Clinical trials: Demyelinating Diseases
Multiple Sclerosis
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VT7208 in Healthy Participants and MS Patients
Part 1 of this study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of VT7208 in healthy volunteers.
- Trial name
- NCT07085507
- Testing
- VT7208
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vidya Therapeutics Inc
Canavan Disease
rAAV-Olig001-ASPA Gene Therapy for Treatment of Children With Typical Canavan Disease
Canavan Disease is a congenital white matter disorder caused by mutations to the gene encoding for aspartoacylase (ASPA). Expression of ASPA is restricted to oligodendrocytes, the sole white matter producing lineage in the brain.
- Trial name
- CAN-GT (NCT04833907)
- Testing
- rAAV-Olig001-ASPA, Levetiracetam, Prednisone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Myrtelle Inc.
Multiple Sclerosis
Development of a Novel Functional Eye-Tracking Software Application for Multiple Sclerosis
This study aims to develop and validate a sensitive and non-invasive eye-tracking software application. This study will obtain participant responses to brief cognitive tests designed to evaluate several key functions known to be…
- Trial name
- NCT05061953
- Testing
- Eye-Tracking
- Where
- 2 sites in Canada
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Innodem Neurosciences
Multiple Sclerosis, Mitochondrial Alteration
Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) and is one of the most common neurological diseases, often leading to disability of the patients.
- Trial name
- MS-MIDY (NCT03052595)
- Testing
- Oral glucose tolerance test, Testing of autonomous nervous system function, Stroop test
- Where
- Slovakia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Multiple Sclerosis
Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with Multiple Sclerosis.
- Trial name
- STEM (NCT03983681)
- Testing
- Strategy-Based Training to Enhance Memory (STEM)
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis, Neurophysiologic Abnormality
Investigation The Effect of Conventional Vs. Individualized tDCS Intensity to Achieve Uniform E-Fields
Background: Replications of studies employing transcranial direct stimulation (tDCS) shows great variations in physiological and behavioral outcomes.
- Trial name
- NCT05962281
- Testing
- Transcranial direct current stimulation (tDCS)
- Volunteers
- 30 people
- Sponsor
- Koen Cuypers
Multiple Sclerosis, Gait Disorders, Neurologic
Multi-joint Muscle Fatigability and Gait Performance in People With Multiple Sclerosis
The purpose of this study is to compare walking to leg strength and endurance in people with multiple sclerosis (PwMS). Using these findings, we hope to be better understand what causes PwMS to have problems walking.
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Fatigue
- Trial name
- MS_Gait (NCT03735654)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Relapsing-Remitting Multiple Sclerosis
Combination Therapy (Provigil + Avonex) to Treat Cognitive Problems in MS
MS has been associated with fatigue, attention problems, and a number of cognitive difficulties. There is no treatment approved yet to treat these problems.
- Trial name
- NCT00210301
- Testing
- Provigil (modafinil)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Institute for Clinical Research
Progressive Multiple Sclerosis (PMS)
The Effects of a 12-week In-phase Bilateral Exercise Programme on the Corticospinal Plasticity in People With Progressive Multiple Sclerosis
This study investigates whether a structured exercise program using coordinated movements of both arms can improve brain and motor function in people with Progressive Multiple Sclerosis (MS).
- Trial name
- NCT07548242
- Testing
- In-Phase Bilateral Upper Limb Exercise Program
- Where
- Cyprus
- Volunteers
- 5 people
- Sponsor
- Marinos Chatzikonstantinou
Multiple Sclerosis
Effect of a Mobile Health App on Pain and Quality of Life in Patients With Neuropathic Pain in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, leading to inflammation, neurodegeneration, and a range of physical and invisible symptoms.
- Trial name
- NCT06982742
- Testing
- Mobile Health App for Neuropathic Pain Management in MS
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Meryem Kocaslan Toran
Multiple Sclerosis
The Feasibility of Frame Running as an Exercise Option for People With Multiple Sclerosis
There is ample evidence that regular exercise can reduce MS specific symptoms and improve health and wellbeing in people with MS.
- Trial name
- NCT05234879
- Testing
- Frame Running
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Queen Margaret University
Multiple Sclerosis, Pregnancy
Immune System Effects in Children Born to Women With Multiple Sclerosis Treated With Monoclonal Antibody Therapy During Pregnancy
The goal of this observational study is to learn about consequences for the child when the mother is treated with rituximab (or other monoclonal CD-20 antibodies) before or during pregnancy.
- Trial name
- NCT07149662
- Testing
- monoclonal CD-20 antibodies, No Drug, Other treatment
- Where
- Sweden
- Volunteers
- 111 people
- Sponsor
- Region Stockholm
Guillain-Barre Syndrome
Ultrasonography and Electrophysiology in GBS
Description of the time course of nerve ultrasonography changes in correlation to nerve conduction studies (NCS) and clinical course.
- Trial name
- NCT05284786
- Testing
- nerve ultrasonography
- Volunteers
- 45 people
- Sponsor
- Assiut University
Multiple Sclerosis
A Multi-Site Trial of MS INFoRm (Fatigue Management Resource)
People with MS commonly experience extreme fatigue that negatively impacts their ability to engage in a full range of daily activities, quality of life, and employment.
- Trial name
- NCT03362541
- Testing
- MS INFoRm, Usual Care Control Group
- Where
- 3 sites in Canada
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Dr. Marcia Finlayson
Multiple Sclerosis
Comprehensive Fall Prevention and Detection in Multiple Sclerosis
The purpose of this study is to examine whether an exercise and educational classroom program can help reduce falls in people with Multiple Sclerosis who fall frequently.
- Trial name
- FFF (NCT02583386)
- Testing
- Free From Falls fall prevention program, Electronic Fall Detector
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Portland VA Medical Center
Multiple Sclerosis
Efficacy and Safety of GTR in Comparison to Copaxone®
The purpose of this study is demonstrate that efficacy and safety of Synthon's glatiramer acetate (GTR) is equivalent to Copaxone® (Teva) in patients with relapsing remitting multiple sclerosis
- Trial name
- GATE (NCT01489254)
- Testing
- Glatiramer Acetate (GTR), Glatiramer Acetate (Copaxone®)
- Where
- 133 sites in United States, Belarus and 17 more
- Volunteers
- 794 people
- Sponsor
- Synthon BV
Autoimmune Encephalomyelitis
Neuroinflammatory PET Imaging in Autoimmune Encephalomyelitis
Autoimmune encephalomyelitis is a heterogeneous group of central nervous system (CNS) autoimmune diseases characterized by the production of anti-neuron-associated autoantibodies which target neuronal surface proteins, synaptic…
- Trial name
- NCT05293405
- Testing
- 18F-DPA-714 PET
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Multiple Sclerosis (MS)
Serious Game Rehabilitation and Brain Plasticity in MS
This prospective, interventional, longitudinal, multicentre study aims to evaluate the impact of the "Serious game", an innovative cognitive remediation tool on brain reorganization in Multiple sclerosis patients, using…
- Trial name
- REVEILLE (NCT07474129)
- Testing
- Serious Game
- Volunteers
- 40 people
- Sponsor
- Lille Catholic University
Multiple Sclerosis, Relapsing-Remitting
Effects of Chiropractic Care on Cytokine Levels in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with an imbalance between pro- and anti-inflammatory markers (cytokines) resulting in a demyelinating and neurodegenerative disease.
- Trial name
- NCT04972929
- Testing
- Spinal Manipulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis
A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis
The main purpose of this study is to evaluate the safety and efficacy of LY3541860 in adult participants with multiple sclerosis that gets worse and gets better.
- Trial name
- NCT06220669
- Testing
- LY3541860
- Where
- 20 sites in United States, France and 5 more
- Volunteers
- 63 people
- Sponsor
- Eli Lilly and Company