclerosis
Mass Balance Study of MT-1303
The purpose of this study is to investigate the absorption, metabolism and excretion of MT-1303 in healthy subjects.
- Trial name
- NCT02293967
- Testing
- MT-1303
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma Corporation
Multiple Sclerosis, Clinically Isolated System
Betaferon® Regulatory Post-Marketing Surveillance
To identify problems/questions about following items in the clinical practice using Betaferon 1. Unknown adverse event (especially serious adverse event) 2. Identification of adverse event occurred in the real practice 3.
- Trial name
- NCT01414816
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Where
- South Korea
- Volunteers
- 355 people
- Sponsor
- Bayer
SCAD, Addison Disease
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
- Conditions
- SCAD, Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome
- Trial name
- NCT03941184
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic
Multiple Sclerosis
Relationship of Position Sense With Gait and Balance in Patients With Multiple Sclerosis
Balance and gait disturbances are among the most common problems in patients with Multiple Sclerosis (MS). There is evidence of decreased foot sole sensation in MS patients.
- Trial name
- NCT04547400
- Testing
- assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis, Spasticity, Muscle
A Study to Evaluate the Long-term Safety of Arbaclofen Extended-Release Tablets for Patients With Spasticity Due to MS
Spasticity is a common complication in MS and occurs in up to 84% of patients. The main sign of spasticity is resistance to passive limb movement characterized by increased resistance to stretching, clonus, and exaggerated deep…
- Trial name
- OS440-3005 (NCT03319732)
- Testing
- Arbaclofen
- Where
- United States
- Volunteers
- 323 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Multiple Sclerosis
Relationship Between Cognition, Workforce Participation and Well-Being in Individuals With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic neurodegenerative disease and a leading cause of reduced workforce participation due to neurological illness in Western countries.
- Trial name
- NCT07211516
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Region Gävleborg
Multiple Sclerosis, Relapsing-Remitting
Monitoring of Patients Followed for a Multiple Sclerosis and Treated by Dimethyl-fumarate
The dimethyl fumarate is an oral drug, indicated in the treatment of the relapsing-remitting multiple sclerosis (MS) , which efficacy and safety has been assessed and validated in two randomised, placebo phase-controlled III…
- Trial name
- SURV-SEP (NCT02901106)
- Testing
- Dimethyl fumarate
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Multiple Sclerosis
Impact of Annual Versus Biannual Infusions of Ocrelizumab in Patients With Active MS,After 2 Years of Initial Treatment, on Freedom From Radiological Disease Activity at Two Years: a Multicenter Randomized Controlled Non-inferiority Trial
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and the leading cause of severe non-traumatic disability in young people, affecting 110,000 people in France.
- Trial name
- WINDOCRE (NCT05999604)
- Testing
- Ocrelizumab Injection [Ocrevus]
- Where
- 11 sites in France
- Volunteers
- 244 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Multiple Sclerosis
Kesimpta® (Ofatumumab) in Swiss Multiple Sclerosis Patients - an Observational Study
This is a multi-center, observational study carried out in Switzerland that aims to describe the effects of Ofatumumab in a setting of routine medical care.
- Trial name
- KOSMOS (NCT05285904)
- Testing
- Ofatumumab
- Where
- 13 sites in Switzerland
- Volunteers
- 107 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Implementing Physical Activity Guidelines for Adults With MS
The proposed project will evaluate two methods of implementation of the new Physical Activity Guidelines (PAGs) for Adults with Multiple Sclerosis (MS) living in two Ontario communities.
- Trial name
- NCT02100020
- Testing
- Direct Referral to physical activity
- Where
- 2 sites in Canada
- Volunteers
- 94 people
- Sponsor
- McMaster University
Multiple Sclerosis
Prediction of Non-motor Symptoms in Fully Ambulatory MS Patients Using Vocal Biomarkers
The investigator will set up a study evaluating vocal biomarkers in people with MS in order to identify persons with non-motor symptoms: depression, cognitive deterioration, and fatigue.
- Trial name
- COMMITMENT (NCT05561621)
- Testing
- Voice analysis
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Multiple Sclerosis (MS) - Relapsing-remitting
Educational Programs Based on Healthy Habits to Improve Quality of Life and Psychosocial Profile in Women With Neurodegenerative Diseases: the ADVICE Protocol Study (Phase 2)
This phase of the project aims to compare in-person, supervised educational programs (EP) with online self-guided EPs in individuals with relapsing-remitting multiple sclerosis.
- Trial name
- ADVICE Phase 2 (NCT06884579)
- Testing
- Strength training, nutrition, and behavioral training, Self-Guided and Unsupervised Program with General Recommendations
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Almeria
Multiple Sclerosis
Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS
Several investigations have suggested that polyunsaturated fatty acids may promote therapeutic effects in MS. This pilot study will determine whether omega-6 polyunsaturated fatty acids (PUFAs),in the form of linoleic acid,can…
- Trial name
- PLACATE-MS (NCT00638196)
- Testing
- Linoleic Acid/Oleic Acid
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Rochester
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